The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis
Abstract
Various studies have investigated whether single nucleotide polymorphisms (SNPs) in the gene purinergic receptor P2X7 (P2RX7), and rs2230912 specifically, were associated with mood disorders. While some studies found positive evidence, a large number of studies reported no significant associations. In a previously published meta-analysis, Feng et al. did not find a significant association and only moderate odds ratios (ORs) in case-control studies. They reported significant findings only for family-based studies. We revisited this finding and conducted a meta-analysis including 8,652 cases and 11,153 controls, adding unpublished results from the Munich Antidepressant Response Signature (MARS) study. We found a significant association between rs2230912 and combined mood disorders (major depressive disorder (MDD) or bipolar disorder (BD)) for the allelic, dominant and heterozygous-disadvantage model, all withstanding the threshold of correction for multiple testing. Stratifying by disorder revealed significant findings for the MDD-subgroup (OR of 1.12 for the allelic model), while the BD-subgroup presented with a lower effect size (OR of 1.05) and no significance. P2RX7 encodes a purinergic receptor which is expressed in the brain and also localized in immune cells. Animal studies and functional studies will be necessary to enlighten its involvement in the etiology of mood disorders and its applicability for pharmacological purposes.
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The latter meta-analysis reported a positive association with rs2230912 polymorphism and MDD.
“while the latter one reported a positive association with rs2230912 polymorphism and MDD [76].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [76]
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- Authors
- Czamara, D., Müller-Myhsok, B., & Lucae, S.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Czamara, D.
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 82
- Pages
- 272-277
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2767524142
- Cited by
- 60
- References
- 36
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 7
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- P2X7 receptor, major depressive disorder, bipolar disorder, mood disorders, genetic association, single nucleotide polymorphisms, genetic susceptibility
- MeSH terms
- Bipolar Disorder, Depression, Major Depressive Disorder, Humans, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Receptors, Purinergic P2X7
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