The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.
Cancer risk among users of neuroleptic medication: a population-based cohort study
Open accessAbstract
It has been suggested that neuroleptic medication may decrease cancer risk. We compared cancer risks in a population-based cohort study of 25,264 users (>or=2 prescriptions) of neuroleptic medications in the county of North Jutland, Denmark, during 1989-2002, with that of county residents who did not receive such prescriptions. Statistical analyses were based on age-standardisation and Poisson regression analysis, adjusting for age, calendar period, COPD, liver cirrhosis or alcoholism, use of NSAID, and, for breast cancer, additionally for use of hormone therapy, age at first birth, and number of children. Use of neuroleptic medications was associated with a decreased risk for rectal cancer in both women and men (adjusted IRRs of 0.61 (95% confidence interval, 0.41-0.91) and 0.82 (0.56-1.19), respectively) and for colon cancer in female users (0.78; 0.62-0.98). Some risk reduction was seen for prostate cancer (0.87; 0.69-1.08), but breast cancer risk was close to unity (0.93; 0.74-1.17). Overall, treatment with neuroleptic medications was not related to a reduced risk of cancer, but for cancers of the rectum, colon and prostate there were suggestive decreases in risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The majority of the studies in which the risk of breast cancer has been investigated in patients treated with conventional AP (465-468) did not uncover an increased risk of breast cancer, an exception being the cohort study by Wang et al (469).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [468]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smoking and Mental Illness: A Population-Based Prevalence Study
Lasser, K., Boyd, J. W., Woolhandler, S., Himmelstein, D. U., McCormick, D., & Bor, D. H. (2000) · JAMA · doi:10.1001/jama.284.20.2606 · Cited by 2,508
The Danish National Hospital Register. A valuable source of data for modern health sciences.
Andersen, T. F., Madsen, M., Jørgensen, J. O. L., Mellemkjoer, L., & Olsen, J. H. (1999) · PubMed · Cited by 2,026
Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430
Prevalence of smoking among psychiatric outpatients
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.8.993 · Cited by 1,058
Colorectal Cancer: Molecules and Populations
Potter, J. D. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.11.916 · Cited by 876
The Danish Cancer Registry--history, content, quality and use.
Storm, H. H., Michelsen, E. V., Clemmensen, I. H., & Pihl, J. (1997) · PubMed · Cited by 790
The Danish Psychiatric Central Register.
Munk‐Jørgensen, P., & Mortensen, P. B. (1997) · PubMed · Cited by 698
Self-citationThe Danish prescription registries.
Gaist, D., Sørensen, H. T., & Hallas, J. (1997) · PubMed · Cited by 570
Self-citationSchizophrenia and smoking: an epidemiological survey in a state hospital
de León, J., Dadvand, M., Canuso, C. M., Odom-White, A., Stanilla, J. K., & Simpson, G. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.453 · Cited by 417
Leonard, S. S., Adler, L. E., Benhammou, K., Berger, R., Breese, C. R., Drebing, C. J., Gault, J., Lee, M. J., Logel, J., D, A. O. M., et al. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00677-3 · Cited by 298
Incidence of Cancer Among Persons With Schizophrenia and Their Relatives
Lichtermann, D., Ekelund, J., Pukkala, E., Tanskanen, A., & Lönnqvist, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.573 · Cited by 292 · cited 5×
“…findings (Overall, 1978; Schyve, 1978; Wagner & Mantel, 1978; Kanhouwa et al, 1984; Nakane et al, 1986; Gulbinat et al, 1992; Halbreich et al, 1996; Lichtermann et al, 2001), although a more recent cohort study reported a relative risk of 1.16 (95% CI, 1.07–1.26) for breast cancer associated with…”
BackgroundInfluentialElevated prolactin levels in patients with schizophrenia: mechanisms and related adverse effects
Halbreich, U. M., Kinon, B. J., Gilmore, J. A., & Kahn, L. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00112-9 · Cited by 248
Dopamine Antagonists and the Development of Breast Cancer
Wang, P. S., Walker, A. M., Tsuang, M. T., Orav, E. J., Glynn, R. J., Levin, R., & Avorn, J. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1147 · Cited by 196
The incidence of cancer in schizophrenic patients.
Mortensen, P. B. (1989) · Journal of Epidemiology and Community Health · doi:10.1136/jech.43.1.43 · Cited by 175
Self-citationEpidemiology of Non-Steroidal Anti-Inflammatory Drugs and Cancer
Baron, J. A. (2003) · KARGER eBooks · doi:10.1159/000071364 · Cited by 161
The occurence of cancer in first admitted schizophrenic patients
Mortensen, P. B. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90028-0 · Cited by 142
Self-citationRisk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993
Dalton, S. O., Mellemkjær, L., Thomassen, L., Mortensen, P. B., & Johansen, C. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.11.009 · Cited by 142
Self-citationCalmodulin: a potential target for cancer chemotherapeutic agents.
Hait, W. N., & Lazo, J. S. (1986) · Journal of Clinical Oncology · doi:10.1200/jco.1986.4.6.994 · Cited by 125
Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?
Catts, V. S., & Catts, S. V. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00077-8 · Cited by 119
Addictive behaviors among hospitalized psychiatric patients
O’Farrell, T. J., Connors, G. J., & Upper, D. (1983) · Addictive Behaviors · doi:10.1016/0306-4603(83)90032-1 · Cited by 112
The Danish National Health Service Register. A tool for primary health care research.
Olivarius, N. D. F., Hollnagel, H., Krasnik, A., Pedersen, P. A., & Thorsen, H. (1997) · PubMed · Cited by 111
Cancer incidence of schizophrenic patients. Results of record linkage studies in three countries
Gulbinat, W., Dupont, A., Jablensky, A., Jensen, O. M., Marsella, A., Nakane, Y., & Sartorius, N. (1992) · British Journal of Psychiatry · doi:10.1192/s0007125000297080 · Cited by 110
Effects of psychotropic drugs on cell proliferation and differentiation
Nordenberg, J., Fenig, E., Landau, M., Weizman, R., & Weizman, A. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00156-2 · Cited by 103
Neuroleptic-induced Prolactin Level Elevation and Breast Cancer
Schyve, P. M. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770350017001 · Cited by 97
Are chronic psychiatric patients at increased risk for developing breast cancer?
Halbreich, U. M., Shen, J., & Panaro, V. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.4.559 · Cited by 96
Neuroleptic medication and reduced risk of prostate cancer in schizophrenic patients
Mortensen, P. B. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb10325.x · Cited by 90
Self-citationNielsen, G. L., Sørensen, H. T., Zhou, W., Steffensen, F. H., & Olsen, J. (1997) · International Journal of Risk & Safety in Medicine · doi:10.3233/jrs-1997-10309 · Cited by 89
Self-citationRisk of Breast Cancer According to Use of Antidepressants, Phenothizaines, and Anthistamines
Kelly, J. P., Rosenberg, L., Palmer, J. R., Rao, R. S., Strom, B. L., Stolley, P. D., Zauber, A. G., & Shapiro, S. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010091 · Cited by 89
Cancer Therapy: Phenothiazines in an Unexpected Role
Gr, J. (1985) · Tumori Journal · doi:10.1177/030089168507100608 · Cited by 59
A Needs Survey among Patients in Leros Asylum
Bouras, N., Webb, Y., Clifford, P., Papadatos, Y., & Zouni, M. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.1.75 · Cited by 58
Avoidable cancers in the Nordic countries. Tobacco smoking.
Dreyer, L., Winther, J. F., Pukkala, ., & Andersen, A. (1997) · PubMed · Cited by 57
Dreyer, L., Winther, J. F., Pukkala, ., & Andersen, A. (1997) · Apmis · doi:10.1111/j.1600-0463.1997.tb05609.x · Cited by 54
Prior Psychiatric Treatment and the Development of Breast Cancer
Overall, J. E. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770310104009 · Cited by 33
Breast cancer at a psychiatric hospital before and after the introduction of neuroleptic agents.
Wagner, S., & Mantel, N. (1978) · PubMed · Cited by 28
Phenothiazines and breast cancer.
Kanhouwa, S., Gowdy, J. M., & Solomon, J. D. (1984) · PubMed · Cited by 26
[Diagnosis of cancer and autopsy rate in schizophrenic patients].
Mortensen, P. B. (1987) · PubMed · Cited by 8
Self-citation
Research works printed but not linked: 3
- Dupont A, Møller Jensen O, Strömgren E, Jablensky A (1986) Incidence of cancer in patients diagnosed as schizophrenic in Denmark. In ten Horn GHMM, Giel R, Gulbinat W, Henderson JH (eds) Psychiatric Case Registries in Public Health. Amsterdam: Elsevier Science Publisherws, pp 229–239
- Mortensen PB (1987) Cancerdiagnostik og autopsifrekvens blandt skziofrene patienter. Ugeskr Laeger 149: 1973–1975
- Nakane Y, Ohta Y (1986) The example of linkage with a cancer register. In ten Horn GHMM, Giel R, Gulbinat W, Henderson JH (eds) Psychiatric Case Registries in Public Health. Amsterdam: Elsevier, pp 240–245
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329
Coloma, P. M., Schuemie, M. J., Trifirò, G., Gini, R., Herings, R. M. C., Hippisley‐Cox, J., Mazzaglia, G., Giaquinto, C., Corrao, G., Pedersen, L. H., et al. (2010) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2053 · Cited by 270
Callaghan, R. C., Veldhuizen, S., Jeysingh, T., Orlan, C., Graham, C., Kakouris, G., Remington, G., & Gatley, J. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.09.014 · Cited by 255
Risk of Malignancy in Patients With Schizophrenia or Bipolar Disorder: Nested Case-Control Study
Hippisley-Cox, J., Vinogradova, Y., Coupland, C., & Parker, C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.12.1368 · Cited by 214
Metadata
- Authors
- Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S.
- Affiliations
- Danish Cancer Society (DK)
- Aarhus University Hospital (DK)
- International Epidemiology Institute (US)
- Aarhus University (DK)
- Corresponding author
- Dalton, S O
- Venue
- British Journal of Cancer
- Published
- 2006-08-22
- Volume
- 95
- Issue
- 7
- Pages
- 934-939
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2360537
- OpenAlex
- W2023544789
- Cited by
- 123
- References
- 38
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 16 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 6
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Kræftens Bekæmpelse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- antipsychotic drugs, cancer risk, rectal cancer, colon cancer, prostate cancer, breast cancer, prescription drug use
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Schizophrenia, Antipsychotic Agents, Cohort Studies, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
