Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis
Abstract
Objective: Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method: A meta‐analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first‐degree relatives and compared with general population samples. Results: The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95–1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01–1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84–0.94) and parents (SIR = 0.90, CI 0.88–0.93) was significantly reduced. A meta‐regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion: The meta‐analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect.
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Other studies found an increased or no different overall risk of cancer in patients with schizophrenia compared to the general population.
“On the other hand, other studies found an increased (9,21,28,(449)(450)(451) or no different (292,419,452,453) overall risk of cancer in patients with schizophrenia compared to the general population.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [453]
Cites
Excess mortality of mental disorder
Harris, C., & Barraclough, B. (1998) · British Journal of Psychiatry · doi:10.1192/bjp.173.1.11 · Cited by 1,881 · see citing works
de Leon, J., & Diaz, F. J. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.02.010 · Cited by 1,276 · see citing works
<i>Meta-analysis</i> Spurious precision? Meta-analysis of observational studies
Egger, M., Schneider, M., & Smith, G. D. (1998) · BMJ · doi:10.1136/bmj.316.7125.140 · Cited by 997 · see citing works
Medical Comorbidity in Schizophrenia
Jeste, D. V., Gladsjo, J. A., Lindamer, L. A., & Lacro, J. P. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.3.413 · Cited by 614 · see citing works
Medical complications of anorexia nervosa and bulimia nervosa
Mitchell, J. E., & Crow, S. J. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000228768.79097.3e · Cited by 492 · see citing works
Mortality and Causes of Death in First Admitted Schizophrenic Patients
Mortensen, P. B., & Juel, K. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.2.183 · Cited by 412 · see citing works
Mortality in a Cohort of Patients with Schizophrenia: A Record Linkage Study*
Newman, S. C., & Bland, R. C. (1991) · The Canadian Journal of Psychiatry · doi:10.1177/070674379103600401 · Cited by 372 · see citing works
Greenland, S. (2001) · Biostatistics · doi:10.1093/biostatistics/2.4.463 · Cited by 359 · see citing works
Shapiro, S. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117324 · Cited by 354 · see citing works
Medical comorbidity in women and men with schizophrenia: A population-based controlled study
Carney, C. P., Jones, L., & Woolson, R. F. (2006) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2006.00563.x · Cited by 343 · see citing works
Marks, R. (2000) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2000.00693.x · Cited by 342 · see citing works
Mental disorders and cause-specific mortality
Joukamaa, M., HeliöVaara, M., Knekt, P., Aromaa, A., Raitasalo, R., & Lehtinen, V. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.179.6.498 · Cited by 328 · see citing works
Incidence of Cancer Among Persons With Schizophrenia and Their Relatives
Lichtermann, D., Ekelund, J., Pukkala, E., Tanskanen, A., & Lönnqvist, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.573 · Cited by 292 · cited 7× · see citing works
“(6) Finland 1971–1996 20 914 ⁄ 18 217 Dalton et al.”
BackgroundResultInfluentialApoptotic mechanisms and the synaptic pathology of schizophrenia
Glantz, L. A., Gilmore, J. H., Lieberman, J. A., & Jarskog, L. F. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.08.014 · Cited by 289 · see citing works
At least one in seven cases of cancer is caused by smoking. Global estimates for 1985
Parkin, D. M., Pisani, P., López, A. D., & Masuyer, E. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590411 · Cited by 277 · see citing works
Theories of schizophrenia: a genetic-inflammatory-vascular synthesis
Hanson, D. R., & Gottesman, I. I. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-7 · Cited by 274 · see citing works
Tworoger, S. S., Sluss, P. M., & Hankinson, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3369 · Cited by 247 · see citing works
Heterogeneity in Meta-analysis of Data from Epidemiologic Studies: A Commentary
Colditz, G. A., Burdick, E., & Mosteller, F. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117644 · Cited by 245 · see citing works
SMOKING AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Sethi, J. M., & Rochester, C. L. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70008-3 · Cited by 234 · see citing works
Apoptotic mechanisms in the pathophysiology of schizophrenia
Jarskog, L. F., Glantz, L. A., Gilmore, J. H., & Lieberman, J. A. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.010 · Cited by 214 · see citing works
Adjustment of meta-analyses on the basis of quality scores should be abandoned
Herbison, P., Hay-Smith, J., & Gillespie, W. J. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.03.008 · Cited by 207 · see citing works
Dopamine Antagonists and the Development of Breast Cancer
Wang, P. S., Walker, A. M., Tsuang, M. T., Orav, E. J., Glynn, R. J., Levin, R., & Avorn, J. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1147 · Cited by 196 · see citing works
Invited commentary: benefits of heterogeneity in meta-analysis of data from epidemiologic studies
Berlin, J. A. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117645 · Cited by 191 · see citing works
Smoking-attributable mortality and years of potential life lost — United States, 1988
SAM (1991) · Patient Education and Counseling · doi:10.1016/0738-3991(91)90081-f · Cited by 185 · see citing works
The incidence of cancer in schizophrenic patients.
Mortensen, P. B. (1989) · Journal of Epidemiology and Community Health · doi:10.1136/jech.43.1.43 · Cited by 175 · see citing works
Excess cancer mortality in Western Australian psychiatric patients due to higher case fatality rates
Lawrence, D., D'Arcy, C., Holman, J., Jablensky, A. V., Threfall, T. J., & Fuller, S. A. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101005382.x · Cited by 174 · cited 1× · see citing works
“(34) Western Australia 1982–1995 Lawrence et al.”
Engeland, A., Andersen, A., Haldorsen, T., & Tretli, S. (1996) · Cancer Causes & Control · doi:10.1007/bf00051881 · Cited by 163 · see citing works
Reduced cancer incidence among patients with schizophrenia
Barak, Y., Achiron, A., Mandel, M., Mirecki, I., & Aizenberg, D. (2005) · Cancer · doi:10.1002/cncr.21574 · Cited by 159 · see citing works
Cancer in schizophrenia: is the risk higher or lower?
Grinshpoon, A., Barchana, M., Ponizovsky, A., Lipshitz, I., Nahon, D., Tal, O., Weizman, A., & Levav, I. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.06.016 · Cited by 157 · see citing works
The occurence of cancer in first admitted schizophrenic patients
Mortensen, P. B. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90028-0 · Cited by 142 · see citing works
Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993
Dalton, S. O., Mellemkjær, L., Thomassen, L., Mortensen, P. B., & Johansen, C. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.11.009 · Cited by 142 · see citing works
Mortality and causes of death in schizophrenic patients in Denmark
Mortensen, P. B., & Juel, K. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb05466.x · Cited by 138 · see citing works
Prevalence of Hyperprolactinemia in Schizophrenia
Montgomery, J., Winterbottom, E., Jessani, M., Kohegyi, E., Fulmer, J., Seamonds, B., & Josiassen, R. C. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n1108 · Cited by 130 · see citing works
Cancer risk among users of neuroleptic medication: a population-based cohort study
Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603259 · Cited by 123 · see citing works
Schizophrenia and cancer: an epidemiological study
Goldacre, M. J., Kurina, L. M., Wotton, C. J., Yeates, D., & Seagroatt, V. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.4.334 · Cited by 123 · see citing works
Prolactin and breast cancer risk
Tworoger, S. S., & Hankinson, S. E. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.01.032 · Cited by 119 · see citing works
Risk Factors for Bladder Cancer
Janković, S., & Radosavljević, V. (2007) · Tumori Journal · doi:10.1177/030089160709300102 · Cited by 119 · see citing works
Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?
Catts, V. S., & Catts, S. V. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00077-8 · Cited by 118 · see citing works
Self-citationPhysical health and schizophrenia
Mitchell, A. J., & Malone, D. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000228767.71473.9e · Cited by 112 · see citing works
Cancer incidence of schizophrenic patients. Results of record linkage studies in three countries
Gulbinat, W., Dupont, A., Jablensky, A., Jensen, O. M., Marsella, A., Nakane, Y., & Sartorius, N. (1992) · British Journal of Psychiatry · doi:10.1192/s0007125000297080 · Cited by 110 · see citing works
The effect of lifestyle factors on gynaecological cancer
Rieck, G. C., & Fiander, A. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2005.10.010 · Cited by 99 · see citing works
Engeland, A., Haldorsen, T., Andersen, A., & Tretli, S. (1996) · Cancer Causes & Control · doi:10.1007/bf00052943 · Cited by 97 · see citing works
Preventable physical illness in people with mental illness
Lawrence, D. M., Holman, D., & Jablensky, A. V. (2001) · UWA Profiles and Research Repository (UWA) · Cited by 93 · see citing works
Neuroleptic medication and reduced risk of prostate cancer in schizophrenic patients
Mortensen, P. B. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb10325.x · Cited by 90 · see citing works
Health behavior in psychiatric in‐patients compared with a German general population sample
Kilian, R., Becker, T. M., Krüger, K., Schmid, S., & Frasch, K. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00850.x · Cited by 88 · see citing works
Detection of functional single-nucleotide polymorphisms that affect apoptosis
Harris, S. L., Gil, G. A., Robins, H. S., Hu, W., Hirshfield, K. M., Bond, E. E., Bond, G. L., & Levine, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508390102 · Cited by 81 · see citing works
Neuroleptic treatment and other factors modifying cancer risk in schizophrenic patients
Mortensen, P. B. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02839.x · Cited by 75 · see citing works
Pulmonary function, smoking cessation and 30 year mortality in middle aged Finnish men
Pelkonen, M. (2000) · Thorax · doi:10.1136/thorax.55.9.746 · Cited by 71 · see citing works
Risk for Cancer in Parents of Patients With Schizophrenia
Dalton, S. O., Laursen, T. M., Mellemkjær, L., Johansen, C., & Mortensen, P. B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.903 · Cited by 69 · see citing works
Schizophrenia and the risk for breast cancer
Dalton, S. O., Laursen, T. M., Mellemkjær, L., Johansen, C., & Mortensen, P. B. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00430-9 · Cited by 61 · see citing works
Trends in smoking prevalence in Danish adults, 1964—1994
Osler, M., Prescott, E., Gottschau, A., Bjerg, A., Hein, H. O., Sjøl, A., & Schnohr, P. (1998) · Scandinavian Journal of Social Medicine · doi:10.1177/14034948980260041101 · Cited by 60 · see citing works
Smoking in First-Episode Patients With Schizophrenia
McEvoy, J. P., & Brown, S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1120a · Cited by 60 · see citing works
Cancer risk among parents and siblings of patients with schizophrenia
Levav, I., Lipshitz, I., Novikov, I., Pugachova, I., Kohn, R., Barchana, M., Ponizovsky, A. M., & Werner, H. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.024943 · Cited by 59 · see citing works
A Needs Survey among Patients in Leros Asylum
Bouras, N., Webb, Y., Clifford, P., Papadatos, Y., & Zouni, M. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.1.75 · Cited by 58 · see citing works
Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines
Catts, V. S., Catts, S. V., McGrath, J. J., Feron, F. P., McLean, D. E., Coulson, E. J., & Lutze-Mann, L. H. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.03.016 · Cited by 53 · see citing works
Self-citationHelakorpi, S., Martelin, T., Torppa, J., Patja, K., Vartiainen, E., & Uutela, A. (2004) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2003.015925 · Cited by 49 · see citing works
Jablensky, A. V., & Lawrence, D. M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.579 · Cited by 45 · see citing works
Baldwin, J. A. (1980) · Springer eBooks · doi:10.1007/978-94-009-8706-7_21 · Cited by 44 · see citing works
Health Behaviors and Health Status of Older Women With Schizophrenia
Dickerson, F., Pater, A., & Origoni, A. E. (2002) · Psychiatric Services · doi:10.1176/appi.ps.53.7.882 · Cited by 37 · see citing works
Kahn, L. S., Fox, C. H., Krause-Kelly, J., Berdine, D. E., & Cadzow, R. B. (2006) · Women & Health · doi:10.1300/j013v42n03_07 · Cited by 34 · see citing works
[Diagnosis of cancer and autopsy rate in schizophrenic patients].
Mortensen, P. B. (1987) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Firth, J., Siddiqi, N., Koyanagi, A., Siskind, D., Rosenbaum, S., Galletly, C., Allan, S., Caneo, C., Carney, R., Carvalho, A. F., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30132-4 · Cited by 1,531 · see citing works
Premature Mortality Among Adults With Schizophrenia in the United States
Olfson, M., Gerhard, T., Huang, C., Crystal, S., & Stroup, T. S. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1737 · Cited by 1,083 · see citing works
Schizophrenia, “just the facts” 4. Clinical features and conceptualization
Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.005 · Cited by 1,031 · see citing works
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study
Crump, C., Winkleby, M. A., Sundquist, K., & Sundquist, J. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050599 · Cited by 619 · see citing works
Cancer-Related Mortality in People With Mental Illness
Kisely, S. R., Crowe, E., & Lawrence, D. M. (2012) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.278 · Cited by 364 · see citing works
Inflammation and the two-hit hypothesis of schizophrenia
Feigenson, K. A., Kusnecov, A., & Silverstein, S. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.006 · Cited by 280 · see citing works
Callaghan, R. C., Veldhuizen, S., Jeysingh, T., Orlan, C., Graham, C., Kakouris, G., Remington, G., & Gatley, J. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.09.014 · Cited by 255 · see citing works
Tabarés-Seisdedos, R., & Rubenstein, J. L. R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.2 · Cited by 225 · see citing works
Levitt, P., & Campbell, D. B. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37934 · Cited by 234 · see citing works
Influence of antipsychotics on mortality in schizophrenia: systematic review
Weinmann, S., Read, J., & Aderhold, V. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.05.018 · Cited by 224 · see citing works
Ibáñez, K., Boullosa, C., Tabarés‐Seisdedos, R., Baudot, A., & Valencia, A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004173 · Cited by 203 · see citing works
Catalá-López, F., Suárez‐Pinilla, M., Suárez‐Pinilla, P., Valderas, J. M., Gómez-Beneyto, M., Martı́nez, S., Balanzá‐Martínez, V., Climent, J., Valencia, A., McGrath, J. J., et al. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000356498 · Cited by 201 · see citing works
Cancer care for individuals with schizophrenia
Irwin, K. E., Henderson, D. C., Knight, H. P., & Pirl, W. F. (2013) · Cancer · doi:10.1002/cncr.28431 · Cited by 191 · see citing works
Review: Mortality in schizophrenia: a measurable clinical endpoint
Bushe, C. J., Taylor, M., & Haukka, J. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810382468 · Cited by 185 · see citing works
Cancer diagnosis in people with severe mental illness: practical and ethical issues
Howard, L. M., Barley, E. A., Davies, E., Rigg, A. S., Lempp, H. K., Rose, D. S., Taylor, D. M., & Thornicroft, G. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70085-1 · Cited by 182 · see citing works
Cancer mortality in patients with schizophrenia: An 11‐year prospective cohort study
Tran, E., Rouillon, F., Loze, J., Casadebaig, F., Philippe, A., Vitry, F., & Limosin, F. (2009) · Cancer · doi:10.1002/cncr.24383 · Cited by 173 · see citing works
Cigarette smoking and mortality risk in people with schizophrenia
Kelly, D. L., McMahon, R. P., Wehring, H. J., Liu, F., Mackowick, K. M., Boggs, D. L., Warren, K. R., Feldman, S., Shim, J.-C., Love, R. C., et al. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp152 · Cited by 158 · see citing works
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases
Tabarés‐Seisdedos, R., Dumont, N., Baudot, A., Valderas, J. M., Climent, J., Valencia, A., Crespo‐Facorro, B., Vieta, E., Gómez-Beneyto, M., Martı́nez, S., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70041-9 · Cited by 136 · see citing works
A cohort study on mental disorders, stage of cancer at diagnosis and subsequent survival
Chang, C., Hayes, R. D., Broadbent, M. T. M., Hotopf, M. H., Davies, E., Møller, H., & Stewart, R. J. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004295 · Cited by 133 · see citing works
Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia
Zhuo, C., Wang, D., Zhou, C., Chen, C., Li, J., Tian, H., Li, S., Ji, F., Liu, C., Chen, M., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00001 · Cited by 127 · see citing works
Wiklund, E. D., Catts, V. S., Catts, S. V., Ng, T. F., Whitaker, N. J., Brown, A. J., & Lutze-Mann, L. H. (2009) · International Journal of Cancer · doi:10.1002/ijc.24813 · Cited by 119 · see citing works
Self-citationInverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders
Tabarés‐Seisdedos, R., & Rubenstein, J. L. R. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3464 · Cited by 114 · see citing works
Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia
Koga, M., Ishiguro, H., Yazaki, S., Horiuchi, Y., Arai, M., Niizato, K., Iritani, S., Itokawa, M., Inada, T., Iwata, N., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp166 · Cited by 112 · see citing works
Cancer screening, prevention, and treatment in people with mental illness
Weinstein, L., Stefancic, A., Cunningham, A., Hurley, K., Cabassa, L., & Wender, R. (2015) · Ca · doi:10.3322/caac.21334 · Cited by 93 · see citing works
The evolutionary paradox and the missing heritability of schizophrenia
van Dongen, J., & Boomsma, D. I. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32135 · Cited by 106 · see citing works
Excess medical comorbidity and mortality across the lifespan in schizophrenia.
Brink, M., Green, A., Bojesen, A. B., Lamberti, J. S., Conwell, Y., & Andersen, K. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.10.020 · Cited by 103 · see citing works
Ji, J., Sundquist, K., Ning, Y., Kendler, K. S., Sundquist, J., & Chen, X. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs065 · Cited by 104 · see citing works
Hert, M. A. F. D., Peuskens, J., Sabbe, T., Mitchell, A. J., Stubbs, B., Neven, P., Wildiers, H. P. M. W., & Detraux, J. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12459 · Cited by 98 · see citing works
Goriely, A., McGrath, J. J., Hultman, C. M., Wilkie, A. O. M., & Malaspina, D. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12101352 · Cited by 96 · see citing works
Cancer incidence in a sample of Maryland residents with serious mental illness
McGinty, E., Zhang, Y.-Y., Guallar, E., Ford, D., Steinwachs, D., Dixon, L., Keating, N., & Daumit, G. (2012) · Psychiatric Services · doi:10.1176/appi.ps.201100169 · Cited by 84 · see citing works
The incidence rate of cancer in patients with schizophrenia: A meta-analysis of cohort studies
Li, H., Li, J., Yu, X., Zheng, H., Sun, X., Lü, Y., Zhang, Y., Li, C., & Bi, X. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.08.065 · Cited by 96 · see citing works
Association of Schizophrenia With the Risk of Breast Cancer Incidence
Zhuo, C., & Triplett, P. T. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.4748 · Cited by 96 · see citing works
Kisely, S. R., Forsyth, S. J., & Lawrence, D. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415577979 · Cited by 95 · see citing works
Review: Are there modifiable risk factors which will reduce the excess mortality in schizophrenia?
Wildgust, H. J., & Beary, M. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810384639 · Cited by 93 · see citing works
Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management
Holt, R. I. G., & Peveler, R. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03814.x · Cited by 92 · see citing works
What Can Stutterers Learn from the Neurodiversity Movement?
Constantino, C. (2018) · Seminars in Speech and Language · doi:10.1055/s-0038-1667166 · Cited by 92 · see citing works
Lin, G., Chen, Y.-J., Kuo, D.-J., Jaiteh, L. E. S., Wu, Y., Lo, T.-S., & Li, Y.-H. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr162 · Cited by 90 · see citing works
DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond
Markkanen, E., Meyer, U., & Dianov, G. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060856 · Cited by 84 · see citing works
RYBAKOWSKI, J. K. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/904836 · Cited by 82 · see citing works
Review: Cancer and schizophrenia: is there a paradox?
Hodgson, R. E., Wildgust, H. J., & Bushe, C. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810385489 · Cited by 83 · see citing works
Hayashi‐Takagi, A., Vawter, M. P., & Iwamoto, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.035 · Cited by 80 · see citing works
Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia.
Rybakowski, J. K., Skibinska, M., Kapelski, P., Kaczmarek, L., & Hauser, J. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.02.005 · Cited by 76 · see citing works
Beary, M., Hodgson, R., & Wildgust, H. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112440512 · Cited by 79 · see citing works
Schizophrenia and breast cancer incidence
Bushe, C., Bradley, A. J., Wildgust, H. J., & Hodgson, R. E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.07.012 · Cited by 77 · see citing works
The paradox of premature mortality in schizophrenia: new research questions
Wildgust, H. J., Hodgson, R. E., & Beary, M. (2010) · Journal of Psychopharmacology · doi:10.1177/1359786810382149 · Cited by 74 · see citing works
Cardiovascular diseases among patients with schizophrenia
Azad, M. C., Shoesmith, W. D., Mamun, M. A., Abdullah, A. F., Naing, D. K. S., Phanindranath, M., & Turin, T. C. (2015) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2015.11.012 · Cited by 74 · see citing works
Davis, L., Bogner, E., Coburn, N. G., Hanna, T. P., Kurdyak, P. A., Groome, P. A., & Mahar, A. L. (2019) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2019-212311 · Cited by 73 · see citing works
Cause and Rate of Death in People With Schizophrenia Across the Lifespan
Kredentser, M. S., Martens, P. J., Chochinov, H. M., & Prior, H. J. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08711 · Cited by 64 · see citing works
Impact of socioeconomic deprivation on rate and cause of death in severe mental illness
Martin, J. L., McLean, G., Park, J. B., Martin, D. J., Connolly, M., Mercer, S. W., & Smıth, D. J. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0261-4 · Cited by 59 · see citing works
Dysfunction in the coagulation system and schizophrenia
Hoirisch-Clapauch, S., Amaral, O. B., Mezzasalma, M. A., Panizzutti, R., & Nardi, A. E. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.204 · Cited by 57 · see citing works
Female schizophrenia patients and risk of breast cancer: A population-based cohort study
Chou, A. I. W., Wang, Y.-C., Lin, C., & Kao, C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.019 · Cited by 56 · see citing works
Schizophrenia and Cancer: In 2010 Do We Understand the Connection?
Bushe, C., & Hodgson, R. E. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501203 · Cited by 55 · see citing works
Crespi, B. J. (2011) · Autism Research · doi:10.1002/aur.208 · Cited by 54 · see citing works
Association between schizophrenia and genetic variation in DCC: a case–control study
Grant, A., Fathalli, F., Rouleau, G., Joober, R., & Flores, C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.023 · Cited by 53 · see citing works
A shared genetic contribution to breast cancer and schizophrenia
Lu, D., Song, J., Lu, Y., Fall, K., Chen, X., Fang, F., Landén, M., Hultman, C. M., Czene, K., Sullivan, P. F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18492-8 · Cited by 53 · see citing works
Ishikawa, H., Yasunaga, H., Matsui, H., Fushimi, K., & Kawakami, N. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.156265 · Cited by 53 · see citing works
Salazar, C., Ruiz‐Hincapie, P., & Ruíz, L. M. (2018) · Cells · doi:10.3390/cells7100154 · Cited by 52 · see citing works
Pettersson, D. R., Gissler, M., Hällgren, J., Ösby, U., Westman, J., & Bobo, W. V. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s204579602000044x · Cited by 52 · see citing works
Gabilondo, A., Alonso-Morán, E., Nuño-Solínis, R., Orueta, J. F., & Iruín, Á. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.12.011 · Cited by 51 · see citing works
The physical health of the seriously mentally ill: an overview of the literature
Collins, E., Tranter, S., & Irvine, F. E. (2011) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2011.01831.x · Cited by 49 · see citing works
Bushe, C., Bradley, A., & Pendlebury, J. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2010.010025 · Cited by 48 · see citing works
Gassó, P., Mas, S., Molina-Andreu, O., Lafuente, A., Bernardo, M., & Parellada, E. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.09.017 · Cited by 47 · see citing works
Wang, Y., Huang, N., Li, H., Liu, S., Chen, X., Yu, S., Wu, N., Bian, X., Shen, H., Li, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16400 · Cited by 48 · see citing works
Refining and integrating schizophrenia pathophysiology – Relevance of the allostatic load concept
Misiak, B., Frydecka, D., Zawadzki, M., Krefft, M., & Kiejna, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.004 · Cited by 47 · see citing works
Clozapine Induces Autophagic Cell Death in Non-Small Cell Lung Cancer Cells
Yin, Y., Lin, C.-C., Chen, T., Chen, J., Tsai, H., Wang, C.-Y., & Chen, S. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369751 · Cited by 47 · see citing works
Inhibition of cancer stem cells promoted by Pimozide
Gonçalves, J. M., Silva, C. A. B., Rivero, E. R. C., & Cordeiro, M. M. R. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13049 · Cited by 45 · see citing works
Matheson, S. L., Shepherd, A. M., & Carr, V. J. (2014) · Psychological Medicine · doi:10.1017/s0033291714000166 · Cited by 42 · see citing works
Burdick, K. E., DeRosse, P., Kane, J. M., Lencz, T., & Malhotra, A. K. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050615 · Cited by 43 · see citing works
Trifluoperazine Activates FOXO1-Related Signals to Inhibit Tumor Growth in Hepatocellular Carcinoma
Jiang, J., Huang, Z., Chen, X., Luo, R., Cai, H., Wang, H., Zhang, H., Sun, T., & Zhang, Y. (2017) · DNA and Cell Biology · doi:10.1089/dna.2017.3790 · Cited by 42 · see citing works
Review of Mendelian Randomization Studies on Ovarian Cancer
Guo, J.-Z., Xiao, Q., Gao, S., Li, X., Wu, Q., & Gong, T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.681396 · Cited by 44 · see citing works
Ellingrod, V. L., Taylor, S. F., Brook, R. D., Evans, S. J., Zöllner, S. K., Grove, T. B., Gardner, K. M., Bly, M. J., Pop‐Busui, R., & Dalack, G. W. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.031 · Cited by 40 · see citing works
Lung cancer incidence in patients with schizophrenia: meta-analysis
Zhuo, C., Zhuang, H., Gao, X., & Triplett, P. T. (2019) · The British Journal of Psychiatry · doi:10.1192/bjp.2019.23 · Cited by 40 · see citing works
Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R. (2022) · Cells · doi:10.3390/cells11121930 · Cited by 39 · see citing works
Comorbidity of mental and physical disorders
(2014) · Key Issues in Mental Health · doi:10.1159/isbn.978-3-318-02604-7 · Cited by 37 · see citing works
Cancer incidence in people with affective disorder: nationwide cohort study in Taiwan, 1997–2010
Hung, Y., Yang, S.-Y., Huang, M., Lung, F., Lin, S., Chen, K., Kuo, C., & Chen, Y. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.144741 · Cited by 36 · see citing works
Wootten, J. C., Wiener, J. C., Blanchette, P., & Anderson, K. K. (2022) · Cancer Epidemiology · doi:10.1016/j.canep.2022.102233 · Cited by 36 · see citing works
Identification of shared genetic variants between schizophrenia and lung cancer
Zuber, V., Jönsson, E. G., Frei, O., Witoelar, A., Thompson, W. K., Schork, A. J., Bettella, F., Wang, Y., Djurovic, S., Smeland, O. B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-16481-4 · Cited by 35 · see citing works
Dalton, S. O., Suppli, N. P., Ewertz, M., Kroman, N. T., Grassi, L. G., & Johansen, C. (2018) · The Breast · doi:10.1016/j.breast.2018.06.002 · Cited by 35 · see citing works
Ferentinos, P. P., & Dikeos, D. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283568537 · Cited by 35 · see citing works
Transcriptomic and Genetic Associations between Alzheimer’s Disease, Parkinson’s Disease, and Cancer
Forés-Martos, J., Boullosa, C., Domínguez, D. R., Sánchez-Valle, J., Suay‐García, B., Climent, J., Falcó, A., Valencia, A., Puig‐Butillé, J. A., Puig, S., et al. (2021) · Cancers · doi:10.3390/cancers13122990 · Cited by 34 · see citing works
Mental health among nonelderly adult cancer survivors: A national estimate
Ji, X., Cummings, J. R., Marchak, J. G., Han, X., & Mertens, A. C. (2020) · Cancer · doi:10.1002/cncr.32988 · Cited by 33 · see citing works
Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy
Xing, Y., Wei, X., Wang, M., Liu, Y., Sui, Z., Wang, X., Zhang, Y., Fei, Y.-H., Jiang, Y., Chen, L., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.043 · Cited by 32 · see citing works
Discovery and development of integrative biological markers for schizophrenia
Oertel‐Knöchel, V., Bittner, R. A., Knöchel, C., Prvulovic, D., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.006 · Cited by 32 · see citing works
Kisely, S., Alotiby, M. K. N., Protani, M. M., Soole, R., Arnautovska, U., & Siskind, D. (2023) · Psycho-Oncology · doi:10.1002/pon.6120 · Cited by 31 · see citing works
Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
Fujii, T., Uchiyama, H., Yamamoto, N., Hori, H., Tatsumi, M., Ishikawa, M., Arima, K., Higuchi, T., & Kunugi, H. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.004 · Cited by 30 · see citing works
Chen, M., Tsai, S., Su, T., Li, C., Lin, W., Cheng, C., Chen, T., & Bai, Y. (2021) · International Journal of Cancer · doi:10.1002/ijc.33914 · Cited by 29 · see citing works
Went, M., Sud, A., Mills, C., Hyde, A., Culliford, R., Law, P., Vijayakrishnan, J., Gockel, I., Maj, C., Schumacher, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46927-z · Cited by 28 · see citing works
Fujiwara, M., Yamada, Y., Shimazu, T., Kodama, M., So, R., Matsushita, T., Yoshimura, Y., Horii, S., Fujimori, M., Takahashi, H., et al. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13348 · Cited by 28 · see citing works
Catts, V. S., Catts, S. V., Jablensky, A. V., Chandler, D., Weickert, C. S., & Lavin, M. F. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.565073 · Cited by 28 · see citing works
Self-citationPreventing breast cancer in women with schizophrenia
Seeman, M. V. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01626.x · Cited by 27 · see citing works
Schizophrenia as segmental progeria
Papanastasiou, E., Gaughran, F., & Smith, S. M. (2011) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2011.110051 · Cited by 27 · see citing works
Glioma in Schizophrenia: Is the Risk Higher or Lower?
Gao, X., Mi, Y., Guo, N., Xu, H., Jiang, P., Zhang, R., Xu, L., & Gou, X. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00289 · Cited by 26 · see citing works
Risk of prostate cancer in patients with schizophrenia
Raviv, G., Laufer, M., Baruch, Y., & Barak, Y. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.05.007 · Cited by 25 · see citing works
Brink, M., Green, A., Bojesen, A. B., Lamberti, J. S., Conwell, Y., & Andersen, K. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.12.015 · Cited by 25 · see citing works
Cieślik-Boczula, K., Świątek, P., Jaszczyszyn, A., Zawilska, P., Gąsiorowski, K., Malinka, W., & Köhler, G. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp410882r · Cited by 23 · see citing works
Sujitha, S., Kumar, D. T., Doss, C. G. P., Aavula, K., Ramésh, R., Lakshmanan, S., Gunasekaran, S., & Anilkumar, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147348 · Cited by 22 · see citing works
Kopylov, A. T., Petrovskiy, D. V., Stepanov, A. A., Rudnev, V. R., Malsagova, K. A., Butkova, T. V., Zakharova, N. V., Kostyuk, G. P., Kulikova, L. I., Enikeev, D. V., et al. (2021) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2021.103890 · Cited by 22 · see citing works
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study
Albayrak, Y., Beyazyüz, M., Küfeciler, T., Bulut, L., Ünsal, C., Baykal, S., Akyol, E., Kuloğlu, M., & Hashimoto, K. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106993 · Cited by 22 · see citing works
Catalá-López, F., Hutton, B., Driver, J. A., Page, M. J., Ridao-López, M., Valderas, J. M., Alonso‐Arroyo, A., Forés-Martos, J., Martı́nez, S., Gènova-Maleras, R., et al. (2017) · Systematic Reviews · doi:10.1186/s13643-017-0466-y · Cited by 21 · see citing works
- Authors
- Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J.
- Affiliations
- The University of Queensland (AU)
- The University of Sydney (AU)
- Royal Brisbane and Women's Hospital (AU)
- Corresponding author
- Catts, V. S.
- Catts, S. V.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2008-03-10
- Volume
- 117
- Issue
- 5
- Pages
- 323-336
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W1965388866
- Cited by
- 209
- References
- 63
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 13
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- schizophrenia, cancer incidence, lung cancer, breast cancer, first-degree relatives, siblings, parents, smoking, standardized incidence ratio, cancer risk
- MeSH terms
- Aged, Urinary Bladder Neoplasms, Humans, Lung Neoplasms, Neoplasms, Risk Factors, Schizophrenia, Incidence, Prevalence
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