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Cited by 178interferon and immune responsesCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

The Multiple Roles of Interferon Regulatory Factor family in Health and Disease

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Wang, Lian, Zhu, Yanghui, Zhang, Nan, Xian, Yali, Tang, Yu, Ye, Jing, Reza, Fekrazad, He, Gu +2 more·2024·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-024-01980-4PMC PMC11486635
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Abstract

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of various diseases, such as infectious diseases, autoimmune disorders, metabolic diseases, and cancers. In this context, IRFs display a dichotomous nature, functioning as both tumor suppressors and promoters, contingent upon the specific disease milieu. Post-translational modifications of IRFs, including phosphorylation and ubiquitination, play a crucial role in modulating their function, stability, and activation. As prospective biomarkers and therapeutic targets, IRFs present promising opportunities for disease intervention. Further research is needed to elucidate the precise mechanisms governing IRF regulation, potentially pioneering innovative therapeutic strategies, particularly in cancer treatment, where the equilibrium of IRF activities is of paramount importance.

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  • The transcription factor hematopoiesis associated factor 1 complex (HAF1) forms dimeric or trimeric configurations with PU.1, IRF1, and IRF8.

    “The transcription factor hematopoiesis associated factor 1 complex (HAF1) is known to form dimeric or trimeric configurations with the transcription factors, PU.1, IRF1, and IRF8 [61, 62].”

    From Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease (2026) · cites this paper as [62]

    The section on myeloid differentiation says IRF8 forms complexes with PU.1 and IRF1, but it does not identify those complexes as HAF1 or describe dimeric and trimeric HAF1 configurations. Searches for HAF1, its expanded name, and the claimed configurations found no passage addressing that point in our copy; section page numbers are unavailable. (LLM, conf=0.73)

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Authors
Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X.
Affiliations
  • Sichuan University (CN)
  • Chengdu University of Traditional Chinese Medicine (CN)
  • Aja University of Medical Sciences (IR)
Corresponding author
  • Wen, Xiang
  • Jiang, Xian
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2024-10-09
Volume
9
Issue
1
Pages
282-282
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-024-01980-4
PMC
PMC11486635
OpenAlex
W4403245544
Cited by
178
References
28
Citations by year
2026: 102 · 2025: 74 · 2024: 1 · 2023: 1
FWCI
7.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (82273559, 82103757)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
interferon regulatory factors, transcription factors, immune regulation, host defense, autoimmune disease, infectious diseases, metabolic disorders, cancer, post-translational modification, phosphorylation, ubiquitination, biomarkers, therapeutic target
MeSH terms
Animals, Autoimmune Diseases, Humans, Neoplasms, Phosphorylation, Protein Processing, Post-Translational, Interferon Regulatory Factors, Ubiquitination

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