The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Synaptic plasticity and mood disorders
Abstract
Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.
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“The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes (reviewed in Duman, 2002; Payne et al., 2002) much like sleep deprivation (Cirelli et al., 2004), although on a longer time course.”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Duman, 2002
Citations
Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
McEwen, B. S., & Sapolsky, R. M. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80028-x · Cited by 1,889
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Research works printed but not linked: 4
- Thome J, Sakai N, Shin KH, Steffen C, Impey S, Storm DR et al. Regulation of cAMP-response-element promoter activity by antidepressant treatment in CRE-lacZ transgenic mice Soc Neurosci 1998 24: 1844
- Shirayama Y, Chen ACH, Duman RS . Antidepressant-like effects of BDNF and NT-3 in behavioral models of depression Soc Neurosci 2000 26: 1042
- Jacobs B, Fornal CA . Chronic fluoxetine treatment increases hippocampal neurogenesis in rats: a novel theory of depression Soc Neurosci Abstracts, Miami, FL 1999
- Kim J-E, Nakagawa S, Duman RS . Chronic administration of rolipram, a cAMP phosphodiesterase-4 inhibitor, upregulates neurogenesis in the adult mouse hippocampus Soc Neurosci Abs 2000 26: 2316
Cited by
Sorted by citations
Trajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503
Brain foods: The effects of nutrients on brain function.
Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372
Psychedelics promote structural and functional neural plasticity
Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.022 · Cited by 1,207
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 891
The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain
Sheng, J., Shui, L., Wang, Y., Cui, R., & Zhang, X. (2017) · Neural Plasticity · doi:10.1155/2017/9724371 · Cited by 852
Metadata
- Authors
- Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, R S
- ORCID
- Duman, R S
- Venue
- Molecular Psychiatry
- Published
- 2002-01
- Volume
- 7
- Issue
- S1
- Pages
- S29-S34
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1983914274
- Cited by
- 363
- References
- 46
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders
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