The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins
Abstract
Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n=69) were compared to typically developing children (n=35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.
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“Elevated plasma cytokine levels (IL-1β, IL-6, IL-12p40 and TNFα) [82–84], altered immunoglobulin levels [85, 86], elevated levels of complement proteins [87], and increased chemokine levels (CCL2, CCL5 and CCL11) [88] are reported in the plasma of young children with AD compared with matched typically developing children.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [87]
Citations
Cites
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Perkins, D. N., Pappin, D., Creasy, D. M., & Cottrell, J. S. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19991201)20:18 · Cited by 8,264
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Stanford-Binet Intelligence Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_70151 · Cited by 1,671
An overview of the immune system
Parkin, J., & Cohen, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04904-7 · Cited by 1,593
Autism screening questionnaire: diagnostic validity
Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999) · British Journal of Psychiatry · doi:10.1192/bjp.175.5.444 · Cited by 1,464
Practice parameter: Screening and diagnosis of autism
Filipek, P. A., Accardo, P., Ashwal, S., Baranek, G. T., Cook, E. H., Dawson, G., Gordon, B., Gravel, J. S., Johnson, C. P., Kallen, R. J., et al. (2000) · Neurology · doi:10.1212/wnl.55.4.468 · Cited by 1,106
Research works printed but not linked: 1
- Lord C, Rutter M, DiLavore PC, Risi S . Autism Diagnostic Observation Schedule (ADOS). Western Psychological Services: Los Angeles, CA, 2002.
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Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940
“, 2010) and increased levels of complement components (Corbett et al., 2007).”
BackgroundSelf-citationConsensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
“Elevated plasma cytokine levels (IL-1β, IL-6, IL-12p40, and TNFα) [82–84], altered immunoglobulin levels [85, 86], elevated levels of complement proteins [87], and increased chemokine levels (CCL2, CCL5, and CCL11) [88] are reported in the plasma of young children with AD compared with matched typically developing chi…”
BackgroundSelf-citationThe role of immune dysfunction in the pathophysiology of autism
Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635
“…be associated with the presence of brain-reactive antibodies in the CNS. Similarly, dysregulated complement production in ASD may have a similar effect (Corbett et al., 2007; Odell et al., 2005), as complement opsonization can mediate the phagocytosis of neurons by microglia (Gasque et al., 2002).”
InfluentialSelf-citationMicroglial Activation in Young Adults With Autism Spectrum Disorder
Suzuki, K., Sugihara, G., Ouchi, Y., Nakamura, K., Futatsubashi, M., Takebayashi, K., Yoshihara, Y., Omata, K., Matsumoto, K., Tsuchiya, K. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.272 · Cited by 523
ADHD and autism: differential diagnosis or overlapping traits? A selective review
Taurines, R., Schwenck, C., Westerwald, E., Sachse, M., Siniatchkin, M., & Freitag, C. (2012) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0086-2 · Cited by 301
“Proteins Methods Reference ASD fmr1 -/-mouse in vitro 132 differentially expressed proteins, among others: dynamin1, N-ethylmaleimide sensitive fusion protein attachment protein (SNAP)-beta, syntaxin binding protein 1, calbindin 2, CDCrel-1AI SILAC Liao et al. (2008) Human total brain gray matter Glyoxalase 1 2D-PAGE…”
Influential
Metadata
- Authors
- Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R.
- Affiliations
- University of California Davis Medical Center (US)
- Pharmaceutical Product Development (United States) (US)
- University of California, Davis (US)
- Corresponding author
- Corbett, B A
- Venue
- Molecular Psychiatry
- Published
- 2006-12-26
- Volume
- 12
- Issue
- 3
- Pages
- 292-306
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2011080454
- Cited by
- 197
- References
- 97
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 11 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 4 · 2015: 12 · 2014: 18 · 2013: 14 · 2012: 14
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (5K08NMHO72958)
- National Human Genome Research Institute (R01HG003352)
- National Institute of Neurological Disorders and Stroke (NS044283, R01NS043252, NS028167, P50NS044283, NS043252, R01NS028167)
- National Institute of Environmental Health Sciences (P42-ES-04699, P42ES004699)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- autism spectrum disorder, serum proteomics, apolipoproteins, apolipoprotein B-100, apolipoprotein A-IV, complement system, complement factor H-related proteins, C1q, FN1, differentially expressed proteins, children, high-functioning autism, peripheral blood biomarkers
- MeSH terms
- Apolipoproteins, Autistic Disorder, Child, Child, Preschool, Complement System Proteins, Female, Humans, Male, Mass Spectrometry, Gene Expression, Statistics, Nonparametric, Proteomics
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