Cited by 491Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.

How psychotherapy changes the brain – the contribution of functional neuroimaging

Linden, D E J·2006·Molecular Psychiatry

DOI 10.1038/sj.mp.4001816

Open this paper in CoChat — free account

Abstract

A thorough investigation of the neural effects of psychotherapy is needed in order to provide a neurobiological foundation for widely used treatment protocols. This paper reviews functional neuroimaging studies on psychotherapy effects and their methodological background, including the development of symptom provocation techniques. Studies of cognitive behavioural therapy (CBT) effects in obsessive-compulsive disorder (OCD) were consistent in showing decreased metabolism in the right caudate nucleus. Cognitive behavioural therapy in phobia resulted in decreased activity in limbic and paralimbic areas. Interestingly, similar effects were observed after successful intervention with selective serotonin reuptake inhibitors (SSRI) in both diseases, indicating commonalities in the biological mechanisms of psycho- and pharmacotherapy. These findings are discussed in the context of current neurobiological models of anxiety disorders. Findings in depression, where both decreases and increases in prefrontal metabolism after treatment and considerable differences between pharmacological and psychological interventions were reported, seem still too heterogeneous to allow for an integrative account, but point to important differences between the mechanisms through which these interventions attain their clinical effects. Further studies with larger patient numbers, use of standardised imaging protocols across studies, and ideally integration with molecular imaging are needed to clarify the remaining contradictions. This effort is worthwhile because functional imaging can then be potentially used to monitor treatment effects and aid in the choice of the optimal therapy. Finally, recent advances in the functional imaging of hypnosis and the application of neurofeedback are evaluated for their potential use in the development of psychotherapy protocols that use the direct modulation of brain activity as a way of improving symptoms.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001816

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
A spelling device for the paralysed
Birbaumer, N., Ghanayim, N., Hinterberger, T., Iversen, I., Kotchoubey, B., Kübler, A., Perelmouter, J., Taub, E., & Flor, H. (1999) · Nature · doi:10.1038/18581 · Cited by 1,577
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,334
Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder
Baxter, L. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090009002 · Cited by 1,293
Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191
Modulation of Cortical-Limbic Pathways in Major Depression: Treatment-Specific Effects of Cognitive Behavior Therapy
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068
A Symptom Provocation Study of Posttraumatic Stress Disorder Using Positron Emission Tomography and Script-Driven Imagery
Rauch, S. L. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050014003 · Cited by 1,056
Biology and the Future of Psychoanalysis: A New Intellectual Framework for Psychiatry Revisited
Kandel, E. R. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.505 · Cited by 905
Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15—Labeled Carbon Dioxide and Positron Emission Tomography
Rauch, S. L. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010062008 · Cited by 880
Control over brain activation and pain learned by using real-time functional MRI
deCharms, R. C., Maeda, F., Glover, G. H., Ludlow, D., Pauly, J. M., Soneji, D., Gabrieli, J. D. E., & Mackey, S. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505210102 · Cited by 876
Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859
Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
D’Esposito, M., Deouell, L. Y., & Gazzaley, A. H. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1246 · Cited by 852
Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831
Regional Cerebral Blood Flow in the Amygdala and Medial PrefrontalCortex During Traumatic Imagery in Male and Female Vietnam Veterans With PTSD
Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Peters, P. M., Metzger, L. J., Dougherty, D. D., Cannistraro, P. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.168 · Cited by 790
Activation of Heschl’s Gyrus during Auditory Hallucinations
Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., & Singer, W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80715-1 · Cited by 752
Self-citation
The Functional Neuroanatomy of the Placebo Effect
Mayberg, H. S., Silva, J. A., Brannan, S., Tekell, J. L., Mahurin, R. K., McGinnis, S. M., & Jerabek, P. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.728 · Cited by 731
Different time courses of learning-related activity in the prefrontal cortex and striatum.
Pasupathy, A., & Miller, E. K. (2005) · Nature · doi:10.1038/nature03287 · Cited by 712
Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder
Bremner, J. D., Narayan, M., Staib, L. H., Southwick, S. M., McGlashan, T., & Charney, D. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1787 · Cited by 701
Systematic Changes in Cerebral Glucose Metabolic Rate After Successful Behavior Modification Treatment of Obsessive-Compulsive Disorder
Schwartz, J. M. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020023004 · Cited by 694
Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and Granger causality mapping
Goebel, R., Roebroeck, A. F., Kim, D., & Formisano, E. (2003) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.08.026 · Cited by 678
Neuroimaging studies of mood disorder effects on the brain
Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660
Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder
Breiter, H. C. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070041008 · Cited by 626
Cortical Representation of the Sensory Dimension of Pain
Hofbauer, R. K., Rainville, P., Duncan, G. H., & Bushnell, M. C. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.402 · Cited by 611
Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia
Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T. E., & Brown, G. G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1027 · Cited by 598
Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest
van de Ven, V. G., Formisano, E., Prvulovic, D., Röder, C. H., & Linden, D. E. J. (2004) · Human Brain Mapping · doi:10.1002/hbm.20022 · Cited by 538
Self-citation
Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
Furmark, T., Tillfors, M., Marteinsdottir, I., Fischer, H., Pissiota, A., Långström, B., & Fredrikson, M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.425 · Cited by 530
Dissociation of sensory and affective dimensions of pain using hypnotic modulation.
Rainville, P., Carrier, B., Hofbauer, R. K., Bushnell, C. M., & Duncan, G. H. (1999) · Pain · doi:10.1016/s0304-3959(99)00048-2 · Cited by 530
Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses: An [11C]DASB Positron Emission Tomography Study
Meyer, J. H., Wilson, A. A., Sagrati, S., Hussey, D., Carella, A., Potter, W. Z., Ginovart, N., Spencer, E. P., Cheok, A., & Houle, S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.826 · Cited by 517
Cerebral mechanisms of hypnotic induction and suggestion
Rainville, P., Hofbauer, R. K., Paus, T., Duncan, G. H., Bushnell, M. C., & Price, D. D. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563175 · Cited by 468
Functional Anatomy of Obsessive–Compulsive Phenomena
McGuire, P. K., Bench, C. J., Frith, C., Marks, I. M., Frackowiak, R. S. J., & Dolan, R. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.459 · Cited by 453
“Change the mind and you change the brain”: effects of cognitive-behavioral therapy on the neural correlates of spider phobia
Paquette, V., Lévesque, J., Mensour, B., Leroux, J.-M., Beaudoin, G., Bourgouin, P., & Beauregard, M. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00030-7 · Cited by 452
Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision) (DSM–IV–TR) Washington, DC: American Psychiatric Association 2000. 943 pp. £39.99 (hb). ISBN 0 89042 025 4
Cooper, J. E. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.1.85-a · Cited by 425
Physiological self-regulation of regional brain activity using real-time functional magnetic resonance imaging (fMRI): methodology and exemplary data
Weiskopf, N., Veit, R., Erb, M., Mathiak, K., Grodd, W., Goebel, R., & Birbaumer, N. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00145-9 · Cited by 422
fMRI reveals amygdala activation to human faces in social phobics
Birbaumer, N., Grodd, W., Diedrich, O., Klose, U., Erb, M., Lotze, M., Schneider, F., Weiss, U., & Flor, H. (1998) · NeuroReport · doi:10.1097/00001756-199804200-00048 · Cited by 390
Occupancy of Serotonin Transporters by Paroxetine and Citalopram During Treatment of Depression: A [11C]DASB PET Imaging Study
Meyer, J. H., Wilson, A. A., Ginovart, N., Goulding, V. S., Hussey, D. F., Hood, K., & Houle, S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1843 · Cited by 339
Learned regulation of spatially localized brain activation using real-time fMRI
deCharms, R. C., Kalina Christoff, A., Glover, G. H., Pauly, J. M., Whitfield‐Gabrieli, S., & Gabrieli, J. D. E. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.041 · Cited by 335
Brain Blood Flow Changes in Depressed Patients Treated With Interpersonal Psychotherapy or Venlafaxine Hydrochloride
Martin, S. D., Martin, E., Rai, S. S., Richardson, M. A., & Royall, R. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.641 · Cited by 324
Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: a functional magnetic resonance imaging study
Nakao, T., Nakagawa, A., Yoshiura, T., Nakatani, E., Nabeyama, M., Yoshizato, C., Kudoh, A., Tada, K., Yoshioka, K., Kawamoto, M., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.039 · Cited by 307
The Neurobiology of Mental Illness
Chatterjee, R. B. A. (2005) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.17.4.556 · Cited by 303
A Positron Emission Tomographic Study of Simple Phobic Symptom Provocation
Rauch, S. L. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950130020003 · Cited by 298
FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
Brody, A. L., Saxena, S., Schwartz, J. M., Stoessel, P. W., Maidment, K., Phelps, M. E., & Baxter, L. R. (1998) · Psychiatry Research: Neuroimaging · doi:10.1016/s0925-4927(98)00041-9 · Cited by 285
Brain activation by disgust-inducing pictures in obsessive-compulsive disorder
Shapira, N. A., Liu, Y., He, A. G., Bradley, M. M., Lessig, M. C., James, G. A., Stein, D. J., Lang, P. J., & Goodman, W. K. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00003-9 · Cited by 269
Decrease in Thalamic Volumes of Pediatric Patients With Obsessive-compulsive Disorder Who Are Taking Paroxetine
Gilbert, A. R., Moore, G. J., Keshavan, M. S., Paulson, L. A. D., Narula, V., Mac Master, F. P., Stewart, C. M., & Rosenberg, D. R. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.449 · Cited by 266
Effects of cognitive-behavioral therapy on brain activation in specific phobia
Straube, T., Glauer, M., Dilger, S., Mentzel, H.-J., & Miltner, W. H. R. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.007 · Cited by 264
Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study
Pissiota, A., Frans, Ö., Fernandez, M., von Knorring, L., Fischer, H., & Fredrikson, M. (2002) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060200014 · Cited by 228
The functional neuroanatomy of major depression
Beauregard, M., Leroux, J., Bergman, S., Arzoumanian, Y., Beaudoin, G., Bourgouin, P. M., & Stip, É. (1998) · Neuroreport · doi:10.1097/00001756-199810050-00022 · Cited by 225
Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., & Baxter, L. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.522 · Cited by 210
Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder
Drießen, M., Beblo, T., Mertens, M., Piefke, M., Rullkoetter, N., Saavedra, A. S., Reddemann, L., Rau, H., Markowitsch, H. J., Wulff, H., et al. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.018 · Cited by 192
Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study
Dilger, S., Straube, T., Mentzel, H., Fitzek, C., Reichenbach, J. R., Hecht, H., Krieschel, S., Gutberlet, I., & Miltner, W. H. R. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00647-5 · Cited by 190
The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry
Ebert, D., & Ebmeier, K. P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00320-7 · Cited by 170
Neural correlates of anxiety associated with obsessive–compulsive symptom dimensions in normal volunteers
Mataix-Cols, D., Cullen, S., Lange, K., Zelaya, F., Andrew, C., Amaro, E., Brammer, M. J., Williams, S. C. R., Speckens, A., & Phillips, M. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01504-4 · Cited by 152
Amygdala Volume Reductions in Pediatric Patients with Obsessive–Compulsive Disorder Treated with Paroxetine: Preliminary Findings
Szeszko, P. R., MacMillan, S., McMeniman, M., Lorch, E., Madden, R., Ivey, J., Banerjee, S. P., Moore, G. J., & Rosenberg, D. R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300399 · Cited by 141
Effects of behavior therapy on regional cerebral blood flow in obsessive–compulsive disorder
Nakatani, E. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00069-6 · Cited by 140
Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods.
Rauch, S. L., Whalen, P. J., Curran, T., Shin, L. M., Coffey, B. J., Savage, C. R., McInerney, S. C., Baer, L., & Jenike, M. A. (2001) · PubMed · Cited by 133
Single photon emission computerized tomography assessment of cerebral dopamine D2 receptor blockade in depression before and after sleep deprivation—preliminary results
Ebert, D., Feistel, H., Kaschka, W. P., Barocka, A., & Pirner, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90024-8 · Cited by 133
The change of regional brain metabolism (18FDG PET) in panic disorder during the treatment with cognitive behavioral therapy or antidepressants.
Praško, J. P., Horáček, J., Záleský, R., Kopeček, M., Novák, T., Paskova, B., Skrdlantová, L., Bělohlávek, O., & Höschl, C. (2004) · PubMed · Cited by 130
?-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo
Pirker, W., Asenbaum, S., Kasper, S. F., Walter, H., Angelberger, P., Koch, G., Pozzera, A., Deecke, L., Podreka, I., & Br�cke, T. (1995) · Journal of Neural Transmission · doi:10.1007/bf01276462 · Cited by 127
The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development
Talbot, P. S. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00099-8 · Cited by 119
Neuroanatomical aspects of cognitive-behavioural therapy response in obsessive-compulsive disorder
Schwartz, J. M. (1998) · The British Journal of Psychiatry · doi:10.1192/s0007125000297882 · Cited by 116
The Emerging Dialogue Between Psychoanalysis and Neuroscience: Neuroimaging Perspectives
Beutel, M. E., Stern, E. R., & Silbersweig, D. (2003) · Journal of the American Psychoanalytic Association · doi:10.1177/00030651030510030101 · Cited by 83
Pain Response in Depersonalization: A Functional Imaging Study Using Hypnosis in Healthy Subjects
Röder, C. H., Michal, M., Overbeck, G., van de Ven, V. G., & Linden, D. E. J. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000097970 · Cited by 82
Self-citation
PET Studies of Brain Monoamine Transporters
Laakso, A., & Hietala, J. A. (2000) · Current Pharmaceutical Design · doi:10.2174/1381612003398799 · Cited by 71
Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with [ 11 C]McN 5652
KENT, J. M., Coplan, J. D., Lombardo, I., Hwang, D., Huang, Y. H., Mawlawi, O. R., Heertum, R. V., Slifstein, M., Abi‐Dargham, A., Gorman, J. M., et al. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1218-8 · Cited by 71
Imaging Brain Function with Positron Emission Tomography
Cherry, S. R., & Phelps, M. E. (2002) · Elsevier eBooks · doi:10.1016/b978-012693019-1/50020-4 · Cited by 65
Normalization of Frontal Cerebral Perfusion in Remitted Elderly Major Depression: A 12-Month Follow-Up SPECT Study
Navarro, V., Gastó, C., Lomeña, F., Mateos, J. J., Marcos, T., & Portella, M. J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1051 · Cited by 57
Neurobiology of mental illness, 2nd ed.
Charney, D. S., & Nestler, E. J. (2004) · Cited by 57
SERT and DAT availabilities under citalopram treatment in obsessive–compulsive disorder (OCD)
Pogarell, O. M., Poepperl, G., Mulert, C., Hamann, C., Sadowsky, N., Riedel, M. J., Moeller, H., Hegerl, U., & Tatsch, K. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.01.003 · Cited by 49
Brain reactivity to specific symptom provocation indicates prospective therapeutic outcome in OCD
Hendler, T. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00091-x · Cited by 49
Risperidone-induced rabbit syndrome
Schwartz, M., Berry, A., & Sharf, B. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.3.267b · Cited by 34
Behavior therapy: endogenous serotonin therapy?
Baer, L. (1996) · PubMed · Cited by 25
Adaptivity and Learning — an Interdisciplinary Debate
Kühn, R., Menzel, R., Menzel, W., Ratsch, U., Richter, M. M., & Stamatescu, I.-O. (2003) · Springer eBooks · doi:10.1007/978-3-662-05594-6_1 · Cited by 23
Neuroimaging Profiles and the Differential Therapies of Depression
Thase, M. E. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.651 · Cited by 18
Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: preliminary findings
Road, W., Tyne, N. U., & Be, N. (2004) · Cited by 17
Different fMRI activation patterns of traumatic memory in Borderline personality disorder with and without additional posttraumatic stress disorder
Drießen, M., Beblo, T., Mertens, M., Piefke, M., Rullkötter, N., Saveedra, A. S., Reddemann, L., Rau, H., Markowitsch, H. J., Wulff, H., et al. (2003) · PUB – Publications at Bielefeld University (Bielefeld University) · Cited by 15
Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy: Preliminary Findings
Brody, A. L., Saxena, S., Stoessel, P., Gillies, L. A., Fairbanks, L. A., Alborzian, S., Phelps, M. E., Huang, S.-C., Wu, H.-M., Ho, M. L., et al. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.7.631 · Cited by 5
Cerebral Mechanisms of Learning Revealed by Functional Neuroimaging in Humans
Linden, D. E. J. (2003) · Springer eBooks · doi:10.1007/978-3-662-05594-6_5 · Cited by 3
Self-citation
Funktionelle Bildgebung und Psychotherapie
Linden, D. E. J., Prvulovic, D., Stirn, A., & Maurer, K. (2004) · Max Planck Institute for Plasma Physics · Cited by 2
Self-citation

Flagged first, then by citations

1 of the 80 references couldn’t be matched to a known paper.

Sorted by citations

Neurobiology of resilience
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206
Cognitive theory and therapy of anxiety and depression: Convergence with neurobiological findings
Clark, D. A., & Beck, A. T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.06.007 · Cited by 619
Real-Time Self-Regulation of Emotion Networks in Patients with Depression
Linden, D. E. J., Isabelle, H., Johnston, S. J., Linden, S. C., Ranjit, T., Subramanian, L., Sorger, B., Healy, D., & Goebel, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038115 · Cited by 438
Self-citation
Physiologic correlates of perceived therapist empathy and social-emotional process during psychotherapy.
Marci, C. D., Ham, J., Moran, E., & Orr, S. P. (2007) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000253731.71025.fc · Cited by 364
The Science of Cognitive Therapy
Hofmann, S. G., Asmundson, G. J. G., & Beck, A. T. (2013) · Behavior Therapy · doi:10.1016/j.beth.2009.01.007 · Cited by 366

See all 491

Authors: Linden, D. E. J.
Affiliations: Bangor University (GB)
Corresponding author: Linden, D E J
ORCID: Linden, D E J
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2006-03-07
Volume: 11
Issue: 6
Pages: 528-538
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001816
OpenAlex: W2167882471
Cited by: 491
References: 80
Citations by year: 2026: 8 · 2025: 9 · 2024: 17 · 2023: 14 · 2022: 13 · 2021: 63 · 2020: 14 · 2019: 17 · 2018: 17 · 2017: 23 · 2016: 26 · 2015: 33 · 2014: 31 · 2013: 44 · 2012: 38
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: psychotherapy, functional neuroimaging, cognitive behavioral therapy, obsessive-compulsive disorder, phobia, caudate nucleus, limbic system, selective serotonin reuptake inhibitors, pharmacotherapy, anxiety disorders, depression, treatment monitoring, hypnosis, neurofeedback
MeSH terms: Anxiety Disorders, Mental Disorders, Brain Mapping, Depression, Humans, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Phobic Disorders, Psychotherapy, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Feedback, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How psychotherapy changes the brain – the contribution of functional neuroimaging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks