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Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

Timmann, C, Fuchs, S, Thoma, C, Lepping, B, Brattig, N W, Sievertsen, J, Thye, T, Müller-Myhsok, B, Horstmann, R D·2004·Genes & Immunity
DOI 10.1038/sj.gene.6364094
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Abstract

Since interleukin (IL)-10 is a key mediator of immunosuppression, and immunosuppression is considered an important element of helminth infection, we studied variants of the putative IL-10 gene promoter in 337 individuals from 130 families heavily exposed to infection by the tissue nematode Onchocerca volvulus. As shown by transmission disequilibrium tests, variants of the IL-10 promoter at positions -1082(G/A), -819(C/T), and -592(C/A) in the haplotype of ATA were significantly associated with high peripheral blood cell (PBC) proliferative responses to O. volvulus antigen (OvAg). No associations were observed using phytohemagglutinin-induced PBC proliferation or with qualitative or quantitative phenotypes of onchocerciasis or onchocerciasis-related skin disease. The findings are compatible with the hypothesis that the ATA haplotype causes a decrease in IL-10 production by OvAg-reactive type-1 regulatory T-lymphocytes, thereby alleviating the suppression of other T cells. To our knowledge, this is the first time that an influence of IL-10 promoter variants is shown on the adaptive immune response.

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Metadata

Authors
Timmann, C., Fuchs, S., Thoma, C., Lepping, B., Brattig, N. W., Sievertsen, J., Thye, T., Müller-Myhsok, B., & Horstmann, R. D.
Venue
Genes & Immunity
Publisher
Springer Science and Business Media LLC
Published
2004-05-06
Volume
5
Issue
4
Pages
256-260
ISSN
  • 1466-4879
  • 1476-5470
DOI
10.1038/sj.gene.6364094
Cited by
17
References
2
Language
en
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