The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry
Abstract
Depressive episodes as reversible mental states are likely to be associated with equally reversible brain states. These can be examined with a variety of functional imaging methods using repeated measures designs. Studies using such an approach are reviewed. Changes in medial frontal, and in particular, cingulate cortex are reported in a majority of studies. Similarities and differences between different study results are discussed on the background of the functional neuroanatomy of the anterior cingulate, taking into account a variety of neurotransmitter systems. It is concluded that neuroimaging techniques are starting to equip us to conceptualize functional changes in the limbic loop containing the anterior cingulate as the common denominator of change and therapy effects in depressive states.
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The frontopolar and subgenual cingulate cortex are important nodes in a network of brain regions implicated in the pathogenesis of major depression.
“The frontopolar and subgenual cingulate cortex, which have been linked with the experience of guilt in healthy participants (see above), are important nodes in a network of brain regions that have been implicated in the pathogenesis of major depression (Seminowicz et al. 2004;Ebert and Ebmeier, 1996;Drevets and Sayvitz, 2008;Mayberg, 2007).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Ebert and Ebmeier, 1996
Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · cited 1× · see citing works
“In healthy subjects such different conditions as activation of attentional processes (Petersen et al 1989; Pardo et al 1990; Posner and Petersen 1990; Roland et al 1990; Janer and Pardo 1991; Bench et al 1993), and higher extraversion scores (Haier et al 1987; Ebmeier et al 1994) are associated with an active anterior…”
BackgroundJ Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818 · see citing works
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563 · see citing works
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329 · see citing works
Pardo, J. V., Pardo, P. J., Janer, K. W., & Raichle, M. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.256 · Cited by 1,495 · see citing works
Reduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression
Baxter, L. R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810030049007 · Cited by 1,320 · see citing works
Positron Emission Tomographic Studies of the Processing of Singe Words
Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M. A., & Raichle, M. E. (1989) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1989.1.2.153 · Cited by 1,298 · see citing works
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266 · see citing works
Investigations of the functional anatomy of attention using the stroop test
Bench, C. J., Frith, C., Grasby, P. M., Friston, K. J., Paulesu, E., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Neuropsychologia · doi:10.1016/0028-3932(93)90147-r · Cited by 833 · see citing works
Isaacson, R. L. (1974) · Medical Entomology and Zoology · Cited by 743 · see citing works
The anatomy of melancholia – focal abnormalities of cerebral blood flow in major depression
Bench, C. J., Friston, K. J., Brown, R. G., Scott, L. C., Frackowiak, R. S. J., & Dolan, R. J. (1992) · Psychological Medicine · doi:10.1017/s003329170003806x · Cited by 717 · see citing works
Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674 · see citing works
Wu, J. C., & Bunney, W. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.1.14 · Cited by 614 · see citing works
THE DUALITY OF THE CINGULATE GYRUS IN MONKEY
Baleydier, C., & Mauguı̀ere, F. (1980) · Brain · doi:10.1093/brain/103.3.525 · Cited by 504 · see citing works
Depression in Parkinson??s Disease
STARKSTEIN, S. E., Preziosi, T. J., BOLDUC, P. L., & ROBINSON, R. G. (1990) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199001000-00005 · Cited by 482 · see citing works
Left prefrontal glucose hypometabolism in the depressed state: a confirmation
Martinot, J., Hardy, P., Féline, A., Huret, J. D., Mazoyer, B. M., Attar-Levy, D., Pappatà, S., & Syrota, A. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.10.1313 · Cited by 468 · see citing works
Brain evolution relating to family, play, and the separation call.
Maclean, P. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790270095011 · Cited by 406 · see citing works
Brown, R. M., Crane, A. M., & Goldman, P. S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90132-x · Cited by 330 · see citing works
Derbyshire, S. W. G., Jones, A. K. P., Devani, P., Friston, K. J., Feinmann, C., Harris, M., Pearce, S. A., Watson, J. D. G., & Frackowiak, R. S. J. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.10.1166 · Cited by 318 · see citing works
Effect of sleep deprivation on brain metabolism of depressed patients
Wu, J. C., Gillin, J. C., Buchsbaum, M. S., Hershey, T. G., Johnson, J., & Bunney, W. E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.4.538 · Cited by 290 · see citing works
Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography
Buchsbaum, M. S., Gillin, J. C., Wu, J. C., Hazlett, E. A., Sicotte, N. L., Dupont, R. M., & Bunney, W. E. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90021-0 · Cited by 280 · see citing works
Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity?
Dolan, R. J., Bench, C. J., Liddle, P. F., Friston, K. J., Frith, C. D., Grasby, P. M., & Frackowiak, R. S. (1993) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.12.1290 · Cited by 261 · see citing works
Regional Cerebral Blood Flow in Mood Disorders, III
Nobler, M. S. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110044007 · Cited by 255 · see citing works
(1992) · PubMed · Cited by 226 · see citing works
Brain regions involved in recognizing facial emotion or identity: an oxygen-15 PET study
George, M. S., Ketter, T. A., Gill, D. S., Haxby, J. V., Ungerleider, L. G., Herscovitch, P., & Post, R. M. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.4.384 · Cited by 221 · see citing works
Depression in Parkinson's Disease: A Positron Emission Study
Ring, H. A., Bench, C. J., Trimble, M. R., Brooks, D. J., Frackowiak, R. S. J., & Dolan, R. J. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.165.3.333 · Cited by 219 · see citing works
Personality Dimensions and Arousal
Strelau, J., & Eysenck, H. J. (1987) · Springer eBooks · doi:10.1007/978-1-4899-2043-0 · Cited by 208 · see citing works
Ebert, D., Feistel, H., & Barocka, A. (1991) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(91)90016-j · Cited by 192 · see citing works
Self-citationDopamine D2 receptors in depression measured with single photon emission computed tomography
D'haenen, H. A., & Bossuyt, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91202-5 · Cited by 189 · see citing works
SPECT and PET imaging in mood disorders.
George, M. S., Ketter, T. A., & Post, R. M. (1993) · PubMed · Cited by 171 · see citing works
Austin, M., Dougall, N. J., Ross, M. C., Murray, C., O’Carroll, R. E., Moffoot, A. P. R., Ebmeier, K. P., & Goodwin, G. M. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90032-2 · Cited by 168 · see citing works
Self-citationNeuropsychological dysfunction in depression: the relationship to regional cerebral blood flow
Dolan, R. J., Bench, C. J., Brown, R. G., Scott, L. C., & Frackowiak, R. S. J. (1994) · Psychological Medicine · doi:10.1017/s0033291700028944 · Cited by 155 · see citing works
Ebert, D., Feistel, H., Kaschka, W. P., Barocka, A., & Pirner, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90024-8 · Cited by 133 · see citing works
Self-citationThe frontal lobes: Uncharted provinces of the brain
Goldman‐Rakic, P. S. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80147-2 · Cited by 120 · see citing works
Regional Cerebral Glucose Metabolism in Major Depressive Disorder
Hurwitz, T. A., Clark, C. C., Murphy, E., Klonoff, H., Martin, W. R. W., & Pate, B. D. (1990) · The Canadian Journal of Psychiatry · doi:10.1177/070674379003500807 · Cited by 117 · see citing works
Goodwin, G. M., Austin, M., Dougall, N. J., Ross, M. C., Murray, C. L., O'Carroll, R. E., Moffoot, A. P. R., Prentice, N. P., & Ebmeier, K. P. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90014-b · Cited by 117 · see citing works
Self-citationDiurnal variation of mood and neuropsychological function in major depression with melancholia
Moffoot, A. P. R., O’Carroll, R. E., Bennie, J., Carroll, S., Dick, H., Ebmeier, K. P., & Goodwin, G. M. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90090-6 · Cited by 113 · see citing works
Self-citationDeficits in selective attention following bilateral anterior cingulotomy
Janer, K. W., & Pardo, J. V. (1991) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1991.3.3.231 · Cited by 112 · see citing works
Increased limbic blood flow and total sleep deprivation in major depression with melancholia
Ebert, D., Feistel, H., Barocka, A., & Kaschka, W. P. (1994) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(94)90004-3 · Cited by 108 · see citing works
Self-citationPET Studies of Presynaptic Monoamine Metabolism in Depressed Patients and Healthy Volunteers
Ågren, H., & Reibring, L. (1994) · Pharmacopsychiatry · doi:10.1055/s-2007-1014265 · Cited by 74 · see citing works
Grasby, P. M., Friston, K. J., Bench, C. J., Cowen, P. J., Frith, C., Liddle, P. F., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Psychological Medicine · doi:10.1017/s0033291700025381 · Cited by 60 · see citing works
Scott, A. I. F., Dougall, N. J., Ross, M. C., O’Carroll, R. E., Riddle, W. J. R., Ebmeier, K. P., & Goodwin, G. M. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90148-1 · Cited by 59 · see citing works
Self-citationFunctional anatomy of storage, recall, and recognition of a visual pattern in man
Roland, P. E., Gulyás, B. Z., Rj, S., Böhm, C., & Stone‐Elander, S. (1990) · Neuroreport · doi:10.1097/00001756-199009000-00015 · Cited by 57 · see citing works
The Study of Personality with Positron Emission Tomography
Haier, R. J., Sokolski, K. N., Katz, M., et al. (1987) · Springer eBooks · doi:10.1007/978-1-4899-2043-0_15 · Cited by 56 · see citing works
Ebmeier, K. P., Deary, I. J., O’Carroll, R. E., Prentice, N. P., Moffoot, A. P. R., & Goodwin, G. M. (1994) · Personality and Individual Differences · doi:10.1016/0191-8869(94)90131-7 · Cited by 52 · see citing works
Self-citationPersonality dimensions and arousal
Larsen, R. J. (1987) · Biological Psychology · doi:10.1016/0301-0511(87)90040-8 · Cited by 48 · see citing works
Volk, S., Kaendler, S., Weber, R., Georgi, K., Maul, F. D., Hertel, A., Pflug, B., & Hör, G. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03301.x · Cited by 44 · see citing works
Effect of ECT on Cerebral Blood Flow in Melancholia Assessed with SPECT.
Rosenberg, R., Vorstrup, S., Andersen, A. R., et al. (1988) · PubMed · Cited by 42 · see citing works
Deary, I. J., Ebmeier, K. P., MacLeod, K. M., Dougall, N. J., Hepburn, D. A., Frier, B. M., & Goodwin, G. M. (1994) · Biological Psychology · doi:10.1016/0301-0511(94)90046-9 · Cited by 32 · see citing works
Self-citationA Double FDG/PET Study of the Effects of Scopolamine in Older Adults
Molchan, S. E., Matochik, J. A., Zametkin, A. J., et al. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.21 · Cited by 24 · see citing works
Draper, I. T. (1972) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.35.1.146-c · Cited by 17 · see citing works
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Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029 · see citing works
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Koger, J. V., Benca, R. M., & Davidson, R. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.405 · Cited by 630 · see citing works
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545 · see citing works
How psychotherapy changes the brain – the contribution of functional neuroimaging
Linden, D. E. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001816 · Cited by 491 · see citing works
Recent developments and current controversies in depression
Ebmeier, K. P., Donaghey, C., & Steele, J. D. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67964-6 · Cited by 434 · see citing works
Self-citationNeural and behavioral substrates of mood and mood regulation
Davidson, R. J., Lewis, D. A., Alloy, L. B., Amaral, D. G., Bush, G., Cohen, J. D., Drevets, W. C., Farah, M. J., Kagan, J., McClelland, J. L., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01458-0 · Cited by 411 · see citing works
The functional neuroanatomy of mood disorders
Soares, J. C., & Mann, J. J. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00016-2 · Cited by 379 · see citing works
Dougherty, D. D., Baer, L., Cosgrove, G. R., Cassem, E. H., Price, B. H., Nierenberg, A. A., Jenike, M. A., & Rauch, S. L. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.269 · Cited by 354 · see citing works
Affective Cognition and its Disruption in Mood Disorders
Elliott, R., Zahn, R., Deakin, J. F. W., & Anderson, I. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.77 · Cited by 330 · see citing works
Positron emission tomography imaging in depression: a neural systems perspective
Mayberg, H. S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00104-7 · Cited by 255 · see citing works
ROSENBERG, D. R., MIRZA, Y., RUSSELL, A., TANG, J., SMITH, J. M., BANERJEE, S. P., BHANDARI, R., ROSE, M., IVEY, J., BOYD, C., et al. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000132812.44664.2d · Cited by 246 · see citing works
Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity
Levin, R. L., Heller, W., Mohanty, A., Herrington, J. D., & Miller, G. A. (2007) · Cognitive Therapy and Research · doi:10.1007/s10608-007-9128-z · Cited by 187 · see citing works
Early Identification and Intervention in Depressive Disorders: Towards a Clinical Staging Model
Hetrick, S. E., Parker, A. G., Hickie, I. B., Purcell, R., Yung, A. R., & McGorry, P. D. (2008) · Psychotherapy and Psychosomatics · doi:10.1159/000140085 · Cited by 186 · see citing works
Videbech, P., Ravnkilde, B., Pedersen, T. H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N. A., Andersen, F., Gjedde, A., & Rosenberg, R. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02245.x · Cited by 161 · see citing works
A cognitive neuroscience hypothesis of mood and depression.
Bar, M. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.08.009 · Cited by 152 · see citing works
Opbroek, A., Delgado, P. L., Laukes, C., McGahuey, C., Katsanis, J., Moreno, F. A., & Manber, R. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002870 · Cited by 147 · see citing works
Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
Treadway, M. T., Grant, M. M., Ding, Z., Hollon, S. D., Gore, J. C., & Shelton, R. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004887 · Cited by 142 · see citing works
Jung, H. H., Kim, C.-H., Chang, J. H., Park, Y. G., Chung, S. S., & Chang, J. W. (2006) · Stereotactic and Functional Neurosurgery · doi:10.1159/000095031 · Cited by 140 · see citing works
Alexander, L., Gaskin, P. L. R., Sawiak, S. J., Fryer, T. D., Hong, Y. T., Cockcroft, G. J., Clarke, H. F., & Roberts, A. C. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.021 · Cited by 120 · see citing works
Aerobic Endurance Exercise Improves Executive Functions in Depressed Patients
Kubesch, S., Bretschneider, V., Freudenmann, R., Weidenhammer, N., Lehmann, M., Spitzer, M., & Grön, G. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0905 · Cited by 125 · see citing works
Lythe, K. E., Moll, J., Gethin, J. A., Workman, C. I., Green, S., Lambon Ralph, M. A., Deakin, J. F. W., & Zahn, R. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1813 · Cited by 91 · see citing works
Gillin, J. C., Buchsbaum, M., Wu, J., Clark, C., & Bunney, W. (2001) · Depression and Anxiety · doi:10.1002/da.1045 · Cited by 103 · see citing works
Nobuhara, K., Okugawa, G., Minami, T., Takase, K., Yoshida, T., Yagyu, T., Tajika, A., Sugimoto, T., Tamagaki, C., Ikeda, K., et al. (2004) · Neuropsychobiology · doi:10.1159/000077941 · Cited by 94 · see citing works
Stawicka, Z. M., Massoudi, R., Horst, N. K., Koda, K., Gaskin, P. L. R., Alexander, L., Santangelo, A. M., McIver, L., Cockcroft, G. J., Wood, C. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009657117 · Cited by 22 · see citing works
- Authors
- Ebert, D., & Ebmeier, K. P.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Royal Edinburgh Hospital (GB)
- Corresponding author
- Ebmeier, Klaus P.
- ORCID
- Ebmeier, Klaus P.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 39
- Issue
- 12
- Pages
- 1044-1050
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2027112427
- Cited by
- 170
- References
- 52
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cingulate gyrus, anterior cingulate cortex, depression, functional neuroanatomy, neurotransmitter systems
- MeSH terms
- Brain Mapping, Depressive Disorder, Dominance, Cerebral, Energy Metabolism, Frontal Lobe, Gyrus Cinguli, Humans, Neural Pathways, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Neurotransmitter Agents
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