Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Disturbance of ER redox state, as a consequence of oxidative stress, alteration of calcium homeostasis, or dysregulated chaperones activity, may result in un/misfolded, or aggregated proteins that will be targeted to degradation pathways or accumulate in cells.
“Disturbance of ER redox state, as a consequence of oxidative stress, alteration of calcium homeostasis, or dysregulated chaperones activity, may result in un/misfolded, or aggregated proteins that will be targeted to degradation pathways or accumulate in cells [47].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works
Self-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536 · see citing works
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works
Self-citationAutophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832 · see citing works
ER stress and the unfolded protein response
Schröder, M., & Kaufman, R. J. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.056 · Cited by 1,750 · see citing works
Yin, X.-M., Oltvai, Z., & Korsmeyer, S. (1994) · Nature · doi:10.1038/369321a0 · Cited by 1,383 · see citing works
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1192 · Cited by 1,358 · see citing works
Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8
Yu, L., Alva, A. S., Su, H. C., Dutt, P., Freundt, E. C., Welsh, S. J., Baehrecke, E. H., & Lenardo, M. J. (2004) · Science · doi:10.1126/science.1096645 · Cited by 1,220 · see citing works
Coupling endoplasmic reticulum stress to the cell death program
Rao, R. V., Ellerby, H. M., & Bredesen, D. E. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401378 · Cited by 1,208 · see citing works
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108 · see citing works
Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2
Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.009 · Cited by 1,072 · see citing works
Endoplasmic Reticulum Stress Signaling in Disease
Marciniak, S. J., & Ron, D. (2006) · Physiological Reviews · doi:10.1152/physrev.00015.2006 · Cited by 948 · see citing works
Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934 · see citing works
Cellular response to endoplasmic reticulum stress: a matter of life or death
Boyce, M., & Yuan, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401817 · Cited by 681 · see citing works
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
Zong, W., Li, C., Hatzivassiliou, G., Lindsten, T., Yu, Q., Yuan, J., & Thompson, C. B. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302084 · Cited by 595 · see citing works
Self-citationDifferential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival
Ding, W., Ni, H., Gao, W., Hou, Y., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z.-M., & Yin, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609267200 · Cited by 481 · see citing works
Induction of Autophagy in Axonal Dystrophy and Degeneration
Wang, Q. J., Ding, Y., Kohtz, S., Mizushima, N., Cristea, I. M., Rout, M. P., Chait, B. T., Zhong, Y., Heintz, N., & Yue, Z. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2261-06.2006 · Cited by 308 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 20
- Schroder M et al. Mutat Res 2005; 569: 29-63.
- Marciniak SJ et al. Physiol Rev 2006; 86: 1133-1149.
- Rao RV et al. Cell Death Differ 2004; 11: 372-380.
- Boyce M et al. Cell Death Differ 2006; 13: 363-373.
- Wei MC et al. Science 2001; 292: 727-730.
- Scaffidi P et al. Nature 2002; 418: 191-195.
- Kabeya Y et al. EMBO J 2000; 19: 5720-5728.
- Yin XM et al. Nat Cell Biol 1994; 369: 321-323.
- Shimizu S et al. Nat Cell Biol 2004; 6: 1221-1228.
- Pattingre S et al. Cell 2005; 122: 927-939.
- Hoyer-Hansen M et al. Mol Cell 2007; 25: 193-205.
- Liang XH et al. Nature 1999; 402: 672-676.
- Yue Z et al. Proc Natl Acad Sci USA 2003; 100: 15077-15082.
- Tanida I et al. Autophagy 2005; 1: 84-91.
- Zong WX et al. J Cell Biol 2003; 162: 59-69.
- Ogata M et al. Mol Cell Biol 2006; 26: 9220-9231.
- Kouroku Y et al. Cell Death Differ 2007; 14: 230-239.
- Yu L et al. Science 2004; 304: 1500-1502.
- Ding WX et al. J Biol Chem 2007; 282: 4702-4710.
- Wang QJ et al. J Neurosci 2006; 26: 8057-8068.
Cited by
Sorted by citations
Cellular Stress Responses: Cell Survival and Cell Death
Fulda, S., Gorman, A. M., Hori, O., & Samali, A. (2010) · International Journal of Cell Biology · doi:10.1155/2010/214074 · Cited by 1,508 · see citing works
Life and death partners: apoptosis, autophagy and the cross-talk between them
Eisenberg‐Lerner, A., Bialik, S., Simon, H.-U., & Kimchi, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.33 · Cited by 1,183 · see citing works
Cell death induced by endoplasmic reticulum stress
Iurlaro, R., & Muñoz‐Pinedo, C. (2015) · FEBS Journal · doi:10.1111/febs.13598 · Cited by 1,067 · see citing works
Anti-apoptosis and cell survival: A review
Portt, L., Norman, G., Clapp, C., Greenwood, M., & Greenwood, M. T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.010 · Cited by 640 · see citing works
A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress
Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre d’Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600 · see citing works
Expansion and evolution of cell death programmes
Degterev, A., & Yuan, J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2393 · Cited by 548 · see citing works
Autophagy: for better or for worse
Wirawan, E., Berghe, T. V., Lippens, S., Agostinis, P., & Vandenabeele, P. (2011) · Cell Research · doi:10.1038/cr.2011.152 · Cited by 468 · see citing works
Maycotte, P., & Thorburn, A. M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14627 · Cited by 394 · see citing works
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function
Jaber, N. L., Dou, Z., Chen, J., Catanzaro, J. M., Jiang, Y.-P., Ballou, L. M., Selinger, E. S., Ouyang, X., Lin, R. Z., Zhang, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112848109 · Cited by 386 · see citing works
Self-citationAutophagy and apoptosis in liver injury
Wang, K. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1038685 · Cited by 363 · see citing works
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Gorman, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00402.x · Cited by 362 · see citing works
ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
Dewaele, M., Maes, H., & Agostinis, P. (2010) · Autophagy · doi:10.4161/auto.6.7.12113 · Cited by 307 · see citing works
Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Zhang, Q., Jia, M., Wang, Y., Wang, Q., & Wu, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03697-8 · Cited by 295 · see citing works
New directions in ER stress-induced cell death
Logue, S. E., Cleary, P., Saveljeva, S., & Afshin Samali, A. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0818-6 · Cited by 278 · see citing works
Gözüaçık, D., Bialik, S., Raveh, T. B., Mitou, G., Shohat-Ophir, G., Sabanay, H., Mizushima, N., Yoshimori, T., & Kimchi, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.121 · Cited by 259 · see citing works
Zeng, M., Sang, W., Chen, S., Chen, R., Zhang, H., Xue, F., Li, Z., Liu, Y., Gong, Y., Zhang, H., et al. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.02.023 · Cited by 257 · see citing works
Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential
Basseri, S., & Austin, R. C. (2011) · Biochemistry Research International · doi:10.1155/2012/841362 · Cited by 255 · see citing works
Chiu, H., Xia, T., Lee, Y., Chen, C.-W., Tsai, J., & Wang, Y. (2014) · Nanoscale · doi:10.1039/c4nr05509h · Cited by 255 · see citing works
Fortunato, F., Bürgers, H. F., Bergmann, F., Rieger, P., Büchler, M. W., Kroemer, G., & Werner, J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.003 · Cited by 246 · see citing works
Apoptosis in cancer: Key molecular signaling pathways and therapy targets
Burz, C. C., Berindan‐Neagoe, I., Bălăcescu, O., & Irimie, A. (2009) · Acta Oncologica · doi:10.1080/02841860902974175 · Cited by 244 · see citing works
Cadmium and cellular signaling cascades: interactions between cell death and survival pathways
Thévenod, F., & Lee, W. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1110-9 · Cited by 248 · see citing works
Engin, F., & Hotamışlıgil, G. S. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01282.x · Cited by 245 · see citing works
Bcl-2 family on guard at the ER
Szegezdi, É., Macdonald, D. C., Chonghaile, T. N., Gupta, S., & Afshin Samali, A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00612.2008 · Cited by 241 · see citing works
PUMA- and Bax-induced autophagy contributes to apoptosis
Yee, K. S. Y., Wilkinson, S., James, J., Ryan, K. M., & Vousden, K. H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.28 · Cited by 235 · see citing works
Puyal, J., Ginet, V., & Clarke, P. G. H. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.002 · Cited by 218 · see citing works
Autophagy and Apoptosis Act as Partners to Induce Germ Cell Death after Heat Stress in Mice
Zhang, M., Jiang, M., Bi, Y., Zhu, H., Zhou, Z., & Sha, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041412 · Cited by 197 · see citing works
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi, Y. J., Park, Y. J., Park, J. Y., Jeong, H. O., Kim, D. H., Ha, Y. M., Kim, J. M., Song, Y. M., Heo, H.-S., Yu, B. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043418 · Cited by 192 · see citing works
Regulation of autophagy in mammals and its interplay with apoptosis
Fimia, G. M., & Piacentini, M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0284-z · Cited by 180 · see citing works
Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
Ciechomska, I. A., Goemans, G. C., Skepper, J. N., & Tolkovsky, A. M. (2009) · Oncogene · doi:10.1038/onc.2009.60 · Cited by 180 · see citing works
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Jaeger, P. A., & Wyss‐Coray, T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-16 · Cited by 175 · see citing works
Cell death pathways of particulate matter toxicity
Peixoto, M. S., Galvão, M. F. D. O., & de Medeiros, S. R. B. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.08.076 · Cited by 171 · see citing works
Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response
Doroudgar, S., Thuerauf, D. J., Marcinko, M. C., Belmont, P. J., & Glembotski, C. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018036 · Cited by 162 · see citing works
Cybulsky, A. V. (2012) · Kidney International · doi:10.1038/ki.2012.390 · Cited by 148 · see citing works
The cellular decision between apoptosis and autophagy
Fan, Y., & Zong, W. (2012) · 癌症：英文版 · doi:10.5732/cjc.012.10106 · Cited by 141 · see citing works
Self-citationLife, death and burial: multifaceted impact of autophagy
Galluzzi, L., Morselli, E., Vicencio, J. M., Kepp, O., Joza, N. A., Tajeddine, N., & Kroemer, G. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360786 · Cited by 138 · see citing works
Cohen, J. I., Roychowdhury, S., McMullen, M. R., Stavitsky, A. B., & Nagy, L. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.041 · Cited by 138 · see citing works
Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells
Khan, M. J., Alam, M. R., Waldeck‐Weiermair, M., Karsten, F., Groschner, L. N., Riederer, M., Hallström, S., Rockenfeller, P., Kónya, V., Heinemann, Á., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.319129 · Cited by 134 · see citing works
Kim, K., Moretti, L., Mitchell, L., Jung, D. K., & Lu, J. (2010) · Oncogene · doi:10.1038/onc.2010.74 · Cited by 125 · see citing works
Tsai, Y.-Y., Huang, Y.-H., Chao, Y.-L., Hu, K.-Y., Chin, L., Chou, S.-H., Hour, A., Yao, Y.-D., Tu, C., Liang, Y., et al. (2011) · ACS Nano · doi:10.1021/nn2027775 · Cited by 114 · see citing works
Self-citationAutophagy: A Crucial Moderator of Redox Balance, Inflammation, and Apoptosis in Lung Disease
Nakahira, K., Cloonan, S. M., Mizumura, K., Choi, A. M. K., & Ryter, S. W. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5373 · Cited by 112 · see citing works
Pan, J.-A., Ullman, E., Dou, Z., & Zong, W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05460-11 · Cited by 108 · see citing works
Self-citationAutophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death
Bartolomé, A., Guillén, C., & Benito, M. (2012) · Autophagy · doi:10.4161/auto.21994 · Cited by 103 · see citing works
Autophagy in Pulmonary Diseases
Ryter, S. W., Nakahira, K., Haspel, J. A., & Choi, A. M. K. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153348 · Cited by 102 · see citing works
Csordás, A., Kreutmayer, S. B., Ploner, C., Braun, P. R., Karlas, A., Backović, A., Wick, G., & Bernhard, D. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr165 · Cited by 94 · see citing works
Ryter, S. W., Lee, S., Smith, A., & Choi, A. M. K. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-100js · Cited by 92 · see citing works
The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy
Dou, Z., Chattopadhyay, M., Pan, J.-A., Guerriero, J. L., Jiang, Y.-P., Ballou, L. M., Yue, Z., Lin, R. Z., & Zong, W. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006056 · Cited by 91 · see citing works
Self-citationApoptosis-Modulating Drugs for Improved Cancer Therapy
Ocker, M., & Höpfner, M. (2012) · European Surgical Research · doi:10.1159/000336875 · Cited by 85 · see citing works
Autophagy in breast cancer and its implications for therapy.
Jain, K., Paranandi, K. S., Sridharan, S., & Basu, A. (2013) · PubMed Central · Cited by 84 · see citing works
Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy?
Du, M., Wu, M., Fu, D., Yang, S., Chen, J., Wilson, K., & Lyons, T. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2986-x · Cited by 82 · see citing works
Eum, K., & Lee, M. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0638-8 · Cited by 81 · see citing works
Pratt, Z. L., Zhang, J., & Sugden, B. (2012) · Journal of Virology · doi:10.1128/jvi.06966-11 · Cited by 81 · see citing works
Autophagy in Pulmonary Diseases
Nakahira, K., Pabon Porras, M. A., & Choi, A. M. K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2468so · Cited by 78 · see citing works
Cell organelles as targets of mammalian cadmium toxicity
Lee, W., & Thévenod, F. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02692-8 · Cited by 78 · see citing works
Wu, S., Lan, S., Cheng, D.-E., Chen, W.-K., Shen, C., Lee, Y., Zuchini, R., & Liu, H. (2011) · Neoplasia · doi:10.1593/neo.11888 · Cited by 78 · see citing works
Caro‐Maldonado, A., Tait, S. W. G., Ramírez‐Peinado, S., Ricci, J., Fabregat, I., Green, D. R., & Muñoz‐Pinedo, C. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.21 · Cited by 77 · see citing works
Neuronal death after perinatal cerebral hypoxia‐ischemia: Focus on autophagy—mediated cell death
Descloux, C., Ginet, V., Clarke, P. G. H., Puyal, J., & Truttmann, A. C. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.06.008 · Cited by 76 · see citing works
GSK-3β promotes cell survival by modulating Bif-1-dependent autophagy and cell death
Yang, J., Takahashi, Y., Cheng, E., Liu, J., Terranova, P. F., Zhao, B., Thrasher, J. B., Wang, H., & Li, B. (2010) · Journal of Cell Science · doi:10.1242/jcs.060475 · Cited by 74 · see citing works
Glucose-starved Cells Do Not Engage in Prosurvival Autophagy
Ramírez‐Peinado, S., León‐Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro‐Maldonado, A., Prehn, J. H. M., Ryan, K. M., & Muñoz‐Pinedo, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.490581 · Cited by 74 · see citing works
Maksimovic-Ivanic, D., Mijatovic, S., Harhaji, L., Miljkovic, D., Dabideen, D., Fan Cheng, K., Mangano, K., Malaponte, G., Al-Abed, Y., Libra, M., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2037 · Cited by 74 · see citing works
Ryan, D., Carberry, S., Murphy, Á. C., Lindner, A. U., Fay, J., Hector, S., McCawley, N., Bacon, O., Concannon, C. G., Kay, E. W., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0948-z · Cited by 73 · see citing works
Overexpression of HO-1 assisted PM2.5-induced apoptosis failure and autophagy-related cell necrosis
Zhou, W. J., Yuan, X., Zhang, L., Su, B., Tian, D., Yang, L., Zhao, J., Wang, Y., & Peng, S. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.07.047 · Cited by 70 · see citing works
Late Phase of the Endoplasmic Reticulum Stress Response Pathway Is Regulated by Hog1 MAP Kinase
Bicknell, A. A., Tourtellotte, J., & Niwa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.084681 · Cited by 71 · see citing works
Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
Ryter, S. W., Lee, S., & Choi, A. M. K. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.61 · Cited by 70 · see citing works
Fésüs, L., Demény, M. Á., & Petrovski, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3485 · Cited by 68 · see citing works
Crawford, A. C., Riggins, R. B., Shajahan‐Haq, A. N., Zwart, A. L., & Clarke, R. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008604 · Cited by 67 · see citing works
Pharmacological Modulation of Autophagy During Cardiac Stress
Sciarretta, S., Zhai, P., Volpe, M., & Sadoshima, J. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182575f61 · Cited by 64 · see citing works
Necroptosis: Who Knew There were so Many Interesting Ways to Die?
Fayaz, S. M., Kumar, V. S. S., & Rajanikant, G. K. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660189 · Cited by 64 · see citing works
Deegan, S., Saveljeva, S., Logue, S. E., Pakos‐Zebrucka, K., Gupta, S., Vandenabeele, P., Bertrand, M. J. M., & Afshin Samali, A. (2014) · Autophagy · doi:10.4161/15548627.2014.981790 · Cited by 61 · see citing works
Fink, E. E., Moparthy, S., Bagati, A., Bianchi, A., Lipchick, B. C., Wolff, D. W., Roll, M. V., Wang, J., Liu, S., Bakin, A. V., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.013 · Cited by 61 · see citing works
Survival and death of endoplasmic-reticulum-stressed cells: Role of autophagy
Cheng, Y. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i10.226 · Cited by 58 · see citing works
Zhong, J., Kong, X., Zhang, H., Yu, C., Xu, Y., Kang, J., Yu, H., Yi, H., Yang, X., & Sun, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039378 · Cited by 57 · see citing works
Chiu, H., Fang, W.-H., Chen, Y.-L., Wu, M.-D., Yuan, G., Ho, S., & Wang, Y.-J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040462 · Cited by 57 · see citing works
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells
Jiang, H., Sun, J., Xu, Q., Liu, Y., Wei, J., Young, C. Y. F., Yuan, H., & Lou, H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.285 · Cited by 54 · see citing works
Yagami, T., Yamamoto, Y., & Koma, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1277-4 · Cited by 54 · see citing works
Impaired autophagosome-lysosome fusion in the pathogenesis of pancreatitis
Fortunato, F., & Kroemer, G. (2009) · Autophagy · doi:10.4161/auto.8839 · Cited by 54 · see citing works
Hwang, M.-S., & Baek, W. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.050 · Cited by 53 · see citing works
Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor
Moretti, L., Kim, K. W., Jung, D. K., Willey, C. D., & Lu, J. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0893 · Cited by 53 · see citing works
Galluzzi, L., Santi, M. D., Crinelli, R., Marco, C. D., Zaffaroni, N., Duranti, A., Brandi, G., & Magnani, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043249 · Cited by 52 · see citing works
Kim, D., Li, B., Rhew, K. Y., Oh, H., Lim, H., Lee, W., Chae, H., & Kim, H. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0718-2 · Cited by 46 · see citing works
Tu, Y., Kaipparettu, B. A., Ma, Y., & Wong, L.-J. C. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.04.015 · Cited by 46 · see citing works
Chiarelli, N., Carini, G., Zoppi, N., Ritelli, M., & Colombi, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0191220 · Cited by 45 · see citing works
Autophagy During Vertebrate Development
Aburto, M. R., Hurlé, J. M., Varela‐Nieto, I., & Magariños, M. (2012) · Cells · doi:10.3390/cells1030428 · Cited by 45 · see citing works
Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
Baranski, Z., de Jong, Y., Ilkova, T., Peterse, E. F. P., Cleton-Jansen, A., van de Water, B., Hogendoorn, P. C. W., Bovée, J. V. M. G., & Danen, E. H. J. (2015) · Oncotarget · doi:10.18632/oncotarget.5333 · Cited by 45 · see citing works
Autophagy: An Integral Component of the Mammalian Stress Response.
Ryter, S. W., & Choi, A. M. K. (2013) · PubMed · Cited by 44 · see citing works
Anticancer Effect of a Curcumin Derivative B63: ROS Production and Mitochondrial Dysfunction
Zheng, A., Li, H., Wang, X., Feng, Z., Xu, J., Cao, K. J., Zhou, B., Wu, J., & Liu, J. (2014) · Current Cancer Drug Targets · doi:10.2174/1568009613666131126115444 · Cited by 44 · see citing works
Ullman, E., Pan, J.-A., & Zong, W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05452-11 · Cited by 44 · see citing works
Self-citationNgoc, L. T. N., Lee, Y., Chun, H., Moon, J., Choi, J. S., Park, D., & Lee, Y. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121175 · Cited by 44 · see citing works
Evidence for Cortical Neuronal Loss in Male Type 2 Diabetic Goto-Kakizaki Rats
Hussain, S., Mansouri, S., Sjöholm, Å., Patrone, C., & Darsalia, V. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131958 · Cited by 41 · see citing works
Zou, X., Xu, J., Yao, S., Li, J., Yang, Y., & Yang, L. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079012 · Cited by 41 · see citing works
Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives
Zhang, C., Li, J., Tang, Q., Li, L., & Cao, D. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02472-x · Cited by 43 · see citing works
Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity
Thévenod, F., & Lee, W. (2015) · Toxics · doi:10.3390/toxics3020130 · Cited by 41 · see citing works
Valdés, A., Artemenko, K. A., Bergquist, J., García‐Cañas, V., & Cifuentes, A. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00154 · Cited by 40 · see citing works
Eum, K., & Lee, M. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0034-6 · Cited by 40 · see citing works
Yadav, R. K., Lee, G., Lee, H.-Y., Li, B., Jung, H.-E., Rashid, H.-O., Choi, M. K., Yadav, B. K., Kim, W. H., Kim, K., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1082021 · Cited by 38 · see citing works
The Cellular Decision Between Apoptosis and Autophagy
Fan, Y., Ullman, E., & Zong, W. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-9 · Cited by 37 · see citing works
Self-citationRole of the unfolded protein response in the pathogenesis of Parkinson’s disease
Varma, D. V. S. N. S., & Sen, D. (2015) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2015-2012 · Cited by 35 · see citing works
Dual effect of capsaicin on cell death in human osteosarcoma G292 cells
Chien, C., Ma, K., Lee, H., Liu, P., Li, Y.-H., Huang, Y.-S., & Chueh, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.08.011 · Cited by 31 · see citing works
Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis
Pan, J.-A., Fan, Y., Gandhirajan, R. K., Madesh, M., & Zong, W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441063 · Cited by 29 · see citing works
Self-citationHorne, T. K., & Cronjé, M. J. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12761 · Cited by 29 · see citing works
Elkis, Y., Cohen, M., Yaffe, E., Satmary-Tusk, S., Feldman, T., Hikri, E., Nyska, A., Feiglin, A., Ofran, Y., Shpungin, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00832-w · Cited by 28 · see citing works
- Authors
- Ullman, E., Fan, Y., Stawowczyk, M., Chen, H.-M., Yue, Z., & Zong, W.-X.
- Affiliations
- Stony Brook University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zong, W-X
- Venue
- Cell Death & Differentiation
- Published
- 2007-10-05
- Volume
- 15
- Issue
- 2
- Pages
- 422-425
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3140950
- OpenAlex
- W2060342342
- Cited by
- 161
- References
- 22
- Citations by year
- 2025: 1 · 2024: 5 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 21
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Breast Cancer Research Foundation
- Ministero della Salute
- Istituto Pasteur-Fondazione Cenci Bolognetti
- Stony Brook University
- National Cancer Institute (R01CA129536, K01CA098092)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- autophagy, necrosis, endoplasmic reticulum stress, unfolded protein response, Bax, Bak, Bcl-xL, Bcl-2 family proteins, ER stress-induced cell death, autophagy inhibition
- MeSH terms
- Animals, Autophagy, Endoplasmic Reticulum, Fibroblasts, Mice, Mutant Strains, Necrosis, Apoptosis, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
