Cited by 123Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesPorphyrin Metabolism and Disorders

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Porphyrin Formation in Actinic Keratosis and Basal Cell Carcinoma after Topical Application of Methyl 5-Aminolevulinate

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Angell-Petersen, Even, Sørensen, Roar, Warloe, Trond, Soler, Ana Maria, Moan, Johan, Peng, Qian, Giercksky, Karl-Erik·2006·Journal of Investigative Dermatology

DOI 10.1038/sj.jid.5700048

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Abstract

Photodynamic therapy using topical methyl 5-aminolevulinate (MAL) is a new treatment modality for basal cell carcinoma (BCC) and actinic keratosis (AK). MAL induces endogenous porphyrins, which act as photosensitizers. Pharmacokinetic studies of the porphyrin-inducing effect of MAL creams (Metvix) applied in different concentrations (16-160 mg/g) and application times are presented. Surface fluorescence measurements were used to monitor porphyrin accumulation in 18 superficial BCCs and 32 AKs. For both lesion types, the fluorescence increased during the first 13 of 28 hours of continuous MAL application. A 20-fold site-to-site variation was observed, and there were no significant MAL concentration dependencies. The selectivity between lesions and normal skin was 10-fold during the first hours and decreased throughout the application time. Fluorescence microscopy images of tissue sections from 32 nodular BCCs were analyzed to calculate the porphyrin content in tumor tissue as a function of depth. Significant correlation to MAL concentration was seen within the tumors treated for 3 hours. Increase to 18-hour MAL application enhanced the fluorescence levels in superficial tumor layers, but not in deep layers. In conclusion, application of the 160 mg/g cream for 3 hours gave advantageous porphyrin distributions for all types of lesions.

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“of lesions 0 0 1 2 2 Proportion (95% CI) of lesions, % 0 (0-100) 0 (0-100) 2 (0-10) 4 (1-13) 4 (1-13)c Lesion size, mmd 10 0 0 0 0 0 10 and 20 0 0 1 2 2”
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Authors: Angell-Petersen, E., Sørensen, R., Warloe, T., Soler, A. M., Moan, J., Peng, Q., & Giercksky, K.-E.
ORCID: Warloe, Trond
Peng, Qian
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2006-02
Volume: 126
Issue: 2
Pages: 265-271
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/sj.jid.5700048
OpenAlex: W2135267652
Cited by: 123
References: 43
Citations by year: 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 6.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3591 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: Smith and Nephew
Topics: Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords: porphyrin accumulation, actinic keratosis, basal cell carcinoma, photodynamic therapy, topical photosensitizer, skin fluorescence, nodular basal cell carcinoma, superficial basal cell carcinoma
MeSH terms: Administration, Topical, Aged, Aminolevulinic Acid, Basal Cell Carcinoma, Double-Blind Method, Female, Humans, Keratosis, Male, Microscopy, Fluorescence, Monitoring, Physiologic, Ointments, Photochemotherapy, Porphyrins, Prospective Studies, Skin Neoplasms, Photosensitizing Agents

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Porphyrin Formation in Actinic Keratosis and Basal Cell Carcinoma after Topical Application of Methyl 5-Aminolevulinate

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