CoChat
Sign Up
Cited by 232Alcohol Consumption and Health EffectsNutritional Studies and DietBlood properties and coagulation

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study

Sierksma, A, van der Gaag, MS, Kluft, C, Hendriks, HFJ·2002·European Journal of Clinical Nutrition
DOI 10.1038/sj.ejcn.1601459
Open this paper in CoChat — free account

Abstract

Objective To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.Design Randomized, diet-controlled, cross-over study.Setting The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands.Subjects Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.Interventions Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects.Results Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P< or =0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.Conclusions Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.Sponsorship Dutch Foundation for Alcohol Research (SAR).

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.ejcn.1601459

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 33 references

Research works printed but not linked: 3

  1. Anonymous. 1995 Guideline for Good Clinical Practice CPMP/ICH/135. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use
  2. Snedecor GW, Cochran WG . 1980 Statistical Methods 7th edn, p 1 Ames, IA: The Iowa State University Press
  3. Westerterp KR . 1996 Effect of moderate alcohol consumption on energy expenditure Alcohol Res. 1: 187–189

Cited by

Sorted by citations

Items 201–232 of 232

Related

See all

Metadata

Authors
Sierksma, A., van der Gaag, M., Kluft, C., & Hendriks, H.
Affiliations
Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author
Hendriks, HFJ
ORCID
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2002-11-01
Volume
56
Issue
11
Pages
1130-1136
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/sj.ejcn.1601459
OpenAlex
W2076812730
Cited by
231
References
33
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 16
FWCI
10.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • TNO Repository (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords
moderate drinking, beer, C-reactive protein, fibrinogen, acute phase proteins, cardiovascular risk, postmenopausal women, middle-aged men, controlled diet
MeSH terms
Alcohol Drinking, Beer, C-Reactive Protein, Cardiovascular Diseases, Diet, Female, Fibrinogen, Humans, Cholesterol, HDL, Liver, Male, Middle Aged, Triglycerides, Postmenopause, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review