Cited by 641Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

The DOI matches its Crossref record; 426 of the 426 references it cites were found in a registry or an index.

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Cryan, J F, Mombereau, C·2004·Molecular Psychiatry

Open this paper in CoChat — free account

Abstract

The ability to modify mice genetically has been one of the major breakthroughs in modern medical science affecting every discipline including psychiatry. It is hoped that the application of such technologies will result in the identification of novel targets for the treatment of diseases such as depression and to gain a better understanding of the molecular pathophysiological mechanisms that are regulated by current clinically effective antidepressant medications. The advent of these tools has resulted in the need to adopt, refine and develop mouse-specific models for analyses of depression-like behavior or behavioral patterns modulated by antidepressants. In this review, we will focus on the utility of current models (eg forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, drug-withdrawal-induced anhedonia) and research strategies aimed at investigating novel targets relevant to depression in the mouse. We will focus on key questions that are considered relevant for examining the utility of such models. Further, we describe other avenues of research that may give clues as to whether indeed a genetically modified animal has alterations relevant to clinical depression. We suggest that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depression-related pathology.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001457

Cites

426 of 426 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217

Show all 424 references

Research works printed but not linked: 6

Frazer A . Antidepressants. J Clin Psychiatry 1997; 58(Suppl 6): 9–25.
Guscott MR . The effect of 5-HT7 receptor knockout in mouse forced swim test. Abstract from Conference “Serotonin: From the Molecule to Clinic” 2000, p 81.
Mombereau C, Kaupmann K, Sansig S, van der Putten H, Cryan JF . GABAB receptors play a key role in the modulation of anxiety, depression-related behaviours. Behav Pharmacol 2003; 14(Suppl 1): 24.
Caldarone BJ, Karthigeyan K, Picciotto MR . Behavioral responses to a tricyclic antidepressant in knockout mice lacking the Beta-2-subunit of nicotinic receptor. Program No. 136.1 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2002 (online).
Pudiak CM, Rahman Z, Gold SJ, Neve RL, Barrot M, Nestler EJ . The involvement of RGS9-2 in depression and anxiety-like behavior. Program No. 644.17 2002 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2002 (online).
Cryan JF, Hirsch BR, Jin S-H, Lucki I, Thomas SA . Reduced sensitivity to the antidepressant-like effects of SSRIs in dopamine-Beta -hydroxylase deficient mice. Program No. 665.9 2001 Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC, 2001 (online).

Sorted by citations

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Self-citation
The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice
Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674
Self-citation
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Self-citation
Epigenetic transmission of the impact of early stress across generations
Franklin, T. B., Russig, H., Weiss, I. C., Gräff, J., Linder, N., Michalon, A., Vizi, S., & Mansuy, I. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.036 · Cited by 1,125
Forced swimming test in mice: A review of antidepressant activity
Petit-Demouliere, B., Chenu, F., & Bourin, M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2048-7 · Cited by 1,003
Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice
Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952
Self-citation
Using the rat forced swim test to assess antidepressant-like activity in rodents
Slattery, D. A., & Cryan, J. F. (2012) · Nature Protocols · doi:10.1038/nprot.2012.044 · Cited by 903
Self-citation
Machine Learning for Precision Psychiatry: Opportunities and Challenges
Bzdok, D., & Meyer‐Lindenberg, A. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.11.007 · Cited by 888
Measuring emotional processes in animals: the utility of a cognitive approach
Paul, E. S., Harding, E. J., & Mendl, M. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.002 · Cited by 856
Cognitive bias as an indicator of animal emotion and welfare: Emerging evidence and underlying mechanisms
Mendl, M., Burman, O. H. P., Parker, R. M. A., & Paul, E. S. (2009) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2009.02.023 · Cited by 809
Mania-like behavior induced by disruption of CLOCK
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803
Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain–gut axis alterations
van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789
Self-citation
The Forced Swim Test as a Model of Depressive-like Behavior
Yankelevitch-Yahav, R., Franko, M., Huly, A., & Doron, R. (2015) · Journal of Visualized Experiments · doi:10.3791/52587 · Cited by 754
Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
Dranovsky, A., & Hen, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.082 · Cited by 663
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 662
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 569
Role of GABA in anxiety and depression
Kalueff, A. V., & Nutt, D. (2006) · Depression and Anxiety · doi:10.1002/da.20262 · Cited by 563
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541
Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes
d’Aquino, R., ROSA, A. D., Lanza, V. B., Tirino, V., Laino, L., Graziano, A., Desiderio, V., Laino, G., & Papaccio, G. (2009) · European Cells and Materials · doi:10.22203/ecm.v018a07 · Cited by 535
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528
Stress and the dopaminergic reward system
Baik, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00532-4 · Cited by 477
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459
Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice
Mineur, Y. S., Belzung, C., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.029 · Cited by 459
Sex differences in animal models of psychiatric disorders
Kokras, N., & Dalla, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12710 · Cited by 441
The advances of post-stroke depression: 2021 update
Guo, J., Wang, J., Sun, W., & Liu, X. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10597-4 · Cited by 434
Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression
Cryan, J. F., & Kaupmann, K. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.11.004 · Cited by 429
Self-citation
Melancholic microbes: a link between gut microbiota and depression
Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12198 · Cited by 424
Self-citation
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704774104 · Cited by 424
A prospective cohort study investigating factors associated with depression during medical internship
Sen, S., Kranzler, H. R., Krystal, J. H., Speller, H., Chan, G., Gelernter, J., & Guille, C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.41 · Cited by 411
Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology
Bangasser, D. A., Curtis, A., Reyes, B. A. S., Bethea, T. T., Parastatidis, I., Ischiropoulos, H., Van Bockstaele, E. J., & Valentino, R. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.66 · Cited by 401
Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions
Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M., Hörtnagl, H., Flor, H., Henn, F. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0736-05.2005 · Cited by 382
Immobility in the forced swim test is adaptive and does not reflect depression
Molendijk, M. L., & de Kloet, E. R. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.028 · Cited by 368
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365
Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism
de Kloet, E. R., & Molendijk, M. L. (2016) · Neural Plasticity · doi:10.1155/2016/6503162 · Cited by 353
Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior
Mombereau, C., Kaupmann, K., Froestl, W., Sansig, G., van der Putten, H., & Cryan, J. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300413 · Cited by 353
Self-citation
Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects
Govindarajan, A., Rao, B. S. S., Nair, D., Trinh, M. A., Mawjee, N., Tonegawa, S., & Chattarji, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605180103 · Cited by 340
Animal models of mood disorders: recent developments
Cryan, J. F., & Slattery, D. A. (2006) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280117733 · Cited by 331
Self-citation
Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment
Cryan, J. F., Page, M. E., & Lucki, I. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0093-5 · Cited by 321
Self-citation
Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
Lemos, J. C., Wanat, M. J., Smith, J. S., Reyes, B. A. S., Hollon, N. G., Bockstaele, E. J. V., Chavkin, C., & Phillips, P. E. M. (2012) · Nature · doi:10.1038/nature11436 · Cited by 319
Behavioral animal models of depression
Yan, H., Cao, X., Das, M. K., Zhu, X., & Gao, T. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0323-7 · Cited by 312
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296
“One of the first animal models demonstrated to separate susceptible and resilient phenotypes is learned helplessness (LH) (18) (19).”
Background
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight
Revel, F. G., Moreau, J., Pouzet, B., Mory, R., Bradaïa, A., Buchy, D., Metzler, V., Chaboz, S., Zbinden, K. G., Galley, G., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.57 · Cited by 288
What's wrong with my mouse model?
Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285
5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
Hedlund, P. B., Huitron-Resendiz, S., Henriksen, S. J., & Sutcliffe, J. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.012 · Cited by 281
A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear
Siegmund, A., & Wotjak, C. T. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.017 · Cited by 281
Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin.
Veenema, A. H., Blume, A., Niederle, D., Buwalda, B., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05045.x · Cited by 271
Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety
Krömer, S. A., Kessler, M. S., Milfay, D., Birg, I., Bunck, M., Czibere, L., Panhuysen, M., Pütz, B., Deussing, J. M., Holsboer, F., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0115-05.2005 · Cited by 269
Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
Mosienko, V., Bert, B., Beis, D. M., Matthes, S., Fink, H., Bäder, M., & Alenina, N. V. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.44 · Cited by 266
Chronic stress impacts the cardiovascular system: animal models and clinical outcomes
Golbidi, S., Frisbee, J. C., & Laher, I. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00859.2014 · Cited by 262
Animal tests for anxiety-like and depression-like behavior in rats
Belovičová, K., Bögi, E., Csatlósová, K., & Dubovický, M. (2017) · Interdisciplinary Toxicology · doi:10.1515/intox-2017-0006 · Cited by 258
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors
Cryan, J. F., O’Leary, O. F., Jin, S., Friedland, J. C., Ouyang, M., Hirsch, B. R., Page, M. E., Dalvi, A., THOMAS, S. A., & Lucki, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401080101 · Cited by 256
Self-citation
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 242
IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors
Chourbaji, S., Urani, A., Inta, I., Sanchis-Segura, C., Brandwein, C., Zink, M., Schwaninger, M., & Gass, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.001 · Cited by 241
Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes
Sukoff Rizzo, S. J., Neal, S. J., Hughes, Z. A., Beyna, M., Rosenzweig-Lipson, S., Moss, S. J., & Brandon, N. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.120 · Cited by 241
Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia
Bitanihirwe, B. K., Peleg-Raibstein, D., Mouttet, F., Feldon, J., & Meyer, U. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.129 · Cited by 237
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
Hickey, M. A., Kosmalska, A., Enayati, J., Cohen, R. E., Zeitlin, S. O., Levine, M. S., & Chesselet, M. ‐. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.041 · Cited by 236
The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent
Bosch, O. J., Nair, H. P., Ahern, T. H., Neumann, I. D., & Young, L. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.154 · Cited by 216
Learned helplessness: Validity and reliability of depressive-like states in mice
Chourbaji, S., Zacher, C., Sanchis-Segura, C., Dormann, C., Vollmayr, B., & Gass, P. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.09.002 · Cited by 216
Animal models of depression in drug discovery: A historical perspective
McArthur, R. A., & Borsini, F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.005 · Cited by 215
Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice
Landgraf, D., Long, J. E., Proulx, C. D., Barandas, R., Malinow, R., & Welsh, D. K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1050 · Cited by 212
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202
Self-citation
The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents
Malkesman, O., Scattoni, M. L., Paredes, D., Tragon, T. R., Pearson, B. L., Shaltiel, G., Chen, G., Crawley, J. N., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.018 · Cited by 202
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 201
17β-Estradiol-induced antidepressant-like effect in the Forced Swim Test is absent in estrogen receptor-β knockout (BERKO) mice
Rocha, B. A. G., Fleischer, R., Schaeffer, J. M., Rohrer, S. P., & Hickey, G. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2078-1 · Cited by 201
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders
Leopoldo, M., Lacivita, E., Berardi, F., Perrone, R., & Hedlund, P. B. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.013 · Cited by 198
Animal models of depression
Deussing, J. M. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.11.003 · Cited by 197
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Revel, F. G., Moreau, J., Gainetdinov, R. R., Ferragud, A., Velázquez-Sánchez, C., Sotnikova, T. D., Morairty, S. R., Harmeier, A., Zbinden, K. G., Norcross, R. D., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.014 · Cited by 195
Rodent models in depression research: Classical strategies and new directions
Pollak, D. D., Rey, C. E., & Monje, F. J. (2010) · Annals of Medicine · doi:10.3109/07853891003769957 · Cited by 190
Transcriptional regulation at a HTR1A polymorphism associated with mental illness
François, B. L., Czesak, M., Steubl, D., & Albert, P. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.046 · Cited by 190
Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications
Bilsland, J. G., Wheeldon, A., Mead, A., Znamenskiy, P., Almond, S., Waters, K. A., Thakur, M., Beaumont, V., Bonnert, T. P., Heavens, R., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301446 · Cited by 188
Identifying fast-onset antidepressants using rodent models
Ramaker, M. J., & Dulawa, S. C. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.36 · Cited by 183
Neurobehavioral deficits in db/db diabetic mice
Sharma, A. N., Elased, K. M., Garrett, T. L., & Lucot, J. B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.002 · Cited by 182
Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis
Stephan, K. E., Bach, D. R., Fletcher, P. C., Flint, J., Frank, M. J., Friston, K. J., Heinz, A., Huys, Q. J. M., Owen, M. J., Binder, E. B., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00361-2 · Cited by 180
Tobacco addiction and the dysregulation of brain stress systems
Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 181
Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
Moreau, M. M., André, C., O’Connor, J. C., Dumich, S. A., Woods, J. A., Kelley, K. W., Dantzer, R., Lestage, J., & Castanon, N. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.001 · Cited by 180
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test
O’Leary, O. F., Bechtholt, A. J., Crowley, J. J., Hill, T. E., Page, M. E., & Lucki, I. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0728-9 · Cited by 179
Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders
Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00016 · Cited by 178
Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism
Gigliucci, V., O’Dowd, G., Casey, S., Egan, D., Gibney, S., & Harkin, A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3024-x · Cited by 177
Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania
Shaltiel, G., Maeng, S., Malkesman, O., Pearson, B., Schloesser, R. J., Tragon, T., Rogawski, M., Gasior, M., Luckenbaugh, D., Chen, G., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.20 · Cited by 173
Feeling Strained? Influence of Genetic Background on Depression-Related Behavior in Mice: A Review
Jacobson, L. H., & Cryan, J. F. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9106-3 · Cited by 172
Self-citation
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170
Progressive Loss of Dopaminergic Neurons in the Ventral Midbrain of Adult Mice Heterozygote forEngrailed1
Sonnier, L., Pen, G. L., Hartmann, A., Bizot, J., Trovero, F., Krebs, M., & Prochiantz, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4583-06.2007 · Cited by 168
High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome
Hassan, A. M., Mancano, G., Kashofer, K., Fröhlich, E. E., Matak, A., Mayerhofer, R., Reichmann, F., Olivares, M., Neyrinck, A. M., Delzenne, N. M., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1465713 · Cited by 166
Circadian rhythms and depression: Human psychopathology and animal models
Kronfeld-Schor, N., & Einat, H. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.020 · Cited by 166
Oxytocin and Social Relationships: From Attachment to Bond Disruption
Bosch, O. J., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_10 · Cited by 162
Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling
Hines, D. J., Schmitt, L. I., Hines, R. M., Moss, S. J., & Haydon, P. G. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.136 · Cited by 160
siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain
Thakker, D. R., Natt, F., Hüsken, D., van der Putten, H., Maier, R., Hoyer, D., & Cryan, J. F. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001687 · Cited by 159
Self-citation
Cellular Plasticity Cascades: Genes-To-Behavior Pathways in Animal Models of Bipolar Disorder
Einat, H., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.004 · Cited by 156
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
Albert, P. R., François, B. L., & Millar, A. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-21 · Cited by 154
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I. N., Sawa, A., Margolis, R. L., Cadet, J. L., Mori, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.144 · Cited by 148
Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity
Schweizer, M., Henniger, M. S. H., & Sillaber, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004326 · Cited by 146
Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease
Chiu, C., Liu, G., Leeds, P. R., & Chuang, D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.128 · Cited by 146
Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism
Lucchina, L., & Depino, A. M. (2013) · Autism Research · doi:10.1002/aur.1338 · Cited by 146
Animal models of CNS disorders
McGonigle, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.016 · Cited by 142
Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles
Bosch, O. J., Dabrowska, J., Modi, M. E., Johnson, Z. V., Keebaugh, A. C., Barrett, C. E., Ahern, T. H., Guo, J., Grinevich, V., Rainnie, D. G., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.011 · Cited by 140
Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens
Alexander, B., Warner-Schmidt, J., Eriksson, T. M., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001079 · Cited by 140
“Killing the Blues”: A role for cellular suicide (apoptosis) in depression and the antidepressant response?
McKernan, D. P., Dinan, T. G., & Cryan, J. F. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.006 · Cited by 139
Self-citation
Stress responses and the mesolimbic dopamine system: Social contexts and sex differences
Trainor, B. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.013 · Cited by 138
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Mineur, Y. S., Somenzi, O., & Picciotto, M. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.006 · Cited by 137

Authors: Cryan, J. F., & Mombereau, C.
Affiliations: Novartis (Switzerland) (CH)
Corresponding author: Cryan, J F
ORCID: Cryan, J F
Mombereau, C
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2004-01-13
Volume: 9
Issue: 4
Pages: 326-357
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001457
OpenAlex: W2155181385
Cited by: 616
References: 424
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 25 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 34 · 2017: 28 · 2016: 25 · 2015: 43 · 2014: 40 · 2013: 26 · 2012: 33
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (U01MH069062, MH69062)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, genetically modified mice, animal models of depression, depression-like behavior, antidepressants, forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, endophenotypes, antidepressant targets
MeSH terms: Animals, Behavior, Animal, Depressive Disorder, Disease Models, Animal, Mice, Mutant Strains, Sensitivity and Specificity, Reproducibility of Results, Animals, Genetically Modified, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks