The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Recent developments in nitric oxide donor drugs
Open accessAbstract
During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune systems. Aside from providing a credible explanation for the actions of organic nitrates and sodium nitroprusside that have long been used in the treatment of angina and hypertensive crises respectively, the discovery generated great hopes for new NO‐based treatments for a wide variety of ailments. Decades later, however, we are still awaiting novel licensed agents in this arena, despite an enormous research effort to this end. This review explores some of the most promising recent advances in NO donor drug development and addresses the challenges associated with NO as a therapeutic agent. British Journal of Pharmacology(2007)151, 305–321; doi:10.1038/sj.bjp.0707224
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Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · cited 2×
“…dysfunction, occurring at a number of levels, including downregulation of eNOS expression and activity, uncoupling of NOS, scavenging of NO by oxygen-centred free radicals and decreased sensitivity of VSMCs to vasodilators, together with NO-independent alterations (Feletou and Vanhoutte, 2006).”
BackgroundMaragos, C. M., Morley, D., Wink, D. A., Dunams, T. M., Saavedra, J. E., Hoffman, A., Bove, A. A., Isaac, L., Hrabie, J. A., & Keefer, L. K. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00115a013 · Cited by 722
Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481
Hallas, J., Dall, M., Andries, A., Andersen, B. S., Aalykke, C., Hansen, J. M., Andersen, M., & Lassen, A. T. (2006) · BMJ · doi:10.1136/bmj.38947.697558.ae · Cited by 403
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400
Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols
Brown, G. C., & Borutaite, V. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.03.016 · Cited by 344
Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.006 · Cited by 343
Non-Heme Iron Nitrosyls in Biology
Butler, A. R., & Megson, I. L. (2002) · Chemical Reviews · doi:10.1021/cr000076d · Cited by 343
Self-citation
Cited by
BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications
McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256
Nitric oxide release: Part II. Therapeutic applications
Carpenter, A. W., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15273h · Cited by 964
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
The potential of nitric oxide releasing therapies as antimicrobial agents
Schairer, D. O., Chouake, J. S., Nosanchuk, J. D., & Friedman, A. J. (2012) · Virulence · doi:10.4161/viru.20328 · Cited by 573
Nitric Oxide Adsorption and Delivery in Flexible MIL-88(Fe) Metal–Organic Frameworks
McKinlay, A. C., Eubank, J. F., Wuttke, S., Xiao, B., Wheatley, P. S., Bazin, P., Lavalley, J.-C., Daturi, M., Vimont, A., De Weireld, G., et al. (2013) · Chemistry of Materials · doi:10.1021/cm304037x · Cited by 294
Metadata
- Authors
- Miller, M. R., & Megson, I. L.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2007-06
- Volume
- 151
- Issue
- 3
- Pages
- 305-321
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1479760463
- Cited by
- 628
- References
- 18
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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