A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix®) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study
Abstract
BACKGROUND: Actinic keratosis (AK) is a very common condition, which has the potential of progressing to squamous cell carcinoma. The present study is a prospective, randomized study comparing the lesion response, cosmetic outcome, patient satisfaction and tolerability of a new treatment modality, photodynamic therapy (PDT), using topical methyl aminolevulinate (Metvix), with the most commonly used standard therapy for AK, cryotherapy. METHODS: A total of 204 patients with clinically diagnosed AK were randomized to either cryotherapy or PDT. The PDT patients were further assigned to an active or placebo group in a random, double-blind manner. Cryotherapy was performed using liquid nitrogen spray in a single freeze-thaw cycle. PDT was performed using 160 mg/g methyl aminolevulinate cream or placebo, a 3-hour application time, red light (570-670 nm) and a total light dose of 75 J/cm(2). PDT was repeated after 7 days. Two sessions of PDT were undertaken, as a previous study had shown a single session had similar efficacy to cryotherapy. Lesion response was assessed clinically after 3 months (complete response or non-complete response). RESULTS: The lesion response rate was 91% in the methyl aminolevulinate PDT group, 68% in the cryotherapy group and 30% in the placebo PDT group. Methyl aminolevulinate PDT was statistically significantly better than both cryotherapy and placebo PDT in terms of response rates and cosmetic outcome. Most patients preferred PDT to other treatments. CONCLUSIONS: PDT with methyl aminolevulinate is an excellent treatment option, particularly for patients with widespread damage or AK lesions in cosmetically sensitive areas.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared with cryotherapy for actinic keratosis MAL-PDT was found to have a better or similar effectiveness (complete response rate 68%-75% after single treatment).
“Compared with cryotherapy for actinic keratosis MAL-PDT was found to have a better or similar effectiveness (complete response rate 68%–75% after single treatment) [129,130].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [130]
Cites
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research
Peng, Q., Berg, K., Moan, J., Kongshaug, M., & Nesland, J. M. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08549.x · Cited by 615 · see citing works
Szeimies, R. (2002) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(02)00056-7 · Cited by 434 · see citing works
Olsen, E. A., Abernethy, M. L., Kulp‐Shorten, C. L., Callen, J. P., Glazer, S. D., Huntley, A. C., McCray, M. K., Monroe, A. B., Tschen, E. H., & Wolf, J. E. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(91)70113-g · Cited by 401 · see citing works
Spontaneous remission of solar keratoses: the case for conservative management
Marks, R., Foley, P. A., Goodman, G. J., Hage, B., & Selwood, T. S. (1986) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1986.tb06644.x · Cited by 319 · see citing works
Self-citationFritsch, C., Homey, B., Stahl, W., Lehmann, P., Ruzicka, T., & Sies, H. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb02492.x · Cited by 192 · see citing works
Prodrugs of 5‐Aminolevullinic Acid for Photodynamic Therapy
Kloek, J., & van Henegouwen, G. M. J. B. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb01868.x · Cited by 182 · see citing works
Jeffes, E. W. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.6.727 · Cited by 177 · see citing works
Szeimies, R., Karrer, S., Sauerwald, A., & Landthaler, M. (2009) · Dermatology · doi:10.1159/000246376 · Cited by 149 · see citing works
Peng, Q., Moan, J. E., Warloe, T., Iani, V., Steen, H. B., Bjørseth, A., & Nesland, J. M. (1996) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(95)07268-3 · Cited by 144 · see citing works
Photodynamic Therapy of Actinic Keratosis With Topical 5-Aminolevulinic Acid
Jeffes, E. W. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890420065007 · Cited by 141 · see citing works
The treatment of actinic keratoses
Dinehart, S. M. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.103338 · Cited by 140 · see citing works
Cryosurgery cure rate of actinic keratoses
Lubritz, R. R., & Smolewski, S. A. (1982) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(82)70143-4 · Cited by 120 · see citing works
Non‐melanotic skin cancer and solar keratoses in Victoria
Marks, R., Ponsford, M. W., Selwood, T. S., Goodman, G. J., & Mason, G. H. (1983) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1983.tb122724.x · Cited by 112 · see citing works
Fink‐Puches, R., Hofer, A., Smolle, J., Kerl, H., & Wolf, P. (1997) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(97)00096-1 · Cited by 91 · see citing works
Topical Aminolevulinic Acid HCl Photodynamic Therapy
Ormrod, D., & Jarvis, B. (2000) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200001020-00009 · Cited by 79 · see citing works
The Biophysical Foundations of Photodynamic Therapy
Moan, J. E., Peng, Q., Sørensen, R. W., Iani, V., & Nesland, J. M. (1998) · Endoscopy · doi:10.1055/s-2007-1001288 · Cited by 76 · see citing works
Manabe, F., Takeshima, H., & Akaza, H. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970301)79:5 · Cited by 25 · see citing works
Treatment of Malignant Cutaneous Tumors
Ulbricht, S. M. (1993) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30782-3 · Cited by 25 · see citing works
Cryosurgery of malignant and premalignant diseases of the skin: A simple approach
Sinclair, R. D., & Dawber, R. P. R. (1995) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.1995.tb00955.x · Cited by 17 · see citing works
TREATMENT OF ACTINIC KERATOSIS
Kestel, J. L. (1970) · Archives of Dermatology · doi:10.1001/archderm.1970.04000090113022 · Cited by 14 · see citing works
(1935) · The British Journal of Psychiatry · doi:10.1192/bjp.81.334.716 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145 · see citing works
The present and future role of photodynamic therapy in cancer treatment
Brown, S. B., Brown, E. A., & Walker, I. O. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01529-3 · Cited by 1,772 · see citing works
Photosensitizers in clinical PDT
Allison, R. R., Downie, G., Cuenca, R. E., Hu, X., Childs, C. J. H., & Sibata, C. H. (2004) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(04)00007-9 · Cited by 1,061 · see citing works
Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy
Detty, M. R., Gibson, S. L., & Wagner, S. J. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm040074b · Cited by 1,048 · see citing works
Oncologic photodynamic therapy photosensitizers: A clinical review
Allison, R. R., & Sibata, C. H. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.02.001 · Cited by 840 · see citing works
Braathen, L. R., Szeimies, R., Basset‐Séguin, N., Bissonnette, R., Foley, P. A., Pariser, D. M., Roelandts, R., Wennberg, A., & Morton, C. A. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.006 · Cited by 658 · see citing works
Self-citationGuidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 469 · see citing works
Guidelines for the management of actinic keratoses
BERKER, D. D., McGregor, J. M., & Hughes, B. R. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07692.x · Cited by 293 · see citing works
Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265 · see citing works
Morton, C., Horn, M., Leman, J., Tack, B., Bedane, C., Tjioe, M., Ibbotson, S., Khemis, A., & Wolf, P. (2006) · Archives of Dermatology · doi:10.1001/archderm.142.6.729 · Cited by 256 · see citing works
5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives
Fotinos, N., Campo, M. A., Popowycz, F., Gurny, R., & Lange, N. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-02-03-ir-794 · Cited by 238 · see citing works
Interventions for actinic keratoses
Gupta, A. K., Paquet, M., Villanueva, E., & Brintnell, W. C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004415.pub2 · Cited by 232 · see citing works
BERKER, D. D., McGregor, J. M., Mustapa, M. F. M., Exton, L. S., Hughes, B. R., McHenry, P. M., Gibbon, K. L., Buckley, D. A., Nasr, I. S., Williamson, C. E. D., et al. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15107 · Cited by 223 · see citing works
Morton, C. A., Campbell, S. M., Gupta, G., Keohane, S. G., Lear, J. T., Zaki, I., Walton, S., Kerrouche, N., Thomas, G., Soto, P., et al. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07470.x · Cited by 211 · see citing works
Tarstedt, M., Rosdahl, I., Berne, B., Svanberg, K., & Wennberg, A. (2005) · Acta Dermato-Venereologica · doi:10.1080/00015550510032887 · Cited by 196 · see citing works
Togsverd‐Bo, K., Haak, C. S., Thaysen‐Petersen, D., Wulf, H. C., Anderson, R. R., & Haedesdal, M. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10893.x · Cited by 194 · see citing works
Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects
Reinehr, C. P. H., & Bakos, R. M. (2019) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2019.10.004 · Cited by 192 · see citing works
Perrett, C. M., McGregor, J. M., Warwick, J., Karran, P., Leigh, I. M., Proby, C. M., & Harwood, C. A. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07616.x · Cited by 188 · see citing works
Review of photodynamic therapy in actinic keratosis and basal cell carcinoma
Larkö, O. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1769 · Cited by 185 · see citing works
A prospective study of the use of cryosurgery for the treatment of actinic keratoses
Thai, K., Fergin, P., Freeman, M., Vinciullo, C., Francis, D., Spelman, L. J., Murrell, D. F., Anderson, C. D., Weightman, W., Reid, C. M., et al. (2004) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2004.02056.x · Cited by 182 · see citing works
Self-citationGuidelines of care for the management of actinic keratosis
Eisen, D. B., Asgari, M. M., Bennett, D. D., Connolly, S. M., Dellavalle, R. P., Freeman, E. E., Goldenberg, G., Leffell, D. J., Peschin, S., Sligh, J. E., et al. (2021) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.02.082 · Cited by 170 · see citing works
Photodynamic therapy in dermatology – an update
Babilas, P., Karrer, S., Sidoroff, A., Landthaler, M., & Szeimies, R. (2005) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2005.00147.x · Cited by 157 · see citing works
Lehmann, P. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07833.x · Cited by 156 · see citing works
Topical photodynamic therapy for prevention of new skin lesions in renal transplant recipients
Wulf, H., Pavel, S., Stender, I., & Bakker-Wensveen, C. (2006) · Acta Dermato Venereologica · doi:10.1080/00015550510042868 · Cited by 155 · see citing works
NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022
Schmults, C. D., Blitzblau, R. C., Aasi, S. Z., Alam, M., Andersen, J., Baumann, B. C., Bordeaux, J. S., Chen, P.-L., Chin, R., Contreras, C. M., et al. (2021) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2021.0059 · Cited by 149 · see citing works
Kaufmann, R., Spelman, L. J., Weightman, W., REIFENBERGER, J., Szeimies, R., Verhaeghe, E., Kerrouche, N., Sorba, V., Villemagne, H., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08488.x · Cited by 145 · see citing works
Self-citationDragieva, G., Prinz, B., Hafner, J., Dummer, R., Burg, G., BINSWANGER, U., & Kempf, W. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06054.x · Cited by 139 · see citing works
ART AND SCIENCE OF PHOTODYNAMIC THERAPY
Pervaiz, S., & Olivo, M. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04406.x · Cited by 139 · see citing works
Photodynamic Therapy: Current Evidence and Applications in Dermatology
Lee, Y., & Baron, E. D. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.08.001 · Cited by 131 · see citing works
Hörfelt, C., Funk, J., Frohm‐Nilsson, M., Edström, D. W., & Wennberg, A.-M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07340.x · Cited by 132 · see citing works
The use of photodynamic therapy in dermatology: results of a consensus conference.
Nestor, M. S., Gold, M. H., Kauvar, A. N. B., Taub, A. F., Geronemus, R. G., Ritvo, E. C., Goldman, M. P., Gilbert, D. J., Richey, D. F., Alster, T. S., et al. (2006) · PubMed · Cited by 128 · see citing works
Moloney, F. J., & Collins, P. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07946.x · Cited by 128 · see citing works
Szeimies, R., Radny, P., Sebastian, M., Borrosch, F., Dirschka, T., Krähn‐Senftleben, G., Reich, K., Pabst, G., Voss, D., Foguet, M., et al. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09873.x · Cited by 128 · see citing works
Terapia fotodinâmica: revisão da literatura e documentação iconográfica
Issa, M. C. A., & Manela‐Azulay, M. (2010) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962010000400011 · Cited by 130 · see citing works
Angell-Petersen, E., Sørensen, R., Warloe, T., Soler, A. M., Moan, J., Peng, Q., & Giercksky, K.-E. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700048 · Cited by 123 · see citing works
Actinic keratosis: correlation between clinical and histological classification systems
Schmitz, L., Kahl, P., Majores, M., Bierhoff, E., Stockfleth, E., & Dirschka, T. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13626 · Cited by 123 · see citing works
Hauschild, A., Stockfleth, E., Popp, G., Borrosch, F., Brüning, H., Dominicus, R., Mensing, H., Reinhold, U., Reich, K., Moor, A. C. E., et al. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09040.x · Cited by 120 · see citing works
Dirschka, T., Gupta, G., Micali, G., Stockfleth, E., Basset‐Séguin, N., del Mármol, V., Dummer, R., Jemec, G. B. E., Malvehy, J., Peris, K., et al. (2016) · Journal of Dermatological Treatment · doi:10.1080/09546634.2016.1254328 · Cited by 113 · see citing works
Wennberg, A.-M., Stenquist, B., Stockfleth, E., Keohane, S., Lear, J. T., Jemec, G., Mork, C., Christensen, E., Kapp, A., Solvsten, H., et al. (2008) · Transplantation · doi:10.1097/tp.0b013e318180731e · Cited by 112 · see citing works
Feldman, S. R., & Fleischer, A. B. (2011) · PubMed · Cited by 110 · see citing works
Photodynamic therapy for non-melanoma skin cancer
Szeimies, R., Morton, C., Sidoroff, A., & Braathen, L. (2005) · Acta Dermato Venereologica · doi:10.1080/00015550510044136 · Cited by 109 · see citing works
Pariser, D. M., Loss, R. W., Jarratt, M., Abramovits, W., SPENCER, J. M., Geronemus, R. G., Bailin, P., & Bruce, S. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.05.031 · Cited by 106 · see citing works
Dréno, B., Amici, J. M., Basset‐Séguin, N., Cribier, B. J., Claudel, J., & Richard, M. A. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12434 · Cited by 101 · see citing works
Short incubation PDT versus 5-FU in treating actinic keratoses.
SMITH, S. R., Piacquadio, D., Morhenn, V. B., Atkin, D. H., & FITZPATRICK, R. E. (2003) · PubMed · Cited by 95 · see citing works
In vitroandin vivocomparison of two different light sources for topical photodynamic therapy
Babilas, P., Kohl, E. A., Maisch, T., Bäcker, H., Groß, B., Branzan, A. L., Bäumler, W., Landthaler, M., Karrer, S., & Szeimies, R. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07143.x · Cited by 94 · see citing works
Lallas, A., Argenziano, G., Zendri, E., Moscarella, E., Longo, C., Grenzi, L., Pellacani, G., & Zalaudek, I. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/era.13.38 · Cited by 93 · see citing works
Photodynamic Therapy in Dermatology: An Update on Applications and Outcomes
MacCormack, M. A. (2008) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2007.12.001 · Cited by 92 · see citing works
Foley, P., Freeman, M., Menter, A., Siller, G., El‐Azhary, R. A., Gebauer, K., Lowe, N. J., Jarratt, M. T., Murrell, D. F., Rich, P., et al. (2009) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2008.04022.x · Cited by 92 · see citing works
Self-citationBay, C., Lerche, C. M., Ferrick, B., Philipsen, P. A., Togsverd‐Bo, K., & Hædersdal, M. (2017) · JAMA Dermatology · doi:10.1001/jamadermatol.2016.5268 · Cited by 91 · see citing works
Szeimies, R.-M., Matheson, R. T., Davis, S. A., Bhatia, A. C., Frambach, Y., Klövekorn, W., Fesq, H., Berking, C., REIFENBERGER, J., & Thaçi, D. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01096.x · Cited by 89 · see citing works
Raspagliesi, F., Fontanelli, R., Rossi, G., Ditto, A., Solima, E., Hanozet, F., & D, S. K. M. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.04.009 · Cited by 83 · see citing works
Photodynamic Therapy and Non-Melanoma Skin Cancer
Griffin, L., & Lear, J. (2016) · Cancers · doi:10.3390/cancers8100098 · Cited by 81 · see citing works
Huyke, C., Reuter, J., Rödig, M., Kersten, A., Laszczyk, M. N., Scheffler, A., Nashan, D., & Schempp, C. M. (2008) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2008.06865.x · Cited by 81 · see citing works
Pagliaro, J. A., Elliott, T., Bulsara, M. K., King, C., & Vinciullo, C. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30011.x · Cited by 81 · see citing works
Self-citationTopical Photodynamic Therapy of Actinic Keratosis in Renal Transplant Recipients
Piaserico, S., Fortina, A. B., Rigotti, P., Rossi, B., Baldan, N., Alaibac, M., & Marchini, F. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.05.040 · Cited by 76 · see citing works
Sotiriou, E., Apalla, Z., Maliamani, F., Zaparas, N., Panagiotidou, D., & Ioannides, D. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03259.x · Cited by 76 · see citing works
Szeimies, R., Stockfleth, E., Popp, G., Borrosch, F., Brüning, H., Dominicus, R., Mensing, H., Reinhold, U., Reich, K., Moor, A. C. E., et al. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09377.x · Cited by 73 · see citing works
Patel, G. B., Armstrong, A. W., & Eisen, D. B. (2014) · JAMA Dermatology · doi:10.1001/jamadermatol.2014.1253 · Cited by 72 · see citing works
Short incubation with methyl aminolevulinate for photodynamic therapy of actinic keratoses
Braathen, L. R., Paredes, B., Saksela, O., Fritsch, C., Gardlo, K., Morken, T., Frölich, K., Warloe, T., Soler, A., & Ros, A. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.03029.x · Cited by 69 · see citing works
Nonsurgical innovations in the treatment of nonmelanoma skin cancer.
Amini, S., Viera, M. H., Valins, W., & Berman, B. (2010) · PubMed Central · Cited by 68 · see citing works
Solar keratosis: Epidemiology, pathogenesis, presentation and treatment
Holmes, C., Foley, P. A., Freeman, M., & Chong, A. H. (2007) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.2007.00339.x · Cited by 67 · see citing works
Self-citationHædersdal, M., Sakamoto, F. H., Farinelli, W. A., Doukas, A. G., Tam, J., & Anderson, R. R. (2014) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22259 · Cited by 65 · see citing works
Clinical efficacy of methyl aminolevulinate (Metvix®) photodynamic therapy
Foley, P. A. (2003) · Journal of Dermatological Treatment · doi:10.1080/jdt.14.s3.15.22 · Cited by 61 · see citing works
Self-citationPhotodynamic therapy: update 2006 Part 2: Clinical results
Calzavara‐Pinton, P., Venturini, M., & Sala, R. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.02038.x · Cited by 59 · see citing works
Zane, C., Facchinetti, E., Rossi, M., Specchia, C., & Calzavara‐Pinton, P. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12844 · Cited by 58 · see citing works
Cutaneous Squamous Cell Carcinoma
Garcia‐Zuazaga, J., & OLBRICHT, S. M. (2008) · Advances in Dermatology · doi:10.1016/j.yadr.2008.09.007 · Cited by 57 · see citing works
Caekelbergh, K., Annemans, L., Lambert, J., & Roelandts, R. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07483.x · Cited by 57 · see citing works
Sotiriou, E., Evangelou, G., Papadavid, E., Apalla, Z., Vrani, F., Vakirlis, E., Panagiotou, M., Stefanidou, M. P., Pombou, T., Krasagakis, K., et al. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14613 · Cited by 55 · see citing works
Aesthetic effects of topical photodynamic therapy
Kohl, E. A., Torezan, L. A. R., Landthaler, M., & Szeimies, R. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03625.x · Cited by 55 · see citing works
Methyl Aminolevulinate: Actinic Keratoses and Bowen's Disease
Morton, C. A. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2006.09.009 · Cited by 55 · see citing works
A clinical review of PDT for cutaneous malignancies
Allison, R. R., Sibata, C. H., Downie, G., & Cuenca, R. E. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.05.002 · Cited by 54 · see citing works
Babilas, P., Travnik, R., Werner, A., Landthaler, M., & Szeimies, R. (2007) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2007.06555.x · Cited by 52 · see citing works
MacCormack, M. A. (2006) · Advances in Dermatology · doi:10.1016/j.yadr.2006.09.008 · Cited by 52 · see citing works
Non‐Melanoma Skin Cancer and Other Epidermal Skin Tumours
Quinn, A., & Perkins, W. A. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch52 · Cited by 52 · see citing works
Simon, J. ‐., Dominicus, R., Karl, L., Rodríguez, R. E., Willers, C., & Dirschka, T. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12702 · Cited by 51 · see citing works
Photodynamic Therapy in the Treatment of Actinic Keratosis†
Stritt, A., Merk, H. F., Braathen, L. R., & von Felbert, V. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00276.x · Cited by 50 · see citing works
An overview of topical photodynamic therapy in dermatology
Ibbotson, S. H. (2009) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2009.12.001 · Cited by 50 · see citing works
Therapeutic strategies for actinic keratoses – a systematic review
Nashan, D., Meiß, F., & Müller, M. L. (2013) · European Journal of Dermatology · doi:10.1684/ejd.2013.1923 · Cited by 49 · see citing works
Photodynamic therapy in dermatology: current concepts in the treatment of skin cancer
Garcia‐Zuazaga, J., Cooper, K. D., & Baron, E. D. (2005) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.5.5.791 · Cited by 50 · see citing works
Terapia fotodinámica en dermatología
Gilaberte, Y., Serra-Guillén, C., Heras, M. A. E. D. L., Ruiz-Rodríguez, R., Fernández-Lorente, M., Benvenuto-Andrade, C., González-Rodríguez, S., & Guillen-Barona, C. (2006) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(06)73359-2 · Cited by 47 · see citing works
von Felbert, V., Hoffmann, G. G., Hoff-Lesch, S., Abuzahra, F., Renn, C. N., Braathen, L. R., & Merk, H. F. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09817.x · Cited by 46 · see citing works
Update on Photodynamic Treatment for Actinic Keratosis
Wiegell, S. R. (2014) · Current problems in dermatology · doi:10.1159/000366548 · Cited by 45 · see citing works
Sotiriou, E., Apalla, Z., Chovarda, E., Goussi, C., Trigoni, A., & Ioannides, D. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04003.x · Cited by 44 · see citing works
Photodynamic Therapy in the Treatment of Rosacea
Nybæk, H., & Jemec, G. B. E. (2005) · Dermatology · doi:10.1159/000086443 · Cited by 44 · see citing works
Zane, C., Facchinetti, E., Rossi, M., Specchia, C., Ortel, B. J., & Calzavara‐Pinton, P. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12847 · Cited by 43 · see citing works
Treatment of actinic keratoses with birch bark extract: a pilot study
Huyke, C., Laszczyk, M. N., Scheffler, A., Ernst, R., & Schempp, C. M. (2006) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2006.05906.x · Cited by 42 · see citing works
Terapia fotodinâmica em dermatologia: princípios básicos e aplicações
Torezan, L. A. R., Niwa, A. B. M., & Neto, C. F. (2009) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962009000500002 · Cited by 40 · see citing works
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis
Chaves, Y. N., Torezan, L. A. R., Lourenço, S. V., & Neto, C. F. (2016) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12281 · Cited by 41 · see citing works
Werner, R. N., Jacobs, A., Rosumeck, S., ERDMANN, R., Sporbeck, B., & Nast, A. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13179 · Cited by 42 · see citing works
Non-surgical treatments of primary, non-melanoma eyelid malignancies: a review
Murchison, A. P., Walrath, J. D., & Washington, C. V. (2010) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2010.02422.x · Cited by 39 · see citing works
Radakovic-Fijan, S., Blecha-Thalhammer, U., Kittler, H., Hönigsmann, H., & Tanew, A. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.06.010 · Cited by 39 · see citing works
Kim, H. S., Yoo, J. Y., Cho, K. H., Kwon, O., & Moon, S. E. (2006) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2005.31003 · Cited by 39 · see citing works
Heppt, M. V., Dykukha, I., Graziadio, S., Salido‐Vallejo, R., Chapman-Rounds, M., & Edwards, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061654 · Cited by 37 · see citing works
Dermatologic management, sun avoidance and vitamin D status in organ transplant recipients (OTR)
Reichrath, J. (2010) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2010.04.001 · Cited by 37 · see citing works
Ko, D., Kim, K., & Song, K. (2014) · Annals of Dermatology · doi:10.5021/ad.2014.26.3.321 · Cited by 36 · see citing works
Actinic keratosis: where do we stand and where is the future going to take us?
Cramer, P., & Stockfleth, E. (2020) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2020.1730810 · Cited by 35 · see citing works
Pharmacological Agents Used in the Prevention and Treatment of Actinic Keratosis: A Review
Arcuri, D., Ramchatesingh, B. L., Lagacé, F., Iannattone, L., Netchiporouk, E., Lefrançois, P., & Litvinov, I. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054989 · Cited by 35 · see citing works
Photodynamic Therapy with Methyl-aminolaevulinic Acid for Mycosis Fungoides
Kim, S., Kang, D. H., Kang, J. H., Baek, J. W., Jeon, Y., & Suh, K. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1261 · Cited by 35 · see citing works
Philipp‐Dormston, W. G. (2014) · Current problems in dermatology · doi:10.1159/000366547 · Cited by 34 · see citing works
Pharmacotherapy of actinic keratosis: an update
Berman, B., & Amini, S. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.716039 · Cited by 34 · see citing works
- Authors
- Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Nguyen, R., Fergin, P., Thai, K., Murrell, D., Weightman, W., Anderson, C., Reid, C., Watson, A., & Foley, P.
- Affiliations
- The Skin Centre, Gold Coast, QLD
- The Perth Surgicentre, Perth, WA
- The Belmont Specialist Clinic, Brisbane, QLD
- Skin and Cancer Foundation (AU)
- St George Hospital (AU)
- Queen Elizabeth Hospital (AU)
- Liverpool Hospital (AU)
- Royal Adelaide Hospital (AU)
- Royal Newcastle Hospital, Newcastle, NSW
- St Vincent's Hospital Melbourne (AU)
- Corresponding author
- Foley, P
- Venue
- Journal of Dermatological Treatment
- Publisher
- Informa UK Limited
- Published
- 2003-01-01
- Volume
- 14
- Issue
- 2
- Pages
- 99-106
- ISSN
- 0954-6634 (ISSN-L)
- 1471-1753
- OpenAlex
- W2007413267
- Cited by
- 285
- References
- 21
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 10 · 2014: 19 · 2013: 5 · 2012: 15
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Treatment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- actinic keratosis, photodynamic therapy, methyl aminolevulinate, cryotherapy, liquid nitrogen spray, cosmetic outcome, patient satisfaction, treatment tolerability, squamous cell carcinoma prevention
- MeSH terms
- Administration, Cutaneous, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Cryosurgery, Double-Blind Method, Female, Humans, Keratosis, Male, Middle Aged, Photochemotherapy, Prospective Studies, Severity of Illness Index, Victoria, Treatment Outcome, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
