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Stem Cells and Their Niches

Moore, Kateri A., Lemischka, Ihor R.·2006·Science
DOI 10.1126/science.1110542
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Abstract

A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells. Here we discuss the stem cell niche concept, highlight recent progress, and identify important unanswered questions. We focus on three mammalian stem cell systems where large numbers of mature cells must be continuously produced throughout adult life: intestinal epithelium, epidermal structures, and bone marrow.

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Metadata

Authors
Moore, K. A., & Lemischka, I. R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2006-03-31
Volume
311
Issue
5769
Pages
1880-1885
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1110542
OpenAlex
W2036795046
Cited by
1,553
References
14
FWCI
81.77
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Stem Cells and Their Niches. https://app.cochat.ai/papers/10.1126/science.1110542
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Moore, K. A., & Lemischka, I. R. (2006). Stem Cells and Their Niches. Science. https://doi.org/10.1126/science.1110542

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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