Chk1 and Chk2 kinases in checkpoint control and cancer

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

DNA double-strand breaks: signaling, repair and the cancer connection

Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics · doi:10.1038/85798 · Cited by 2,455 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,288 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

The CHEK2-Breast Cancer Consortium (2002) · Nature Genetics · doi:10.1038/ng879 · Cited by 1,104 · see citing works

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091 · see citing works

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972 · see citing works

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

Bell, D. W., Varley, J. M., Szydlo, T. E., Kang, D. H., Wahrer, D. C. R., Shannon, K. E., Lubratovich, M. L., Verselis, S. J., Isselbacher, K. J., Fraumeni, J. F., et al. (1999) · Science · doi:10.1126/science.286.5449.2528 · Cited by 899 · see citing works

MDC1 is a mediator of the mammalian DNA damage checkpoint

Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R., & Elledge, S. J. (2003) · Nature · doi:10.1038/nature01446 · Cited by 874 · see citing works

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes & Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787 · see citing works

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

Fernández-Capetillo, Ó., Chen, H. T., Celeste, A., Ward, I. M., Romanienko, P. J., Morales, J. C., Naka, K., Xia, Z., Camerini‐Otero, R. D., Motoyama, N., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb884 · Cited by 644 · see citing works

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13777 · Cited by 583 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

Mammalian G1- and S-phase checkpoints in response to DNA damage

Bártek, J., & Lukas, J. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00280-5 · Cited by 573 · see citing works

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 560 · see citing works

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529 · see citing works

MDC1 is required for the intra-S-phase DNA damage checkpoint

Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature01445 · Cited by 506 · see citing works

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498 · see citing works

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483 · see citing works

Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− micePreprint

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., & Nakayama, K. (2000) · Genes & Development · doi:10.1101/gad.14.12.1439 · Cited by 478 · see citing works

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

Lukas, C., Falck, J., Bartkova, J., Bartek, J., & Lukas, J. (2003) · Nature Cell Biology · doi:10.1038/ncb945 · Cited by 474 · see citing works

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer

Vahteristo, P., Bártková, J., Eerola, H., Syrjäkoski, K., Ojala, S., Kilpivaara, O., Tamminen, A., Kononen, J., Aittomäki, K., Heikkilä, P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341943 · Cited by 467 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription

Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C. W., Appella, E., Nakanishi, M., Suzuki, H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf506 · Cited by 435 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

Ward, I. M., Minn, K. T., van Deursen, J., & Chen, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2556-2563.2003 · Cited by 412 · see citing works

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

Hirao, A., Cheung, A., Duncan, G. S., Girard, P.-M., Elia, A., Wakeham, A. C., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6521-6532.2002 · Cited by 404 · see citing works

Chk2 kinase — a busy messenger

Bártek, J., Falck, J., & Lukas, J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35103059 · Cited by 400 · see citing works

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Falck, J., Petrini, J. H. J., Williams, B. R., Lukas, J., & Bartek, J. (2002) · Nature Genetics · doi:10.1038/ng845 · Cited by 392 · see citing works

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

Xiao, Z., Chen, Z., Gunasekera, A. H., Sowin, T. J., Rosenberg, S. H., Fesik, S., & Zhang, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300229200 · Cited by 388 · see citing works

Chk2 activates E2F-1 in response to DNA damage

Stevens, C., Smith, L. M., & Thangue, N. B. L. (2003) · Nature Cell Biology · doi:10.1038/ncb974 · Cited by 386 · see citing works

Molecular Mechanism of the Interaction between MDM2 and p53

Schön, O., Friedler, A., Bycroft, M., Freund, S. M. V., & Fersht, A. R. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00852-5 · Cited by 349 · see citing works

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

Lou, Z., Minter‐Dykhouse, K., Wu, X., & Chen, J. (2003) · Nature · doi:10.1038/nature01447 · Cited by 328 · see citing works

Activation of mammalian Chk1 during DNA replication arrest

Feijóo, C. G., Hall-Jackson, C. A., Wu, R., Jenkins, D., Leitch, J., Gilbert, D. M., & Smythe, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104099 · Cited by 318 · see citing works

Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability

Mailand, N., Podtelejnikov, A. V., Groth, A., Mann, M., Bartek, J., & Lukas, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf567 · Cited by 315 · see citing works

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

Gatei, M. H., Sloper, K., Sørensen, C. S., Syljuåsen, R. G., Falck, J., Hobson, K., Savage, K. I., Lukas, J., Zhou, B.-B., Bártek, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210862200 · Cited by 300 · see citing works

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Heffernan, T. P., Simpson, D. A., Frank, A. R., Heinloth, A. N., Paules, R. S., Cordeiro-Stone, M., & Kaufmann, W. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8552-8561.2002 · Cited by 251 · see citing works

Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

Zachos, G., Rainey, M. D., & Gillespie, D. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg060 · Cited by 247 · see citing works

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

Yang, S., Kuo, C. S., Bisi, J., & Kim, M. K. (2002) · Nature Cell Biology · doi:10.1038/ncb869 · Cited by 238 · see citing works

Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer

Li, Y., Sun, X., LaMont, J. T., Pardee, A. B., & Li, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0538044100 · Cited by 232 · see citing works

Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2

Li, J., Williams, B. L., Haire, L. F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M. B., Jackson, S. P., & Smerdon, S. J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00527-0 · Cited by 229 · see citing works

Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain

Ahn, J.-Y., Li, X., Davis, H. L., & Canman, C. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200822200 · Cited by 187 · see citing works

Chk2 Activation and Phosphorylation-Dependent Oligomerization

Xu, X., Tsvetkov, L. M., & Stern, D. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4419-4432.2002 · Cited by 183 · see citing works

p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.

Vahteristo, P., Tamminen, A., Karvinen, P., Eerola, H., Eklund, C., Aaltonen, L. A., BLOMQVIST, C. P., Aittomäki, K., & Nevanlinna, H. A. (2001) · PubMed · Cited by 180 · see citing works

Characterization of Tumor-associated Chk2 Mutations

Wu, X., Webster, S. R., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009727200 · Cited by 173 · see citing works

Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint

Groth, A., Lukáš, J., Nigg, E. A., Silljé, H. H. W., Wernstedt, C., Bartek, J. J., & Hansen, K. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg151 · Cited by 166 · see citing works

Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.

Lee, S. B., Kim, S. H., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Jorczak, M. M., Sgroi, D. C., Garber, J. E., Li, F. P., Nichols, K. E., et al. (2001) · PubMed · Cited by 159 · see citing works

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells

Jallepalli, P. V., Lengauer, C., Vogelstein, B., & Bunz, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213159200 · Cited by 154 · see citing works

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

Menoyo, A., Alazzouzi, H., Espín, E., Armengol, M., Yamamoto, H., & Schwartz, S. (2001) · PubMed · Cited by 151 · see citing works

Cell cycle-dependent and ATM-independent expression of human Chk1 kinase

Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Terasawa, M., Tachibana, A., Ikeda, K., & Nakanishi, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202706 · Cited by 150 · see citing works

The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation

Lee, C. H., & Chung, J. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104414200 · Cited by 147 · see citing works

Chk2 is dispensable for p53-mediated G 1 arrest but is required for a latent p53-mediated apoptotic response

Jack, M. T., Woo, R. A., Hirao, A., Cheung, A., Mak, T. W., & Lee, P. W. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152053599 · Cited by 139 · see citing works

Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach

O'Neill, T. B., Giarratani, L., Chen, P., Iyer, L. K., Lee, C. H., Bobiak, M., Kanai, F., Zhou, B. S., Chung, J. H., & Rathbun, G. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111705200 · Cited by 139 · see citing works

Rpb4 and Rpb9 mediate subpathways of transcription‐coupled DNA repair in Saccharomyces cerevisiae

Li, S., & Smerdon, M. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf589 · Cited by 137 · see citing works

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.

Lukas, C., Bártková, J., Latella, L., Falck, J., Mailand, N., Schroeder, T., Sehested, M., Lukáš, J., & Bártek, J. (2001) · PubMed · Cited by 133 · see citing works

Variants in CHEK2 Other than 1100delC Do Not Make a Major Contribution to Breast Cancer Susceptibility

Schutte, M. E. M., Seal, S., Barfoot, R., Meijers-Heijboer, H. E. J., Wasielewski, M., Evans, D. G., Eccles, D., Meijers, C., Lohman, F. P., Klijn, J. G. M., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/373965 · Cited by 133 · see citing works

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

Bertoni, F., Codegoni, A. M., Furlan, D., Tibiletti, M. G., Capella, C., & Broggini, M. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199910)26:2 · Cited by 132 · see citing works

DNA-dependent Acetylation of p53 by the Transcription Coactivator p300

Dornan, D., Shimizu, H., Perkins, N. D., & Hupp, T. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211460200 · Cited by 117 · see citing works

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway

Falck, J., Lukas, C., Protopopova, M., Lukas, J., Selivanova, G., & Bártek, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204811 · Cited by 114 · see citing works

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

McGowan, C. H. (2002) · BioEssays · doi:10.1002/bies.10101 · Cited by 108 · see citing works

Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.

Vassileva, V., Millar, A., Briollais, L., Chapman, W. B., & Bapat, B. V. (2002) · PubMed · Cited by 107 · see citing works

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

Miller, C. W., Ikezoe, T., Krug, U. O., Hofmann, W., Tavor, S., Vegesna, V. R., Tsukasaki, K., Takeuchi, S., & Koeffler, H. P. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1207 · Cited by 98 · see citing works

Concomitant inactivation of p53 and Chk2 in breast cancer

Sullivan, A., Yuille, M., Repellin, C., Reddy, A., Reelfs, O., Bell, A., Dunne, B., Gusterson, B. A., Osin, P., Farrell, P. J., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205207 · Cited by 91 · see citing works

Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway

Weiss, R. S., Matsuoka, S., Elledge, S. J., & Leder, P. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00626-1 · Cited by 91 · see citing works

Mutation analysis of the CHK2gene in families with hereditary breast cancer

Allinen, M., Huusko, P., Mäntyniemi, S., Launonen, V, & Winqvist, R. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1858 · Cited by 85 · see citing works

Therapeutic Exploitation of Checkpoint Defects in Cancer Cells Lacking p53 Function

Dixon, H., & Norbury, C. J. (2002) · Cell Cycle · doi:10.4161/cc.1.6.257 · Cited by 85 · see citing works

CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

Tort, F., Hernandez, S. F., Beà, S., Martı́nez, A., Esteller, M., Herman, J. G., Puig, X., Camacho, E., Sánchez, M., Nayach, I., et al. (2002) · Blood · doi:10.1182/blood-2002-04-1078 · Cited by 81 · see citing works

Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer.

Haruki, N., Saito, H., Tatematsu, Y., Konishi, H., Harano, T., Masuda, A., Osada, H., Fujii, Y., & Takahashi, T. (2000) · PubMed · Cited by 80 · see citing works

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours

Sodha, N., Bullock, S. L., Taylor, R., Mitchell, G., Guertl‐Lackner, B., Williams, R. D., Bevan, S., Bishop, K., McGuire, S., Houlston, R. S., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600637 · Cited by 71 · see citing works

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

Bártková, J., Falck, J., Meyts, E. R., Skakkebæk, N. E., Lukas, J., & Bártek, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204746 · Cited by 69 · see citing works

Genotoxic Stress-Induced Activation of Plk3 is Partly Mediated by Chk2

Xie, S., Wu, H., Wang, Q., et al. (2002) · Cell Cycle · doi:10.4161/cc.1.6.271 · Cited by 68 · see citing works

Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

Ingvarsson, S., Sigbjornsdottir, B. I., Huiping, C., Hafsteinsdottir, S. H., Ragnarsson, G., Barkardottir, R. B., Arason, A., Egilsson, V., & Bergthorsson, J. T. (2002) · Breast Cancer Research · doi:10.1186/bcr435 · Cited by 63 · see citing works

Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias

Hofmann, W., Miller, C. W., Tsukasaki, K., Tavor, S., Ikezoe, T., Hoelzer, D. F., Takeuchi, S., & Koeffler, H. P. (2001) · Leukemia Research · doi:10.1016/s0145-2126(00)00130-2 · Cited by 60 · see citing works

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.

Matsuoka, S., Nakagawa, T., Masuda, A., Haruki, N., Elledge, S. J., & Takahashi, T. (2001) · PubMed · Cited by 58 · see citing works

Mutations of Chk2 in primary hematopoietic neoplasms

Hangaishi, A., Ogawa, S., Qiao, Y., Wang, L., Hosoya, N., Yuji, K., Imai, Y., Takeuchi, K., Miyawaki, S., & Hirai, H. (2002) · Blood · doi:10.1182/blood.v99.8.3075 · Cited by 48 · see citing works

Analysis of CHK2 in vulval neoplasia

Reddy, A., Yuille, M., Sullivan, A., Repellin, C. E., Bell, A., TIDY, J. A., Evans, D. J., Farrell, P. J., Gusterson, B. A., Gasco, M., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600131 · Cited by 38 · see citing works

Analysis of the CHK2 Gene in Lymphoid Malignancies

Tavor, S., Takeuchi, S., Tsukasaki, K., Miller, C. W., Hofmann, W. K., Ikezoe, T., SAID, J. W., & Koeffler, H. P. (2001) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190109064610 · Cited by 34 · see citing works

NMR Solution Structure of Domain 1 of Human Annexin I Shows an Autonomous Folding Unit

Gao, J., Li, Y., & Honggao Yan, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2971 · Cited by 15 · see citing works

Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

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Checking on DNA damage in S phase

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Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

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Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

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SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

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Functional links between telomeres and proteins of the DNA-damage response

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Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis

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Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for <i>CH</i> <i>EK</i> <i>2</i> *1100delC Carriers

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Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

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Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

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Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

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Pot1 and cell cycle progression cooperate in telomere length regulation

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DNA damage repair: anytime, anywhere?

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DNA‐damage‐responsive acetylation of pRb regulates binding to E2F‐1

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Mind the gap: keeping UV lesions in check

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NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

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Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro

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Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

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Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells

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CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response

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Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

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Chapter 16 Chk1 and Chk2 as Checkpoint Targets

Zhang, H., Xiao, Z., & Sowin, T. (2009)

Chk1 and Chk2 as Checkpoint Targets

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Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

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Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways

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