Cited by 209Schizophrenia research and treatmentGenetic Associations and EpidemiologyGlobal Cancer Incidence and Screening

Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis

Catts, V. S., Catts, S. V., O’Toole, B. I., Frost, A. D. J.·2008·Acta Psychiatrica Scandinavica

Abstract

Objective: Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method: A meta‐analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first‐degree relatives and compared with general population samples. Results: The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95–1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01–1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84–0.94) and parents (SIR = 0.90, CI 0.88–0.93) was significantly reduced. A meta‐regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion: The meta‐analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect.

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Crossref · 10.1111/j.1600-0447.2008.01163.x

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Authors
Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J.
Affiliations
  • The University of Queensland (AU)
  • The University of Sydney (AU)
  • Royal Brisbane and Women's Hospital (AU)
Corresponding author
  • Catts, V. S.
  • Catts, S. V.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2008-03-10
Volume
117
Issue
5
Pages
323-336
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W1965388866
Cited by
209
References
63
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 13
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
schizophrenia, cancer incidence, lung cancer, breast cancer, first-degree relatives, siblings, parents, smoking, standardized incidence ratio, cancer risk
MeSH terms
Aged, Urinary Bladder Neoplasms, Humans, Lung Neoplasms, Neoplasms, Risk Factors, Schizophrenia, Incidence, Prevalence

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