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A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins
Abstract
Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n=69) were compared to typically developing children (n=35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.
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“Elevated plasma cytokine levels (IL-1β, IL-6, IL-12p40 and TNFα) [82–84], altered immunoglobulin levels [85, 86], elevated levels of complement proteins [87], and increased chemokine levels (CCL2, CCL5 and CCL11) [88] are reported in the plasma of young children with AD compared with matched typically developing children.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [87]
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Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635
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InfluentialSelf-citationMicroglial Activation in Young Adults With Autism Spectrum Disorder
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InfluentialAn in vivo neuroimmune organoid model to study human microglia phenotypes
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“. And increased levels of inflammatory cytokines have been detected even in peripheral samples such as serum”
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Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 264
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Gesundheit, B., Rosenzweig, J. P., Naor, D., Lerer, B., Zachor, D. A., Procházka, V., Melamed, M., Kristt, D. A., Steinberg, A., Shulman, C., et al. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.05.005 · Cited by 207
“In terms of MHC class III genes, the C4 complement alleles have been linked to ASD [34,35].”
Self-citationEmerging biomarkers in autism spectrum disorder: a systematic review
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“Untargeted analysis of serum has demonstrated involvement of complement (69,70) , cholesterol metabolism (71) and apoptosis proteins (69).”
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“These results are mirrored by proteomic studies of serum, which suggest systematic differences between patients with ASD and controls [59].”
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“However, the participants with autism had lower IQ scores than the TD subjects [22,23].”
BackgroundSelf-citationFactor H-related proteins determine complement-activating surfaces
Józsi, M., Tortajada, A., Uzonyi, B., de Jorge, E. G., & de Córdoba, S. R. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.04.008 · Cited by 149
In Search of Cellular Immunophenotypes in the Blood of Children with Autism
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“More definitive studies have since highlighted the presence of inflammation in the brain and the activation of microglia [11] as well as evidence for altered peripheral immune function in autism, including increased cytokine levels in the plasma such as interleukin (IL)-1b, IL-6, and IL-8 [12], elevated levels of comp…”
BackgroundSelf-citationMicroglia in the pathogenesis of autism spectrum disorders
Koyama, R., & Ikegaya, Y. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.06.005 · Cited by 141
“C1q expression was increased in the peripheral serum of hildren with ASD (Corbett et al., 2007), leading us to hypotheize that elevated levels of complement proteins in the ASD brain romote synaptic pruning by microglia.”
Biomarkers in autism spectrum disorders: Current progress
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Potential biomarkers in psychiatry: focus on the cholesterol system
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“ApoB100 is also found in intermediate density lipoproteins (IDL) and HDL [19].”
BackgroundInfluentialComplement System in Brain Architecture and Neurodevelopmental Disorders
Magdalon, J., Mansur, F., Silva, A. L. T. E., de Goes, V. A., Reiner, O., & Sertie, A. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00023 · Cited by 102
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“Proteomic analyses have also found altered levels of immune system-regulating proteins, such as apolipoprotein in the cerebrospinal fluid and blood of individuals with ASD compared to controls (Corbett et al., 2007; Molloy et al., 2006; Woods et al., 2012; Zimmerman et al., 2005).”
Association Between Autism Spectrum Disorders and Cardiometabolic Diseases
Dhanasekara, C. S., Ancona, D., Cortes, L., Hu, A., Rimu, A. H., Robohm-Leavitt, C., Payne, D., Wakefield, S. M., Mastergeorge, A. M., & Kahathuduwa, C. N. (2023) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2022.5629 · Cited by 107
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Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy
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“The expression of complement or complement and coagulation cascade-related proteins has been frequently reported alteration in the peripheral blood of ASD since the first proteomic studies on peripheral blood in ASD, 18,142,211,220–222 while changes in the brain have also been reported.”
Proteomic research in psychiatry
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“Recently Corbett et al. (2007) analysed the serum proteome in a group of autistic children aged four to six years for differentially expressed proteins (see Table 18).”
BackgroundA Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder
Wetie, A. G. N., Wormwood, K. L., Russell, S., Ryan, J. P., Darie, C. C., & Woods, A. G. (2015) · Autism Research · doi:10.1002/aur.1450 · Cited by 90
“…[Corbett et al., 2007; Momeni, Bergquist, et al. 2012; Momeni, Brudin, et al. 2012)], and in apolipoproteins, which are cholesterol-carrying proteins [Corbett et al., 2007; Momeni, Bergquist, et al., 2012; Momeni, Brudin, et al., 2012; Woods et al., 2012a, b; Ngounou Wetie, Wormwood, et al., 2014].”
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“T3/ASD genes involved in cytoskeleton organization and cell migration (Table 2) are GNAS that codes for G-protein α subunit (Gs-α) (329); FN1 that codes for fibronectin, an extracellular matrix protein involved in cell adhesion and migration, found increased in serum of children with autism (330); SERPINH1 that codes…”
BackgroundImmune Dysregulation in Autism Spectrum Disorder
Hsiao, E. Y. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00009-5 · Cited by 87
The Role of Complement Factor H in Age-related Macular Degeneration: A Review
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“In contrast, increased C1q expression in serum from ASD children may be interpreted as a compensatory elevation to defects in C1q function [242].”
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Napolioni, V., Ober-Reynolds, B., Szelinger, S., Corneveaux, J. J., Pawlowski, T., Ober-Reynolds, S., Kirwan, J., Persico, A. M., Melmed, R. D., Craig, D. W., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-38 · Cited by 76
“Previous studies [14-25] have reported altered cytokine levels in subjects with autism with inconclusive results, perhaps attributable to different types of study design, but also probably reflecting the wide heterogeneity of ASD.”
BackgroundThe Complement System in the Central Nervous System: From Neurodevelopment to Neurodegeneration
Chen, Y., Chu, J. M. T., Chang, R. C., & Wong, G. T. C. (2022) · Biomolecules · doi:10.3390/biom12020337 · Cited by 78
“ASD [15], MS [16–18], ALS [19,20], HD [21]”
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“Defects in complement signaling have been associated with neurodevelopmental abnormalities such as autism, schizophrenia, and 3MC syndrome (Corbett et al., 2007; Rooryck et al., 2011; Sekar et al., 2016).”
BackgroundA novel blood-based biomarker for detection of autism spectrum disorders
Momeni, N., Bergquist, J., Brudin, L. H., Behnia, F., Sivberg, B. V., Joghataei, M. T., & Persson, B. L. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.19 · Cited by 72
“with autism showed differential expression of apolipoproteins and other components of complement proteins.(35) In this study, we undertook a proteomic approach using”
MethodOral microbiota and autism spectrum disorder (ASD)
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“Abnormal cytokine levels, immunoglobulin levels, complement levels, and decreased lymphocyte numbers have been described in children with AU (Ashwood et al. 2006; Warren et al. 1997; Warren et al. 1996; Gupta et al. 1996; Singh and Rivas 2004; McCabe et al. 1991; Corbett et al. 2007).”
BackgroundSelf-citationiTRAQ‐Based Proteomic Analysis Reveals Protein Profile in Plasma from Children with Autism
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“identified differentially expressed peptides using LC-MS/MS, which allowed for the recognition of complement factor H-related protein (FHR1), apolipoprotein (APO) B-100, fibronectin 1 (FN1), and complement C1q as dysregulated proteins in children with ASD compared to control subjects [53].”
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“Interestingly, the genes encoding complement gene C4 have been linked to ASD (Warren et al., 1991, 1994; Odell et al., 2005; Corbett et al., 2007; Mostafa and Shehab, 2010).”
BackgroundSubclinical Inflammatory Status in Rett Syndrome
Cortelazzo, A., Felice, C. D., Guerranti, R., Signorini, C., Leoncini, S., Pecorelli, A., Zollo, G., Landi, C., Valacchi, G., Ciccoli, L., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/480980 · Cited by 68
“All the patients were consecutively admitted to the Rett Syndrome National Reference Centre of the University Hospital of the Azienda Ospedaliera Universitaria Senese (AOUS).”
BackgroundFagan, K. K., Crider, A., Ahmed, A. O., & Pillai, A. (2017) · Complex Psychiatry · doi:10.1159/000465523 · Cited by 69
Alterations in plasma cytokine levels in chinese children with autism spectrum disorder
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“…T helper cell profiles [Ashwood & Wakefield, 2006], reduced levels of immunoglobulins [Heuer et al., 2008], increased levels of complement proteins [Corbett et al., 2007] and altered monocyte responses to stimuli [Molloy et al., 2006; Enstrom, Onore, Van de Water, & Ashwood, 2010; Careaga et al.,…”
BackgroundSarn, N., Jaini, R., Thacker, S., Lee, H., Dutta, R., & Eng, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0681-0 · Cited by 66
Autism: the quest for the genes
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Aberrant Complement System Activation in Neurological Disorders
Ziąbska, K., Ziemka‐Nałęcz, M., Pawelec, P., Sypecka, J., & Zalewska, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094675 · Cited by 54
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“In contrast to Corbett et al. [ 8 ] we have analysed whole proteins—not peptides after tryptic digest—using MALDI-ToF-MS.”
BackgroundMethodInfluentialFHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
Csincsi, Á. I., Szabó, Z., Bánlaki, Z., Uzonyi, B., Cserhalmi, M., Kárpáti, É., Tortajada, A., Caesar, J. J. E., Prohászka, Z., Jokiranta, T. S., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600483 · Cited by 54
“gene is highly expressed in human retinal pigment epithelium (53), altered FHR-1 protein levels were described under inflammatory and disease conditions (54, 55), and mutation in CFHR1”
BackgroundInflammatory Activity in Autism Spectrum Disorder
Tonhajzerová, I., Ondrejka, I., Mestanik, M., Mikolka, P., Hrtánek, I., Mestanikova, A., Bujnakova, I., & Mokrá, D. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_145 · Cited by 57
Microglia-neuron interactions in schizophrenia
Hartmann, S.-M., Heider, J., Wüst, R., Fallgatter, A. J., & Volkmer, H. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1345349 · Cited by 58
Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder
Hicks, S. D., Rajan, A. T., Wagner, K. E., Barns, S., Carpenter, R. L., & Middleton, F. A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00534 · Cited by 53
Advances in Biomarker Studies in Autism Spectrum Disorders
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“Comparison with healthy controls, several up-regulated complement proteins have been reported in the serum of ASD [32], including complement factor H related protein (FHR1), complement C1q and complement factor I (CFI).”
InfluentialMongan, D., Sabherwal, S., Susai, S. R., Föcking, M., Cannon, M. D., & Cotter, D. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.05.036 · Cited by 47
“…ability of serum to lyse sheep erythrocytes sensitised with rabbit immunoglobulin M for classical pathway activity, or unsensitised rabbit erythrocytes for alternative pathway activity under conditions that block functioning of the classical pathway (Costabile, 2010; Oppermann andWurzner, 2010).”
BackgroundCortelazzo, A., Felice, C. D., Guerranti, R., Signorini, C., Leoncini, S., Zollo, G., Leoncini, R., Timperio, A. M., Zolla, L., Ciccoli, L., et al. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500076 · Cited by 46
“Oxidation of apolipoprotein A-I, a major component of HDL in plasma [24, 52] could lead to a cholesterol metabolism dysregulation, as previously reported in this condition [50].”
VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction
Usui, N., Iwata, K., Miyachi, T., Takagai, S., Wakusawa, K., Nara, T., Tsuchiya, K. J., Matsumoto, K., Kurita, D., Kameno, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102917 · Cited by 45
“7h, 7i), indicating APOB is an indicator for ASD diagnosis as previous reported [19].”
BackgroundResultInfluentialNeurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation
Tian, Y., Li, T., Sun, M., Wan, D., Li, Q., Li, P., Zhang, Z. C., Han, J., & Xie, W. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.012 · Cited by 47
“Nutritional and environmental factors play important roles in ASD, and fatty acid metabolism and abnormal membrane fatty acid composition may contribute to this disorder (Wiest et al., 2009).”
InfluentialHypermethylation of the enolase gene (ENO2) in autism
Wang, Y., Fang, Y., Zhang, F., Xu, M., Zhang, J., Yan, J., Ju, W., Brown, W. T., & Zhong, N. A. (2014) · European Journal of Pediatrics · doi:10.1007/s00431-014-2311-9 · Cited by 44
“A proteomic study of serum from children with autism also showed a differential expression of apolipoproteins and components of complement [3].”
BackgroundWei, H., Ma, Y., Liu, J., Ding, C., Hu, F., & Li, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.003 · Cited by 47
“For example, Corbett et al. found that the apolipoproteins and complement proteins were differentially expressed in the serum from children with autism compared to age-matched controls (Corbett et al., 2007).”
ResultWestacott, L. J., & Wilkinson, L. S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.840266 · Cited by 48
“Further research on how biological sex influences complement and microglia interactions during development will be critical to understanding the pathophysiology of neurodevelopmental disorders which show sexually dimorphic prevalence rates such as ASD and schizophrenia.”
BackgroundInfluentialA pilot proteomic study of protein markers in autism spectrum disorder
Wetie, A. G. N., Wormwood, K. L., Thome, J., Dudley, E., Taurines, R., Gerlach, M., Woods, A. G., & Darie, C. C. (2014) · Electrophoresis · doi:10.1002/elps.201300370 · Cited by 40
Mesleh, A. G., Abdulla, S. A., & El‐Agnaf, O. M. A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11010041 · Cited by 41
The potential of biomarkers in psychiatry: focus on proteomics
Sokolowska, I., Wetie, A. G. N., Wormwood, K. L., Thome, J., Darie, C. C., & Woods, A. (2015) · Journal of neural transmission · doi:10.1007/s00702-013-1134-6 · Cited by 37
Kong, S. W., Shimizu‐Motohashi, Y., Campbell, M. G., Lee, I., Collins, C. D., Brewster, S. J., Holm, I. A., Rappaport, L., Kohane, I. S., & Kunkel, L. M. (2013) · Neurogenetics · doi:10.1007/s10048-013-0363-z · Cited by 37
“CNS cytopathology [32], serum and CSF proteomics [33], a gene expression study using postmortem CNS tissue [34], and several gene expression studies using LCL revealed a converging signature of a perturbed immune system[21, 22].”
BackgroundAutism Spectrum Disorders: From Immunity to Behavior
Careaga, M., & Ashwood, P. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-071-7_12 · Cited by 38
Self-citationMass spectrometry as a tool for studying autism spectrum disorder
Woods, A. G., Wetie, A. G. N., Sokolowska, I., Russell, S., Ryan, J. P., Michel, T. M., Thome, J., & Darie, C. C. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-6 · Cited by 36
“The numerous different markers found in ASD samples may be reflective of multiple elements that are disturbed in ASDs and may also reflect ASD heterogeneity.”
Yang, J., Chen, Y., Xiong, X., Zhou, X., Han, L., Ni, L., Wang, W., Wang, X., Zhao, L., Shao, D., et al. (2018) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201700164 · Cited by 37
Pichitpunpong, C., Thongkorn, S., Kanlayaprasit, S., Yuwattana, W., Plaingam, W., Sangsuthum, S., Aizat, W. M., Baharum, S. N., Tencomnao, T., Hu, V. W., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214198 · Cited by 37
Velmeshev, D., Magistri, M., Mazza, E. M. C., Lally, P., Khoury, N., D’Elia, E. R., Bicciato, S., & Faghihi, M. A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01879-5 · Cited by 39
“Interestingly, protein levels of C1QC were shown to be elevated in the serum of ASD patients [28].”
BackgroundSchengrund, C., Ali-Rahmani, F. G., & Ramer, J. C. (2012) · Neurochemical Research · doi:10.1007/s11064-011-0697-6 · Cited by 37
“occur in children with autism is provided by the observation that expression of ApoB-100, a protein needed for transport of very low density lipoproteins (VLDL) from the liver to the circulation as well as for uptake of low density lipoproteins (LDL) from the circulation, was lower in children with autism compared to…”
Salivary proteomics and biomarkers in neurology and psychiatry
Wormwood, K. L., Aslebagh, R., Channaveerappa, D., Dupree, E. J., Borland, M. M., Ryan, J. P., Darie, C. C., & Woods, A. G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400153 · Cited by 36
Prandota, J. (2010) · Research in Autism · doi:10.1016/j.rasd.2010.03.009 · Cited by 34
High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
Momeni, N., Brudin, L. H., Behnia, F., Nordström, B. M., Yosefi-Oudarji, A., Sivberg, B. V., Joghataei, M. T., & Persson, B. L. (2011) · Autism Research and Treatment · doi:10.1155/2012/868576 · Cited by 35
“Although we did not see any clear correlation between medication and distribution for the scatter plot data, it cannot be excluded that some differences in the pattern may be influenced by medication, as has been previously discussed [22].”
BackgroundResultInfluentialCurrent Position and Future Direction of Inflammation in Neuropsychiatric Disorders
Upthegrove, R., Zuelli, F. M. D. G. C., Couch, A. C. M., Barnes, N. M., & Vernon, A. C. (2025) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.1369 · Cited by 40
Vallés, A. S., & Barrantes, F. J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.744597 · Cited by 37
Sepers, B., Erven, J. A. M., Gawehns, F., Laine, V. N., & van Oers, K. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.609061 · Cited by 33
Microglia as possible therapeutic targets for autism spectrum disorders
Andoh, M., Ikegaya, Y., & Koyama, R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.012 · Cited by 31
Westacott, L. J., Humby, T., Haan, N., Brain, S. A., Bush, E., Toneva, M., Baloc, A.-I., Moon, A. L., Reddaway, J., Owen, M. J., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.005 · Cited by 31
From Child-Robot Interaction to Child-Robot-Therapist Interaction: A Case Study in Autism
Giannopulu, I., & Pradel, G. (2012) · Applied Bionics and Biomechanics · doi:10.1155/2012/682601 · Cited by 28
Lee, S. E., West, K. P., Cole, R. N., Schulze, K. J., Wu, L. S., Yager, J. D., Groopman, J. D., & Christian, P. S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.023 · Cited by 28
Translational disease interpretation with molecular networks
Baudot, A., Goméz-López, G., & Valencia, A. (2009) · Genome biology · doi:10.1186/gb-2009-10-6-221 · Cited by 27
Tierney, E., Remaley, A. T., Thurm, A., Jager, L. R., Wassif, C. A., Kratz, L. E., Bailey-Wilson, J. E., Bukelis, I., Sarphare, G., Jung, E. S., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01580-8 · Cited by 26
Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects
Mansur, F., Silva, A. L. T. E., Gomes, A. K. S., Magdalon, J., de Souza, J. S., Griesi‐Oliveira, K., Passos‐Bueno, M. R., & Sertie, A. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147579 · Cited by 29
Trent, S., Fry, J. P., Ojarikre, O. A., & Davies, W. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-21 · Cited by 27
Wijekoon, N., Gonawala, L., Ratnayake, P. D., Dissanayaka, P., Gunarathne, I., Amaratunga, D., Liyanage, R., Senanayaka, S., Wijesekara, S., Gunasekara, H. H., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18530 · Cited by 26
Serologic Markers of Autism Spectrum Disorder
Khramova, T., Kaysheva, A. L., Ivanov, Y. D., Pleshakova, T. O., Iourov, I. Y., Vorsanova, S. G., Yurov, Y. B., Schetkin, A. A., & Archakov, A. I. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0950-9 · Cited by 25
“In another proteomico-peptide study, Corbett et al. (2007) performed a proteomic analysis of serum samples of 69 children with autism aged 4–6.”
Abraham, J. R., Szoko, N., & Natowicz, M. R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_12 · Cited by 25
Urine proteome analysis to evaluate protein biomarkers in children with autism
Suganya, V., Geetha, A., & Sridharan, S. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.015 · Cited by 25
Serum glycopattern and Maackia amurensis lectin-II binding glycoproteins in autism spectrum disorder
Qin, Y., Chen, Y., Yang, J., Wu, F., Zhao, L., Yang, F., Xue, P., Shi, Z., Song, T., & Huang, C. Y. (2017) · Scientific Reports · doi:10.1038/srep46041 · Cited by 24
Rupprecht, R., Rupprecht, C., Benedetto, B. D., & Rammes, G. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1961503 · Cited by 24
“Created with BioRender.com. proteomic study has delineated altered C1q expression in children suffering from autism (Corbett et al. 2007).”
BackgroundThe search for peripheral disease markers in psychiatry by genomic and proteomic approaches
Domenici, E., & Muglia, P. (2007) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.1.2.235 · Cited by 23
Kopylov, A. T., Petrovskiy, D. V., Stepanov, A. A., Rudnev, V. R., Malsagova, K. A., Butkova, T. V., Zakharova, N. V., Kostyuk, G. P., Kulikova, L. I., Enikeev, D. V., et al. (2021) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2021.103890 · Cited by 23
Metadata
- Authors
- Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R.
- Affiliations
- University of California Davis Medical Center (US)
- Pharmaceutical Product Development (United States) (US)
- University of California, Davis (US)
- Corresponding author
- Corbett, B A
- Venue
- Molecular Psychiatry
- Published
- 2006-12-26
- Volume
- 12
- Issue
- 3
- Pages
- 292-306
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2011080454
- Cited by
- 197
- References
- 97
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 11 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 4 · 2015: 12 · 2014: 18 · 2013: 14 · 2012: 14
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (5K08NMHO72958)
- National Human Genome Research Institute (R01HG003352)
- National Institute of Neurological Disorders and Stroke (NS044283, R01NS043252, NS028167, P50NS044283, NS043252, R01NS028167)
- National Institute of Environmental Health Sciences (P42-ES-04699, P42ES004699)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- autism spectrum disorder, serum proteomics, apolipoproteins, apolipoprotein B-100, apolipoprotein A-IV, complement system, complement factor H-related proteins, C1q, FN1, differentially expressed proteins, children, high-functioning autism, peripheral blood biomarkers
- MeSH terms
- Apolipoproteins, Autistic Disorder, Child, Child, Preschool, Complement System Proteins, Female, Humans, Male, Mass Spectrometry, Gene Expression, Statistics, Nonparametric, Proteomics
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