The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
TRPM7, a novel regulator of actomyosin contractility and cell adhesion
Open accessAbstract
Actomyosin contractility regulates various cell biological processes including cytokinesis, adhesion and migration. While in lower eukaryotes, alpha-kinases control actomyosin relaxation, a similar role for mammalian alpha-kinases has yet to be established. Here, we examined whether TRPM7, a cation channel fused to an alpha-kinase, can affect actomyosin function. We demonstrate that activation of TRPM7 by bradykinin leads to a Ca(2+)- and kinase-dependent interaction with the actomyosin cytoskeleton. Moreover, TRPM7 phosphorylates the myosin IIA heavy chain. Accordingly, low overexpression of TRPM7 increases intracellular Ca2+ levels accompanied by cell spreading, adhesion and the formation of focal adhesions. Activation of TRPM7 induces the transformation of these focal adhesions into podosomes by a kinase-dependent mechanism, an effect that can be mimicked by pharmacological inhibition of myosin II. Collectively, our results demonstrate that regulation of cell adhesion by TRPM7 is the combined effect of kinase-dependent and -independent pathways on actomyosin contractility.
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Cites
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LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
Nadler, M. J. S., Hermosura, M. C., Inabe, K., Perraud, A.-L., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J.-P., Penner, R., Scharenberg, A. M., et al. (2001) · Nature · doi:10.1038/35079092 · Cited by 922
TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities
Runnels, L. W., Yue, L., & Clapham, D. E. (2001) · Science · doi:10.1126/science.1058519 · Cited by 733
Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7
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Podosomes: adhesion hot-spots of invasive cells
Linder, S., & Aepfelbacher, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00128-4 · Cited by 614
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Self-citationGelsolin, a Multifunctional Actin Regulatory Protein
Sun, H. Q., Yamamoto, M., Mejillano, M., & Yin, H. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33179 · Cited by 597
Src protein–tyrosine kinase structure and regulation
Roskoski, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.171 · Cited by 596
The TRPM7 channel is inactivated by PIP2 hydrolysis
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Integrin signaling to the actin cytoskeleton
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Cited by
Cellular magnesium homeostasis
Romani, A. M. P. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.010 · Cited by 531
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Prevarskaya, N., Zhang, L., & Barritt, G. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.05.006 · Cited by 355
Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J., & Monteith, G. R. (2014) · Oncogene · doi:10.1038/onc.2013.187 · Cited by 333
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Metadata
- Authors
- Clark, K., Langeslag, M., van Leeuwen, B., Ran, L., Ryazanov, A. G., Figdor, C. G., Moolenaar, W. H., Jalink, K., & van Leeuwen, F. N.
- Venue
- The EMBO Journal
- Published
- 2006-01-12
- Volume
- 25
- Issue
- 2
- Pages
- 290-301
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W1989168851
- Cited by
- 354
- References
- 33
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Clark, K., Langeslag, M., van Leeuwen, B., Ran, L., Ryazanov, A. G., Figdor, C. G., Moolenaar, W. H., Jalink, K., & van Leeuwen, F. N. (2006). TRPM7, a novel regulator of actomyosin contractility and cell adhesion. The EMBO Journal. https://doi.org/10.1038/sj.emboj.7600931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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