Cited by 79Bipolar Disorder and TreatmentGenetic Associations and EpidemiologySchizophrenia research and treatment

A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

Shink, E, Morissette, J, Sherrington, R, Barden, N·2005·Molecular Psychiatry

Abstract

Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.

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Crossref · 10.1038/sj.mp.4001601

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  • The gene encoding P2X7R is located in a susceptibility locus of relevance to depression in humans.

    “which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans.”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [69]

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Authors
Shink, E., Morissette, J., Sherrington, R., & Barden, N.
Affiliations
Centre hospitalier de l'Université Laval (CA)
Corresponding author
Barden, N
Venue
Molecular Psychiatry
Published
2004-10-19
Volume
10
Issue
6
Pages
545-552
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2017296923
Cited by
79
References
70
Citations by year
2026: 1 · 2022: 4 · 2021: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 5
FWCI
6.90
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar disorder, genetic susceptibility, chromosome 12q24, microsatellite markers, genome scan, model-independent analysis, mood disorders
MeSH terms
Adult, Bipolar Disorder, Chromosomes, Human, Pair 12, Genetic Testing, Humans, Genetic Linkage, Lod Score, Middle Aged, Models, Genetic, Pedigree, Polymorphism, Genetic, Quebec, Genome, Microsatellite Repeats, Genetic Predisposition to Disease

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