Cited by 232Alcohol Consumption and Health EffectsNutritional Studies and DietBlood properties and coagulation

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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study

Sierksma, A, van der Gaag, MS, Kluft, C, Hendriks, HFJ·2002·European Journal of Clinical Nutrition

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Abstract

Objective To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.Design Randomized, diet-controlled, cross-over study.Setting The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands.Subjects Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.Interventions Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects.Results Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P< or =0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.Conclusions Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.Sponsorship Dutch Foundation for Alcohol Research (SAR).

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Authors: Sierksma, A., van der Gaag, M., Kluft, C., & Hendriks, H.
Affiliations: Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Hendriks, HFJ
ORCID: Sierksma, A
Kluft, C
Venue: European Journal of Clinical Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2002-11-01
Volume: 56
Issue: 11
Pages: 1130-1136
ISSN: 0954-3007 (ISSN-L)
1476-5640
DOI: 10.1038/sj.ejcn.1601459
OpenAlex: W2076812730
Cited by: 231
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 16
FWCI: 10.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: European Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
TNO Repository (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords: moderate drinking, beer, C-reactive protein, fibrinogen, acute phase proteins, cardiovascular risk, postmenopausal women, middle-aged men, controlled diet
MeSH terms: Alcohol Drinking, Beer, C-Reactive Protein, Cardiovascular Diseases, Diet, Female, Fibrinogen, Humans, Cholesterol, HDL, Liver, Male, Middle Aged, Triglycerides, Postmenopause, Cross-Over Studies

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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study

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