Cited by 197Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersAdvanced Proteomics Techniques and Applications

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A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins

Corbett, B A, Kantor, A B, Schulman, H, Walker, W L, Lit, L, Ashwood, P, Rocke, D M, Sharp, F R·2007·Molecular Psychiatry

DOI 10.1038/sj.mp.4001943

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Abstract

Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n=69) were compared to typically developing children (n=35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.

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Authors: Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R.
Affiliations: University of California Davis Medical Center (US)
Pharmaceutical Product Development (United States) (US)
University of California, Davis (US)
Corresponding author: Corbett, B A
ORCID: Corbett, B A
Schulman, H
Ashwood, P
Rocke, D M
Sharp, F R
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2006-12-26
Volume: 12
Issue: 3
Pages: 292-306
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001943
OpenAlex: W2011080454
Cited by: 197
References: 97
Citations by year: 2026: 3 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 11 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 4 · 2015: 12 · 2014: 18 · 2013: 14 · 2012: 14
FWCI: 2.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (5K08NMHO72958)
National Human Genome Research Institute (R01HG003352)
National Institute of Neurological Disorders and Stroke (NS044283, R01NS043252, NS028167, P50NS044283, NS043252, R01NS028167)
National Institute of Environmental Health Sciences (P42-ES-04699, P42ES004699)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: autism spectrum disorder, serum proteomics, apolipoproteins, apolipoprotein B-100, apolipoprotein A-IV, complement system, complement factor H-related proteins, C1q, FN1, differentially expressed proteins, children, high-functioning autism, peripheral blood biomarkers
MeSH terms: Apolipoproteins, Autistic Disorder, Child, Child, Preschool, Complement System Proteins, Female, Humans, Male, Mass Spectrometry, Gene Expression, Statistics, Nonparametric, Proteomics

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A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins

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