Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study
Abstract
Summary Patients with combat-related posttraumatic stress disorder (PTSD) show altered cognitive and affective processing and symptomatic responding following exposure to trauma reminders. Previous symptom provocation studies using brain imaging have involved Vietnam veterans. In this study neural correlates were investigated in patients with PTSD resulting from trauma in more recent war zones. (15)Oxygen water and positron emission tomography were used to measure regional cerebral blood flow (rCBF) in patients with war- and combat-related chronic PTSD during exposure to combat and neutral sounds. Self-reports and heart rate confirmed symptomatic responding during traumatic stimulation. The war-related condition, as compared to the neutral, increased rCBF in the right sensorimotor areas (Brodmann areas 4/6), extending into the primary sensory cortex (areas 1/2/3), and the cerebellar vermis. RCBF also increased in the right amygdala and in the periaqueductal gray matter adjacent to the pons. During provocation rCBF was lowered in the right retrosplenial cortex (areas 26/29/30 extending into area 23). Symptom provocation in PTSD promote sensorimotor, amygdaloid and midbrain activation. We conclude that perceptually induced symptom activation in PTSD is associated with an emotionally determined motor preparation and propose that subcortically initiated rather than cortically controlled memory mechanisms determine this pattern.
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Current research indicates increased amygdala activation during a traumatic affective experience.
“Current research indicates an increased level of amygdala activation during a traumatic affective experience.”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Pissiota et al. (2002)
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Self-citation
- Authors
- Pissiota, A., Frans, Ö., Fernandez, M., von Knorring, L., Fischer, H., & Fredrikson, M.
- Affiliations
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Harvard University (US)
- ORCID
- Fischer, Håkan
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2002-04
- Volume
- 252
- Issue
- 2
- Pages
- 68-75
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2092796129
- Cited by
- 228
- References
- 52
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 11 · 2013: 5 · 2012: 8
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, combat-related PTSD, symptom provocation, regional cerebral blood flow, sensorimotor cortex, amygdala, periaqueductal gray, cerebellar vermis, retrosplenial cortex, war veterans, trauma reminders, emotional memory, motor preparation
- MeSH terms
- Adult, Amygdala, Anxiety Disorders, Brain, Cerebrovascular Circulation, Cognition Disorders, Heart Rate, Humans, Male, Middle Aged, Pons, Psychology, Somatoform Disorders, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Mood Disorders
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