ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064

MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA

Xu, C., Zhang, L., Duan, L.-N., & Lu, C. (2016) · Oncotarget · doi:10.18632/oncotarget.12794 · Cited by 24

Histone variants: the artists of eukaryotic chromatin

Li, M., & Fang, Y. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4817-4 · Cited by 27

Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells

Vlatkovic, T., Veldwijk, M. R., Giordano, F. A., & Herskind, C. (2022) · Cancers · doi:10.3390/cancers14030701 · Cited by 26

γ H2AX in the S Phase after UV Irradiation Corresponds to DNA Replication and Does Not Report on the Extent of DNA Damage

Dhuppar, S., Roy, S., & Mazumder, A. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00328-20 · Cited by 24

CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response

Marazita, M. C., Ogara, M. F., Sonzogni, S. V., Martí, M., Dusetti, N. J., Pignataro, O. P., & Cánepa, E. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035638 · Cited by 22

Phosphorylated histone H2A.x in porcine embryos produced by IVF and somatic cell nuclear transfer

Bohrer, R. C., Che, L., Gonçalves, P. B. D., Duggavathi, R., & Bordignon, V. (2013) · Reproduction · doi:10.1530/rep-13-0271 · Cited by 23

RAP80 Responds to DNA Damage Induced by Both Ionizing Radiation and UV Irradiation and Is Phosphorylated at Ser205

Yan, J., Yang, X.-P., Kim, Y. S., & Jetten, A. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5950 · Cited by 22

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction

Katsura, M., Tsuruga, T., Date, O., Yoshihara, T., Ishida, M., Tomoda, Y., Okajima, M., Takaku, M., Kurumizaka, H., Kinomura, A., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp262 · Cited by 22

Brusatol’s anticancer activity and its molecular mechanism: a research update

Xi, W., Zhao, C., Wu, Z., Ye, T., Zhao, R., Jiang, X., & Ling, S. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae017 · Cited by 21

Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress

Choi, S., Jang, H., Roe, J., Kim, S., Cho, E., & Youn, H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1319 · Cited by 22

Oxoguanine Glycosylase 1 (OGG1) Protects Cells from DNA Double-Strand Break Damage Following Methylmercury (MeHg) Exposure

Ondovcik, S. L., Tamblyn, L., McPherson, J. P., & Wells, P. G. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs138 · Cited by 21

Interplay of DNA damage and cell cycle signaling at the level of human replication protein A

Borgstahl, G. E. O., Brader, K., Mosel, A., Liu, S., Kremmer, E., Goettsch, K. A., Kolar, C., Nasheuer, H., & Oakley, G. G. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.05.005 · Cited by 23

The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR

Brem, R., Fernet, M., Chapot, B., & Hall, J. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.02.002 · Cited by 20

DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated

Matsumoto, Y., Anie Day De Castro, A. S. A., Modak, C., & Shimada, M. (2021) · Genes · doi:10.3390/genes12081143 · Cited by 21

Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling

Schmalz, M. F., Liang, X., Wieser, I., Gruschel, C., Muskalla, L., Stöckl, M. T., Nitschke, R., Linz, N., Leitenstorfer, A., Vogel, A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220132120 · Cited by 20

Distinct regulation of ATM signaling by DNA single-strand breaks and APE1

Zhao, H., Li, J., You, Z., Lindsay, H. D., & Yan, S. (2024) · Nature Communications · doi:10.1038/s41467-024-50836-6 · Cited by 22

DNA Replication Arrest in Response to Genotoxic Stress Provokes Early Activation of Stress-Activated Protein Kinases (SAPK/JNK)

Damrot, J., Helbig, L., Roos, W. P., Quirós, S., Kaina, B., & Fritz, G. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.12.015 · Cited by 20

gamma-H2AX: A potential biomarker in breast cancer

Palla, V., Karaolanis, G., Valavanis, C., Stanc, G., Tzaida, O., Trihia, H., Patapis, P., Dimitroulis, D., & Perrea, D. N. (2019) · Tumor Biology · doi:10.1177/1010428319878536 · Cited by 20

Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Tatewaki, N., Konishi, T., Nakajima, Y., Nishida, M., Saito, M., Eitsuka, T., Sakamaki, T., Ikekawa, N., & Nishida, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147570 · Cited by 21

Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

Bai, L., Michael, W. M., & Yan, S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.006 · Cited by 19

A-T neurodegeneration and DNA damage-induced transcriptional stress

Paull, T. T., & Woolley, P. R. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103647 · Cited by 17

Artemis‐dependent DNA double‐strand break formation at stalled replication forks

Unno, J., Takagi, M., Piao, J., Sugimoto, M., Honda, F., Maeda, D., Masutani, M., Kiyono, T., Watanabe, F., Morio, T., et al. (2013) · Cancer Science · doi:10.1111/cas.12144 · Cited by 19

Involvement of p29 in DNA damage responses and Fanconi anemia pathway

Chu, P., Wang, T., Lu, Y., Chou, C.-K., Yang, Y., & Chang, M.-S. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp204 · Cited by 19

Endothelin‐1 and α‐melanocortin have redundant effects on global genome repair in UV‐irradiated human melanocytes despite distinct signaling pathways

Swope, V. B., Starner, R. J., Rauck, C., & Abdel‐Malek, Z. A. (2020) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12823 · Cited by 18

Cancer-associated transcription factors in DNA damage response

Kciuk, M., Gielecińska, A., Kołat, D., Kałuzińska‐Kołat, Ż., & Kontek, R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188757 · Cited by 19

Induction of Non-Targeted Stress Responses in Mammary Tissues by Heavy Ions

Wang, T. J. C., Wu, C., Chai, Y., Lam, R. K. K., Hamada, N., Kakinuma, S., Uchihori, Y., Yu, K. N., & Hei, T. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136307 · Cited by 18

Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts

Emami, S. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1034 · Cited by 17

The PIM-2 Kinase Is an Essential Component of the Ultraviolet Damage Response That Acts Upstream to E2F-1 and ATM

Zirkin, S., Davidovich, A., & Don, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458851 · Cited by 18

Inhibition of nucleotide excision repair and damage response signaling by dibromoacetonitrile: A novel genotoxicity mechanism of a water disinfection byproduct

Komaki, Y., & Ibuki, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127194 · Cited by 17

Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

Rodríguez, A., Torres, L., Juárez, U., Sosa, D., Azpeitia, E. M., Teresa, B. G., Barberena, E. C., Ortiz, R., Salazar, A. M., Ostrosky‐Wegman, P., et al. (2015) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-015-0011-4 · Cited by 22

Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells

SHIMIZU, N., Nakajima, N. I., Tsunematsu, T., Ogawa, I., Kawai, H., Hirayama, R., Fujimori, A., Yamada, A., Okayasu, R., Ishimaru, N., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446351 · Cited by 18

DNA damage response links calpain to cellular senescence

Demarchi, F., Cataldo, F., Bertoli, C., & Schneider, C. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10637 · Cited by 18

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

Helbig, L., Damrot, J., Hülsenbeck, J., Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B., & Fritz, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190645 · Cited by 17

Targeting Angiogenesis by Blocking the ATM–SerRS–VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth

Song, Y., Lu, H., Wang, Q., & Xiang, R. (2019) · Cancers · doi:10.3390/cancers11121847 · Cited by 17

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

Ragland, R. L., Arlt, M. F., Hughes, E. D., Saunders, T. L., & Glover, T. W. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9195-4 · Cited by 17

Epidermal Growth Factor Receptor Pathway Mitigates UVA-Induced G2/M Arrest in Keratinocyte Cells

Jean, C., Hernandez-Pigeon, H., Blanc, A., Charvéron, M., & Laurent, G. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700863 · Cited by 17

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

Beumer, J. H., Fu, K. Y., Anyang, B. N., Siegfried, J. M., & Bakkenist, C. J. (2015) · BMC Cancer · doi:10.1186/s12885-015-1649-3 · Cited by 17

The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil

Kiweler, N., Schwarz, H., Nguyen, A., Matschos, S., Mullins, C. S., Piée‐Staffa, A., Brachetti, C., Roos, W. P., Schneider, G., Linnebacher, M., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09731-3 · Cited by 16

A Kinase-Independent Role for the Rad3ATR-Rad26ATRIP Complex in Recruitment of Tel1ATM to Telomeres in Fission Yeast

Subramanian, L., & Nakamura, T. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000839 · Cited by 16

Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal Loss

Lee, Y., Brown, E. J., Chang, S. S., & McKinnon, P. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4245-13.2014 · Cited by 16

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation in human peripheral blood mononuclear cells

Bakkenist, C. J., Czambel, R. K., Hershberger, P. A., Tawbi, H. A.-H., Beumer, J. H., & Schmitz, J. C. (2015) · Oncoscience · doi:10.18632/oncoscience.162 · Cited by 16

Genetic Interactions of the Aspergillus nidulans atmAATM Homolog With Different Components of the DNA Damage Response Pathway

Malavazi, I., Lima, J. F., de Castro, P. A., Savoldi, M., Goldman, M. H. S., & Goldman, G. H. (2008) · Genetics · doi:10.1534/genetics.107.080879 · Cited by 15

Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer

Qin, S., Kitty, I., Hao, Y., Zhao, F., & Kim, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210212 · Cited by 14

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression

Yamazaki, H., Shirakawa, K., Matsumoto, T., Kazuma, Y., Matsui, H., Horisawa, Y., Stanford, E., Sarca, A. D., Shirakawa, R., Shindo, K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0223463 · Cited by 15

Regulation of ATR-dependent DNA damage response by nitric oxide

Yeo, C. T., Stancill, J. S., Oleson, B. J., Schnuck, J. K., Stafford, J. D., Naatz, A., Hansen, P. A., & Corbett, J. A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100388 · Cited by 16

Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte

Reichman, R. D., Alleva, B., & Smolikove, S. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-44820-6_5 · Cited by 21

Part I—mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways

Aqil, M., Elseth, K. M., Vesper, B. J., Deliu, Z., Aydogan, B., Xue, J., & Radosevich, J. A. (2013) · Tumor Biology · doi:10.1007/s13277-013-1318-6 · Cited by 15

Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

Wang, W. T., Catto, J. W. F., & Meuth, M. (2014) · Oncogene · doi:10.1038/onc.2014.221 · Cited by 14

The role of the Fanconi anemia network in the response to DNA replication stress

Gari, K., & Constantinou, A. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903154150 · Cited by 14

Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders

O’Driscoll, M. (2008) · Current Genomics · doi:10.2174/138920208784340795 · Cited by 15

Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion

Nguyen, A., Dzulko, M., Murr, J., Yun, Y., Schneider, G., & Krämer, O. (2021) · Cells · doi:10.3390/cells10102520 · Cited by 10

A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo

Comiskey, D. F., Jacob, A. G., Sanford, B. L., Montes, M., Goodwin, A., Steiner, H. E., Matsa, E., Tapia-Santos, A. S., Bebee, T. W., Grieves, J. L., et al. (2017) · Oncogene · doi:10.1038/onc.2017.282 · Cited by 13

EZH2 suppresses the nucleotide excision repair in nasopharyngeal carcinoma by silencing XPA gene

Huang, Y. J., Wang, X., Niu, X., Wang, X., Jiang, R., Xu, T., Liu, Y., Liang, L., Ou, X., Xing, X., et al. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22507 · Cited by 12

Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor‐related cytotoxicity

Patel, A., Seraia, E., Ebner, D. V., & Ryan, A. J. (2020) · International Journal of Cancer · doi:10.1002/ijc.32966 · Cited by 11

The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection

Trigg, B., Lauer, K. B., dos Santos, P. F., Coleman, H. M., Balmus, G., Mansur, D. S., & Ferguson, B. J. (2017) · Viruses · doi:10.3390/v9110342 · Cited by 11

Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906

Soares, D. G., Battistella, A., Rocca, C. J., Matuo, R., Henriques, J. A. P., Larsen, A. K., & Escargueil, A. E. (2011) · Biochemical Journal · doi:10.1042/bj20101770 · Cited by 11

A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation

Benzina, S., Pitaval, A., Lemercier, C., Lustremant, C., Frouin, V., Wu, N., Papine, A., Soussaline, F., Romeo, P.-H., & Gidrol, X. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1901-7 · Cited by 10

Ataxia Telangiectasia and Rad3-Related Overexpressing Cancer Cells Induce Prolonged G 2 Arrest and Develop Resistance to Ionizing Radiation

Kim, Y.-M., Lee, Y. M., Park, S., & Pyo, H. (2011) · DNA and Cell Biology · doi:10.1089/dna.2010.1141 · Cited by 10

Dynamic changes to survivin subcellular localization are initiated by DNA damage

Wall, N. R., Asumen, M. G., Ifeacho, T. V., Pfandl, C., & Cockerham, L. (2010) · OncoTargets and Therapy · doi:10.2147/ott.s11484 · Cited by 10

Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition

Tomko, R. J., Azang-Njaah, N. N., & Reese, C. E. (2009) · Cell Cycle · doi:10.4161/cc.8.2.7595 · Cited by 10

RNF8 promotes efficient DSB repair by inhibiting the pro‐apoptotic activity of p53 through regulating the function of Tip60

Chen, H., Shan, J., Liu, J., Feng, Y., Ke, Y., Qi, W., Liu, W., & Zeng, X. (2020) · Cell Proliferation · doi:10.1111/cpr.12780 · Cited by 9

DNA damage repair is suppressed in porcine aged oocytes

Lin, T., Sun, L., Lee, J. E., Kim, S. Y., & Jin, D. I. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e90 · Cited by 9

A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks

Suzuki, K., Yamauchi, M., Oka, Y., Suzuki, M., & Yamashita, S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq226 · Cited by 10

PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response

Serafim, R. B., Cardoso, C. C., Arfelli, V. C., Valente, V., & Archangelo, L. F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166382 · Cited by 8

Recent Advances in ATM Inhibitors As Potential Therapeutic Agents

Dong, C., Wang, Y., Tu, Z., Yan, J., Jiang, Y., Lu, T., Chen, Y., & Liu, H. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0252 · Cited by 8

Polyaromatic Hydrocarbons Cause Histone H2AX Phosphorylation in the S-phase of the Cell Cycle

Shimohara, C., Sawai, T., & Yagi, T. (2008) · Genes and Environment · doi:10.3123/jemsge.30.92 · Cited by 8

Asynchronously Replicating Eu/Heterochromatic Regions Shape Chromosome Damage

Tomaso, M. V. D., Martínez‐López, W., & Palitti, F. (2010) · Cytogenetic and Genome Research · doi:10.1159/000298820 · Cited by 7

TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC−/− Mice

Hu, L., Huang, W., Bei, L., Broglie, L. A., & Eklund, E. A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700931 · Cited by 7

ATM serine-1981 phosphorylation is a plausible biomarker

Bakkenist, C. J., Beumer, J. H., & Schmitz, J. C. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1084205 · Cited by 7

BMI1 reduces ATR activation and signalling caused by hydroxyurea

Lin, X., Wei, F., Whyte, P., & Tang, D. (2017) · Oncotarget · doi:10.18632/oncotarget.21111 · Cited by 7

Abrogation of ATR function preferentially augments cisplatin-induced cytotoxicity in PTEN-deficient breast cancer cells

Zhao, J., Yang, J., Li, K., Chen, Y., Tang, M., Zhu, H.-L., Nie, C.-I., Yuan, Z., & Zhao, X.-Y. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110740 · Cited by 6

Chk2 Protects against Radiation-Induced Genomic Instability

MacLaren, A., Slavin, D. A., & McGowan, C. H. (2009) · Radiation Research · doi:10.1667/rr1603.1 · Cited by 6

Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response

Hou, J., Gao, Y., Han, B., Yan, S., Wei, S., & Gao, X. (2025) · Science Advances · doi:10.1126/sciadv.ado7660 · Cited by 5

Targeting DNA-PK

Novotný, J. P., Mariño‐Enríquez, A., & Fletcher, J. A. (2023) · Cancer treatment and research · doi:10.1007/978-3-031-30065-3_16 · Cited by 5

Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients

Duthoo, E., Beyls, E., Backers, L., Guðjόnsson, Þ., Huang, P., Jonckheere, L., Riemann, S., Parton, B., Du, L., Debacker, V., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20241432 · Cited by 5

Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection

Hainley, L. E., Hughson, M. S., Narendran, A., Smith, R., Arthur, J., Hayner‐Buchan, A., Conti, D. J., Lehman, J. M., & Friedrich, T. D. (2021) · Viruses · doi:10.3390/v13071353 · Cited by 5

Investigation of the Cytotoxic and Antiproliferative Effects of Liposomal Daunorubicin on Human Colorectal Cancer (HCT116) Cell Line

Hadi-al-Ward, N. A., Ebrahimi, M., & Karizi, S. Z. (2024) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-144287 · Cited by 5

Hypoxia and the DNA Damage Response

Olcina, M. M., & Hammond, E. M. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9167-5_2 · Cited by 5

Novel targets for ATM-deficient malignancies

Winkler, J., Hofmann, K., & Chen, S. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29905 · Cited by 5

To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?

Subramanian, L. (2010) · Frontiers in bioscience · doi:10.2741/3664 · Cited by 5

Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework

Wang, Y., Guo, Z., Chen, X., Zhang, W., Lü, A., & Wang, Y. (2015) · Molecular BioSystems · doi:10.1039/c5mb00304k · Cited by 4

Determination of the DNA repair pathways utilised by acute lymphoblastic leukaemia cells following daunorubicin treatment

Al-Aamri, H. M., Irving, H. R., Meehan-Andrews, T., & Bradley, C. (2019) · BMC Research Notes · doi:10.1186/s13104-019-4663-8 · Cited by 4

Chapter 6 Application of New Methods for Detection of DNA Damage and Repair

Svetlova, M., Solovjeva, L. V., & Tomilin, N. (2009) · International review of cytology · doi:10.1016/s1937-6448(09)77006-6 · Cited by 4

Coupling between nucleotide excision repair and gene expression

Botto, A. E. C., Muñoz, J. C., & Muñoz, M. J. (2018) · RNA Biology · doi:10.1080/15476286.2018.1464354 · Cited by 3

Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair

Mian, E., & Wiesmüller, L. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6955-5_23 · Cited by 3

DNA Damage Signaling Downstream of ATM

Bunz, F. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8044-1_2 · Cited by 4

DNA Double Helix Unwinding Triggers Transcription Block-Dependent Apoptosis: A Semiquantitative Probe of the Response of ATM, RNAPII, and p53 to Two DNA Intercalators

Zhang, Z., Wang, Y., Song, T., Gao, J., Wu, G., Zhang, J., & Qian, X. H. (2009) · Chemical Research in Toxicology · doi:10.1021/tx800288v · Cited by 3

Sensitivity to methylmercury toxicity is enhanced in oxoguanine glycosylase 1 knockout murine embryonic fibroblasts and is dependent on cellular proliferation capacity

Ondovcik, S. L., Tamblyn, L., McPherson, J. P., & Wells, P. G. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.02.018 · Cited by 3

Analysis from the perspective of cilia: the protective effect of PARP inhibitors on visual function during light-induced damage

Che, L., Song, J., Lou, Y., & Li, G. (2019) · International Ophthalmology · doi:10.1007/s10792-019-01245-y · Cited by 3

Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA

Lima, J. F., Malavazi, I., Ferreira, M. E. D. S., Savoldi, M., Mota, A. O., Capellaro, J. L., Goldman, M. H. S., & Goldman, G. H. (2007) · Molecular Genetics and Genomics · doi:10.1007/s00438-007-0307-0 · Cited by 3

Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells

Li, X., Le, Y., Li, Y., Chen, S., Guo, L., Fu, X., Manjanatha, M. G., & Mei, N. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.01.012 · Cited by 2

Cell Death in Response to Genotoxic Stress and DNA Damage

Lopez‐Bergami, P., & Ronai, Z. A. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.008 · Cited by 2

The Impact of Post-Translational Regulation of Histone on Cancer Metastasis and Cancer Chemoresistance

Liu, L., Yuan, P., Doğan, S., Zhu, F., & Duan, Q. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0099-9 · Cited by 2

DNA Damage: Cellular Responses, Repair, and Cancer Treatment

Cartwright, B. M., Musich, P. R., & Zou, Y. (2017) · Current human cell research and applications · doi:10.1007/978-981-10-7296-3_6 · Cited by 3

PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells

Huang, Y., Ohno, O., & Miyamoto, K. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1585744 · Cited by 2

Hypoxia and Modulation of Cellular Radiation Response

Hammond, E. M., Olcina, M. M., & Giaccia, A. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8044-1_6 · Cited by 2

Methods for the Assessment of Telomere Status

Nakamura, A. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_15 · Cited by 2

DNA Damage Response and the Balance Between Cell Survival and Cell Death

Kaina, B., Roos, W. P., & Christmann, M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_7 · Cited by 2

Curriculum Vitae Personal Data

Selmeczi, D. (2008) · Cited by 2

Expression of miRNAs Associated With Embryo Development and DNA Damage Response in Porcine Embryos

Pineda, G., Facioli, F. L., de Macedo, M. P., Guay, V., Currin, L., Gutierrez, K., Bordignon, V., & Glanzner, W. G. (2025) · Molecular Reproduction and Development · doi:10.1002/mrd.70069 · Cited by 1

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 303

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

Gatei, M. H., Sloper, K., Sørensen, C. S., Syljuåsen, R. G., Falck, J., Hobson, K., Savage, K. I., Lukas, J., Zhou, B.-B., Bártek, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210862200 · Cited by 312

DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases

Yajima, H., Lee, K.-J., Zhang, S., Kobayashi, J., & Chen, B. P. C. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.036 · Cited by 124

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410873200 · Cited by 216

The role of ATM and ATR in DNA damage-induced cell cycle control.

Goodarzi, A. A., Block, W. D., & Lees‐Miller, S. P. (2003) · PubMed · Cited by 98