Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Chk1 and Chk2 kinases in checkpoint control and cancer

Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085

Untitled work

(1999) · PubMed · Cited by 1,030

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsPreprint

Liu, M., Pereira, F. A., Price, S. D., Chu, M.-J., Shope, C. D., Himes, D., Eatock, R. A., Brownell, W. E., Lysakowski, A., & Tsai, M. (2000) · Genes & Development · doi:10.1101/gad.840500 · Cited by 625

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 588

Genetic control of cell division patterns in the Drosophila embryo

Edgar, B. A., & O’Farrell, P. H. (1989) · Cell · doi:10.1016/0092-8674(89)90183-9 · Cited by 577

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

Lopez‐Girona, A., Furnari, B. A., Mondésert, O., & Russell, P. R. (1999) · Nature · doi:10.1038/16488 · Cited by 574

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Bulavin, D. V., Higashimoto, Y., Popoff, I., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., & Fornace, A. J. (2001) · Nature · doi:10.1038/35075107 · Cited by 531

Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition.

Hoffmann, I., Draetta, G. F., & Karsenti, E. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06750.x · Cited by 495

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 472

Cdc25A is a novel phosphatase functioning early in the cell cycle.

Jinno, S., Suto, K., Nagata, A., Igarashi, M., Kanaoka, Y., Nojima, H., & Okayama, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06417.x · Cited by 452

Regulating mammalian checkpoints through Cdc25 inactivation

Donzelli, M., & Draetta, G. F. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor887 · Cited by 451

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Valerio Dorrello, N., Hershko, A., Pagano, M., & Draetta, G. F. (2003) · Nature · doi:10.1038/nature02082 · Cited by 447

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes & Development · doi:10.1101/gad.842500 · Cited by 417

Control of mitosis by changes in the subcellular location of cyclin-B1–Cdk1 and Cdc25C

Takizawa, C. G., & Morgan, D. O. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00149-6 · Cited by 390

Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability

Mailand, N., Podtelejnikov, A. V., Groth, A., Mann, M., Bartek, J., & Lukas, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf567 · Cited by 315

The cdc25B phosphatase is essential for the G 2/M phase transition in human cells

Lammer, C., Wagerer, S., Saffrich, R., Mertens, D., Ansorge, W. J., & Hoffmann, I. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2445 · Cited by 305

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25Preprint

Kumagai, A., & Dunphy, W. G. (1999) · Genes & Development · doi:10.1101/gad.13.9.1067 · Cited by 303

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

Blasina, A., de Weyer, I. V., Laus, M. C., Luyten, W. H. M. L., Parker, A. E., & McGowan, C. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80041-4 · Cited by 301

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

Lee, J., Kumagai, A., & Dunphy, W. G. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.551 · Cited by 287

DNA-replication checkpoint control at the Drosophila midblastula transition

Sibon, O. C. M., Stevenson, V. A., & Theurkauf, W. E. (1997) · Nature · doi:10.1038/40439 · Cited by 258

The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts

Kumagai, A., Guo, Z., Emami, K. H., Wang, S. X., & Dunphy, W. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1559 · Cited by 238

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7488-7497.2003 · Cited by 234

Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways

Rhind, N., & Russell, P. R. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3889 · Cited by 217

Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1

Furnari, B. A., Blasina, A., Boddy, M. N., McGowan, C. H., & Russell, P. R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.833 · Cited by 217

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

Molinari, M., Mercurio, C., Dominguez, J., Goubin, F., & Draetta, G. F. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd018 · Cited by 213

Checkpoint Pathways Come of Age

Nurse, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80476-6 · Cited by 201

Chk2 Activation and Phosphorylation-Dependent Oligomerization

Xu, X., Tsvetkov, L. M., & Stern, D. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4419-4432.2002 · Cited by 183

Cell-cycle checkpoint kinases: checking in on the cell cycle

Walworth, N. C. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00154-x · Cited by 146

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

Shimuta, K., Nakajo, N., Uto, K., Hayano, Y., Okazaki, K., & Sagata, N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf357 · Cited by 126

p21CIP1 and Cdc25A: Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases

Saha, P., Eichbaum, Q. G., Silberman, E. D., Mayer, B. J., & Dutta, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4338 · Cited by 108

Regulation of Human Cdc25A Stability by Serine 75 Phosphorylation Is Not Sufficient to Activate a S-phase Checkpoint

Goloudina, A. R., Yamaguchi, H., Chervyakova, D. B., Appella, E., Fornace, A. J., & Bulavin, D. V. (2003) · Cell Cycle · doi:10.4161/cc.2.5.482 · Cited by 92

Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation

Katsuragi, Y., & Sagata, N. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0874 · Cited by 78

Roles of Active Site Residues and the NH2-terminal Domain in the Catalysis and Substrate Binding of Human Cdc25

Xu, X., & Burke, S. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5118 · Cited by 71

Cytoplasmic Occurrence of the Chk1/Cdc25 Pathway and Regulation of Chk1 in Xenopus Oocytes

Oe, T., Nakajo, N., Katsuragi, Y., Okazaki, K., & Sagata, N. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9968 · Cited by 50

The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle

Okamoto, K., Nakajo, N., & Sagata, N. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2472 · Cited by 48

The C-Terminal Tail of the Dual-Specificity Cdc25B Phosphatase Mediates Modular Substrate Recognition

Wilborn, M., Free, S., Ban, A., & Rudolph, J. (2001) · Biochemistry · doi:10.1021/bi015638h · Cited by 36

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836

Roles of Chk1 in cell biology and cancer therapy

Zhang, Y., & Hunter, T. (2014) · International Journal of Cancer · doi:10.1002/ijc.28226 · Cited by 462

DNA damage checkpoints in mammals

Niida, H., & Nakanishi, M. (2005) · Mutagenesis · doi:10.1093/mutage/gei063 · Cited by 447

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Patil, M., Pabla, N., & Dong, Z. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1307-3 · Cited by 317

Cdc25: mechanisms of checkpoint inhibition and recovery

Karlsson, C., & Millar, J. B. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.002 · Cited by 288

The role of Cdc25 phosphatases in cell cycle checkpoints

Hoffmann, I. (2000) · PROTOPLASMA · doi:10.1007/bf01279894 · Cited by 21

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7488-7497.2003 · Cited by 234

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

Chk1 versus Cdc25: Chking One’s Levels of Cellular Proliferation

Lam, M. H., & Rosen, J. M. (2004) · Cell Cycle · doi:10.4161/cc.3.11.1225 · Cited by 33

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage

Schmitt, E., Boutros, R., Froment, C., Monsarrat, B., Ducommun, B., & Dozier, C. (2006) · Journal of Cell Science · doi:10.1242/jcs.03200 · Cited by 107