The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways
Open accessAbstract
The nuclear factor (NF)-kappaB pathway is a paradigm for gene expression control by ubiquitin-mediated protein degradation. In stimulated cells, phosphorylation by the IkappaB kinase (IKK) complex primes NF-kappaB-inhibiting IkappaB molecules for lysine (Lys)-48-linked polyubiquitination and subsequent destruction by the 26S proteasome. However, recent studies indicate that the ubiquitin (Ub) system controls NF-kappaB pathways at many levels. Ub ligases are activated by different upstream signalling pathways, and they function as central regulators of IKK and c-Jun amino-terminal kinase activation. The assembly of Lys 63 polyUb chains provides docking surfaces for the recruitment of IKK-activating complexes, a reaction that is counteracted by deubiquitinating enzymes. Furthermore, Ub conjugation targets upstream signalling mediators as well as nuclear NF-kappaB for post-inductive degradation to limit the duration of signalling.
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“Extracellular inflammatory signals including lipopolysaccharide (LPS), pro-inflammatory cytokines, reactive oxygen species, advanced glycation end products, and oxidized low-density lipoprotein trigger the phosphorylation of IKKβ, which in turn phosphorylates IκBα for ubiquitination and degradation by proteasome [13–18].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [15]
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint
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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
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The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
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The NF- B Family of Transcription Factors and Its RegulationPreprint
Oeckinghaus, A., & Ghosh, S. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000034 · Cited by 2,944
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350
Ea, C.-K., Deng, L., Xia, Z.-P., Pineda, G., & Chen, Z. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.026 · Cited by 1,026
Nonproteolytic Functions of Ubiquitin in Cell Signaling
Chen, Z. J., & Sun, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.014 · Cited by 948
Ubiquitylation and cell signaling
Haglund, K., & Đikić, I. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600808 · Cited by 736
Metadata
- Authors
- Krappmann, D., & Scheidereit, C.
- Affiliations
- Max Delbrück Center (DE)
- Corresponding author
- Scheidereit, Claus
- Venue
- The EMBO Reports
- Published
- 2005-04-01
- Volume
- 6
- Issue
- 4
- Pages
- 321-326
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1299290
- OpenAlex
- W2169463874
- Cited by
- 128
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- ubiquitin conjugation, NF-κB signaling, IκB kinase, IκB degradation, Lys63-linked polyubiquitination, E3 ubiquitin ligase, deubiquitinase, c-Jun N-terminal kinase, 26S proteasome, signal termination
- MeSH terms
- Enzyme Activation, Gene Expression Regulation, Humans, Models, Biological, Signal Transduction, NF-kappa B, Protein Serine-Threonine Kinases, Ubiquitin, I-kappa B Kinase
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