Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans
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Mice have been the driving force behind research into caloric restriction, and the use of recombinant inbred lines such as the BXD mouse strains now offer insights into the role of genetic background effects and can help translate differences between gene variants into meaningful data for human populations and disease.
“For example, mice have been the driving force behind research into CR (300), and the use of recombinant inbred lines such as the BXD mouse strains now offer insights into the role of genetic background effects and can help translate the differences between gene variants into meaningful data for human populations and disease.”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [300]
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
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- Authors
- Demetrius, L.
- Affiliations
- Harvard University (US)
- Corresponding author
- Demetrius, Lloyd
- ORCID
- Demetrius, Lloyd
- Venue
- The EMBO Reports
- Published
- 2005-07-01
- Volume
- 6
- Issue
- S1
- Pages
- S39-S44
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1369270
- OpenAlex
- W1591032344
- Cited by
- 257
- References
- 23
- Citations by year
- 2026: 19 · 2025: 16 · 2024: 18 · 2023: 15 · 2022: 18 · 2021: 22 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 11 · 2013: 8 · 2012: 10
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- aging, anti-aging interventions, translational research, animal models
- MeSH terms
- Adult, Aged, Aging, Animals, Energy Metabolism, Humans, Longevity, Neoplasms, Obesity, Species Specificity, Reproducibility of Results, Entropy, Models, Animal, Caloric Restriction, Mice
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