ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

Rai, P., He, F., Kwang, J., Engelward, B. P., & Chow, V. T. K. (2016) · Scientific Reports · doi:10.1038/srep22972 · Cited by 65

Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairPreprint

Kilkenny, M. L., Doré, A. S., Roe, S. M., Nestoras, K., Ho, J. C.-Y., Watts, F. Z., & Pearl, L. H. (2008) · Genes & Development · doi:10.1101/gad.472808 · Cited by 62

Primary Microcephaly, Impaired DNA Replication, and Genomic Instability Caused by Compound HeterozygousATRMutations

Benhelli‐Mokrani, H., Gaillard, L., Biasutto, P., Guen, T. L., Touzot, F., Vasquez, N., Komatsu, J., Conseiller, E., Pïcard, C., Gluckman, É., et al. (2012) · Human Mutation · doi:10.1002/humu.22245 · Cited by 66

Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

Hustedt, N., Gasser, S. M., & Shimada, K. (2013) · Genes · doi:10.3390/genes4030388 · Cited by 62

Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses

Zhao, Y., Long, M. J. C., Wang, Y., Zhang, S., & Aye, Y. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00556 · Cited by 60

Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues

Birkelbach, M. A., Ferraiolo, N., Gheorghiu, L., Pfäffle, H. N., Daly, B. D. T., Ebright, M. I., Spencer, C., O’Hara, C., Whetstine, J. R., Benes, C. H., et al. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31827ecf83 · Cited by 59

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

Hubackova, S., Davidova, E., Boukalova, S., Kovarova, J., Bajzikova, M., Coelho, A., Terp, M. G., Ditzel, H. J., Rohlena, J., & Neuzil, J. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2224-7 · Cited by 58

Give me a break: How telomeres suppress the DNA damage response

Denchi, E. L. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.013 · Cited by 61

Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks

Harding, S. M., & Bristow, R. G. (2012) · Cell Cycle · doi:10.4161/cc.19824 · Cited by 54

The Caenorhabditis elegans Werner Syndrome Protein Functions Upstream of ATR and ATM in Response to DNA Replication Inhibition and Double-Strand DNA Breaks

Lee, S., Gartner, A., Hyun, M., Ahn, B., & Koo, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000801 · Cited by 58

Modeling ATM mutant proteins from missense changes confirms retained kinase activity

Barone, G., Groom, A., Reiman, A., Srinivasan, V., Byrd, P. J., & Taylor, A. M. R. (2009) · Human Mutation · doi:10.1002/humu.21034 · Cited by 60

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress

Lloyd, R. L., Urban, V., Muñoz‐Martínez, F., Ayestaran, I., Thomas, J. C., de Renty, C., O’Connor, M. J., Forment, J. V., Galanty, Y., & Jackson, S. P. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab628 · Cited by 56

Phosphorylation: The Molecular Switch of Double-Strand Break Repair

Summers, K. C., Shen, F., Potchanant, E. A. S., Phipps, E. A., Hickey, R. J., & Malkas, L. H. (2011) · International Journal of Proteomics · doi:10.1155/2011/373816 · Cited by 57

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis

Feehan, R. P., & Shantz, L. M. (2016) · Biochemical Journal · doi:10.1042/bcj20160471 · Cited by 54

Working on Genomic Stability: From the S-Phase to Mitosis

Ovejero, S., Bueno, A., & Sacristán, M. P. (2020) · Genes · doi:10.3390/genes11020225 · Cited by 61

Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53

Yamaguchi, M., Fujimori-Tonou, N., Yoshimura, Y., Kishi, T., Okamoto, H., & Masai, I. (2008) · Development · doi:10.1242/dev.011015 · Cited by 51

EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases

Cousineau, I., & Belmaaza, A. (2011) · Molecular Genetics and Genomics · doi:10.1007/s00438-011-0612-5 · Cited by 57

Chromatin Response to DNA Double-Strand Break Damage

Bao, Y. (2011) · Epigenomics · doi:10.2217/epi.11.14 · Cited by 51

Interplay Between DNA Tumor Viruses and the Host DNA Damage Response

McFadden, K., & Luftig, M. A. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-37765-5_9 · Cited by 50

Oxygen sensing and the DNA-damage response

Hammond, E. M., Kaufmann, M. R., & Giaccia, A. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.10.002 · Cited by 51

TopBP1 associates with NBS1 and is involved in homologous recombination repair

Morishima, K., Sakamoto, S., Kobayashi, J., Izumi, H., Suda, T., Matsumoto, Y., Tauchi, H., Ide, H., Komatsu, K., & Matsuura, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.086 · Cited by 49

Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival

Herrero, A. B., & Gutierrez, N. C. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00098 · Cited by 50

Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells

Wakasugi, M., Sasaki, T., Matsumoto, M., Nagaoka, M., Inoue, K., Inobe, M., Horibata, K., Tanaka, K., & Matsunaga, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589747 · Cited by 48

Loss of Emi1-Dependent Anaphase-Promoting Complex/Cyclosome Inhibition Deregulates E2F Target Expression and Elicits DNA Damage-Induced Senescence

Verschuren, E. W., Ban, K. H.-K., Masek, M. A., Lehman, N. L., & Jackson, P. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00908-07 · Cited by 52

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

Köcher, S., Rieckmann, T., Rohaly, G., Mansour, W. Y., Dikomey, E., Dornreiter, I., & Dahm‐Daphi, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks604 · Cited by 49

Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription

Velichko, A. K., Petrova, N. V., Luzhin, A. V., Strelkova, O. S., Ovsiannikova, N. L., Kireev, I. I., Petrova, N. V., Razin, S. V., & Kantidze, O. L. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz436 · Cited by 48

Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses

Anderson, C. W., & Appella, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00264-3 · Cited by 49

Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation

Muñoz, M. J., Moreno, N. N., Giono, L. E., Botto, A. E. C., Dujardin, G., Bastianello, G., Lavore, S., Torres-Méndez, A., Menck, C. F. M., Blencowe, B. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.066 · Cited by 45

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging

Bonsignore, L. A., Tooley, J. G., Hoose, P. M. V., Wang, E., Cheng, A., Cole, M. P., & Tooley, C. E. S. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.012 · Cited by 44

Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle

Chiu, H., Huang, W., Liao, T., Wu, H., Munir, M., Shih, W.-L., & Liu, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162356 · Cited by 45

Misrepair in Context: TGFβ Regulation of DNA Repair

Liu, Q., Lopez, K. A. P., Murnane, J. P., Humphrey, T. C., & Barcellos‐Hoff, M. H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00799 · Cited by 44

ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability

Goetz, E. M., Shankar, B. S., Zou, Y. S., Morales, J. C., Luo, X., Araki, S., Bachoo, R. M., Mayo, L. D., & Boothman, D. A. (2011) · Oncogene · doi:10.1038/onc.2011.92 · Cited by 42

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

Izumi, N., Yamashita, A., & Ohno, S. (2012) · Nucleus · doi:10.4161/nucl.18926 · Cited by 48

Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death

Chen, L.-H., Chu, P., Lee, Y., Tu, P., Chi, C., Lee, H., & Chiou, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13011209 · Cited by 43

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

Noonan, E. M., Shah, D., Yaffe, M. B., Lauffenburger, D. A., & Samson, L. D. (2012) · Integrative Biology · doi:10.1039/c2ib20091k · Cited by 41

Replication stress response in cancer stem cells as a target for chemotherapy

Manic, G., Sistigu, A., Corradi, F., Musella, M., Maria, R. D., & Vitale, I. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.08.003 · Cited by 42

Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM

Carballo, J. A., & Rita, S. (2007) · Chromosome Research · doi:10.1007/s10577-007-1145-y · Cited by 42

Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination

Tripathi, V., Kaur, S., & Sengupta, S. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm238 · Cited by 44

Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.

Shin, A., Lee, K.-M., Ahn, B., Park, C., Noh, S.-K., Park, D.-Y., Ahn, S. H., Yoo, K.-Y., & Kang, D. (2008) · PubMed · Cited by 42

Gold-Containing Indoles as Anticancer Agents That Potentiate the Cytotoxic Effects of Ionizing Radiation

Craig, S. N., Gao, L., Lee, I. J.-A., Gray, T., & Berdis, A. J. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2005942 · Cited by 42

ATM, radiation, and the risk of second primary breast cancer

Bernstein, J. L., WECARE Study Collaborative Group, & Concannon, P. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1344363 · Cited by 41

Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis

Stephan, H., Concannon, C., Kremmer, E., Carty, M. P., & Nasheuer, H. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp605 · Cited by 42

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1

Stiff, T., Cerosaletti, K. M., CONCANNON, P. J., O’Driscoll, M., & Jeggo, P. A. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn220 · Cited by 42

DNA damage response signaling: A common link between cancer and cardiovascular diseases

Nikfarjam, S., & Singh, K. K. (2022) · Cancer Medicine · doi:10.1002/cam4.5274 · Cited by 45

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

Jones, G. N., Rooney, C., Griffin, N., Roudier, M. P., Young, L. A., Garcia-Trinidad, A., Hughes, G. D., Whiteaker, J. R., Wilson, Z., Odedra, R., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0286-4 · Cited by 40

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage

Fernandez, A., Artola, M., Leon, S., Otegui, N., Jimeno, A., Serrano, D., & Calvo, A. (2025) · Cells · doi:10.3390/cells14100748 · Cited by 46

Implication of Posttranslational Histone Modifications in Nucleotide Excision Repair

Li, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012461 · Cited by 40

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

Douarre, C., Mergui, X., Sidibe, A., Gómez, D., Alberti, P., Mailliet, P., Trentesaux, C., & Riou, J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt073 · Cited by 42

Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability

Mognato, M., Burdak‐Rothkamm, S., & Rothkamm, K. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108346 · Cited by 42

Identification of Carboxyl-terminal MCM3 Phosphorylation Sites Using Polyreactive Phosphospecific Antibodies

Shi, Y., Dodson, G. E., Mukhopadhyay, P. S., Shanware, N. P., Trinh, A. T., & Tibbetts, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609256200 · Cited by 39

The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response—Biological and Clinical Aspects

Medová, M., Aebersold, D. M., & Zimmer, Y. (2013) · Cancers · doi:10.3390/cancers6010001 · Cited by 39

Importance of PIKKs in NF-κB activation by genotoxic stress

Sabatel, H., Pirlot, C., Piette, J. G., & Habraken, Y. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.105 · Cited by 39

WWOX modulates the ATR-mediated DNA damage checkpoint response

Abu-Odeh, M., Heerema, N. A., & Aqeilan, R. I. (2015) · Oncotarget · doi:10.18632/oncotarget.6571 · Cited by 40

Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells

Liu, Y., Gao, F., Jiang, H., Niu, L., Bi, Y., Young, C. Y. F., Yuan, H., & Lou, H. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.05.022 · Cited by 41

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

Manthey, K. C., Opiyo, S. O., Glanzer, J. G., Dimitrova, D. D., Elliott, J., & Oakley, G. G. (2007) · Journal of Cell Science · doi:10.1242/jcs.004580 · Cited by 40

Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo

Wang, H., Lee, A. Y., Chou, W., Wu, C., Tseng, C., Liu, K. Y.-T., Lin, W.-L., Chang, F., Chuang, D., Hunyadi, A., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0921 · Cited by 39

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

Craig, A. L., Holcakova, J., Finlan, L. E., Nekulova, M., Hrstka, R., Gueven, N., DiRenzo, J., Smith, G., Hupp, T. R., & Vojtesek, B. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-195 · Cited by 37

ATF7 mediates TNF-α–induced telomere shortening

Maekawa, T., Liu, B., Nakai, D., Yoshida, K., Nakamura, K., Yasukawa, M., Koike, M., Takubo, K., Chatton, B., Ishikawa, F., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky155 · Cited by 42

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation

Dzulko, M., Pons, M., Henke, A., Schneider, G., & Krämer, O. H. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188453 · Cited by 39

Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide

Sato, Y., Kurose, A., Ogawa, A., Ogasawara, K., Traganos, F., Darżynkiewicz, Z., & Sawai, T. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.5.7740 · Cited by 37

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

Gatei, M. H., Kijas, A. W., Biard, D. S. F., Dörk, T., & Lavin, M. F. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu141 · Cited by 38

Limited nucleotide pools restrict Epstein–Barr virus-mediated B-cell immortalization

Hafez, A. Y., Messinger, J. E., McFadden, K., Fenyőfalvi, G., Shepard, C., Lenzi, G. M., Kim, B., & Luftig, M. A. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.46 · Cited by 36

Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts

Prasad, R. Y., Chastain, P. D., Nikolaishvili‐Feinberg, N., Smeester, L., Kaufmann, W. K., & Fry, R. C. (2012) · Nanotoxicology · doi:10.3109/17435390.2012.710659 · Cited by 36

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints

Neumann, J., Boerries, M., Köhler, R., Giaisi, M., Krammer, P. H., Busch, H. S., & Li‐Weber, M. (2013) · International Journal of Cancer · doi:10.1002/ijc.28521 · Cited by 36

DNA Protein Kinase–Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells

Arlander, S. J. H., Greene, B. T., Innes, C. L., & Paules, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-0675 · Cited by 36

DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress

Wang, C.-Y., Huang, E. Y.-H., Huang, S.-C., & Chung, B.-C. (2014) · Oncogene · doi:10.1038/onc.2014.74 · Cited by 35

Induction of DNA Double-Strand Breaks and Cellular Migration Through Bystander Effects in Cells Irradiated With the Slit-Type Microplanar Beam of the Spring-8 Synchrotron

Kashino, G., Kondoh, T., Nariyama, N., Umetani, K., Ohigashi, T., Shinohara, K., Kurihara, A., Fukumoto, M., Tanaka, H., Maruhashi, A., et al. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.09.060 · Cited by 35

ATM activation in hypoxia - causes and consequences

Olcina, M. M., Grand, R. J. A., & Hammond, E. M. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29903 · Cited by 37

Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response

Lopez, K. E., & Bouchier‐Hayes, L. (2022) · Cells · doi:10.3390/cells11121887 · Cited by 38

Caffeine inhibits UV-mediated NF-κB activation in A2058 melanoma cells: an ATM-PKCδ-p38 MAPK-dependent mechanism

Ravi, D., Muniyappa, H., & Das, K. C. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9628-x · Cited by 35

CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair

Duquette, M. L., Zhu, Q., Taylor, E. R., Tsay, A. J., Shi, L. Z., Berns, M. W., & McGowan, C. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003050 · Cited by 39

The Connection Between Cell Fate and Telomere

Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_3 · Cited by 39

The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma

Kiyohara, E., Tamai, K., Katayama, I., & Kaneda, Y. (2011) · Gene Therapy · doi:10.1038/gt.2011.123 · Cited by 34

Simian Virus 40 Activates ATR-Δp53 Signaling To Override Cell Cycle and DNA Replication Control

Rohaly, G., Korf, K., Dehde, S., & Dornreiter, I. (2010) · Journal of Virology · doi:10.1128/jvi.00122-10 · Cited by 33

ATM and KAT5 safeguard replicating chromatin against formaldehyde damage

Ortega-Atienza, S., Wong, V. C., DeLoughery, Z. J., Łuczak, M. W., & Zhitkovich, A. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv957 · Cited by 33

Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

Bunimovich, Y. L., Nair‐Gill, E., Riedinger, M., McCracken, M. N., Cheng, D., McLaughlin, J., Radu, C. G., & Witte, O. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104125 · Cited by 32

Inactivation of the Nijmegen Breakage Syndrome Gene Leads to Excess Centrosome Duplication via the ATR/BRCA1 Pathway

Shimada, M., Sagae, R., Kobayashi, J., Habu, T., & Komatsu, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3016 · Cited by 33

The Incidence of DNA Double-Strand Breaks Is Higher in Late-Cleaving and Less Developmentally Competent Porcine Embryos1

Bohrer, R. C., Coutinho, A. R. S., Duggavathi, R., & Bordignon, V. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.130542 · Cited by 33

Bifunctional DNA Alkylator 1,3-Bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway

Cui, B., Johnson, S. P., Bullock, N., Ali‐Osman, F., Bigner, D. D., & Friedman, H. S. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.053124 · Cited by 32

Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

Manoel-Caetano, F. S., Rossi, A. F. T., de Morais, G. C., Severino, F. E., & Silva, A. E. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.03.007 · Cited by 30

Inhibition of histone deacetylases enhances DNA damage repair in SCNT embryos

Bohrer, R. C., Duggavathi, R., & Bordignon, V. (2014) · Cell Cycle · doi:10.4161/cc.29215 · Cited by 31

Phosphorylation of Cyclin D1 Regulated by ATM or ATR Controls Cell Cycle Progression

Hitomi, M., Yang, K., Stacey, A. W., & Stacey, D. W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02047-07 · Cited by 29

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

Huang, Y., & Ratovitski, E. A. (2010) · Aging · doi:10.18632/aging.100249 · Cited by 28

ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice

Valdés-Sánchez, L., de la Cerda, B., Diaz-Corrales, F. J. J., Massalini, S., Chakarova, C. F., Wright, A. F., & Bhattacharya, S. S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds563 · Cited by 28

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

Elvers, I., Hagenkort, A., Johansson, F., Djureinovic, T., Lagerqvist, A., Schultz, N., Stoimenov, I., Erixon, K., & Helleday, T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks646 · Cited by 27

Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly

Callén, E., Nussenzweig, M. C., & Nussenzweig, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210873 · Cited by 29

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Liang, N., He, Q., Liu, X., & Sun, H. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3385 · Cited by 28

The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis

Zhang, X., Trépanier, V., Beaujois, R., Viranaïcken, W., Drobetsky, E. A., & DesGroseillers, L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw057 · Cited by 27

Gamma-radiation-induced ATM-dependent signalling in human T-lymphocyte leukemic cells, MOLT-4.

Tichý, A., Záškodová, D., Řezáčová, M., Vávrová, J., Vokurková, D., Pejchal, J., Vilasová, Z., Cerman, J., & Österreicher, J. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3248 · Cited by 26

A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage

Whiteaker, J. R., Zhao, L., Saul, R., Kaczmarczyk, J. A., Schoenherr, R. M., Moore, H. D., Jones-Weinert, C. W., Ivey, R. G., Lin, C., Hiltke, T., et al. (2018) · Radiation Research · doi:10.1667/rr14963.1 · Cited by 28

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders

O’Driscoll, M. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.02.010 · Cited by 27

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress

Vasudevarao, M. D., Pena, D. P., Ihle, M., Bongiovanni, C., Maity, P., Geissler, D., Mohammadi, H. F., Rall-Scharpf, M., Niemann, J., Mommersteeg, M. T. M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56993-6 · Cited by 26

ATR promotes cilia signalling: links to developmental impacts

Stiff, T., Tena, T. C., O’Driscoll, M., Jeggo, P. A., & Philipp, M. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw034 · Cited by 26

A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability

Li, P., Ma, X., Adams, I. R., & Yuan, P. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.551 · Cited by 23

Double‐strand DNA breaks are mainly repaired by the homologous recombination pathway in early developing swine embryos

Bohrer, R. C., Dicks, N., Gutierrez, K., Duggavathi, R., & Bordignon, V. (2017) · The FASEB Journal · doi:10.1096/fj.201700800r · Cited by 25

ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways

Fedak, E. A., Adler, F. R., Abegglen, L. M., & Schiffman, J. D. (2021) · Bulletin of Mathematical Biology · doi:10.1007/s11538-021-00868-6 · Cited by 29

DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets

Lozinski, M., Bowden, N. A., Graves, M. C., Fay, M. F., & Tooney, P. A. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00613-0 · Cited by 30

PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension

Lampron, M.-C., Vitry, G., Nadeau, V., Grobs, Y., Paradis, R., Samson, N., Tremblay, È., Boucherat, O., Meloche, J., Bonnet, S., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313763 · Cited by 24

DNA damage detected with γH2AX in endometrioid adenocarcinoma cell lines

Kurose (2010) · International Journal of Oncology · doi:10.3892/ijo_00000589 · Cited by 24

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 303

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

Gatei, M. H., Sloper, K., Sørensen, C. S., Syljuåsen, R. G., Falck, J., Hobson, K., Savage, K. I., Lukas, J., Zhou, B.-B., Bártek, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210862200 · Cited by 312

DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases

Yajima, H., Lee, K.-J., Zhang, S., Kobayashi, J., & Chen, B. P. C. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.036 · Cited by 124

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410873200 · Cited by 216

The role of ATM and ATR in DNA damage-induced cell cycle control.

Goodarzi, A. A., Block, W. D., & Lees‐Miller, S. P. (2003) · PubMed · Cited by 98