Cited by 167Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysSignaling Pathways in Disease

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Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

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Nair, S, Doh, S T, Chan, J Y, Kong, A-N, Cai, L·2008·British Journal of Cancer

DOI 10.1038/sj.bjc.6604703PMC PMC2607222

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Abstract

Many studies have implicated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kappaB1 (Nfkb1) in inflammation and cancer. However, the regulatory potential for crosstalk between these two important transcription factors in inflammation and carcinogenesis has not been explored. To delineate conserved transcription factor-binding site signatures, we performed bioinformatic analyses on the promoter regions of human and murine Nrf2 and Nfkb1. We performed multiple sequence alignment of Nrf2 and Nfkb1 genes in five mammalian species - human, chimpanzee, dog, mouse and rat - to explore conserved biological features. We constructed a canonical regulatory network for concerted modulation of Nrf2 and Nfkb1 involving several members of the mitogen-activated protein kinase (MAPK) family and present a putative model for concerted modulation of Nrf2 and Nfkb1 in inflammation/carcinogenesis. Our results reflect potential for putative crosstalk between Nrf2 and Nfkb1 modulated through the MAPK cascade that may influence inflammation-associated etiopathogenesis of cancer. Taken together, the elucidation of potential relationships between Nrf2 and Nfkb1 may help to better understand transcriptional regulation, as well as transcription factor networks, associated with the etiopathogenesis of inflammation and cancer.

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Saw, C. L. L., & Kong, A. T. (2011) · Springer eBooks · doi:10.1007/978-94-007-2630-7_4
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Authors: Nair, S., Doh, S. T., Chan, J. Y., Kong, A.-N., & Cai, L.
Affiliations: Rutgers, The State University of New Jersey (US)
University of California, Irvine (US)
Corresponding author: Cai, L
ORCID: Nair, S
Chan, J Y
Cai, L
Venue: British Journal of Cancer
Publisher: Springer Science and Business Media LLC
Published: 2008-12
Volume: 99
Issue: 12
Pages: 2070-2082
ISSN: 0007-0920 (ISSN-L)
1532-1827
DOI: 10.1038/sj.bjc.6604703
PMC: PMC2607222
OpenAlex: W2059649811
Cited by: 167
References: 58
Citations by year: 2026: 8 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 16 · 2016: 13 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 10
FWCI: 2.20
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.springer.com/tdm (unspecified)
Locations: British Journal of Cancer (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institutes of Health
National Cancer Institute (CA133675, R01CA094828, R21CA133675)
National Institute of Environmental Health Sciences (P30ES005022)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Nrf2, NFKB1, transcription factor crosstalk, inflammation, carcinogenesis, MAPK signaling, transcription factor binding sites, promoter analysis, transcriptional regulation, inflammation-associated cancer
MeSH terms: Amino Acid Sequence, Animals, Binding Sites, Cell Transformation, Neoplastic, Humans, Inflammation, Molecular Sequence Data, Gene Expression Regulation, Neoplastic, Sequence Alignment, Conserved Sequence, Computational Biology, Microarray Analysis, NF-E2-Related Factor 2, Mice, Rats, NF-kappa B p50 Subunit

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Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

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