Cited by 363Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Synaptic plasticity and mood disorders

Duman, R S·2002·Molecular Psychiatry

DOI 10.1038/sj.mp.4001016

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Abstract

Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.

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Authors: Duman, R. S.
Affiliations: Yale University (US)
Corresponding author: Duman, R S
ORCID: Duman, R S
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 7
Issue: S1
Pages: S29-S34
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001016
OpenAlex: W1983914274
Cited by: 363
References: 46
Citations by year: 2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
MeSH terms: Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders

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