The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair

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3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival

Balta, G. S. G., Monzel, C., Kleber, S., Beaudouin, J., Balta, E., Kaindl, T., Chen, S., Gao, L., Thiemann, M., Wirtz, C. R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.054 · Cited by 34 · see citing works

CD95 Is Part of a Let-7/p53/miR-34 Regulatory Network

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Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells

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CNS Macrophages Control Neurovascular Development via CD95L

Chen, S. X., Tisch, N., Kegel, M., Yerbes, R., Hermann, R., Hudalla, H., Zuliani, C., Balta, G. S. G., Zwadlo, K., von Engelhardt, J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.056 · Cited by 31 · see citing works

Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation

Krzyżowska, M., Kowalczyk, A., Skulska, K., Thörn, K., & Eriksson, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714821 · Cited by 33 · see citing works

Brain aging and rejuvenation at single-cell resolution

Sun, E., Nagvekar, R., Pogson, A. N., & Brunet, A. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.007 · Cited by 33 · see citing works

Modulation of CD8 + memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer

Zhang, J., Zhao, Y., Lv, Y.-P., Cheng, P., Chen, W., Duan, M., Teng, Y., Wang, T., Peng, L., Mao, F.-Y., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1412900 · Cited by 30 · see citing works

Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells

de Mendoza, T. H., Pérez‐García, C. G., Kroll, T. T., Hoong, N., O’Leary, D. D. M., & Verma, I. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114226108 · Cited by 30 · see citing works

The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

Twohig, J. P., Cuff, S. M., Yong, A. A., & Wang, E. C. Y. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.041 · Cited by 29 · see citing works

A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats.

Wang, J., Chen, W., & Wang, Y. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.18.003 · Cited by 29 · see citing works

Tunable, bioactive protein conjugated hyaluronic acid hydrogel for neural engineering applications

Shendi, D., Dede, A., Yin, Y., Wang, C., Valmikinathan, C. M., & Jain, A. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02235e · Cited by 28 · see citing works

Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450

Nabeel, A. I. (2020) · Tumor Biology · doi:10.1177/1010428320909999 · Cited by 27 · see citing works

FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors

Ho, I. A. W., Ng, W. H., & Lam, P. Y. P. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-270 · Cited by 27 · see citing works

Role of the RB-Interacting Proteins in Stem Cell Biology

Mushtaq, M., Gaza, H. V., & Kashuba, E. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.04.002 · Cited by 27 · see citing works

FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Li, L.-J., Chang, P. M., Li, C., Chang, Y., Lai, T., Su, C., Chen, C., Chang, W., Hsiao, M., & Feng, S. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00899-5 · Cited by 26 · see citing works

mTOR (Mammalian Target of Rapamycin): Hitting the Bull’s Eye for Enhancing Neurogenesis After Cerebral Ischemia?

Gao, J., Yao, M., Chang, D., & Liu, J. (2022) · Stroke · doi:10.1161/strokeaha.122.040376 · Cited by 26 · see citing works

Circuit mechanisms of GluA1-dependent spatial working memory

Freudenberg, F., Marx, V., Seeburg, P. H., Sprengel, R., & Celikel, T. (2013) · Hippocampus · doi:10.1002/hipo.22184 · Cited by 26 · see citing works

Anti‐ F as conjugated hyaluronic acid microsphere gels for neural stem cell delivery

Shendi, D., Albrecht, D. R., & Jain, A. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35930 · Cited by 25 · see citing works

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks

Seyrek, K., & Lavrik, I. N. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01540-0 · Cited by 25 · see citing works

CD95 is cytoprotective for intestinal epithelial cells in colitis

Park, S.-M., Chen, L., Zhang, M., Ashton‐Rickardt, P. G., Turner, J. R., & Peter, M. E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21195 · Cited by 24 · see citing works

CD95 signaling in colorectal cancer

Hoogwater, F. J. H., Steller, E. J. A., Westendorp, B. F., Rinkes, I. H. M. B., & Kranenburg, O. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.007 · Cited by 23 · see citing works

Modulation of Hippocampal Neuroplasticity by Fas/CD95 Regulatory Protein 2 (Faim2) in the Course of Bacterial Meningitis

Tauber, S. C., Harms, K., Falkenburger, B. H., Weis, J., Sellhaus, B., Nau, R., Schulz, J. B., & Reich, A. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000020 · Cited by 23 · see citing works

miRNAs Stem Cell Reprogramming for Neuronal Induction and Differentiation

Perruisseau-Carrier, C., Jurga, M., Forraz, N., & McGUCKIN, C. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8179-z · Cited by 22 · see citing works

TWEAK regulates proliferation and differentiation of adult neural progenitor cells

Schölzke, M. N., Röttinger, A., Murikinati, S. R., Gehrig, N., Leib, C., & Schwaninger, M. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.10.004 · Cited by 22 · see citing works

Interleukin 7 Up-regulates CD95 Protein on CD4+ T Cells by Affecting mRNA Alternative Splicing

Yin, Y., Zhang, S., Luo, H., Zhang, X., Geng, G., Li, J., Guo, X., Cai, W., Li, L., Liu, C., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.598631 · Cited by 22 · see citing works

Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model

Ferrari, D., Zalfa, C., Nodari, L. R., Gelati, M., Carlessi, L., Delia, D., Vescovi, A. L., & Filippis, L. D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0873-5 · Cited by 21 · see citing works

Neocortical Microdissection at Columnar and Laminar Resolution for Molecular Interrogation

Kole, K., & Celikel, T. (2018) · Current Protocols in Neuroscience · doi:10.1002/cpns.55 · Cited by 21 · see citing works

Chronic Hypoxia Impairs Murine Hippocampal Development and Depletes the Postnatal Progenitor Pool by Attenuating Mammalian Target of Rapamycin Signaling

Raman, L., Kong, X., Gilley, J. A., & Kernie, S. G. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e3182218622 · Cited by 21 · see citing works

Panax notoginseng Saponins Stimulates Neurogenesis and Neurological Restoration After Microsphere-Induced Cerebral Embolism in Rats Partially Via mTOR Signaling

Gao, J., Liu, J., Yao, M., Zhang, W., Yang, B., & Wang, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.889404 · Cited by 20 · see citing works

Fas Ligand-Fas Signaling Participates in Light-Induced Apoptotic Death in Photoreceptor Cells

Chang, Q., Peter, M. E., & Grassi, M. A. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8928 · Cited by 20 · see citing works

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement

Kim, S., Kim, N., Lee, J., Kim, S., Hong, J., Son, S., & Heo, W. D. (2020) · Science Advances · doi:10.1126/sciadv.aaz9691 · Cited by 19 · see citing works

Cross-talk between CD4+ T-cells and neural stem/progenitor cells

Knight, J. C., Hackett, C., Breton, J., & Mao‐Draayer, Y. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.03.030 · Cited by 19 · see citing works

Role of brominated diphenly ether‐209 in the differentiation of neural stem cells in vitro

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Increase in soluble CD95L during subacute phases after human spinal cord injury: a potential therapeutic target

Biglari, B., Büchler, A., Swing, T., Biehl, E., Roth, H. J., Brückner, T., Schmidmaier, G., Ferbert, T., Gerner, H. J., & Moghaddam, A. (2012) · Spinal Cord · doi:10.1038/sc.2012.139 · Cited by 18 · see citing works

Serum sCD95L concentration in patients with spinal cord injury

Biglari, B., Büchler, A., Swing, T., Child, C., Biehl, E., Reitzel, T., Bruckner, T., Ferbert, T., Korff, S., Rief, H., et al. (2015) · Journal of International Medical Research · doi:10.1177/0300060514559794 · Cited by 18 · see citing works

FasR and FasL in colorectal cancer

Szaryńska, M., Olejniczak-Kęder, A., Wierzbicki, P., Kobiela, J., Łaski, D., Śledziński, Z., Adrych, K., Guzek, M., & Kmieć, Z. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4083 · Cited by 17 · see citing works

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Raats, D., Frenkel, N. C., van Schelven, S. J., Rinkes, I. H. M. B., Laoukili, J., & Kranenburg, O. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.87 · Cited by 14 · see citing works

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Hughes, S., & Celikel, T. (2019) · BioEssays · doi:10.1002/bies.201900088 · Cited by 14 · see citing works

CD95/Fas in the Brain—Not Just a Killer

Beier, C. P., & Schulz, J. B. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.07.008 · Cited by 13 · see citing works

Clobetasol propionate enhances neural stem cell and oligodendrocyte differentiation

Shi, W., Bi, S., Dai, Y., Yang, K., Zhao, Y., & Zhang, Z. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7692 · Cited by 13 · see citing works

Panax notoginseng saponins stimulates the differentiation and neurite development of C17.2 neural stem cells against OGD/R injuries via mTOR signaling

Gao, J., Yao, M., Zhang, Y., Jiang, Y., & Liu, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116260 · Cited by 12 · see citing works

The effect of Fas/FasL pathway blocking on apoptosis and stemness within breast cancer tumor microenvironment (preclinical study)

Shousha, S. A. A., Baheeg, S., Ghoneim, H., Zoheir, M. A., Hemida, M. F., & Shahine, Y. M. (2023) · Breast Disease · doi:10.3233/bd-220077 · Cited by 12 · see citing works

sCD95L in serum after spinal cord injury

Moghaddam, A., Sperl, A., Heller, R. A., Gerner, H. J., & Biglari, B. (2016) · Spinal Cord · doi:10.1038/sc.2016.44 · Cited by 12 · see citing works

FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression

Santos, M., Carvalho, S., Lima, L., Mota-Pereira, J., Pimentel, P., Maia, D., Correia, D., Gomes, S., Cruz, A., & Medeiros, R. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.027 · Cited by 11 · see citing works

Resistance of Human Liver Mesenchymal Stem Cells to FAS-Induced Cell Death

Kholodenko, I. V., Gisina, A. M., Manukyan, G. V., Majouga, A. G., Svirshchevskaya, E. V., Kholodenko, R. V., & Yarygin, K. N. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44080236 · Cited by 11 · see citing works

Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia

Chung, S., Yi, Y., Ullah, I., Chung, K., Park, S., Lim, J., Kim, C., Pyun, S.-H., Kim, M., Kim, D., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010661 · Cited by 10 · see citing works

Cell death in glioblastoma and the central nervous system

Malone, K., LaCasse, E. C., & Beug, S. T. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01007-8 · Cited by 10 · see citing works

mTOR

Castellanos, M., Gubern, C., & Kádár, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00012-8 · Cited by 10 · see citing works

Alterations of the frequency and functions of follicular regulatory T cells and related mechanisms in HIV infection

Zhao, S., Xu, W. L., Tu, B., Hong, W., Zhang, Z., Chen, W., & Zhao, M. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.09.014 · Cited by 10 · see citing works

EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory

Barth, K., Vasić, V., McDonald, B., Heinig, N., Wagner, M.-C., Schumann, U., Roehlecke, C., Bicker, F., Schumann, L., Radyushkin, K., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04685-z · Cited by 10 · see citing works

CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells

Tan, L., Zhang, C., Dematos, J., Kuang, L., Jung, J. U., & Liang, X. (2016) · Journal of Virology · doi:10.1128/jvi.00668-16 · Cited by 9 · see citing works

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury

Dehler, S., Lou, W. P.-K., Gao, L., Skabkin, M. A., Dällenbach, S., Neumann, A., & Martín-Villalba, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00443 · Cited by 9 · see citing works

Neurogenesis in the Damaged Mammalian Brain

Nakafuku, M., & Grande, A. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00074-5 · Cited by 8 · see citing works

DICE

Peter, M. E. (2014) · Cell Cycle · doi:10.4161/cc.28673 · Cited by 8 · see citing works

Editors' Notes

(2009) · Cell stem cell · doi:10.1016/j.stem.2009.07.014

Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus

Zhu, D. Y., Lau, L. W., Liu, S. H., Wei, J., & Lu, Y. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401063101 · Cited by 178 · see citing works

CD95/Fas mediates cognitive improvement after traumatic brain injury

Beier, C. P., Kölbl, M., Beier, D., Woertgen, C., Bogdahn, U., & Brawanski, A. T. (2007) · Cell Research · doi:10.1038/cr.2007.60 · Cited by 12 · see citing works

Targeting Adult Neurogenesis for Poststroke Therapy

Lu, J., Manaenko, A., & Hu, Q. (2017) · Stem Cells International · doi:10.1155/2017/5868632 · Cited by 54 · see citing works

Neural stem cell transplantation in the hippocampus of rats with cerebral ischemia/reperfusion injury Activation of the phosphatidylinositol-3 kinase/Akt pathway and increased brain-derived neurotrophic factor expression

Yu, Zhao, Sheng-Tao, YAO, Y., Shijun, & Wang (2010) · 中国神经再生研究：英文版 · Cited by 2 · see citing works