Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts
Abstract
Reverse transcription polymerase chain reaction revealed expression of mRNA for particular subunits of ionotropic glutamate receptors (iGluR) in primary cultures of rat calvarial osteoblastic cells under immature to mature states. These included GluR3, KA1 and KA2 subunits, in addition to NR1 and NR2D subunits. These results suggest that glutamate may play an unidentified role in mechanisms associated with cellular development through particular subunits of iGluR in rat calvarial osteoblasts.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GRIK5, GRM4, and GRM8 along with NMDA and AMPA receptor genes are expressed in vitro in developing rat calvarial osteoblasts.
“GRIK5, GRM4, and GRM8 along with NMDA and AMPA receptor genes are expressed in vitro in developing rat calvarial osteoblasts (Hinoi et al., 2001(Hinoi et al., , 2002)).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Hinoi et al., 2002
Cites
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962 · see citing works
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,121 · see citing works
A family of metabotropic glutamate receptors
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90118-w · Cited by 940 · see citing works
A family of metabotropic glutamate receptors
Tanabe, Y. (1992) · Medical Entomology and Zoology · doi:10.11501/3061113 · Cited by 879 · see citing works
Mammalian ionotropic glutamate receptors
Wisden, W., & Seeburg, P. H. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90120-n · Cited by 322 · see citing works
Hohmann, E. L., Elde, R. P., Rysavý, J., Einzig, S., & Gebhard, R. L. (1986) · Science · doi:10.1126/science.3518059 · Cited by 309 · see citing works
Serre, C., Farlay, D., Delmas, P. D., & Chenu, C. (1999) · Bone · doi:10.1016/s8756-3282(99)00215-x · Cited by 259 · see citing works
Glutamate Receptors Are Expressed by Bone Cells and Are Involved in Bone Resorption
Chenu, C., Serre, C., Raynal, C., Burt‐Pichat, B., & Delmas, P. D. (1998) · Bone · doi:10.1016/s8756-3282(97)00295-0 · Cited by 240 · see citing works
Rawlinson, S. C. F., Mosley, J. R., Suswillo, R. F. L., Pitsillides, A. A., & Lanyon, L. E. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100813 · Cited by 176 · see citing works
Patton, A. J., Genever, P. G., Birch, M. A., Suva, L. J., & Skerry, T. M. (1998) · Bone · doi:10.1016/s8756-3282(98)00061-1 · Cited by 175 · see citing works
Peet, N. M., Grabowski, P., LAKETIć‐LJUBOJEVIć, I., & Skerry, T. M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2179 · Cited by 108 · see citing works
Moroni, F., Luzzi, S., Franchi‐Micheli, S., & Zilletti, L. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90229-6 · Cited by 108 · see citing works
Collin, P., Nefussi, J.-R., Wetterwald, A., Nicolas, V., Boy‐Lefèvre, M., Fleisch, H. A., & Forest, N. (1992) · Calcified Tissue International · doi:10.1007/bf00298797 · Cited by 106 · see citing works
Functional characterization of N-methyl-d-aspartic acid-gated channels in bone cells
LAKETIć‐LJUBOJEVIć, I., Suva, L. J., Maathuis, F. J. M., Sanders, D., & Skerry, T. M. (1999) · Bone · doi:10.1016/s8756-3282(99)00224-0 · Cited by 104 · see citing works
Expression of Functional Metabotropic Glutamate Receptors in Primary Cultured Rat Osteoblasts
Gu, Y., & Publicover, S. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004520200 · Cited by 96 · see citing works
de Cristóbal, J., Moro, M. Á., Dávalos, A., Castillo, J., Leza, J. C., Camarero, J., Colado, M. I., Lorenzo, P. L., & Lizasoaín, I. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00600.x · Cited by 91 · see citing works
Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts
Hinoi, E., Fujimori, S., Nakamura, Y., & Yoneda, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4355 · Cited by 80 · see citing works
Self-citationLocalization of [3H]glutamate binding sites in rat adrenal medulla
Yoneda, Y., & Ogita, K. (1986) · Brain Research · doi:10.1016/0006-8993(86)90046-6 · Cited by 75 · see citing works
Self-citationHuggett, J. F., Vaughan‐Thomas, A., & Mason, D. J. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02175-x · Cited by 56 · see citing works
[3H]Glutamate binding sites in the rat pituitary
Yoneda, Y., & Ogita, K. (1986) · Neuroscience Research · doi:10.1016/0168-0102(86)90034-9 · Cited by 50 · see citing works
Self-citationAas, P., Tansø, R., & Fonnum, F. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90235-5 · Cited by 38 · see citing works
Expression of GluR6/7 subunits of kainate receptors in rat adenohypophysis
Hinoi, E., & Yoneda, Y. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00115-7 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Glutamate signaling in peripheral tissues
Hinoi, E., Takarada, T., Ueshima, T., Tsuchihashi, Y., & Yoneda, Y. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03907.x · Cited by 244 · see citing works
Self-citationSigma receptors [σRs]: biology in normal and diseased states
Rousseaux, C. G., & Greene, S. F. (2015) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1015737 · Cited by 122 · see citing works
Modulation of cellular differentiation by N ‐methyl‐ d ‐aspartate receptors in osteoblasts
Hinoi, E., Fujimori, S., & Yoneda, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-0820fje · Cited by 99 · see citing works
Self-citationCancer cell lines release glutamate into the extracellular environment
Seidlitz, E. P., Sharma, M. K., Saikali, Z., Ghert, M. A., & Singh, G. (2009) · Clinical & Experimental Metastasis · doi:10.1007/s10585-009-9277-4 · Cited by 85 · see citing works
Glutamate Signaling System in Bone
Hinoi, E., Takarada, T., & Yoneda, Y. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.215 · Cited by 66 · see citing works
Self-citationThe glutamatergic system outside the CNS and in cancer biology
Kalariti, N., Pissimissis, N., & Koutsilieris, M. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.12.1487 · Cited by 65 · see citing works
Tang, V. (2006) · Biology Direct · doi:10.1186/1745-6150-1-37 · Cited by 66 · see citing works
Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate
Lin, T., Yang, R., Tang, C., Wu, M., & Fu, W. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.04.060 · Cited by 59 · see citing works
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts
Hinoi, E., Fujimori, S., Takarada, T., Taniura, H., & Yoneda, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02223-4 · Cited by 56 · see citing works
Self-citationThe role of glutamate in the regulation of bone mass and architecture.
Skerry, T. M. (2008) · PubMed · Cited by 55 · see citing works
Glutamate receptors in domestication and modern human evolution
O’Rourke, T., & Boeckx, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.004 · Cited by 50 · see citing works
Glutamate Suppresses Osteoclastogenesis through the Cystine/Glutamate Antiporter
Hinoi, E., Takarada, T., Uno, K., Inoue, M., Murafuji, Y., & Yoneda, Y. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061039 · Cited by 51 · see citing works
Self-citationGlutamate signalling and its potential application to tissue engineering of bone
Mason, D. J. (2004) · European Cells and Materials · doi:10.22203/ecm.v007a02 · Cited by 49 · see citing works
Current perspectives on NMDA-type glutamate signalling in bone
Spencer, G. J., McGrath, C. J., & Genever, P. G. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.11.002 · Cited by 45 · see citing works
Brakspear, K. S. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00097 · Cited by 43 · see citing works
Glutamate Signaling in Healthy and Diseased Bone
Cowan, R. W., Seidlitz, E. P., & Singh, G. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00089 · Cited by 37 · see citing works
Wang, L., Hinoi, E., Takemori, A., Takarada, T., & Yoneda, Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706358 · Cited by 36 · see citing works
Self-citationWen, Z., Chang, Y., & Jean, Y. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.03.017 · Cited by 35 · see citing works
Pharmacological Topics of Bone Metabolism: Glutamate as a Signal Mediator in Bone
Takarada, T., & Yoneda, Y. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fm0070243 · Cited by 34 · see citing works
Self-citationOxidative stress as a component of chromium-induced cytotoxicity in rat calvarial osteoblasts
Fu, J. Q., Liang, X., Chen, Y., Tang, L., Zhang, Q., & Dong, Q. G. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9029-7 · Cited by 31 · see citing works
The fast kinetics of AMPA GluR3 receptors is selectively modulated by the TARPs γ4 and γ8
Suzuki, É., Kessler, M., & Arai, A. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.01.018 · Cited by 30 · see citing works
Release of Endogenous Glutamate by AMPA Receptors Expressed in Cultured Rat Costal Chondrocytes
Wang, L., Hinoi, E., Takemori, A., & Yoneda, Y. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.990 · Cited by 29 · see citing works
Self-citationHinoi, E., Wang, L., Takemori, A., & Yoneda, Y. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.025 · Cited by 27 · see citing works
Self-citationAccumulation of [3H]glutamate in cultured rat calvarial osteoblasts
Takarada, T., Hinoi, E., Fujimori, S., Tsuchihashi, Y., Ueshima, T., Taniura, H., & Yoneda, Y. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.020 · Cited by 27 · see citing works
Self-citationTakarada‐Iemata, M., Takarada, T., Hinoi, E., Taniura, H., & Yoneda, Y. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21145 · Cited by 26 · see citing works
Self-citationSerine racemase suppresses chondrogenic differentiation in cartilage in a Sox9‐dependent manner
Takarada, T., Hinoi, E., Takahata, Y., & Yoneda, Y. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21310 · Cited by 25 · see citing works
Self-citationHinoi, E., & Yoneda, Y. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11r03cr · Cited by 23 · see citing works
Self-citationDifferential regulation of cellular maturation in chondrocytes and osteoblasts by glycine
Takahata, Y., Takarada, T., Osawa, M., Hinoi, E., Nakamura, Y., & Yoneda, Y. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0607-7 · Cited by 22 · see citing works
Self-citationGarcía-Gaytán, A. C., Hernández-Abrego, A., Díaz‐Muñoz, M., & Méndez, I. G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1029210 · Cited by 26 · see citing works
Osteoclastogenesis is negatively regulated by D ‐serine produced by osteoblasts
Takarada, T., Takarada‐Iemata, M., Takahata, Y., Yamada, D., Yamamoto, T. M., Nakamura, Y., Hinoi, E., & Yoneda, Y. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24048 · Cited by 19 · see citing works
Self-citationA Review of Glutamate Receptors II: Pathophysiology and Pathology
Rousseaux, C. G. (2008) · Journal of Toxicologic Pathology · doi:10.1293/tox.21.133 · Cited by 19 · see citing works
Uno, K., Takarada, T., Hinoi, E., & Yoneda, Y. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21095 · Cited by 17 · see citing works
Self-citationGlutamate Receptors in Peripheral Tissues: Distribution and Implications for Toxicology
Gill, S., & Pulido, O. M. (2007) · Springer eBooks · doi:10.1007/0-306-48644-x_1 · Cited by 17 · see citing works
Yu, J., Lee, S., Kim, T., & Jang, J. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080407 · Cited by 13 · see citing works
Seidlitz, E. P., Sharma, M. K., & Singh, G. K. J. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-129 · Cited by 13 · see citing works
Functional Glutamate Signaling in Bone
Hinoi, E. (2010) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.130.1175 · Cited by 10 · see citing works
Self-citationThe emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health
Xie, W., Donat, A., Jiang, S., Baranowsky, A., & Keller, J. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.03.033 · Cited by 9 · see citing works
Glutamate signaling in non-neuronal tissues
Hinoi, E., & Yoneda, Y. (2012) · Folia Pharmacologica Japonica · doi:10.1254/fpj.139.165 · Cited by 9 · see citing works
Self-citationYoneyama, M., Kitayama, T., Taniura, H., & Yoneda, Y. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10622 · Cited by 8 · see citing works
Self-citationCamphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression
Lee, S., Kang, N. S., Min, Y. K., & Kim, S. H. (2008) · Amino Acids · doi:10.1007/s00726-008-0208-5 · Cited by 6 · see citing works
Kim, D.-H., Moon, Y.-S., Jung, J., Suh, H., & Song, D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00147-7 · Cited by 5 · see citing works
Lai, Y., Yao, Z., Chang, T., Feng, C., Kuo, T., Luo, Y., Jean, Y., Lin, H. Y., & Wen, Z. (2024) · Environmental Toxicology · doi:10.1002/tox.24447 · Cited by 4 · see citing works
Fujimori, S., Osawa, M., Takarada‐Iemata, M., Hinoi, E., & Yoneda, Y. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.297 · Cited by 4 · see citing works
Self-citationFujimori, S., Hinoi, E., Takarada, T., Takarada‐Iemata, M., Takahata, Y., & Yoneda, Y. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.088 · Cited by 4 · see citing works
Self-citationYoneda, Y. (2017) · Springer eBooks · doi:10.1007/978-3-319-49795-2_8 · Cited by 2 · see citing works
Self-citationDoes Riluzole Influence Bone Formation?
Schroeder, G. D., Kepler, C. K., Grad, S., Alini, M., Fang, T., Markova, D., Koerner, J. D., Rajasekaran, S., Chapman, J. R., Kandziora, F., et al. (2019) · Spine · doi:10.1097/brs.0000000000003022 · Cited by 2 · see citing works
CAPSAZEPINE ATTENUATES CANCER-INDUCED BONE PAIN BY INHIBITING GLUTAMATE RELEASE
Balenko, M. D. (2014) · MacSphere (McMaster University) · doi:10.71548/18108
- Authors
- Hinoi, E., Fujimori, S., Takemori, A., Kurabayashi, H., Nakamura, Y., & Yoneda, Y.
- Affiliations
- Kanazawa University (JP)
- Corresponding author
- Yoneda, Yukio
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 943
- Issue
- 1
- Pages
- 112-116
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1985244216
- Cited by
- 47
- References
- 22
- Citations by year
- 2024: 2 · 2022: 1 · 2019: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 4
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- AMPA receptor subunits, ionotropic glutamate receptors, osteogenic differentiation, calvarial osteoblasts, GluR3, NR1, NR2D, glutamate signaling, mRNA expression, osteoblast maturation
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Osteoblasts, RNA, Messenger, Skull, Rats, Wistar, Receptors, AMPA, Kainic Acid Receptors, Receptors, Kainic Acid, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
