Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,580 · see citing works

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works

Two CD95 (APO‐1/Fas) signaling pathways

Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000 · see citing works

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., et al. (1999) · Nature Medicine · doi:10.1038/5517 · Cited by 2,497 · see citing works

Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.

Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., & Peter, M. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00245.x · Cited by 2,181 · see citing works

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,932 · see citing works

Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815 · see citing works

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,527 · see citing works

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499 · see citing works

FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)

Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., & Peter, M. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2794 · Cited by 1,189 · see citing works

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7795 · Cited by 993 · see citing works

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

Cleveland, D. W., Hwo, S.-Y., & Kirschner, M. W. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90213-3 · Cited by 915 · see citing works

THE NEUROLOGICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS: A CLINICAL-PATHOLOGICAL STUDY OF 24 CASES AND REVIEW OF THE LITERATURE

JOHNSON, R. T., & RICHARDSON, E. P. (1968) · Medicine · doi:10.1097/00005792-196807000-00002 · Cited by 825 · see citing works

Tau protein function in living cells.

Drubin, D. G., & Kirschner, M. W. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2739 · Cited by 745 · see citing works

Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments

Schneider, A., Biernat, J., von Bergen, M., Mandelkow, E., & Mandelkow, E.-M. (1999) · Biochemistry · doi:10.1021/bi981874p · Cited by 564 · see citing works

NEUROPSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS: DIAGNOSIS, CLINICAL SPECTRUM, AND RELATIONSHIP TO OTHER FEATURES OF THE DISEASE

Feinglass, E. J., Arnett, F. C., Dorsch, C. A., Zizic, T. M., & Stevens, M. B. (1976) · Medicine · doi:10.1097/00005792-197607000-00004 · Cited by 530 · see citing works

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Adachi, M., Watanabe‐Fukunaga, R., & Nagata, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1756 · Cited by 509 · see citing works

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

Martín-Villalba, A., Herr, I., Jeremias, I., Hahne, M., Brandt, R., Vogel, J., Schenkel, J., Herdegen, T., & Debatin, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03809.1999 · Cited by 431 · see citing works

Fas engagement induces neurite growth through ERK activation and p35 upregulation

Desbarats, J., Birge, R. B., Mimouni-Rongy, M., Weinstein, D. E., Palerme, J., & Newell, M. K. (2003) · Nature Cell Biology · doi:10.1038/ncb916 · Cited by 312 · see citing works

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

Sneller, M. C., Straus, S. E., Jaffe, E. S., Jaffe, J. S., Fleisher, T. A., Stetler‐Stevenson, M., & Strober, W. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115867 · Cited by 300 · see citing works

Decrease and Gain of Gene Expression Are Equally Discriminatory Markers for Prostate Carcinoma

Ernst, T., Hergenhahn, M., Kenzelmann, M., Cohen, C. D., Bonrouhi, M., Weninger, A., Klären, R., Gröne, E. F., Wiesel, M., Güdemann, C., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61165-0 · Cited by 258 · see citing works

Cellular phosphorylation of tau by GSK-3β influences tau binding to microtubules and microtubule organisation

Wagner, U., Utton, M. A., Gallo, J., & Miller, C. C. J. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.6.1537 · Cited by 255 · see citing works

Autoimmunity - A Perspective

Smith, H. R., & Steinberg, A. D. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.001135 · Cited by 254 · see citing works

Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor

Raoul, C., Henderson, C. E., & Pettmann, B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.1049 · Cited by 244 · see citing works

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

Demjen, D., Klußmann, S., Kleber, S., Zuliani, C., Stieltjes, B., Metzger, C., Hirt, U. A., Walczak, H., Falk, W., Essig, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1007 · Cited by 217 · see citing works

Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases

Oppenheim, R. W., Flavell, R. A., Vinsant, S. L., Prevette, D. M., Kuan, C.-Y., & RAKIC, P. T. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04752.2001 · Cited by 216 · see citing works

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

Martin-Villalba, A., Hahne, M., Kleber, S., Vogel, J., Falk, W., Schenkel, J., & Krammer, P. H. (2001) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400882 · Cited by 209 · see citing works

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane

Cohen, P. L., & Eisenberg, R. A. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90066-g · Cited by 199 · see citing works

Developments in neuronal cell culture

Banker, G., & Goslin, K. (1988) · Nature · doi:10.1038/336185a0 · Cited by 195 · see citing works

Fas/Apo [Apoptosis]-1 and Associated Proteins in the Differentiating Cerebral Cortex: Induction of Caspase-Dependent Cell Death and Activation of NF-κB

Cheema, Z. F., Wade, S. B., Sata, M., Walsh, K., Sohrabji, F., & Miranda, R. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01754.1999 · Cited by 158 · see citing works

Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

Schwab, C., DeMaggio, A. J., Ghoshal, N., Binder, L. I., Kuret, J., & McGeer, P. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00110-x · Cited by 148 · see citing works

The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus

Denburg, S. D., Carbotte, R. M., Ginsberg, J. S., & Denburg, J. A. (1997) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617797003779 · Cited by 138 · see citing works

Neuronal antibodies and cognitive function in systemic lupus erythematosus

Denburg, J. A., Carbotte, R. M., & Denburg, S. D. (1987) · Neurology · doi:10.1212/wnl.37.3.464 · Cited by 134 · see citing works

Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death

Ricci‐Vitiani, L., Pedini, F., Mollinari, C., Condorelli, G., Bonci, D., Bez, A., Colombo, A., Parati, E. A., Peschle, C., & Maria, R. D. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040921 · Cited by 114 · see citing works

Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice

Šakić, B., Szechtman, H., Denburg, J. A., Gorny, G., Kolb, B., & Whishaw, I. Q. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00085-x · Cited by 96 · see citing works

Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosus

Denburg, S. D., & Denburg, J. (2003) · Lupus · doi:10.1191/0961203303lu497oa · Cited by 90 · see citing works

Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study.

Hess, D. C., Taormina, M., Thompson, J. F., Sethi, K. D., Diamond, B., Rao, R., Chamberlain, C. R., & Feldman, D. S. (1993) · PubMed · Cited by 90 · see citing works

Expression of Fas Antigen in the Normal Mouse Brain

Park, C., Sakamaki, K., Tachibana, O., Yamashima, T., Yamashita, J., & Yonehara, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9572 · Cited by 80 · see citing works

Think globally, translate locally: What mitotic spindles and neuronal synapses have in common

Richter, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111146498 · Cited by 79 · see citing works

Neural stem cells and cell death

Ceccatelli, S. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.060 · Cited by 68 · see citing works

High-accuracy amplification of nanogram total RNA amounts for gene profiling

Kenzelmann, M., Klären, R., Hergenhahn, M., Bonrouhi, M., Gröne, H., Schmid, W., & Schütz, G. (2003) · Genomics · doi:10.1016/j.ygeno.2003.09.026 · Cited by 58 · see citing works

The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

Cheema, Z. F., Santillano, D. R., Wade, S. B., Newman, J. M., & Miranda, R. C. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-11 · Cited by 24 · see citing works

Fas ligand mRNA expression in the mouse central nervous system

Shin, D. H., Lee, E., Kim, H. J., Kim, S., Cho, S. S., Chang, K. Y., & Lee, W. J. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00478-7 · Cited by 20 · see citing works

Comparison of neuronal density and subfield sizes in the hippocampus of CD95L‐deficient (gld), CD95‐deficient (lpr) and nondeficient mice

Kovac, A. D., Grammig, J., Mahlo, J., Steiner, B., Roth, K. N., Nitsch, R., & Bechmann, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02060.x · Cited by 16 · see citing works

Life and death in peripheral T cells

Krammer, P. H., Arnold, R., & Lavrik, I. N. (2007) · Nature reviews. Immunology · doi:10.1038/nri2115 · Cited by 652 · see citing works

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond

Dostert, C., Grusdat, M., Letellier, E., & Brenner, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00045.2017 · Cited by 502 · see citing works

The CD95 Receptor: Apoptosis Revisited

Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. Μ., Hueber, A., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J. F., Wajant, H., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.031 · Cited by 396 · see citing works

The role of CD95 and CD95 ligand in cancer

Peter, M. E., Hadji, A., Murmann, A. E., Brockway, S., Putzbach, W., Pattanayak, A., & Ceppi, P. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.3 · Cited by 356 · see citing works

Regulation of CD95/Fas signaling at the DISC

Lavrik, I. N., & Krammer, P. H. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.155 · Cited by 357 · see citing works

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333 · see citing works

Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

Kleber, S., Sancho-Martinez, I., Wiestler, B., Beisel, A., Gieffers, C., Hill, O., Thiemann, M., Mueller, W., Sykora, J., Kuhn, A., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.003 · Cited by 309 · see citing works

Neuronal Apoptosis in Neurodegeneration

Okouchi, M., Ekshyyan, O. Y., Maracine, M., & Aw, T. Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1511 · Cited by 219 · see citing works

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

Azijli, K., Weyhenmeyer, B., Peters, G. J., de Jong, S., & Kruyt, F. A. E. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.28 · Cited by 178 · see citing works

Opposing Roles for Reactive Astrocytes following Traumatic Brain Injury

Laird, M. D., Vender, J. R., & Dhandapani, K. M. (2008) · Neurosignals · doi:10.1159/000111560 · Cited by 171 · see citing works

Surviving apoptosis: life–death signaling in single cells

Flusberg, D. A., & Sorger, P. K. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.03.003 · Cited by 149 · see citing works

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair

Corsini, N. S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.004 · Cited by 129 · see citing works

TNF Alpha and Fas Mediate Tissue Damage and Functional Outcome after Traumatic Brain Injury in Mice

Berrrrpohl, D., You, Z., Lo, E. H., Kim, H.-H., & Whalen, M. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600487 · Cited by 124 · see citing works

CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.

Letellier, E., Kumar, S., Sancho-Martinez, I., Krauth, S. J., Funke-Kaiser, A., Laudenklos, S., Konecki, K., Klussmann, S., Corsini, N. S., Kleber, S., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.011 · Cited by 129 · see citing works

Signaling by death receptors in the nervous system

Haase, G., Pettmann, B., Raoul, C., & Henderson, C. E. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.013 · Cited by 115 · see citing works

Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy

Henshall, D. C. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350421 · Cited by 112 · see citing works

Permissive and Repulsive Cues and Signalling Pathways of Axonal Outgrowth and Regeneration

Hou, S., Jiang, S. X., & Smith, R. A. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)00603-5 · Cited by 110 · see citing works

Analysis of CD95 Threshold Signaling

Lavrik, I. N., Golks, A., Riess, D., Bentele, M., Eils, R., & Krammer, P. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700434200 · Cited by 105 · see citing works

Lifeguard/neuronal membrane protein 35 regulates Fas ligand‐mediated apoptosis in neurons via microdomain recruitment

Fernández, M., Segura, M. F., Solé, C., Colino, A., Comella, J. X., & Ceña, V. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04767.x · Cited by 89 · see citing works

Fas and TRAIL ‘death receptors’ as initiators of inflammation: Implications for cancer

Cullen, S. P., & Martin, S. J. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.01.012 · Cited by 89 · see citing works

Cell death‐independent activities of the death receptors CD 95, TRAILR 1, and TRAILR 2

Siegmund, D., Lang, I., & Wajant, H. (2016) · FEBS Journal · doi:10.1111/febs.13968 · Cited by 83 · see citing works

The Long Form of Fas Apoptotic Inhibitory Molecule Is Expressed Specifically in Neurons and Protects Them against Death Receptor-Triggered Apoptosis

Segura, M. F., Solé, C., Pascual, M., Moubarak, R. S., Pérez‐García, M. J., Gozzelino, R., Iglesias‐Guimarais, V., Badiola, N., Bayascas, J. R., Llecha, N., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3462-07.2007 · Cited by 78 · see citing works

Increased Cell Surface Fas Expression Is Necessary and Sufficient To Sensitize Lung Fibroblasts to Fas Ligation-Induced Apoptosis: Implications for Fibroblast Accumulation in Idiopathic Pulmonary Fibrosis

Wynes, M. W., Edelman, B., Kostyk, A. G., Edwards, M. G., Coldren, C. D., Groshong, S. D., Cosgrove, G. P., Redente, E. F., Bamberg, A., Brown, K. K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100447 · Cited by 68 · see citing works

Life in the Fas lane: differential outcomes of Fas signaling

Brint, E. K., O'Callaghan, G. P., & Houston, A. M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1327-z · Cited by 59 · see citing works

TNFα reverse signaling promotes sympathetic axon growth and target innervation

Kisiswa, L., Osório, C., Erice, C., Vizard, T. N., Wyatt, S. L., & Davies, A. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3430 · Cited by 59 · see citing works

Fas/CD95 Regulatory Protein Faim2 Is Neuroprotective after Transient Brain Ischemia

Reich, A., Spering, C., Gertz, K. R., Harms, C., Gerhardt, E., Kronenberg, G., Nave, K. A., Schwab, M. H., Tauber, S. C., Drinkut, A., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2188-10.2011 · Cited by 57 · see citing works

Death receptor signalling in central nervous system inflammation and demyelination

Guire, C. M., Beyaert, R., & Loo, G. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.09.002 · Cited by 56 · see citing works

TNF‐α‐ and TRAIL‐resistant glioma cells undergo autophagy‐dependent cell death induced by activated microglia

Mora-Rodríguez, R. A., Abschuetz, A., Kees, T., Đokić, I., Joschko, N., Kleber, S., Geibig, R., Mosconi, E., Zentgraf, H., Martín-Villalba, A., et al. (2008) · Glia · doi:10.1002/glia.20785 · Cited by 55 · see citing works

Human and Mouse Colon Cancer Utilizes CD95 Signaling for Local Growth and Metastatic Spread to Liver

Li, H., Fan, X., Stoicov, C., Liu, J. H., Zubair, S., Tsai, E., Marie, R. S., Wang, T. C., Lyle, S. R., Kurt‐Jones, E. A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.004 · Cited by 55 · see citing works

Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers

García-Fuster, M. J., Ramos‐Miguel, A., Rivero, G., Harpe, R. L., Meana, J. J., & García-Sevilla, J. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.002 · Cited by 48 · see citing works

Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?

Reich, A., Spering, C., & Schulz, J. B. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.007 · Cited by 46 · see citing works

Fas activation increases neural progenitor cell survival

Knight, J. C., Scharf, E. L., & Mao‐Draayer, Y. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22253 · Cited by 46 · see citing works

A Novel Juxtamembrane Domain in Tumor Necrosis Factor Receptor Superfamily Molecules Activates Rac1 and Controls Neurite Growth

Ruan, W., Lee, C. T., & Desbarats, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0161 · Cited by 45 · see citing works

A critical role for Fas/CD‐95 dependent signaling pathways in the pathogenesis of hyperoxia‐induced brain injury

Dzietko, M., Boos, V., Sifringer, M., Polley, O., Gerstner, B., Genz, K., Endesfelder, S., Börner, C., Jacotot, E. D., Chauvier, D., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21516 · Cited by 44 · see citing works

Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology

Catts, V. S., & Weickert, C. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035511 · Cited by 42 · see citing works

Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice

Gao, L., Brenner, D., Llorens-Bobadilla, E., Saiz-Castro, G., Frank, T., Wieghofer, P., Hill, O., Thiemann, M., Karray, S., Prinz, M., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20132423 · Cited by 42 · see citing works

Developmental Regulation of Sensory Neurite Growth by the Tumor Necrosis Factor Superfamily Member LIGHT

Gavaldà, N., Gutiérrez, H., & Davies, A. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3566-08.2009 · Cited by 41 · see citing works

Axonal transport of neural membrane protein 35 mRNA increases axon growth

Merianda, T. T., Vuppalanchi, D., Yoo, S., Blesch, A., & Twiss, J. L. (2012) · Journal of Cell Science · doi:10.1242/jcs.107268 · Cited by 40 · see citing works

Fas apoptosis inhibitory molecules: more than death‐receptor antagonists in the nervous system

Planells‐Ferrer, L., Urresti, J., Coccia, E., Galenkamp, K. M. O., Calleja‐Yagüe, I., López‐Soriano, J., Carriba, P., Barneda‐Zahonero, B., Segura, M. F., & Comella, J. X. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13729 · Cited by 40 · see citing works

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death

Carriba, P., Jiménez, S., Navarro, V., Moreno‐González, I., Barneda‐Zahonero, B., Moubarak, R. S., López‐Soriano, J., Gutiérrez, A., Vitórica, J., & Comella, J. X. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.6 · Cited by 40 · see citing works

3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival

Balta, G. S. G., Monzel, C., Kleber, S., Beaudouin, J., Balta, E., Kaindl, T., Chen, S., Gao, L., Thiemann, M., Wirtz, C. R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.054 · Cited by 34 · see citing works

Membrane vesicles shed by oligodendroglioma cells induce neuronal apoptosis

D’Agostino, S., Salamone, M., Liegro, I. D., & Vittorelli, M. L. (2006) · International Journal of Oncology · doi:10.3892/ijo.29.5.1075 · Cited by 37 · see citing works

CD95 Is Part of a Let-7/p53/miR-34 Regulatory Network

Hau, A., Ceppi, P., & Peter, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049636 · Cited by 35 · see citing works

Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: Relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity

Ramos‐Miguel, A., García-Fuster, M. J., Callado, L. F., Harpe, R. L., Meana, J. J., & García-Sevilla, J. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.028 · Cited by 35 · see citing works

Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL

Osório, C., Chacón, P. J., White, M. A., Kisiswa, L., Wyatt, S. L., Rodrı́guez-Tébar, A., & Davies, A. M. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.01.002 · Cited by 34 · see citing works

CNS Macrophages Control Neurovascular Development via CD95L

Chen, S. X., Tisch, N., Kegel, M., Yerbes, R., Hermann, R., Hudalla, H., Zuliani, C., Balta, G. S. G., Zwadlo, K., von Engelhardt, J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.056 · Cited by 31 · see citing works

Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation

Krzyżowska, M., Kowalczyk, A., Skulska, K., Thörn, K., & Eriksson, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714821 · Cited by 33 · see citing works

Genetic determinants of neuronal vulnerability to apoptosis

Almeida, Á. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1029-y · Cited by 32 · see citing works

Effect of Cocaine on Fas-Associated Protein with Death Domain in the Rat Brain: Individual Differences in a Model of Differential Vulnerability to Drug Abuse

García-Fuster, M. J., Clinton, S. M., Watson, S. J., & Akil, H. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.88 · Cited by 32 · see citing works

Immature and Neurally Differentiated Mouse Embryonic Stem Cells Do Not Express a Functional Fas/Fas Ligand System

Brunlid, G., Pruszak, J., Holmes, B., Ole Isacson, A., & Sonntag, K. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0745 · Cited by 31 · see citing works

Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling

García-Fuster, M. J., Ramos‐Miguel, A., Miralles, A., & Garcı́a-Sevilla, J. A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.071 · Cited by 31 · see citing works

Regulation of neurite growth by tumour necrosis superfamily member RANKL

Gutiérrez, H., Kisiswa, L., O’Keeffe, G. W., Smithen, M. J., Wyatt, S. L., & Davies, A. M. (2013) · Open Biology · doi:10.1098/rsob.120150 · Cited by 31 · see citing works

Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells

de Mendoza, T. H., Pérez‐García, C. G., Kroll, T. T., Hoong, N., O’Leary, D. D. M., & Verma, I. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114226108 · Cited by 30 · see citing works

The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

Twohig, J. P., Cuff, S. M., Yong, A. A., & Wang, E. C. Y. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.041 · Cited by 29 · see citing works

CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons

Carriba, P., & Davies, A. M. (2017) · eLife · doi:10.7554/elife.30442 · Cited by 27 · see citing works

Anti-apoptotic gene therapy in Parkinson’s disease

Schulz, J. B. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_70 · Cited by 26 · see citing works

Role of Microglia in Psychostimulant Addiction

da Silva, M. C. M., Iglesias, L. P., Candelario‐Jalil, E., Khoshbouei, H., Moreira, F. A., & de Oliveira, A. C. P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221208142151 · Cited by 24 · see citing works

CD95 signaling in colorectal cancer

Hoogwater, F. J. H., Steller, E. J. A., Westendorp, B. F., Rinkes, I. H. M. B., & Kranenburg, O. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.007 · Cited by 23 · see citing works

Modulation of Hippocampal Neuroplasticity by Fas/CD95 Regulatory Protein 2 (Faim2) in the Course of Bacterial Meningitis

Tauber, S. C., Harms, K., Falkenburger, B. H., Weis, J., Sellhaus, B., Nau, R., Schulz, J. B., & Reich, A. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000020 · Cited by 23 · see citing works

Age-Dependent Maintenance of Motor Controland Corticostriatal Innervation by Death Receptor 3

Twohig, J. P., Roberts, M. I., Gavaldà, N., Rees-Taylor, E. L., Giralt, A., Adams, D., Brooks, S. P., Bull, M. J., Calder, C. J., Cuff, S. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1928-09.2010 · Cited by 23 · see citing works

A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells

Thornhill, P. B., Cohn, J. B., Drury, G. L., Stanford, W. L., Bernstein, A., & Desbarats, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.025 · Cited by 21 · see citing works

Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis

Aebischer, J., Bernard‐Marissal, N., Pettmann, B., & Raoul, C. (2013) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/746845 · Cited by 19 · see citing works

FasR and FasL in colorectal cancer

Szaryńska, M., Olejniczak-Kęder, A., Wierzbicki, P., Kobiela, J., Łaski, D., Śledziński, Z., Adrych, K., Guzek, M., & Kmieć, Z. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4083 · Cited by 17 · see citing works

Non-apoptotic Fas (CD95) Signaling on T Cells Regulates the Resolution of Th2-Mediated Inflammation

Williams, J. W., Ferreira, C. M., Blaine, K. M., Rayon, C., Velázquez, F., Tong, J., Peter, M. E., & Sperling, A. I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02521 · Cited by 17 · see citing works

Wengen, the Sole Tumour Necrosis Factor Receptor in Drosophila, Collaborates with Moesin to Control Photoreceptor Axon Targeting during Development

Ruan, W., Unsain, N., Desbarats, J., Fon, E. A., & Barker, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060091 · Cited by 16 · see citing works

The Death Receptor Antagonist FLIP-L Interacts with Trk and Is Necessary for Neurite Outgrowth Induced by Neurotrophins

Moubarak, R. S., Solé, C., Pascual, M., Gutiérrez, H., Llovera, M., Pérez‐García, M. J., Gozzelino, R., Segura, M. F., Iglesias‐Guimarais, V., Reix, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0537-10.2010 · Cited by 15 · see citing works

Fas/CD95 Ligation Induces Proliferation of Primary Fetal Astrocytes Through a Mechanism Involving Caspase 8-Mediated ERK Activation

Barca‐Mayo, O., Seoane, M., Señarís, R. M., & Arce, V. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350129 · Cited by 14 · see citing works

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

Frazzette, N., Cruz, A. C., Wu, X., Hammer, J. A., Lippincott‐Schwartz, J., Siegel, R. M., & Sengupta, P. (2022) · Cells · doi:10.3390/cells11121908 · Cited by 13 · see citing works

c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells

Waetzig, V., Loose, K., Haeusgen, W., & Herdegen, T. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.014 · Cited by 13 · see citing works

CD95/Fas in the Brain—Not Just a Killer

Beier, C. P., & Schulz, J. B. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.07.008 · Cited by 13 · see citing works

CD95/Fas mediates cognitive improvement after traumatic brain injury

Beier, C. P., Kölbl, M., Beier, D., Woertgen, C., Bogdahn, U., & Brawanski, A. T. (2007) · Cell Research · doi:10.1038/cr.2007.60 · Cited by 12 · see citing works

sCD95L in serum after spinal cord injury

Moghaddam, A., Sperl, A., Heller, R. A., Gerner, H. J., & Biglari, B. (2016) · Spinal Cord · doi:10.1038/sc.2016.44 · Cited by 12 · see citing works

FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression

Santos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., & Medeiros, R. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.027 · Cited by 11 · see citing works

Cell death in glioblastoma and the central nervous system

Malone, K., LaCasse, E. C., & Beug, S. T. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01007-8 · Cited by 10 · see citing works

Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: A δ-opioid tone inhibits FADD

García-Fuster, M. J., Ferrer‐Alcón, M., Martín, M., Kieffer, B. L., Maldonado, R. J., & Garcı́a-Sevilla, J. A. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.08.008 · Cited by 10 · see citing works

The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System

Seyrek, K., Espe, J., Reiss, E., & Lavrik, I. N. (2024) · Cells · doi:10.3390/cells13211814 · Cited by 11 · see citing works

Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors

Kamei, R., Tanaka, H. Y., Kawano, T., Morii, C., Tanaka, S., Nishihara, H., Iwata, C., & Kano, M. R. (2017) · Cancer Science · doi:10.1111/cas.13216 · Cited by 9 · see citing works

DICE

Peter, M. E. (2014) · Cell Cycle · doi:10.4161/cc.28673 · Cited by 8 · see citing works

A role of the Fas system in the pathogenesis of ischemic stroke

Sergeeva, S. P., Савин, A. A., & Litvitskiy, P. F. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2016116323-8 · Cited by 7 · see citing works

Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD

Carriba, P., & Comella, J. X. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00276 · Cited by 7 · see citing works

Expression of CD95 and CD95L on astrocytes in the CA1 area of the immature rat hippocampus after hypoxia-ischemia injury.

Kim, M. J., Lim, H., Yoo, Y. B., Lee, Y. I., Hahm, D., Lee, H., Jung, K. W., Kim, J., Yoe, S. M., Chung, D. C., et al. (2007) · PubMed · Cited by 6 · see citing works

An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex

Kim, S., Shin, J., Oh, H., Ahn, S., Kim, N., & Heo, W. D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.072 · Cited by 5 · see citing works

How CD40L reverse signaling regulates axon and dendrite growth

Carriba, P., & Davies, A. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03563-2 · Cited by 4 · see citing works

Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons

Cho, H. M., & Sun, W. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.3.219 · Cited by 4 · see citing works

Increased anti-apoptotic conditions in the nucleus tractus solitarii of spontaneously hypertensive rat

Gouraud, S. S., Waki, H., Bhuiyan, M. E. R., Takagishi, M., Kohsaka, A., & Maeda, M. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.01.007 · Cited by 4 · see citing works

Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro

Szaryńska, M., Olejniczak-Kęder, A., Zubrzycki, A., Wardowska, A., & Kmieć, Z. (2021) · Applied Sciences · doi:10.3390/app112110009 · Cited by 4 · see citing works

Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study

Shi, J., Liu, W., Song, A., Sanni, T., Deusen, A. L. V., Zunder, E. R., & Deppmann, C. D. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01594-5 · Cited by 7 · see citing works

Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations

Trumpi, K., Steller, E. J. A., de Leng, W. W. J., Raats, D., Nijman, I. J., Morsink, F. H. M., Rinkes, I. H. M. B., & Kranenburg, O. (2015) · Medical Molecular Morphology · doi:10.1007/s00795-015-0129-9 · Cited by 3 · see citing works

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth

Benlefki, S., Younes, R., Challuau, D., Bernard‐Marissal, N., Hilaire, C., Scamps, F., Bowerman, M., Kothary, R., Schneider, B. L., & Raoul, C. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.10.1 · Cited by 3 · see citing works

The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period

Wu, J. J., Li, W. M., Rui-xia, Z. H. A. O., Fang, J., Wang, C., Peng, X. L., Li, X. O., Xiong, J. J., Yang, L., & Zhang, S. J. (2008) · Animal Genetics · doi:10.1111/j.1365-2052.2008.01760.x · Cited by 2 · see citing works

Structural and functional modifications of presynaptic afferents: Do they correlate with learning mechanisms?

Kudryashova, I. V. (2011) · Neurochemical Journal · doi:10.1134/s181971241104009x · Cited by 1 · see citing works

The two sides of Faim2 -- modulation of cell death and regeneration

Falkenburger, B. H. (2017) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2017/2.942x/2017/1.1101 · Cited by 1 · see citing works

Fas/CD95, Lipid Rafts, and Cancer

Mollinedo, F., & Gajate, C. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-56805-8_9 · Cited by 1 · see citing works

Der Einfluss von CD95, Fas auf Motorik, Lernfähigkeit, Regeneration und Apoptose nach Schädelhirntrauma

Berger, M. R. (2010) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.14407

Die Rolle von CD95 im Immunsystem

Hoffmann, J. C., & Krammer, P. H. (2010) · Onkopipeline · doi:10.1007/s15035-010-0179-3

Apoptotic cell death in neural stem cells exposed to toxic stimuli

Tamm, C. (2007) · Figshare

Relevance of death receptors in nervous system: role in the pathogenesis of neurodegenerative diseases and targets for therapy

Segura, M. F., & Comella, J. X. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.2436/20.7010.01.33

Stickoxidmetabolite als Ursache einer differentiellen Myelingenexpression in MS-Läsionen?

Beck, A. K. (2011) · doi:10.53846/goediss-1091

Characterization of the fas death receptor antagonist in the nervous system, lifeguard (LFG)

Urresti, J. (2014) · TDX (Tesis Doctorals en Xarxa)

Die Rolle des CD95/CD95L-Systems bei der Aktivierung primärer humaner T-Lymphozyten

Paulsen, M. (2010) · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)

Comparison of neuronal density and subfield sizes in the hippocampus of CD95L‐deficient (gld), CD95‐deficient (lpr) and nondeficient mice

Kovac, A. D., Grammig, J., Mahlo, J., Steiner, B., Roth, K. N., Nitsch, R., & Bechmann, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02060.x · Cited by 16 · see citing works

Life and Death in the CNS

Chen, S., Hermann, R., Llorens-Bobadilla, E., & Martín-Villalba, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800781-5.00004-9

Fas/CD95/APO‐1 Can Function as a Death Receptor for Neuronal Cells in Vitro and in Vivo and is Upregulated Following Cerebral Hypoxic‐Ischemic Injury to the Developing Rat Brain

Felderhoff‐Mueser, U., Taylor, D. L., Greenwood, K., Kozma, M., Stibenz, D., Joashi, U. C., Edwards, A. D., & Mehmet, B. H. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00239.x · Cited by 145 · see citing works

Caracterización de los antagonistas del receptor de muerte CD95/FAS/APO-1, FAIM y Lifeguard en el sistema nervioso

Ginard, S., & Francisco, M. (2006) · TDX (Tesis Doctorals en Xarxa)

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

Martín-Villalba, A., Herr, I., Jeremias, I., Hahne, M., Brandt, R., Vogel, J., Schenkel, J., Herdegen, T., & Debatin, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03809.1999 · Cited by 431 · see citing works