ATM and ATR: networking cellular responses to DNA damage

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,288 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046 · see citing works

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., & Weissman, A. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8945 · Cited by 1,044 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972 · see citing works

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

Gong, J., Costanzo, A., Yang, H., Melino, G., Kaelin, W. G., Levrero, M., & Wang, J. Y. J. (1999) · Nature · doi:10.1038/21690 · Cited by 923 · see citing works

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes &amp; Development · doi:10.1101/gad.11.24.3471 · Cited by 818 · see citing works

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37538 · Cited by 810 · see citing works

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D. (2000) · Genes &amp; Development · doi:10.1101/gad.14.3.278 · Cited by 805 · see citing works

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786 · see citing works

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

Lavin, M. F., & Shiloh, Y. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.177 · Cited by 642 · see citing works

GADD45 induction of a G ₂ /M cell cycle checkpoint

Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, A. J., & Harris, C. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3706 · Cited by 634 · see citing works

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Zhu, X., Küster, B., Mann, M., Petrini, J. H. J., & de Lange, T. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 602 · see citing works

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13777 · Cited by 583 · see citing works

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

Yuan, Z.-M., Shioya, H., Ishiko, T., Sun, X., Gu, J., Huang, Y., Lu, H., Kharbanda, S. M., Weichselbaum, R. W., & Kufe, D. W. (1999) · Nature · doi:10.1038/21704 · Cited by 574 · see citing works

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

Paull, T. T., & Gellert, M. (1999) · Genes &amp; Development · doi:10.1101/gad.13.10.1276 · Cited by 551 · see citing works

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546 · see citing works

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

Agami, R., Blandino, G., Oren, M., & Shaul, Y. (1999) · Nature · doi:10.1038/21697 · Cited by 544 · see citing works

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Lee, J., Collins, K. M., Brown, A. L., Lee, C. H., & Chung, J. H. (2000) · Nature · doi:10.1038/35004614 · Cited by 529 · see citing works

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

Zhao, S., Weng, Y., Yuan, S. F., Lin, Y.-T., Hsu, H.-C., Lin, S. J., Gerbino, E., Song, M., Zdzienicka, M. Z., Gatti, R. A., et al. (2000) · Nature · doi:10.1038/35013083 · Cited by 483 · see citing works

ATM associates with and phosphorylates p53: mapping the region of interaction

Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S. P., Gatei, M. H., Hobson, K., Taya, Y., Gabrielli, B. G., Chan, D. W., Lees‐Miller, S. P., et al. (1998) · Nature Genetics · doi:10.1038/3882 · Cited by 481 · see citing works

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468 · see citing works

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14973 · Cited by 461 · see citing works

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

Waterman, M. J. F., Stavridi, E. S., Waterman, J. L. F., & Halazonetis, T. D. (1998) · Nature Genetics · doi:10.1038/542 · Cited by 457 · see citing works

Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

Dumaz, N., & Meek, D. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.7002 · Cited by 455 · see citing works

DNA double strand break repair in mammalian cells

Karran, P. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00069-1 · Cited by 447 · see citing works

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Wu, X., Ranganathan, V., Weisman, D., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G. A., et al. (2000) · Nature · doi:10.1038/35013089 · Cited by 446 · see citing works

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 437 · see citing works

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R., & Brady, J. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.33048 · Cited by 423 · see citing works

The G2-phase DNA-damage checkpoint

O’Connell, M. J., Walworth, N. C., & Carr, A. M. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01773-6 · Cited by 385 · see citing works

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

Unger, T., Juven‐Gershon, T., Moallem, E., Berger, M., Sionov, R. V., Lozano, G., Oren, M., & Haupt, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1805 · Cited by 365 · see citing works

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

Li, S., Ting, N. S. Y., Zheng, L., Chen, P., Ziv, Y., Shiloh, Y., Lee, E. Y.-H. P., & Lee, W. (2000) · Nature · doi:10.1038/35018134 · Cited by 336 · see citing works

The controlling role of ATM in homologous recombinational repair of DNA damage

Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K., & Takeda, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.3.463 · Cited by 312 · see citing works

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

Zhou, B. S., Chaturvedi, P., Spring, K. J., Scott, S. P., Johanson, R. A., Mishra, R., Mattern, M. R., Winkler, J. D., & Khanna, K. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10342 · Cited by 278 · see citing works

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

Chen, G., Yuan, S.-S. F., Liu, W., Xu, Y., Trujillo, K., Song, B., Cong, F., Goff, S. P., Wu, Y., Arlinghaus, R., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12748 · Cited by 274 · see citing works

ATM: A mediator of multiple responses to genotoxic stress

Rotman, G., & Shiloh, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203124 · Cited by 272 · see citing works

Sensing and responding to DNA damage

Lowndes, N. F., & Murguía, J. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00050-7 · Cited by 269 · see citing works

Cooperative effects of genes controlling the G2/M checkpointPreprint

Chan, T. A.-T., Hwang, P. M., Hermeking, H., Kinzler, K. W., & Vogelstein, B. (2000) · Genes & Development · doi:10.1101/gad.14.13.1584 · Cited by 262 · see citing works

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei, M. H., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. L., & Khanna, K. K. (2000) · PubMed · Cited by 247 · see citing works

The Mre11 complex and ATM: collaborating to navigate S phase

Petrini, J. H. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00091-0 · Cited by 228 · see citing works

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

Wright, J. A., Keegan, K. S., Herendeen, D. R., Bentley, N. J., Carr, A. M., Hoekstra, M. F., & Concannon, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7445 · Cited by 226 · see citing works

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK

Hall-Jackson, C. A., Cross, D. A. E., MORRICE, N. A., & Smythe, C. (1999) · Oncogene · doi:10.1038/sj.onc.1203077 · Cited by 213 · see citing works

Characterization of ATM Expression, Localization, and Associated DNA-dependent Protein Kinase Activity

Gately, D. P., Hittle, J. C., Chan, G. K. T., & Yen, T. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2361 · Cited by 191 · see citing works

Localization of a Portion of Extranuclear ATM to Peroxisomes

Watters, D. J., Kedar, P. S., Spring, K. J., Björkman, J., Chen, P., Gatei, M. H., Birrell, G. W., Garrone, B., Srinivasa, P., Crane, D. I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34277 · Cited by 190 · see citing works

Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

O'Neill, T., Dwyer, A. J., Ziv, Y., Chan, D. W., Lees-Miller, S. P., Abraham, R. H., Lai, J. H., Hill, D., Shiloh, Y., Cantley, L. C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001002200 · Cited by 189 · see citing works

A mechanistic basis for Mre11-directed DNA joining at microhomologies

Paull, T. T., & Gellert, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110144297 · Cited by 188 · see citing works

The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage Response

Petrini, J. H. J. (1999) · The American Journal of Human Genetics · doi:10.1086/302391 · Cited by 185 · see citing works

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM

Smith, G. C. M., Cary, R. B., Lakin, N. D., Hann, B. C., Teo, S., Chen, D. J., & Jackson, S. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11134 · Cited by 173 · see citing works

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

Barlow, C., Ribaut‐Barassin, C., Zwingman, T. A., Pope, A. J., Brown, K. D., Owens, J. W., Larson, D. M., Harrington, E. A., Haeberlé, A., Mariani, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.871 · Cited by 170 · see citing works

Linking DNA damage and neurodegeneration

Rolig, R. L., & McKinnon, P. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01625-8 · Cited by 167 · see citing works

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

Jeggo, P. A., Carr, A. M., & Lehmann, A. R. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01511-x · Cited by 156 · see citing works

Signaling to p53: breaking the posttranslational modification code.

Appella, E., & Anderson, C. W. (2000) · PubMed · Cited by 142 · see citing works

c-Abl: activation and nuclear targets

Shaul, Y. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400626 · Cited by 138 · see citing works

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

Lakin, N. D., Hann, B. C., & Jackson, S. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202973 · Cited by 130 · see citing works

Requirement of ATM in Phosphorylation of the Human p53 Protein at Serine 15 following DNA Double-Strand Breaks

Nakagawa, K., Taya, Y., Tamai, K., & Yamaizumi, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2828 · Cited by 130 · see citing works

Purification and Characterization of ATM from Human Placenta

Chan, D. W., Son, S.-C., Block, W. D., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P., Goodarzi, A. A., Pelley, J. L., Taya, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7803 · Cited by 122 · see citing works

Recruitment of ATM Protein to Double Strand DNA Irradiated with Ionizing Radiation

Suzuki, K., Kodama, S., & Watanabe, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25571 · Cited by 115 · see citing works

Environmental signals and cell fate specification in premigratory neural crest

Dorsky, R. I., Moon, R. T., & Raible, D. W. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 111 · see citing works

Sensing of Ionizing Radiation-induced DNA Damage by ATM through Interaction with Histone Deacetylase

Kim, G. D., Choi, Y. H., Dimtchev, A., Jeong, S. J., Dritschilo, A., & Jung, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31127 · Cited by 109 · see citing works

Molecular Association between ATR and Two Components of the Nucleosome Remodeling and Deacetylating Complex, HDAC2 and CHD4

Schmidt, D. R., & Schreiber, S. L. (1999) · Biochemistry · doi:10.1021/bi991614n · Cited by 82 · see citing works

Rearranging Views on Neurogenesis

Chun, J. J. M., & Schatz, D. G. (1999) · Neuron · doi:10.1016/s0896-6273(00)80671-6 · Cited by 77 · see citing works

The YeastTEL1Gene Partially Substitutes for HumanATMin Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells

Fritz, E., Friedl, A. A., Zwacka, R. M., Eckardt‐Schupp, F., & Meyn, M. S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.8.2605 · Cited by 32 · see citing works

p73: Structure and function

Ichimiya, S., Nakagawara, A., Sakuma, Y., Kimura, S., Ikeda, T., Satoh, M., Takahashi, N., Sato, N., & Mori, M. (2000) · Pathology International · doi:10.1046/j.1440-1827.2000.01090.x · Cited by 26 · see citing works

Conserved genetic programs in insect and mammalian brain development

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ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes &amp; Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409 · see citing works

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

The Fanconi anaemia/BRCA pathway

D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc970 · Cited by 822 · see citing works

DNA damage responses to oxidative stress

Barzilai, A., & Yamamoto, K.-I. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.002 · Cited by 796 · see citing works

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Maya, R., Balass, M., Kim, S.-T., Shkedy, D., Leal, J.-F. M., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., et al. (2001) · Genes &amp; Development · doi:10.1101/gad.886901 · Cited by 716 · see citing works

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527 · see citing works

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y., & Ohno, S. (2001) · Genes &amp; Development · doi:10.1101/gad.913001 · Cited by 420 · see citing works

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384 · see citing works

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

Barzilai, A. (2002) · DNA Repair · doi:10.1016/s1568-7864(01)00007-6 · Cited by 359 · see citing works

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299 · see citing works

ATM: Genome stability, neuronal development, and cancer cross paths

(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)83007-4 · Cited by 299 · see citing works

Human Claspin Is Required for Replication Checkpoint Control

Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301136200 · Cited by 244 · see citing works

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains

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Preferential binding of ATR protein to UV-damaged DNA

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