A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12
Abstract
Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.
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The gene encoding P2X7R is located in a susceptibility locus of relevance to depression in humans.
“which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [69]
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- Authors
- Shink, E., Morissette, J., Sherrington, R., & Barden, N.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Barden, N
- Venue
- Molecular Psychiatry
- Published
- 2004-10-19
- Volume
- 10
- Issue
- 6
- Pages
- 545-552
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2017296923
- Cited by
- 79
- References
- 70
- Citations by year
- 2026: 1 · 2022: 4 · 2021: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, genetic susceptibility, chromosome 12q24, microsatellite markers, genome scan, model-independent analysis, mood disorders
- MeSH terms
- Adult, Bipolar Disorder, Chromosomes, Human, Pair 12, Genetic Testing, Humans, Genetic Linkage, Lod Score, Middle Aged, Models, Genetic, Pedigree, Polymorphism, Genetic, Quebec, Genome, Microsatellite Repeats, Genetic Predisposition to Disease
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