Cited by 641Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Cryan, J F, Mombereau, C·2004·Molecular Psychiatry

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Abstract

The ability to modify mice genetically has been one of the major breakthroughs in modern medical science affecting every discipline including psychiatry. It is hoped that the application of such technologies will result in the identification of novel targets for the treatment of diseases such as depression and to gain a better understanding of the molecular pathophysiological mechanisms that are regulated by current clinically effective antidepressant medications. The advent of these tools has resulted in the need to adopt, refine and develop mouse-specific models for analyses of depression-like behavior or behavioral patterns modulated by antidepressants. In this review, we will focus on the utility of current models (eg forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, drug-withdrawal-induced anhedonia) and research strategies aimed at investigating novel targets relevant to depression in the mouse. We will focus on key questions that are considered relevant for examining the utility of such models. Further, we describe other avenues of research that may give clues as to whether indeed a genetically modified animal has alterations relevant to clinical depression. We suggest that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depression-related pathology.

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Items 201–400 of 426

Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment
Spyraki, C., & Fibiger, H. C. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90431-2 · Cited by 150
Sex with knockout models: behavioral studies of estrogen receptor α1Published on the World Wide Web on 26 April 1999.1
Rissman, E. F., Wersinger, S. R., Fugger, H. N., & Foster, T. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01452-3 · Cited by 149
In search of a better mouse test.
Wahlsten, D., Rustay, N., Metten, P., & Crabbe, J. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00033-x · Cited by 149
Limitations on the use of the C57BL/6 mouse in the tail suspension test
Mayorga, A. J., & Lucki, I. (2001) · Psychopharmacology · doi:10.1007/s002130100687 · Cited by 147
Reward Value of Cigarette Smoking for Comparably Heavy Smoking Schizophrenic, Depressed, and Nonpatient Smokers
Spring, B. J., Pingitore, R., & McChargue, D. E. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.316 · Cited by 145
Severe Impairment of NMDA Receptor Function in Mice Carrying Targeted Point Mutations in the Glycine Binding Site Results in Drug-Resistant Nonhabituating Hyperactivity
Ballard, T. M., Pauly-Evers, M., Higgins, G. A., Ouagazzal, A., Mutel, V., Borroni, E., Kemp, J. A., Bluethmann, H., & Kew, J. N. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06713.2002 · Cited by 141
5-Hydroxytryptamine (5-HT)1A Autoreceptor Adaptive Changes in Substance P (Neurokinin 1) Receptor Knock-Out Mice Mimic Antidepressant-Induced Desensitization
Froger, N., Gardier, A. M., Moratalla, R., Alberti, I., Léna, I., Boni, C., Felipe, C. D., Rupniak, N. M. J., Hunt, S. P., Jacquot, C., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08188.2001 · Cited by 140
Hippocampal atrophy in major depression: a result of depression-induced neurotoxicity?
Sheline, Y. I. (1996) · PubMed · Cited by 137
Treatment strategies for chronic and refractory obsessive-compulsive disorder.
Rasmussen, S. A., & Eisen, J. A. (1997) · PubMed · Cited by 137
Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects
Bissette, G., Klimek, V., Pan, J., Stockmeier, C., & Ordway, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300191 · Cited by 136
Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring
Alonso, S. J., Arévalo, R., Afonso, D., & Rodrı́guez, M. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90538-y · Cited by 135
Circadian rhythms and depression: effects of exercise in an animal model
Solberg, L. C., Horton, T. H., & Turek, F. W. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r152 · Cited by 134
Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression
Ordway, G. A., Schenck, J. E., Stockmeier, C. A., May, W., & Klimek, V. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01728-6 · Cited by 134
Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin
Brotto, L. A., Barr, A. M., & Gorzalka, B. B. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00491-x · Cited by 134
Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-α gene: implications for emotional behavior
Yamada, K., Iida, R., Miyamoto, Y., Saito, K., Sekikawa, K., Seishima, M., & Nabeshima, T. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00375-1 · Cited by 134
Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat
Shen, Y., Connor, T. J., Nolan, Y. M., Kelly, J. P., & Leonard, B. E. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00430-0 · Cited by 130
Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice
Liu, X., & Gershenfeld, H. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01028-3 · Cited by 130
Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs.
Cryan, J. F., Dalvi, A., Jin, S., Hirsch, B. R., Lucki, I., & THOMAS, S. A. (2001) · PubMed · Cited by 129
Self-citation
Stressor-provoked behavioral changes in six strains of mice.
Shanks, N. M., & Anisman, H. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.6.894 · Cited by 128
Repeated variable prenatal stress alters pre‐ and postsynaptic gene expression in the rat frontal pole
Kinnunen, A., Koenig, J. I., & Bilbe, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01873.x · Cited by 127
?-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo
Pirker, W., Asenbaum, S., Kasper, S. F., Walter, H., Angelberger, P., Koch, G., Pozzera, A., Deecke, L., Podreka, I., & Br�cke, T. (1995) · Journal of Neural Transmission · doi:10.1007/bf01276462 · Cited by 127
HPA axis dysregulation in mice overexpressing corticotropin releasing hormone
Groenink, L., Dirks, A., Verdouw, P. M., Schipholt, M. L., Veening, J. G., van der Gugten, J., & Olivier, B. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01334-3 · Cited by 126
Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180
Stork, O., Welzl, H., Wolfer, D. P., Schuster, T., Mantei, N., Stork, S., Hoyer, D., Lipp, H., Obata, K., & Schachner, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00197.x · Cited by 125
Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced swimming test
Gavioli, E. C., Marzola, G., Guerrini, R., Bertorelli, R., Zucchini, S., de Lima, T. C. M., Rae, G. A., Salvadori, S., Regoli, D. C., & Calò, G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02603.x · Cited by 125
The effects of chronic mild stress on male Sprague–Dawley and Long Evans rats
Bielajew, C. H., Konkle, A. T. M., & Merali, Z. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00222-x · Cited by 124
Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder
Yamada, S., Yamamoto, M., Ozawa, H., Riederer, P. F., & Saito, T. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0810-8 · Cited by 124
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
Sallinen, J., Haapalinna, A., MacDonald, E., Viitamaa, T., Lähdesmäki, J., Rybnikova, E. A., Pelto‐Huikko, M., Kobilka, B. K., & Scheinin, M. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000543 · Cited by 124
Murine models of depression
Dalvi, A., & Lucki, I. (1999) · Psychopharmacology · doi:10.1007/s002130051131 · Cited by 123
Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT2C Receptor Mutant Mice
Nonogaki, K., Abdallah, L., Goulding, E. H., Bonasera, S. J., & Tecott, L. H. (2003) · Diabetes · doi:10.2337/diabetes.52.2.315 · Cited by 123
Clinical significance of psychoneuroendocrinology in psychiatry: focus on the thyroid and adrenal.
Brown, R. (1989) · PubMed · Cited by 121
The Genes and Brains of Mice and Men
Tecott, L. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.646 · Cited by 120
Sex differences in emotional and cognitive behaviour in mammals including man: Adaptive and neural bases
Gray, J. A., & Buffery, A. W. H. (1971) · Acta Psychologica · doi:10.1016/0001-6918(71)90014-x · Cited by 119
Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: interstrain and interindividual differences
Nielsen, C. K., Arnt, J., & Sánchez, C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00110-2 · Cited by 119
Functional Consequences of 5-HT Transporter Gene Disruption on 5-HT1AReceptor-Mediated Regulation of Dorsal Raphe and Hippocampal Cell Activity
la Cour, C. M., Boni, C., Hanoun, N., Lesch, K., Hamon, M., & Lanfumey, L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02178.2001 · Cited by 118
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome
Shinohara, T. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.11.1163 · Cited by 118
Involvement of 5-HT 1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models
Overstreet, D. H., Commissaris, R. C., Garza, R. D. L., File, S. E., Knapp, D. J., & Seiden, L. S. (2003) · Stress · doi:10.1080/1025389031000111311 · Cited by 117
Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation
Borsini, F., Lecci, A., Sessarego, A., Frassine, R., & Meli, A. (1989) · Psychopharmacology · doi:10.1007/bf00442247 · Cited by 117
The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation
Schmidt, M. V., Oitzl, M. S., Levine, S. D., & de Kloet, E. R. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00519-9 · Cited by 116
OLFACTORY BULB ABLATION IN THE RAT: BEHAVIOURAL CHANGES AND THEIR REVERSAL BY ANTIDEPRESSANT DRUGS
van Riezen, H., Schmieden, H., & Wren, A. F. (1977) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1977.tb07530.x · Cited by 115
Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat
Blokland, A., Lieben, C. K. J., & Deutz, N. E. P. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600112 · Cited by 114
Neonatal Administration of the Selective Serotonin Reuptake Inhibitor Lu 10–134-C Increases Forced Swimming-Induced Immobility in Adult Rats: A Putative Animal Model of Depression?
Hansen, H. H., Sánchez, C., & Meier, E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37125-3 · Cited by 112
Imaging brain activity in conscious animals using functional MRI
Lahti, K. M., Ferris, C. F., Li, F., Sotak, C. H., & King, J. A. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00037-5 · Cited by 111
Models of cognitive impairment: cognitive changes in depression.
Weingartner, H., & Silberman, E. K. (1982) · PubMed · Cited by 110
Additivity of neurochemical changes in learned helplessness and imipramine
Sherman, A. D., & Petty, F. (1982) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(82)90978-5 · Cited by 109
Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in MicePreprint
Yoshikawa, T., Watanabe, A., Ishitsuka, Y., Nakaya, A., & Nakatani, N. (2002) · Genome Research · doi:10.1101/gr.222602 · Cited by 108
Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients
Lechín, F., van der Dijs, B., Orozco, B., Lechin, M. E., Báez, S., Lechin, A. E., Rada, I., Acosta, E., Arocha, L., Jiménez, V., et al. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00258-5 · Cited by 107
Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour
Papaioannou, A., Gerozissis, K., Prokopiou, A., Bolaris, S., & Stylianopoulou, F. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00334-5 · Cited by 107
Alcohol and genetics: New models
Crabbe, J. C. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10984 · Cited by 107
Is immobility of rats in the forced swim test “behavioral despair?”
Nishimura, H., Tsuda, A., Oguchi, M., Ida, Y., & Tanaka, M. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90266-1 · Cited by 106
Searching—waiting strategy: A candidate for an evolutionary model of depression?
Thierry, B., Stéru, L., Chermat, R., & Simon, P. (1984) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(84)90555-7 · Cited by 106
G Protein‐Coupled Cyclic AMP Signaling in Postmortem Brain of Subjects with Mood Disorders
Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., Reiach, J. S., & Young, L. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731121.x · Cited by 104
Modulating limbic-cortical circuits in depression: Targets of antidepressant treatments
Mayberg, H. S. (2002) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2002.35223 · Cited by 102
Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine
Harkin, A., Houlihan, D. D., & Kelly, J. P. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600201 · Cited by 102
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
Shekhar, A., McCann, U., Meaney, M. J., Blanchard, D. C., Davis, M., Frey, K. A., Liberzon, I., Overall, K. L., Shear, M., Tecott, L. H., et al. (2001) · Psychopharmacology · doi:10.1007/s002130100859 · Cited by 101
The fallacy of behavioral phenotyping without standardisation
van der Staay, F. J., & Steckler, T. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00007.x · Cited by 100
Desmethylimipramine (DMI) counteracts learned helplessness in rats
Leshner, A. I., Remler, H., Biegon, A. R., & Samuel, D. (1979) · Psychopharmacology · doi:10.1007/bf00427633 · Cited by 99
Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression.
Kubera, M., Symbirtsev, A., Basta‐Kaim, A., Borycz, J. A., Roman, A., Papp, M., & Claësson, M. H. (1996) · PubMed · Cited by 99
Use of Dopamine-β-hydroxylase-Deficient Mice to Determine the Role of Norepinephrine in the Mechanism of Action of Antidepressant Drugs
Cryan, J. F., Dalvi, A., Jin, S., Hirsch, B. R., Lucki, I., & THOMAS, S. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29424-6 · Cited by 99
Self-citation
Impaired Lymphocyte Stimulation by Mitogens in Severely Depressed Patients
Maes, M. H. J., Bosmans, E., Suy, E., Minner, B., & Raus, J. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.155.6.793 · Cited by 98
Social isolation after a single defeat reduces striatal dopamine transporter binding in rats
Isovich, E., Engelmann, M., Landgraf, R., & Fuchs, E. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01492.x · Cited by 96
Altered regulation of the 5‐HT system in the brain of MAO‐A knock‐out mice
Evrard, A., Malagié, I., Laporte, A., Boni, C., Hanoun, N., Trillat, A., Seif, I., Maeyer, E. D., Gardier, A. M., Hamon, M., et al. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01917.x · Cited by 96
Repeated Phencyclidine Treatment Induces Negative Symptom-like Behavior in Forced Swimming Test in Mice Imbalance of Prefrontal Serotonergic and Dopaminergic Functions
Noda, Y. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00138-x · Cited by 96
Lower Sensitivity to Stress and Altered Monoaminergic Neuronal Function in Mice Lacking the NMDA Receptor ε4 Subunit
Miyamoto, Y., Yamada, K., Noda, Y., Mori, H., Mishina, M., & Nabeshima, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02335.2002 · Cited by 95
Amino acid levels in depression: A preliminary investigation
Honig, A., Bartlett, J. R., Bouras, N., & Bridges, P. K. (1988) · Journal of Psychiatric Research · doi:10.1016/0022-3956(88)90001-5 · Cited by 94
Endocrine Profile and Neuroendocrine Challenge Tests in Transgenic Mice Expressing Antisense RNA against the Glucocorticoid Receptor
Barden, N., Stec, I. S. M., Montkowski, A., Holsboer, F., & Reul, J. M. H. M. (2008) · Neuroendocrinology · doi:10.1159/000127240 · Cited by 94
Effects of Withdrawal from an Escalating Dose Schedule of d-Amphetamine on Sexual Behavior in the Male Rat
Barr, A. M., Fiorino, D. F., & Phillips, A. G. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00156-2 · Cited by 91
Neuroadaptations to chronic exposure to drugs of abuse: Relevance to depressive symptomatology seen across psychiatric diagnostic categories
Markou, A., & Kenny, P. J. (2002) · Neurotoxicity Research · doi:10.1080/10298420290023963 · Cited by 87
Reversal of helpless behavior by serotonin uptake blockers in rats
Martin, P., Soubrié, P., & Puech, A. J. (1990) · Psychopharmacology · doi:10.1007/bf02244061 · Cited by 86
Brain Output Dysregulation Induced by Olfactory Bulbectomy: An Approximation in the Rat of Major Depressive Disorder in Humans?
Jesberger, J. A., & Richardson, J. S. (1988) · International Journal of Neuroscience · doi:10.3109/00207458808990688 · Cited by 86
Effects of antidepressants and anticholinergics in a mouse “behavioral despair” test
Browne, R. G. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90483-7 · Cited by 86
The Human Genome Project and Its Impact on Psychiatry
Cowan, W. M., Kopnisky, K. L., & Hyman, S. E. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142853 · Cited by 86
Mouse models for psychiatric disorders
Seong, E., Seasholtz, A. F., & Burmeister, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02807-x · Cited by 86
Differential Effects of Prenatal Stress in Two Inbred Strains of Rats
Stöhr, T., Wermeling, D. S., Szuran, T. F., Pliška, V., Domeney, A. M., Welzl, H., Weiner, I., & Feldon, J. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00541-8 · Cited by 85
Genetic Regulation of Extracellular Serotonin by 5-Hydroxytryptamine1A and 5-Hydroxytryptamine1BAutoreceptors in Different Brain Regions of the Mouse
Knobelman, D. A., Hen, R., & Lucki, I. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29477-5 · Cited by 84
Behavioral screen for antidepressants: The effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule
Seiden, L. S., Dahms, J. L., & Shaughnessy, R. A. (1985) · Psychopharmacology · doi:10.1007/bf00431684 · Cited by 83
In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs
Rénéric, J.-P., Bouvard, M. P., & Stinus, L. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00203-6 · Cited by 83
Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat
Mar, A. C., Spreekmeester, E., & Rochford, J. M. (2000) · Psychopharmacology · doi:10.1007/s002130000400 · Cited by 82
Harnessing the mouse to unravel the genetics of human disease
Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., & Crabbe, J. C. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00011.x · Cited by 82
Animal Models in Biological Psychiatry
Sarter, M. F., & Bruno, J. P. (2002) · Biological Psychiatry · doi:10.1002/0470854871.chiii · Cited by 81
Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: implications for allostatic load
Tannenbaum, B. M., Tannenbaum, G. S., Sudom, K., & Anisman, H. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03273-0 · Cited by 80
Differential effects of peripheral and central anosmia producing techniques on spontaneous behavior patterns
Sieck, M. H., & Baumbach, H. D. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90096-1 · Cited by 80
Behavioural phenotyping of mouse mutants
van der Staay, F. J., & Steckler, T. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00278-9 · Cited by 78
Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice
Kubera, M., Simbirtsev, A. S., Mathison, R., & Maes, M. H. J. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00184-0 · Cited by 77
Amphetamine withdrawal: A behavioral evaluation
Kokkinidis, L., Zacharko, R. M., & Anisman, H. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90501-1 · Cited by 77
Adrenal Gland Enlargement in Major Depression
Phillips, J. J. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820220089012 · Cited by 77
Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice
El-Ghundi, M., O’Dowd, B. F., Erclik, M. S., & George, S. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02496.x · Cited by 76
Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice
Caldarone, B. J., Karthigeyan, K., Harrist, A. V., Hunsberger, J. G., Wittmack, E. K., King, S. L., Jatlow, P. I., & Picciotto, M. R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1518-7 · Cited by 75
Chronic stress impairs rotarod performance in rats: implications for depressive state
Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., & Tabira, T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00636-0 · Cited by 74
Neonatal treatment with clomipramine increased immobility in the forced swim test: An attribute of animal models of depression
Velázquez‐Moctezuma, J., & Ruiz, O. D. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90022-8 · Cited by 73
Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test
Alcaro, A., Cabib, S., Ventura, R., & Puglisi‐Allegra, S. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1161-8 · Cited by 73
The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice
Kubera, M., Holáň, V., Mathison, R., & Maes, M. H. J. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00026-3 · Cited by 73
Influence of olfactory bulbectomy and subsequent imipramine treatment on 5‐hydroxytryptaminergic presynapses in the rat frontal cortex: behavioural correlates
Grecksch, G., Zhou, D., Franke, C., Schröder, U., Sabel, B. A., Becker, A., & Huether, G. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701530 · Cited by 72
Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background
Caldarone, B. J., George, T. P., Zachariou, V., & Picciotto, M. R. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00271-9 · Cited by 72
Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor
Stec, I. S. M., Barden, N., Reul, J. M. H. M., & Holsboer, F. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90031-0 · Cited by 71
Genetics and genomics of behavioral and psychiatric disorders
Inoue, K., & Lupski, J. R. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00057-1 · Cited by 71
Behavioral responses to social stress in noradrenaline transporter knockout mice: Effects on social behavior and depression
Haller, J., Bakos, N., Rodriguiz, R. M., Caron, M. G., Wetsel, W. C., & Liposits, Z. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00789-x · Cited by 70
AN ANIMAL MODEL OF ANHEDONIA
Willner, P., Muscat, R., & Papp, M. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00286 · Cited by 70
Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment
Nowak, G., Li, Y., & Paul, I. A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00585-4 · Cited by 69
Overview of the past contributions of animal models and their changing place in psychiatry
McKinney, W. T. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.20292 · Cited by 68
A pretest procedure reliably predicts performance in two animal models of inescapable stress
Drugan, R. C., Skolnick, P., Paul, S. M., & Crawley, J. N. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90403-6 · Cited by 68
Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice
Pattij, T., Broersen, L. M., van der Linde, J., Groenink, L., van der Gugten, J., Maes, R. A. A., & Olivier, B. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00345-5 · Cited by 68
Effect of mild chronic stress, as a model of depression, on the immunoreactivity of C57BL⧹6 mice
Kubera, M., Basta‐Kaim, A., Holáň, V., Simbirtsev, A. S., Roman, A., Pigareva, N. V., Prokopieva, E., & Sham, J. (1998) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00050-2 · Cited by 67
Effects of Antidepressant Drugs on Rats Bred for Low Activity in the Swim Test
West, C. H. K., & Weiss, J. M. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00076-8 · Cited by 66
An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross
Liu, X., & Gershenfeld, H. K. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00033-9 · Cited by 66
An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression
Wrynn, A. S., MacSweeney, C. P., Franconi, F., Lemaire, L. P., Pouliquen, D., Herlidou, S., Leonard, B. E., Gandon, J., & de Certaines, J. D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02619-6 · Cited by 66
Modeling Geriatric Depression in Animals: Biochemical and Behavioral Effects of Olfactory Bulbectomy in Young Versus Aged Rats
Slotkin, T. A., Miller, D. B., Fumagalli, F., McCook, E. C., Zhang, J., Bissette, G., & Seidler, F. J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38141-8 · Cited by 66
Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).
Santarelli, L., Gobbi, G., Blier, P., & Hen, R. (2002) · PubMed · Cited by 65
Behavioral despair in mice after prenatal stress
Alonso, S. J., Damas, C., & Navarro, E. (2000) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179902 · Cited by 63
Olfactory bulbectomy temporarily impairs Morris maze performance: An ACTH(4?9) analog accellerates return of function
VANRIJZINGEN, I., Gispen, W. H., & Spruijt, B. M. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00032-e · Cited by 63
Combining pindolol and paroxetine in an animal model of chronic antidepressant action—can early onset of action be detected?
Cryan, J. F., McGrath, C., Leonard, B. E., & Norman, T. R. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00402-6 · Cited by 63
Self-citation
Regional Patterns of Compensation following Genetic Deletion of Either 5-Hydroxytryptamine1A or 5-Hydroxytryptamine1B Receptor in the Mouse
Knobelman, D. A., Hen, R., Blendy, J. A., & Lucki, I. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29478-7 · Cited by 63
Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression
Uzunova, V., Ceci, M., Kohler, C., Uzunov, D. P., & Wrynn, A. S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02577-0 · Cited by 62
Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala
Sullivan, G. M., Apergis, J., Gorman, J. M., & LeDoux, J. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01733-x · Cited by 62
A further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients
Maes, M., Bosmans, E., Suy, E., Minner, B., & Raus, J. (1991) · Psychological Medicine · doi:10.1017/s0033291700020419 · Cited by 62
Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?
David, D. J. P., Dhonnchadha, B. Á. N., Jolliet, P., Hascoët, M., & Bourin, M. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00351-x · Cited by 61
How Do Antidepressants Work? Prospects for Genetic Analysis of Drug Mechanisms
Schafer, W. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80042-2 · Cited by 60
Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology
Taghzouti, K., Lamarque, S., Kharouby, M., & Simon, H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00156-5 · Cited by 60
Strain-specific effects of antidepressants on escape deficits induced by inescapable shock
Shanks, N. M., & Anisman, H. (1989) · Psychopharmacology · doi:10.1007/bf00634465 · Cited by 60
Sex Differences in Mesolimbic Dopamine Responses to Ethanol and Relationship to Ethanol Intake in Rats
Blanchard, B. A., & Glick, S. D. (2002) · Springer eBooks · doi:10.1007/0-306-47138-8_15 · Cited by 59
Differential galanin receptor‐1 and galanin expression by 5‐HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species‐dependent modulation of serotonin transmission
Larm, J. A., Shen, P., & Gundlach, A. L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02471.x · Cited by 59
Use of the automated tail suspension test for the primary screening of psychotropic agents.
Porsolt, R. D., Chermat, R., Lenègre, A., Avril, I., Janvier, S., & Stéru, L. (1987) · PubMed · Cited by 59
Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice.
Yamano, M., Yuki, H., Yasuda, S., & Miyata, K. (2000) · PubMed · Cited by 58
Chronic mild stress and depressive disorder: a useful new model?
Reid, I., Forbes, N., Stewart, C. A., & Matthews, K. (1997) · Psychopharmacology · doi:10.1007/s002130050471 · Cited by 58
Pharmacological effects of venlafaxine, a new antidepressant, given repeatedly, on the α 1 -adrenergic, dopamine and serotonin systems
Maj, J., & Rogóż, Z. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050151 · Cited by 57
Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test
Anraku, T., Ikegaya, Y., Matsuki, N., & Nishiyama, N. (2001) · Psychopharmacology · doi:10.1007/s002130100793 · Cited by 57
Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study
Watanabe, A., Tohyama, Y., Nguyen, K. Q., Hasegawa, S., Debonnel, G., & Dikšić, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01702.x · Cited by 56
Melatonin protects against the effects of chronic stress on sexual behaviour in male rats
Brotto, L. A., Gorzalka, B. B., & LaMarre, A. K. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00018 · Cited by 56
Evolutionary psychiatry. Adaptationist and nonadaptationist conceptualizations
Dubrovsky, B. O. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00243-3 · Cited by 56
In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment
Tauscher, J. T., Pirker, W., de Zwaan, M., Asenbaum, S., Brücke, T., & Kasper, S. F. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00013-3 · Cited by 56
A prescription to resist proscriptions for murine models of depression
Lucki, I. (2000) · Psychopharmacology · doi:10.1007/s002130000561 · Cited by 55
Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior
Kafkafi, N., Pagis, M., Lipkind, D., Mayo, C. L., Bemjamini, Y., Golani, I., & Elmer, G. I. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00003-2 · Cited by 55
A genetic mouse model of helplessness sensitive to imipramine
Vaugeois, J., Odièvre, C., Loisel, L., & Costentin, J. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00800-x · Cited by 54
Prevalence, recognition, and treatment of comorbid depression and anxiety.
Rapaport, M. H. (2001) · PubMed · Cited by 53
Enhancement of immobility in mouse forced swimming test by treatment with human interferon
Makino, M., Kitano, Y., Hirohashi, M., & Takasuna, K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00474-9 · Cited by 53
Potentiation of the time-dependent, antidepressant-induced changes in the agonistic behaviour of resident rats by the 5-HT1A receptor antagonist, WAY-100635
Mitchell, P. J., & Redfern, P. H. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00016 · Cited by 53
Influence of a natural stressor (predator odor) on locomotor activity in the meadow vole (Microtus pennsylvanicus): modulation by sex, reproductive condition and gonadal hormones
Perrot-Sinal, T. S., Ossenkopp, K., & Kavaliers, M. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00054-2 · Cited by 52
Onset of the Effects of the 5-HT1A Antagonist, WAY-100635, Alone, and in Combination With Paroxetine, on Olfactory Bulbectomy and 8-OH-DPAT–Induced Changes in the Rat
Cryan, J. F., McGrath, C., Leonard, B. E., & Norman, T. R. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00245-7 · Cited by 52
Self-citation
Ventricular enlargement and caudate hyperdensity in elderly depressives
Beats, B. C., Levy, R., & Förstl, H. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90306-7 · Cited by 51
Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats
Ho, Y., Chang, Y.-C., Liu, T.-M., Tai, M.-Y., Wong, C., & Tsai, Y. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01152-6 · Cited by 51
Chronic Stress Effects on Sexual Behavior in Male and Female Rats
Gorzalka, B. B., Hanson, L., & Brotto, L. A. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00106-3 · Cited by 51
Repeated Injections of Interferon-α A/D in Balb/c Mice: Behavioral Effects
Dunn, A. L., & Crnic, L. S. (1993) · Brain Behavior and Immunity · doi:10.1006/brbi.1993.1011 · Cited by 50
Susceptibility and resistance of rats to stress-induced decreases in swim-test activity: a selective breeding study
Scott, P. A., Cierpial, M. A., Kilts, C. D., & Weiss, J. M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00093-5 · Cited by 50
Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine
Lin, D. C.-H., Bruijnzeel, A. W., Schmidt, P., & Markou, A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00366-4 · Cited by 49
Dissociation of multiple behavioral effects between olfactory bulbectomized C57B1/6J and DBA/2J mice
Otmakhova, N. A., Gurevich, E. V., Katkov, Y. A., Nesterova, I. V., & Bobkova, N. V. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90329-z · Cited by 49
Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress.
McNish, K. A., & Davis, M. J. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.1.80 · Cited by 48
Reduced attention in mice overproducing corticotropin-releasing hormone
van Gaalen, M. M., Stenzel‐Poore, M. P., Holsboer, F., & Steckler, T. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00381-9 · Cited by 48
Stressor-induced alterations in serotonergic activity in an animal model of depression
Connor, T. J., Song, C., Leonard, B. E., Anisman, H., & Merali, Z. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00015 · Cited by 48
A chronic treatment with fluoxetine decreases 5-HT1A receptors labeling in mice selected as a genetic model of helplessness
Naudon, L., Yacoubi, M. E., Vaugeois, J., Leroux‐Nicollet, I., & Costentin, J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02548-9 · Cited by 47
Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: In vivo studies with [125i]rti‐55
Scheffel, U., Kim, S. E., Cline, E. J., & Kuhar, M. J. (1994) · Synapse · doi:10.1002/syn.890160403 · Cited by 47
Chronic mild stress-induced reductions in saccharin intake depend upon feeding status
Hatcher, J. P., Bell, D. J., Reed, T., & Hagan, J. J. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100408 · Cited by 47
Role of Aversively Motivated Behavior in the Olfactory Bulbectomy Syndrome
Primeaux, S. D., & Holmes, P. V. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00027-x · Cited by 46
Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression
Stock, H. S., Ford, K., & Wilson, M. A. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00318-x · Cited by 45
ONTOGENIES IN MICE SELECTED FOR HIGH VOLUNTARY WHEEL-RUNNING ACTIVITY. I. MEAN ONTOGENIES
Morgan, T. J., Garland, T., & Carter, P. A. (2003) · Evolution · doi:10.1111/j.0014-3820.2003.tb01556.x · Cited by 45
Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests
Russig, H., Pezze, M. A., Bahr, N. I., Pryce, C. R., Feldon, J., & Murphy, C. A. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200302000-00001 · Cited by 45
Reduction of depressive-like behavior in mice lacking angiotensinogen
Okuyama, S., Sakagawa, T., Sugiyama, F., Fukamizu, A., & Murakami, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00002-6 · Cited by 44
Effects of ramp shortening during linear phase of relaxation on [Ca2+]i in intact skeletal muscle fibers
Jiang, Y., & Julian, F. J. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c152 · Cited by 44
The Reductions in Sweetened Milk Intake Induced by Interleukin-1 and Endotoxin Are Not Prevented by Chronic Antidepressant Treatment
Dunn, A. J., & Swiergiel, A. H. (2001) · NeuroImmunoModulation · doi:10.1159/000049021 · Cited by 43
Intravenous self‐administration of amphetamine is increased in a rat model of depression
Holmes, P. V., Masini, C. V., Primeaux, S. D., Garrett, J. L., Zellner, A. S., Stogner, K. A., Duncan, A. A., & Crystal, J. D. (2002) · Synapse · doi:10.1002/syn.10105 · Cited by 43
5-HT4 receptors do not mediate the antidepressant-like behavioral effects of fluoxetine in a modified forced swim test
Cryan, J. F., & Lucki, I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00858-x · Cited by 43
Self-citation
Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT1B receptor knock-out mice
Malagié, I., David, D. J. P., Jolliet, P., Hen, R., Bourin, M., & Gardier, A. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01604-7 · Cited by 42
Cholinergic blockade impairs performance in operant DNMTP in two inbred strains of mice
Estapé, N., & Steckler, T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00747-x · Cited by 42
Hyperactivity of hypothalamic pituitary axis in neonatal clomipramine model of depression
Prathiba, J., Kumar, K. B., & Karanth, K. S. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050135 · Cited by 42
Bulbectomy-induced loss of raphe neurons is counteracted bt antidepressant treatment
Nesterova, I. V., Gurevich, E. V., Nesterov, V. I., Otmakhova, N. A., & Bobkova, N. V. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(96)00163-7 · Cited by 42
Interleukin-6 Involvement in Antidepressant Action of Hypericum Perforatum
Calapai, G., Crupi, A., Firenzuoli, F., Inferrera, G., Ciliberto, G., Parisi, A., Sarro, G. D., & Caputi, A. P. (2001) · Pharmacopsychiatry · doi:10.1055/s-2001-15507 · Cited by 41
Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder
Bayer, T. A., Schramm, M., Feldmann, N., Knable, M. B., & Falkai, P. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00115-9 · Cited by 41
Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsy
Yacoubi, M. E., Ledent, C. A., Parmentier, M., Costentin, J., & Vaugeois, J. (2001) · Neuroreport · doi:10.1097/00001756-200104170-00024 · Cited by 40
Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice
Gilliss, B. M., Malanga, C. J., Pieper, J. O., & Carlezon, W. A. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1153-8 · Cited by 40
Autoradiographic distribution of cholinergic muscarinic receptors and serotonin2 receptors in olfactory bulbectomized (OB) rats after chronic treatment with mianserin and desipramine
Earley, B., Glennon, M. J., Lally, M., Leonard, B. E., & Junien, J. (1994) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470090603 · Cited by 40
Influence of olfactory bulbectomy and the serotonergic system upon intermale aggression and maternal behavior in the mouse
Neckers, L. Μ., ZARROW, M. X., Myers, M. M., & Denenberg, V. H. (1975) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(75)90170-7 · Cited by 39
Cerebral ventricular size and cognitive impairment in depression
Kellner, C. H., Rubinow, D. R., & Post, R. M. (1986) · Journal of Affective Disorders · doi:10.1016/0165-0327(86)90007-8 · Cited by 39
An Investigation of Serotonergic Involvement in the Regulation of ACTH and Corticosterone in the Olfactory Bulbectomized Rat
Marcilhac, A., Faudon, M., Anglade, G., Hery, F., & Siaud, P. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00024-6 · Cited by 38
Prenatal ethanol exposure impairs lesion-induced plasticity in a dopaminergic synapse after maturity
Gottesfeld, Z., Garcia, C., Lingham, R. B., & Chronister, R. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90143-7 · Cited by 38
Effects of fluoxetine and olfactory bulbectomy on mouse circadian activity rhythms
Possidente, B. P., Lumia, A. R., McGinnis, M. Y., Rapp, M., & McEldowney, S. (1996) · Brain Research · doi:10.1016/0006-8993(95)01490-x · Cited by 37
The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression
Kubera, M., Basta‐Kaim, A., & Papp, M. (1995) · Immunopharmacology · doi:10.1016/0162-3109(95)00026-p · Cited by 36
Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis
Moldin, S. O., Farmer, M. E., Chin, H. R., & Battey, J. F. (2001) · Mammalian Genome · doi:10.1007/s00335-001-4005-7 · Cited by 35
Effect of Chronic Administration of Antidepressants on α2-Adrenoceptors in the Locus Coeruleus and Its Projection Fields in Rat Brain Determined by Quantitative Autoradiography
Kovachich, G. B., Frazer, A., & Aronson, C. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.7 · Cited by 35
Development of open‐field behavior in mice: Effects of age and experience
Dixon, L. K., & DeFries, J. C. (1968) · Developmental Psychobiology · doi:10.1002/dev.420010207 · Cited by 35
Effects of bulbectomy and subsequent antidepressant treatment on brain 5-HT2 and 5-HT1A receptors in mice
Gurevich, E. V., Александрова, И. А., Otmakhova, N. A., Katkov, Y. A., Nesterova, I. V., & Bobkova, N. V. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90087-a · Cited by 34
Reduced anxiety- and depression-like behaviors in Emx1 homozygous mutant mice
Cao, B., & Li, Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02461-7 · Cited by 34
Corticotropin-Releasing Hormone1 Receptors Mediate Consensus Interferon-α YM643-Induced Depression-Like Behavior in Mice
Yamano, M., Yuki, H., Yasuda, S., & Miyata, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35275-9 · Cited by 34
Selective breeding for increased cholinergic function: biometrical genetic analysis of muscarinic responses.
Overstreet, D. H., Russell, R. W., Hay, D. A., & Crocker, A. D. (1992) · PubMed · Cited by 33
Effects of bilateral olfactory bulbectomy on N‐methyl‐ D ‐aspartate receptor function: Autoradiographic and behavioral studies in the rat
Robichaud, M., Beauchemin, V., Lavoie, N., Dennis, T., & Debonnel, G. (2001) · Synapse · doi:10.1002/syn.1105 · Cited by 33
The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT1B receptor knockout mice
de Groote, L., Olivier, B., & Westenberg, H. G. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01417-6 · Cited by 33
Differential effects of olfactory bulbectomy on GABAA and GABAB receptors in the rat brain
Dennis, T., Beauchemin, V., & Lavoie, N. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90320-s · Cited by 32
Changes in defensive behaviors following olfactory bulbectomy in male and female rats
Stock, H. S., Hand, G. A., Ford, K., & Wilson, M. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02421-0 · Cited by 31
Divergent levels of anxiety in mice selected for differences in sensitivity to a convulsant agent
Suaudeau, C., Rinaldi, D., Lepicard, E. M., Venault, P., Crusio, W. E., Costentin, J., & Chapouthier, G. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00383-8 · Cited by 29
Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats
Holmes, P. V. (1999) · Neuropeptides · doi:10.1054/npep.1999.0031 · Cited by 28
Anxiety associated with comorbid depression.
Möller, H. (2002) · PubMed · Cited by 27
Action of antidepressant drugs on maternal stress-induced hypoactivity in female rats
Alonso, S. J., Castellano, M. A., Quintero, M., & Navarro, E. (1999) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.1999.21.4.538181 · Cited by 27
Mother nature meets mother nurture
Crabbe, J. C., & Phillips, T. J. (2003) · Nature Neuroscience · doi:10.1038/nn0503-440 · Cited by 26
Escape deficits induced by uncontrollable foot-shock in recombinant inbred strains of mice
Shanks, N. M., & Anisman, H. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90538-5 · Cited by 26
An Evolutionary Approach to Psychiatry
Joness, I., & Blackshaw, J. K. (2000) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2000.00704.x · Cited by 26
Clozapine promotes approach-oriented behavior in male mice.
Dixon, A. K., Huber, C., & Lowe, D. (1994) · PubMed · Cited by 26
Mouse Molecular Genetic Technologies
Tecott, L. H. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.995 · Cited by 25
Selective breeding of 5-HT1A receptor-mediated responses: application to emotion and receptor action
Knapp, D. J., Sim‐Selley, L. J., Breese, G. R., & Overstreet, D. H. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00415-9 · Cited by 25
Tonic immobility in guinea pigs: A behavioural response for detecting an anxiolytic-like effect?
Olsen, C. K., Hogg, S. L., & Bluhm, M. D. L. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200207000-00002 · Cited by 25
Hierarchical strategy for phenotypic analysis in mice
Gold, L. H. (1999) · Psychopharmacology · doi:10.1007/s002130051127 · Cited by 24
Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats
Barr, A. M., Zis, A. P., & Phillips, A. G. (2001) · Psychopharmacology · doi:10.1007/s002130100906 · Cited by 24
Desipramine administration in the olfactory bulbectomized rat: changes in brain β‐adrenoceptor and 5‐HT2A binding sites and their relationship to behaviour
Mudunkotuwa, N. T., & Horton, R. W. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15310.x · Cited by 24
Changes in Tonic Immobility and the GABA–Benzodiazepine System in Response to Handling in the Chick
Fluck, E. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00554-0 · Cited by 24

Flagged first, then by citations

Research works printed but not linked: 6

Frazer A . Antidepressants. J Clin Psychiatry 1997; 58(Suppl 6): 9–25.
Guscott MR . The effect of 5-HT7 receptor knockout in mouse forced swim test. Abstract from Conference “Serotonin: From the Molecule to Clinic” 2000, p 81.
Mombereau C, Kaupmann K, Sansig S, van der Putten H, Cryan JF . GABAB receptors play a key role in the modulation of anxiety, depression-related behaviours. Behav Pharmacol 2003; 14(Suppl 1): 24.
Caldarone BJ, Karthigeyan K, Picciotto MR . Behavioral responses to a tricyclic antidepressant in knockout mice lacking the Beta-2-subunit of nicotinic receptor. Program No. 136.1 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2002 (online).
Pudiak CM, Rahman Z, Gold SJ, Neve RL, Barrot M, Nestler EJ . The involvement of RGS9-2 in depression and anxiety-like behavior. Program No. 644.17 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2002 (online).
Cryan JF, Hirsch BR, Jin S-H, Lucki I, Thomas SA . Reduced sensitivity to the antidepressant-like effects of SSRIs in dopamine-Beta -hydroxylase deficient mice. Program No. 665.9 2001 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2001 (online).

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Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Self-citation
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Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674
Self-citation
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Self-citation
Epigenetic transmission of the impact of early stress across generations
Franklin, T. B., Russig, H., Weiss, I. C., Gräff, J., Linder, N., Michalon, A., Vizi, S., & Mansuy, I. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.036 · Cited by 1,125
Forced swimming test in mice: A review of antidepressant activity
Petit-Demouliere, B., Chenu, F., & Bourin, M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2048-7 · Cited by 1,003

See all 641

Authors: Cryan, J. F., & Mombereau, C.
Affiliations: Novartis (Switzerland) (CH)
Corresponding author: Cryan, J F
ORCID: Cryan, J F
Mombereau, C
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2004-01-13
Volume: 9
Issue: 4
Pages: 326-357
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001457
OpenAlex: W2155181385
Cited by: 616
References: 424
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 25 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 34 · 2017: 28 · 2016: 25 · 2015: 43 · 2014: 40 · 2013: 26 · 2012: 33
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (U01MH069062, MH69062)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, genetically modified mice, animal models of depression, depression-like behavior, antidepressants, forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, endophenotypes, antidepressant targets
MeSH terms: Animals, Behavior, Animal, Depressive Disorder, Disease Models, Animal, Mice, Mutant Strains, Sensitivity and Specificity, Reproducibility of Results, Animals, Genetically Modified, Mice

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In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

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