Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,460 · see citing works

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060 · see citing works

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., & Diehl, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8477-8486.2004 · Cited by 986 · see citing works

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

Kobayashi, A., Kang, M.-I., Watai, Y., Tong, K. I., Shibata, T., Uchida, K., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.221-229.2006 · Cited by 933 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

Itoh, K., Tong, K. I., & Yamamoto, M. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.075 · Cited by 866 · see citing works

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

Nguyen, T., Yang, C. S., & Pickett, C. B. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.033 · Cited by 463 · see citing works

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502402102 · Cited by 459 · see citing works

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2002) · Gene · doi:10.1016/s0378-1119(02)00788-6 · Cited by 456 · see citing works

Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound

Braun, S., Hanselmann, C., Gassmann, M. G., auf dem Keller, U., Born-Berclaz, C., Chan, K., Kan, Y. W., & Werner, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5492-5505.2002 · Cited by 410 · see citing works

Inhibition of 7,12-Dimethylbenz(a)anthracene-Induced Skin Tumorigenesis in C57BL/6 Mice by Sulforaphane Is Mediated by Nuclear Factor E2–Related Factor 2

Xu, C., Huang, M., Shen, G., Yuan, X., Lin, W., Khor, T. O., Conney, A. H., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0300 · Cited by 379 · see citing works

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

Motohashi, H., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305902101 · Cited by 363 · see citing works

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

Xu, Z., Chen, L., Leung, L., Yen, T. S. B., Lee, C., & Chan, J. Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500660102 · Cited by 291 · see citing works

Targeted disruption of the ubiquitous CNC‐bZIP transcription factor, Nrf‐1, results in anemia and embryonic lethality in mice

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Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

Dinkova‐Kostova, A. T., Jenkins, S. N., Fahey, J. W., Ye, L., Wehage, S. L., Liby, K. T., Stephenson, K. K., Wade, K. L., & Talalay, P. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.09.012 · Cited by 230 · see citing works

Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide

Pi, J., Qu, W., Reece, J. M., Kumagai, Y., & Waalkes, M. P. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00341-0 · Cited by 228 · see citing works

NADPH Oxidase and ERK Signaling Regulates Hyperoxia-induced Nrf2-ARE Transcriptional Response in Pulmonary Epithelial Cells

Papaiahgari, S. R., Kleeberger, S. R., Cho, H., Kalvakolanu, D. V., & Reddy, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408275200 · Cited by 167 · see citing works

Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis

Hirota, A., Kawachi, Y., Itoh, K., Nakamura, Y., Xu, X., Banno, T., Takahashi, T., Yamamoto, M. P., & Otsuka, F. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23670.x · Cited by 162 · see citing works

Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

Johnson, D. A., Andrews, G. K., Xu, W., & Johnson, J. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00913.x · Cited by 156 · see citing works

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

Li, J., Stein, T. D., & Johnson, J. A. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00209.2003 · Cited by 154 · see citing works

Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development

Chen, L., Kwong, M., Lu, R., Ginzinger, D. G., Lee, C., Leung, L., & Chan, J. Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4673-4686.2003 · Cited by 139 · see citing works

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Devling, T. W. P., LINDSAY, C. D., McLellan, L. I., McMahon, M. J., & Hayes, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501475102 · Cited by 122 · see citing works

Nrf Transcription Factors in Keratinocytes Are Essential for Skin Tumor Prevention but Not for Wound Healing

Keller, U. A. D., Huber, M., Beyer, T. A., Kümin, A., Siemes, C., Braun, S., Bugnon, P., Mitropoulos, V., Johnson, D. A., Johnson, J. A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3773-3784.2006 · Cited by 122 · see citing works

Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion

Gills, J. J., Jeffery, E. H., Matusheski, N. V., Moon, R. C., Lantvit, D. D., & Pezzuto, J. M. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.05.007 · Cited by 112 · see citing works

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the <i>Nrf3</i> Locus

Derjuga, A., Gourley, T. S., Holm, T. M., Heng, H. H. Q., Shivdasani, R. A., Ahmed, R., Andrews, N. C., & Blank, V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3286-3294.2004 · Cited by 100 · see citing works

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

Pedersen, T. X., Leethanakul, C., Patel, V., Mitola, D. J., Lund, L. R., Danø, K., Johnsen, M., Gutkind, J. S., & Bugge, T. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206614 · Cited by 80 · see citing works

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

Haridas, V., Hanausek, M., Nishimura, G., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418699 · Cited by 72 · see citing works

Electrophilic Chemicals but not UV Irradiation or Reactive Oxygen Species Activate Nrf2 in Keratinocytes In Vitro and In Vivo

Durchdewald, M., Beyer, T. A., Johnson, D. A., Johnson, J. A., Werner, S., & Keller, U. A. D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700585 · Cited by 53 · see citing works

Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms

Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works

The role of transcription factor Nrf2 in skin cells metabolism

Gęgotek, A., & Skrzydlewska, E. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1554-2 · Cited by 180 · see citing works

Heme oxygenase–1 protects human melanocytes from H2O2–induced oxidative stress via the Nrf2–ARE pathway

Jian, Z., Li, K., Liu, L., Zhang, Y., Zhou, Z., Li, C., & Gao, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.56 · Cited by 175 · see citing works

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

Schäfer, M., Dütsch, S., auf dem Keller, U., Navid, F., Schwarz, A., Johnson, D. A., Johnson, J. A., & Werner, S. (2010) · Genes &amp; Development · doi:10.1101/gad.568810 · Cited by 175 · see citing works

Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy

Zhu, B., Tang, L., Chen, S., Yin, C., Peng, S., Li, X., Liu, T., Liu, W., Han, C., Stawski, L., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0314-0 · Cited by 117 · see citing works

Resveratrol, 4′ Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health

Lephart, E. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061193 · Cited by 50 · see citing works

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works

Nitroxide delivery system for Nrf2 activation and skin protection

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Morphomechanical programming of morphogenesis in Cnidarian embryos

Kraus, Y. A. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052061yk · Cited by 31 · see citing works

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