Abolition of chondral mineralization by group III metabotropic glutamate receptors expressed in rodent cartilage
Open accessAbstract
1 Previous studies have demonstrated the functional expression by osteoblasts of glutamate (Glu) signaling machineries responsible for the stimulation of cell proliferation and differentiation in bone, while there is no information available on the expression of the Glu signaling system by cartilage to date. 2 In cultured mouse embryonic metatarsals isolated before vascularization, chondral mineralization was almost completely inhibited in the presence of the group III metabotropic Glu receptor (mGluR) agonist L-(1)-2-amino-4-phosphonobutyrate (L-AP4) in a manner sensitive to an antagonist, with the total length being unchanged. 3 A group II mGluR agonist was similarly more effective in inhibiting the mineralization than a group I mGluR agonist, while none of ionotropic GluR agonists drastically affected the mineralization. 4 Both histological and in situ hybridization analyses revealed that L-AP4 specifically inhibited chondral mineralization, without apoptotic cell death, in cultured metatarsals. 5 In addition to the constitutive expression of mRNA for particular mGluRs in both cultured mouse metatarsals and rat costal chondrocytes, L-AP4 significantly inhibited the accumulation of cyclic AMP by forskolin and parathyroid hormone in a manner sensitive to a group III mGluR antagonist in cultured chondrocytes. 6 Moreover, L-AP4 drastically inhibited the expression of osteopontin mRNA in both cultured metatarsals and chondrocytes. 7 These results suggest that Glu may at least in part play a role as a signal mediator in mechanisms associated with chondral mineralization through the group III mGluR subtype functionally expressed by chondrocytes in rodent cartilage.
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Glutamate signaling genes are widely expressed in tissues beyond the CNS, including osteoblasts, osteoclasts, melanocytes, and chondrocytes.
“Glutamate signaling genes are also widely expressed in tissues beyond the CNS, including osteoblasts, osteoclasts, melanocytes, and chondrocytes (Wang et al., 2005;Hoogduijn et al., 2006;Devi et al., 2013;Julio-Pieper et al., 2011;Matta, 2013).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Wang et al., 2005
Some evidence for direct effects of glutamate signaling derives from the fact that glutamate receptor, transporter, and other signaling genes identified in different domestication studies are expressed in melanocytes, osteoblasts, osteoclasts, chondrocytes, and other tissues beyond the CNS.
“Some evidence for this derives from the fact that glutamate receptor, transporter, and other signaling genes identified in different domestication studies are expressed in melanocytes, osteoblasts, osteoclasts, chondrocytes, and other tissues beyond the CNS (Wang et al., 2005;Hoogduijn et al., 2006;Devi et al., 2013;Julio-Pieper et al., 2011;Matta, 2013).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Wang et al., 2005
Group II and III metabotropic receptors have been shown to prevent mineralization of chondrocytes, implicating them in cartilage development.
“Group II and III metabotropic receptors have been shown to prevent mineralization of chondrocytes, implicating them in cartilage development (Wang et al., 2005;Matta, 2013).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Wang et al., 2005
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- Authors
- Wang, L., Hinoi, E., Takemori, A., Takarada, T., & Yoneda, Y.
- Affiliations
- Kanazawa University (JP)
- Corresponding author
- Yoneda, Yukio
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2005-11
- Volume
- 146
- Issue
- 5
- Pages
- 732-743
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1751195
- OpenAlex
- W2089939109
- Cited by
- 36
- References
- 36
- Citations by year
- 2021: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- group III metabotropic glutamate receptors, L-AP4, cartilage, chondrocytes, osteopontin, cyclic AMP, parathyroid hormone, glutamate signaling, costal cartilage, osteoblasts
- MeSH terms
- Cyclic AMP, Animals, Base Sequence, Calcification, Physiologic, Cartilage, Cells, Cultured, Female, Organ Culture Techniques, Rats, Wistar, DNA Primers, Receptors, Metabotropic Glutamate, Reverse Transcriptase Polymerase Chain Reaction, Mice, Rats
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