Short-term exposure to air pollution and inflammation-sensitive biomarkers
Abstract
Objectives To evaluate the effect of short-term exposure to air pollutants on inflammation-sensitive biomarkers in apparently healthy individuals.Methods We enrolled all participants from The Tel-Aviv Sourasky Medical Center inflammation survey held between 2003 and 2006, excluding participants with an acute or chronic inflammatory disease, pregnancy, steroidal or nonsteroidal treatment, or a recent invasive procedure. Additional subjects were excluded for living more than 11km from the nearest air pollution monitoring station. Analysis was performed separately for men and women. Linear regression models were fitted for each inflammatory variable against air pollutant variables (particulate matter under 10microm, sulfur dioxide, nitrogen dioxide, carbon monoxide, and ozone) for increasing lag times of up to 7 days, and adjusted for all possible and known confounding parameters.Results The study population comprised 3659 individuals (2203 males and 1456 females). We found a statistically significant negative correlation in the male population between air pollutants, mainly NO2, SO2, and CO, and fibrinogen in several lag days. A positive correlation was found for PM10 at day 7. No such correlation was found for CRP and WBC, or for the female population.Conclusion Our findings do not support the potential link between short-term exposure to air pollution and enhanced inflammation as a possible explanation for increased cardiovascular morbidity. Additional large-scale population-based studies with good methodological design are needed in order to clarify this issue.
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Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen, von Willebrand factor, and plasminogen activator inhibitor-1.
“Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen (48–50), von Willebrand factor (49), and plasminogen activator inhibitor-1 (48).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [50]
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- Authors
- Steinvil, A., Kordova-Biezuner, L., Shapira, I., Berliner, S., & Rogowski, O.
- Affiliations
- Tel Aviv University (IL)
- Ministry of Environmental Protection (IL)
- Corresponding author
- Rogowski, Ori
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 106
- Issue
- 1
- Pages
- 51-61
- ISSN
- 0013-9351 (ISSN-L)
- OpenAlex
- W2072784396
- Cited by
- 120
- References
- 56
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Environmental Protection
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- short-term air pollution exposure, inflammatory markers, fibrinogen, C-reactive protein, white blood cell count, nitrogen dioxide, sulfur dioxide, carbon monoxide, ozone, PM10, cardiovascular morbidity, sex differences, healthy adults
- MeSH terms
- Air Pollutants, Environmental Monitoring, Female, Health Surveys, Humans, Inflammation, Israel, Male, Middle Aged, Seasons, Time Factors, Urbanization, Biomarkers, Inhalation Exposure
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