The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Synaptic plasticity and mood disorders
Abstract
Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.
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“The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes (reviewed in Duman, 2002; Payne et al., 2002) much like sleep deprivation (Cirelli et al., 2004), although on a longer time course.”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Duman, 2002
Citations
Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
McEwen, B. S., & Sapolsky, R. M. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80028-x · Cited by 1,889
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106
Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2000) · Synapse · doi:10.1002/1098-2396(20010101)39:1 · Cited by 944
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841
Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons
Riccio, A., Ahn, S., Davenport, C. M., Blendy, J. A., & Ginty, D. D. (1999) · Science · doi:10.1126/science.286.5448.2358 · Cited by 802
Increased neurogenesis in a model of electroconvulsive therapy
Madsen, T. M., Treschow, A., Bengzon, J., Bolwig, T. G., Lindvall, O., & Tingström, A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00228-6 · Cited by 765
Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion
Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738
Neuronal plasticity and survival in mood disorders
Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652
Enhancement of Hippocampal Neurogenesis by Lithium
Chen, G., Rajkowska, G., Du, F., Seraji‐Bozorgzad, N., & Manji, H. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751729.x · Cited by 603
Opiates inhibit neurogenesis in the adult rat hippocampus
Eisch, A. J., Barrot, M., Schad, C. A., Self, D. W., & Nestler, E. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120552597 · Cited by 599
cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 509
Mamounas, L., Blue, M., Siuciak, J. A., & Altar, C. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07929.1995 · Cited by 474
CREB Couples Neurotrophin Signals to Survival Messages
Finkbeiner, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)80866-1 · Cited by 455
Neurogenesis in adulthood: a possible role in learning
Gould, E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01310-8 · Cited by 432
Barad, M., Bourtchouladze, R., Winder, D. G., Golan, H. M., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15020 · Cited by 430
Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression
Russo-Neustadt, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00059-7 · Cited by 411
Manji, H. K., Moore, G. J., & Chen, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00979-3 · Cited by 352
Tianeptine attenuates stress-induced morphological changes in the hippocampus
Watanabe, Y., Gould, E., Daniels, D. C., Cameron, H. A., & McEwen, B. S. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90830-w · Cited by 338
The Relationship between Neuronal Survival and Regeneration
Goldberg, J. L., & Barres, B. A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.579 · Cited by 338
Chen, A. C. H., Shirayama, Y., Shin, K.-H., Neve, R. L., & Duman, R. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01114-8 · Cited by 316
Increased temporal cortex CREB concentrations and antidepressant treatment in major depression
Young, L. T., Dowlatshahi, D. D., MacQUEEN, G. M., & Wang, J. F. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79827-5 · Cited by 306
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro
Manev, H., Uz, T., Smalheiser, N. R., & Manev, R. M. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00904-3 · Cited by 220
Angelucci, F., Mathé, A. A., & Aloe, L. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000615)60:6 · Cited by 173
Dawirs, R. R., Hildebrandt, K., & Teuchert, G. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050061 · Cited by 148
Smith, M. A., Makino, S., Altemus, M., Michelson, D., Hong, S. K., Květňanský, R., & Post, R. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8788 · Cited by 110
Linden, A.-M., Väisänen, J., Lakso, M., Nawa, H., Wong, G., & Ċastrén, E. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:14:1-2:027 · Cited by 73
Konradi, C. L., & Heckers, S. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00546-h · Cited by 70
EFFECTS OF HALOPERIDOL ON CELL PROLIFERATION IN THE EARLY POSTNATAL RAT BRAIN
Backhouse, B., Barochovsky, O., Malik, C., Patel, A. J., & Lewis, P. D. (1982) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1982.tb00266.x · Cited by 34
Ozaki, T. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00493-3 · Cited by 13
Flagged first, then by citations
Research works printed but not linked: 4
- Thome J, Sakai N, Shin KH, Steffen C, Impey S, Storm DR et al. Regulation of cAMP-response-element promoter activity by antidepressant treatment in CRE-lacZ transgenic mice Soc Neurosci 1998 24: 1844
- Shirayama Y, Chen ACH, Duman RS . Antidepressant-like effects of BDNF and NT-3 in behavioral models of depression Soc Neurosci 2000 26: 1042
- Jacobs B, Fornal CA . Chronic fluoxetine treatment increases hippocampal neurogenesis in rats: a novel theory of depression Soc Neurosci Abstracts, Miami, FL 1999
- Kim J-E, Nakagawa S, Duman RS . Chronic administration of rolipram, a cAMP phosphodiesterase-4 inhibitor, upregulates neurogenesis in the adult mouse hippocampus Soc Neurosci Abs 2000 26: 2316
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Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372
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Metadata
- Authors
- Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, R S
- ORCID
- Duman, R S
- Venue
- Molecular Psychiatry
- Published
- 2002-01
- Volume
- 7
- Issue
- S1
- Pages
- S29-S34
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1983914274
- Cited by
- 363
- References
- 46
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders
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