Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene
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Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact with ERBB4, to identify genes and pathways that might contribute to schizophrenia susceptibility. We identified the MAGI scaffolding proteins as ERBB4-binding proteins. After validating the interaction of MAGI proteins with ERBB4 in mammalian cells, we demonstrated that ERBB4 expression, alone or in combination with ERBB2 or ERBB3, led to the tyrosine phosphorylation of MAGI proteins, and that this could be further enhanced with receptor activation by neuregulin. As MAGI proteins were previously shown to interact with receptor phosphotyrosine phosphatase beta/zeta (RPTPbeta), we postulated that simultaneous binding of MAGI proteins to RPTPbeta and ERBB4 forms a phosphotyrosine kinase/phosphotyrosine phosphatase complex. Studies in cultured cells confirmed both a spatial and functional association between ERBB4, MAGI and RPTPbeta. Given the evidence for this functional association, we examined the genes coding for MAGI and RPTPbeta for genetic association with schizophrenia in a Caucasian United Kingdom case-control cohort (n= approximately 1400). PTPRZ1, which codes for RPTPbeta, showed significant, gene-wide and hypothesis-wide association with schizophrenia in our study (best individual single-nucleotide polymorphism allelic P=0.0003; gene-wide P=0.0064; hypothesis-wide P=0.026). The data provide evidence for a role of PTPRZ1, and for RPTPbeta signaling abnormalities, in the etiology of schizophrenia. Furthermore, the data indicate a role for RPTPbeta in the modulation of ERBB4 signaling that may in turn provide further support for an important role of neuregulin/ERBB4 signaling in the molecular basis of schizophrenia.
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Polymorphisms of genes encoding for several CSPGs have been associated with schizophrenia.
“Finally, polymorphisms of genes encoding for several CSPGs have been associated with SZ.5, 6, 7”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [5]
CSPGs are involved in the pathophysiology of schizophrenia.
“Emerging evidence from human postmortem, animal model and genetic studies points to their involvement in the pathophysiology of schizophrenia (SZ).1, 2, 3, 4, 5, 6, 7”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [5]
Abnormal glutamatergic transmission, polymorphisms of genes encoding for some PNN components, and altered CSPG expression in glial cells may, independently or in conjunction, cause defective PNN maturation.
“Abnormal glutamatergic transmission, polymorphisms of genes encoding for some of their components and altered CSPG expression in glial cells may, independently or in conjunction, cause defective PNN maturation.3, 5, 6, 7, 59”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [5]
Genetic susceptibility for schizophrenia is associated with genes encoding PNN components, matrix-regulating molecules, and immune system factors.
“We integrate these considerations with results from recent genetic studies showing genetic susceptibility for schizophrenia associated with genes encoding for PNN components, matrix-regulating molecules and immune system factors.”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Buxbaum et al., 2008
Several vulnerability genes for schizophrenia encode PNN components and enzymes involved in ECM remodeling.
“Our findings, together with recent findings from genetic studies showing that several vulnerability genes for SZ encode PNN components and enzymes involved in ECM remodeling (Buxbaum et al., 2008; Cichon et al., 2011; Dow et al., 2011; Groszewska et al., 2011; Ripke and Consortium, 2011; Ripke et al., 2013; Ripke and Schizophrenia Working Group of the Psychiatric Genomics, 2014; Rybakowski et al.,”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Buxbaum et al., 2008
Genetic vulnerabilities in CSPG genes such as PTPRZ1 and neurocan may reduce CSPG synthesis in schizophrenia.
“In addition, recently reported genetic vulnerabilities for CSPG genes, including PTPRZ1 and neurocan (Buxbaum et al., 2008; Muhleisen et al., 2012; Ripke and Schizophrenia Working Group of the Psychiatric Genomics, 2014), may contribute to decrease CSPG synthesis in SZ.”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Buxbaum et al., 2008
Genes encoding PNN structural constituents and regulators of PNN formation have been linked to schizophrenia.
“recent evidence linking genes encoding structural constituents of PNNs and those that regulate their formation to schizophrenia”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Buxbaum et al., 2008
A case-control genetic study found that the PTPRZ1 gene is associated with schizophrenia.
“On the basis of a genetic case-control study that revealed association between the PTPRZ1 gene (which encodes RPTPβ also known as phosphacan) and schizophrenia (Buxbaum et al., 2008)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Buxbaum et al., 2008
Cites
A novel genetic system to detect protein–protein interactions
Fields, S., & Song, O.-K. (1989) · Nature · doi:10.1038/340245a0 · Cited by 6,152 · see citing works
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090 · see citing works
Nyholt, D. R. (2004) · The American Journal of Human Genetics · doi:10.1086/383251 · Cited by 1,699 · see citing works
Efficiency and power in genetic association studies
de Bakker, P. I. W., Yelensky, R., Pe’er, I., Gabriel, S., Daly, M. J., & Altshuler, D. (2005) · Nature Genetics · doi:10.1038/ng1669 · Cited by 1,678 · see citing works
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671 · see citing works
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
Self-citationPedigree disequilibrium tests for multilocus haplotypes.
Dudbridge, F. (2003) · Genetic Epidemiology · doi:10.1002/gepi.10252 · Cited by 1,135 · see citing works
Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 973 · see citing works
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Tkachev, D., Mimmack, M., Ryan, M. M., Wayland, M., Freeman, T., Jones, P., Starkey, M., Webster, M., Yolken, R., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 940 · see citing works
A review of diffusion tensor imaging studies in schizophrenia
Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769 · see citing works
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659 · see citing works
The deaf and the dumb: the biology of ErbB-2 and ErbB-3
Citri, A. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00101-5 · Cited by 591 · see citing works
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Hahn, C.-G., Wang, H.-Y., Cho, D.-S., Talbot, K., Gur, R. E., Berrettini, W. H., Bakshi, K. P., Kamins, J., Borgmann‐Winter, K. E., Siegel, S. J., et al. (2006) · Nature Medicine · doi:10.1038/nm1418 · Cited by 564 · see citing works
Truncated product method for combining P ‐values
Zaykin, D. V., Анатольевич, Ж. Л., Westfall, P. H., & Weir, B. S. (2002) · Genetic Epidemiology · doi:10.1002/gepi.0042 · Cited by 508 · see citing works
Neuregulin and ErbB receptor signaling pathways in the nervous system
Buonanno, A., & Fischbach, G. D. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00210-5 · Cited by 505 · see citing works
Electron microscopy of oligodendroglia in severe mental illness
Uranova, N., Orlovskaya, D., Vikhreva, O., Zimina, I., Kolomeets, N., Vostrikov, V., & Rachmanova, V. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00528-7 · Cited by 495 · see citing works
Flynn, S. W., Lang, D. J., MacKay, A. L., Goghari, V. M., Vavasour, I. M., Whittall, K. P., Smith, G. N., Arango, V., Mann, J. J., Dwork, A. J., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001337 · Cited by 439 · see citing works
Hof, P. R., Haroutunian, V., Friedrich, V. L., Byne, W., Buitron, C., Perl, D. P., & Davis, K. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00237-3 · Cited by 433 · see citing works
Self-citationLaw, A. J., Lipska, B. K., Weickert, C. S., Hyde, T. M., Straub, R. E., Hashimoto, R., Harrison, P. J., Kleinman, J. E., & Weinberger, D. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602002103 · Cited by 403 · see citing works
Wu, X., Hepner, K., Castelino‐Prabhu, S., Do, D., Kaye, M. B., Yuan, X., Wood, J., Ross, C. A., Sawyers, C. L., & Whang, Y. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4233 · Cited by 398 · see citing works
Peles, E., Nativ, M., Campbell, P. L., Sakurai, T., Martinez, R., Lev, S., Clary, D. O., Schilling, J., Barnea, G., Plowman, G. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90312-7 · Cited by 397 · see citing works
Self-citationMilev, P., Friedlander, D. R., Sakurai, T., Karthikeyan, L., Flad, M., Margolis, R. K., Grumet, M., & Margolis, R. U. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1703 · Cited by 328 · see citing works
Self-citationTumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4
Río, C., Buxbaum, J. D., Peschon, J. J., & Corfas, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10379 · Cited by 309 · see citing works
Self-citationMaurel, P., Rauch, U., Flad, M., Margolis, R. K., & Margolis, R. U. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2512 · Cited by 305 · see citing works
Meta-analysis shows strong positive association of the neuregulin 1 ( NRG1 ) gene with schizophrenia
Li, D., Collier, D. A., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl122 · Cited by 295 · see citing works
Microarray analysis of postmortem temporal cortex from patients with schizophrenia
Aston, C., Jiang, L., & Sokolov, B. P. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20208 · Cited by 283 · see citing works
Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia
Hashimoto, R., Straub, R. E., Weickert, C. S., Hyde, T. M., Kleinman, J. E., & Weinberger, D. R. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001434 · Cited by 283 · see citing works
Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
Anton, E. S., Ghashghaei, H. T., Weber, J. L., McCann, C. M., Fischer, T. M., Cheung, I. D., Gassmann, M., Messing, A., Klein, R., Schwab, M. H., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1345 · Cited by 256 · see citing works
The involvement of ErbB4 with schizophrenia: Association and expression studies
Silberberg, G., Darvasi, A., Pinkas‐Kramarski, R., & Navon, R. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30275 · Cited by 251 · see citing works
The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system
Levy, J. B., Canoll, P., Silvennoinen, O., Barnea, G., Morse, B., Honegger, A., Huang, J., Cannizzaro, L. A., Park, S., & Druck, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82237-2 · Cited by 229 · see citing works
Katsel, P., Davis, K. L., & HAROUTUNIAN, V. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.06.007 · Cited by 223 · see citing works
Self-citationAssociation of the NRG1 gene and schizophrenia: a meta-analysis
Munafo, M. R., Thiselton, D. L., Clark, T. G., & Jonathan Flint, C. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001817 · Cited by 220 · see citing works
Milev, P., Maurel, P., Häring, M., Margolis, R. K., & Margolis, R. U. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15716 · Cited by 210 · see citing works
Åberg, K., Saetre, P., Jareborg, N., & Jazin, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601213103 · Cited by 208 · see citing works
Norton, N., Moskvina, V., Morris, D. W., Bray, N. J., Zammit, S., Williams, N. M., Williams, H. J., Preece, A. C., Dwyer, S., Wilkinson, J. C., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30236 · Cited by 185 · see citing works
Self-citationBarnea, G., Grumet, M., Milev, P., Silvennoinen, O., Levy, J. B., Sap, J., & Schlessinger, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36625-5 · Cited by 182 · see citing works
Ghashghaei, H. T., Weber, J., Pevny, L., Schmid, R. S., Schwab, M. H., Lloyd, K. C. K., Eisenstat, D. D., Lai, C., & Anton, E. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510410103 · Cited by 179 · see citing works
Sakurai, T., Lustig, M., Nativ, M., Hemperly, J., Schlessinger, J., Peles, E., & Grumet, M. (1997) · Journal of Cell Biology · doi:10.1083/jcb.136.4.907 · Cited by 176 · see citing works
Self-citationNuclear localization and possible functions of receptor tyrosine kinases
Carpenter, G. F. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00015-2 · Cited by 169 · see citing works
Multiple novel transcription initiation sites for NRG1
Steinthórsdóttir, V., Stefánsson, H., Ghosh, S., Birgisdottir, B., Bjornsdottir, S., Fasquel, A. C., Ólafsson, Ó., Stefánsson, K., & Gulcher, J. R. (2004) · Gene · doi:10.1016/j.gene.2004.07.029 · Cited by 168 · see citing works
Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
Norton, N., Williams, N. M., Williams, H. J., Spurlock, G., Kirov, G., Morris, D. W., Hoogendoorn, B., Owen, M. J., & O’Donovan, M. C. (2002) · Human Genetics · doi:10.1007/s00439-002-0706-6 · Cited by 165 · see citing works
Self-citationKainulainen, V., Sundvall, M., Määttä, J. A., Santiestevan, E., Klagsbrun, M., & Elenius, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8641 · Cited by 161 · see citing works
O’Tuathaigh, C. M. P., Babovic, D., O’Meara, G. F., Clifford, J. J., Croke, D. T., & Waddington, J. L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.04.002 · Cited by 151 · see citing works
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383.
Tolkacheva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A. C., & Chan, A. M.-L. (2001) · PubMed · Cited by 149 · see citing works
Sim, F. J., Lang, J. K., Waldau, B., Roy, N. S., Schwartz, T. E., Pilcher, W. H., Chandross, K. J., Natesan, S., Merrill, J. E., & Goldman, S. A. (2006) · Annals of Neurology · doi:10.1002/ana.20812 · Cited by 147 · see citing works
An update on the genetics of schizophrenia
Norton, N., Williams, H. J., & Owen, M. J. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000214341.52249.59 · Cited by 145 · see citing works
Self-citationDiffusion Tensor Imaging in Schizophrenia
Buchsbaum, M. S., Friedman, J. I., Buchsbaum, B. R., Chu, K.-W., Hazlett, E. A., Newmark, R. E., Schneiderman, J. S., Torosjan, Y., Tang, C. Y., Hof, P. R., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.028 · Cited by 141 · see citing works
Self-citationHarroch, S., Furtado, G. C., Brück, W., D, J. R. M., Lafaille, J. J., Chao, M. V., Buxbaum, J. D., & Schlessinger, J. (2002) · Nature Genetics · doi:10.1038/ng1004 · Cited by 140 · see citing works
Self-citationMaeda, N., Hamanaka, H., Oohira, A., & Noda, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00069-h · Cited by 134 · see citing works
MAGUKs in synapse assembly and function: an emerging view
Montgomery, J. M., Zamorano, P. L., & Garner, C. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3364-5 · Cited by 128 · see citing works
Georgieva, L., Moskvina, V., Peirce, T., Norton, N., Bray, N. J., Jones, L., Holmans, P., MacGregor, S., Zammit, S., Wilkinson, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603029103 · Cited by 125 · see citing works
Self-citationPeirce, T., Bray, N. J., Williams, N. M., Norton, N., Moskvina, V., Preece, A. C., Haroutunian, V. H., Buxbaum, J. D., Owen, M. J., & O’Donovan, M. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.18 · Cited by 124 · see citing works
Self-citationRimer, M., Barrett, D. W., Maldonado, M. A., Vock, V. M., & Gonzalez-Lima, F. (2005) · Neuroreport · doi:10.1097/00001756-200502280-00014 · Cited by 120 · see citing works
Human QKI, a new candidate gene for schizophrenia involved in myelination
Åberg, K. A., Saetre, P., Lindholm, E., Ekholm, B., Pettersson, U., Adolfsson, R., & JAZIN, E. E. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30243 · Cited by 116 · see citing works
Sugai, T., Kawamura, M., Iritani, S., Araki, K., Makifuchi, T., Imai, C., Nakamura, R., Kakita, A., Takahashi, H., & Nawa, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.011 · Cited by 115 · see citing works
Receptor and nonreceptor protein tyrosine phosphatases in the nervous system
Paul, S., & Lombroso, P. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3123-7 · Cited by 108 · see citing works
Steiner, H., Blum, M., Kitai, S. T., & Fedi, P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7163 · Cited by 106 · see citing works
Design of Case‐controls Studies with Unscreened Controls
Moskvina, V., Holmans, P., Schmidt, K. M., & Craddock, N. J. (2005) · Annals of Human Genetics · doi:10.1111/j.1529-8817.2005.00175.x · Cited by 101 · see citing works
Self-citationSnyder, S. E., Li, J., Schauwecker, P. E., McNeill, T. H., & Salton, S. R. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00039-3 · Cited by 97 · see citing works
Canoll, P., Barnea, G., Levy, J. B., Sap, J., Ehrlich, M. E., Silvennoinen, O., Schlessinger, J., & Musacchio, J. M. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90035-9 · Cited by 97 · see citing works
Garwood, J., Heck, N., Reichardt, F., & Faissner, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211721200 · Cited by 94 · see citing works
Protein tyrosine phosphatase receptor type Z is inactivated by ligand‐induced oligomerization
Fukada, M., Fujikawa, A., Chow, J. P. H., Ikematsu, S., Sakuma, S., & Noda, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.041 · Cited by 91 · see citing works
Sakurai, T., Friedlander, D. R., & Grumet, M. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960315)43:6 · Cited by 84 · see citing works
Self-citationNishiwaki, T., Maeda, N., & Noda, M. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021959 · Cited by 83 · see citing works
O’Tuathaigh, C. M. P., O'Sullivan, G. J., Kinsella, A., Harvey, R. P., Tighe, O., Croke, D. T., & Waddington, J. L. (2005) · Neuroreport · doi:10.1097/01.wnr.0000192738.31029.0a · Cited by 79 · see citing works
Milev, P., Meyer‐Puttlitz, B., Margolis, R. K., & Margolis, R. U. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24650 · Cited by 76 · see citing works
Adamsky, K., Arnold, K., Sabanay, H., & Peles, E. (2003) · Journal of Cell Science · doi:10.1242/jcs.00302 · Cited by 76 · see citing works
Byne, W. M., KIDKARDNEE, S., TATUSOV, A., Yiannoulos, G., Buchsbaum, M. S., & HAROUTUNIAN, V. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.03.029 · Cited by 73 · see citing works
Katsel, P., Davis, K. L., & Haroutunian, V. H. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63003-6 · Cited by 56 · see citing works
Self-citationOhyama, K., Kawano, H., Asou, H., Fukuda, T., Oohira, A., Uyemura, K., & Kawamura, K. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00220-4 · Cited by 56 · see citing works
Fukada, M., Kawachi, H., Fujikawa, A., & Noda, M. (2004) · Methods · doi:10.1016/j.ymeth.2004.07.008 · Cited by 54 · see citing works
Revest, J.-M., Faivre-Sarrailh, C., Maeda, N., Noda, M., Schachner, M., & Rougon, G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00521.x · Cited by 52 · see citing works
Wan, C., Yang, Y., Feng, G., Gu, N., Liu, H., Zhu, S., He, L., & Wang, L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.051 · Cited by 51 · see citing works
Hayashi, N., Miyata, S., Yamada, M., Kamei, K., & Oohira, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.017 · Cited by 46 · see citing works
Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios
Yang, Y., Qin, W. D., Shugart, Y. Y., He, G., Liu, X. M., Zhou, J. P., Zhao, X., Chen, Q., La, Y., Xu, Y., et al. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.11.013 · Cited by 43 · see citing works
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan
Barnea, G., Grumet, M., Sap, J., Margolis, R. U., & Schlessinger, J. (1994) · Cell · doi:10.1016/0092-8674(94)90328-x · Cited by 33 · see citing works
Jones, F. E., Golding, J. P., & Gassmann, M. (2003) · Cell Cycle · doi:10.4161/cc.2.6.598 · Cited by 27 · see citing works
A family‐based and case‐control association study of SOX10 in schizophrenia
Iwamoto, K., Bundo, M., Yamada, K., Takao, H., Iwayama, Y., Yoshikawa, T., & Kato, T. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30304 · Cited by 21 · see citing works
Cortical neurons express PSI, a novel isoform of phosphacan/RPTPbeta
Heck, N., Klausmeyer, A., Faissner, A., & Garwood, J. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1135-3 · Cited by 15 · see citing works
Li, J., Tullai, J. W., Yu, W.-H. A., & Salton, S. R. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00175-2 · Cited by 12 · see citing works
Meyer-Puttlitz (1996) · doi:10.1002/(sici)1096-9861(19960226)366:1
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Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800 · see citing works
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
Rosenberg, A. B., Roco, C. M., Muscat, R. A., Kuchina, A., Sample, P., Yao, Z., Graybuck, L. T., Peeler, D. J., Mukherjee, S., Chen, W., et al. (2018) · Science · doi:10.1126/science.aam8999 · Cited by 1,422 · see citing works
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860 · see citing works
Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder
Holmans, P., Green, E. K., Pahwa, J. S., Ferreira, M. A. R., Purcell, S. M., Sklar, P., Owen, M. J., O'Donovan, M. C., & Craddock, N. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.05.011 · Cited by 378 · see citing works
Self-citationEmerging Roles for CSF-1 Receptor and its Ligands in the Nervous System
Chiţu, V., Gökhan, Ş., Nandi, S., Mehler, M. F., & Stanley, E. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.03.005 · Cited by 354 · see citing works
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.004 · Cited by 337 · see citing works
Self-citationPantazopoulos, H., Woo, T.-U. W., Lim, M. P., Lange, N., & Berretta, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.196 · Cited by 296 · see citing works
Merkurjev, D., Hong, W., Iida, K., Oomoto, I., Goldie, B. J., Yamaguti, H., Ohara, T., Kawaguchi, S., Hirano, T., Martin, K. C., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0173-6 · Cited by 237 · see citing works
Proteoglycans and neuronal migration in the cerebral cortex during development and disease
Maeda, N. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00098 · Cited by 181 · see citing works
Extracellular matrix abnormalities in schizophrenia
Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works
Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34
Nandi, S., Cioce, M., Yeung, Y.-G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H.-Y., Gökhan, Ş., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442731 · Cited by 170 · see citing works
Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
Perineuronal nets in brain physiology and disease
Testa, D., Prochiantz, A., & Nardo, A. A. D. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.011 · Cited by 141 · see citing works
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 118 · see citing works
Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities
Hendriks, W. J. A. J., & Pulido, R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.022 · Cited by 113 · see citing works
Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease
Sethi, M. K., & Zaia, J. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9900-6 · Cited by 109 · see citing works
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
Roussos, P., & Haroutunian, V. H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00005 · Cited by 94 · see citing works
Shah, A., & Lodge, D. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.145 · Cited by 87 · see citing works
Höistad, M. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.009.2009 · Cited by 87 · see citing works
Genomic imprinting in the development and evolution of psychotic spectrum conditions
Crespi, B. J. (2008) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2008.00050.x · Cited by 86 · see citing works
Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution
Aspatwar, A., Tolvanen, M. E. E., Ortutay, C., & Parkkila, S. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-7359-2_8 · Cited by 80 · see citing works
SLITRK1 Binds 14-3-3 and Regulates Neurite Outgrowth in a Phosphorylation-Dependent Manner
Kajiwara, Y., Buxbaum, J. D., & Grice, D. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.033 · Cited by 73 · see citing works
Self-citationRNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia
Chang, X., Liu, Y., Hahn, C.-G., Gur, R. E., Abou‐Sleiman, P. M., & Hakonarson, H. H. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.154 · Cited by 74 · see citing works
Roles of glial cells in schizophrenia: Possible targets for therapeutic approaches
Takahashi, N., & Sakurai, T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.001 · Cited by 67 · see citing works
Self-citationDanielson, E., Zhang, N., Metallo, J., Kaleka, K. S., Shin, S. M., Gerges, N. Z., & Lee, S. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0025-12.2012 · Cited by 61 · see citing works
Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins
Cijsouw, T., Ramsey, A. M., Lam, T. T., Carbone, B. E., Blanpied, T. A., & Biederer, T. (2018) · Proteomes · doi:10.3390/proteomes6040048 · Cited by 58 · see citing works
New insights into the roles of the contactin cell adhesion molecules in neural development.
Mohebiany, A., Harroch, S., & Bouyain, S. (2014) · Advances in neurobiology · doi:10.1007/978-1-4614-8090-7_8 · Cited by 53 · see citing works
Self-citationEvolution of alternative splicing in primate brain transcriptomes
Lin, L., Shen, S., Jiang, P., Sato, S., Davidson, B. L., & Xing, Y. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq201 · Cited by 52 · see citing works
Xia, Z., Ouyang, D., Li, Q., Li, M., Zou, Q., Li, L., Yi, W., & Zhou, E. (2019) · Journal of Cancer · doi:10.7150/jca.28231 · Cited by 52 · see citing works
MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia
Karlsson, R., Graae, L., Lekman, M., Wang, D., Favis, R., Axelsson, T., Galter, D., Belin, A. C., & Paddock, S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.020 · Cited by 51 · see citing works
Aguiar, R. S., Pohl, F. B., de Morais, G. L., Nogueira, F. C. S., de Carvalho, J. B., Guida, L. D. C., Arge, L. W. P., Melo, A., Moreira, M. E. L., Cunha, D. P., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aay6736 · Cited by 51 · see citing works
Perineuronal Nets: Subtle Structures with Large Implications
Carceller, H., Gramuntell, Y., Klimczak, P., & Nácher, J. (2022) · The Neuroscientist · doi:10.1177/10738584221106346 · Cited by 48 · see citing works
Takahashi, N., Sakurai, T., Bozdagi-Gunal, O., Dorr, N. P., Moy, J., Krug, L., Gama-Sosa, M. A., Elder, G. A., Koch, R. J., Walker, R. H., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.8 · Cited by 48 · see citing works
Self-citationProteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
Pantazopoulos, H., Boyer-Boiteau, A., Holbrook, E. H., Jang, W., Hahn, C.-G., Arnold, S. E., & Berretta, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.013 · Cited by 47 · see citing works
“CSPG functions, including regulation of neuronal differentiation and migration, are highly relevant to the pathophysiology of SZ.”
BackgroundSchinke, T., Gebauer, M., Schilling, A. F., Lamprianou, S., Priemel, M., Müldner, C., Neunaber, C., Streichert, T., Ignatius, A. A., Harroch, S., et al. (2007) · Bone · doi:10.1016/j.bone.2007.11.009 · Cited by 40 · see citing works
Self-citationGlia‐related genes and their contribution to schizophrenia
Wang, C., Aleksić, B., & Ozaki, N. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12290 · Cited by 38 · see citing works
Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations
Sandau, U., Alderman, Z., Corfas, G., Ojeda, S., & Raber, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036424 · Cited by 35 · see citing works
Self-citationLauriat, T. L., Shiue, L., Haroutunian, V. H., Verbitsky, M., Ares, M., Ospina, L. H., & McInnes, L. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21534 · Cited by 34 · see citing works
Pereira, A. M., Sugiharto-Winarno, A., Zhang, B., Malcolm, P., Fink, G., & Sundram, S. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001404 · Cited by 33 · see citing works
Boll, I., Jensen, P., Schwämmle, V., & Larsen, M. R. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001896 · Cited by 32 · see citing works
Klimczak, P., Rizzo, A., Castillo-Gómez, E., Pérez-Rando, M., Gramuntell, Y., Beltrán, M. A. C. S., & Nácher, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.733989 · Cited by 29 · see citing works
Clozapine-Induced ERK1 and ERK2 Signaling in Prefrontal Cortex Is Mediated by the EGF Receptor
Pereira, A. M., Fink, G., & Sundram, S. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9188-5 · Cited by 27 · see citing works
Cressant, A., Dubreuil, V., Kong, J., Kranz, T. M., Lazarini, F., Launay, J., Callebert, J., Sap, J., Malaspina, D., Granon, S., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4490-8 · Cited by 27 · see citing works
Self-citationProteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases
Hendriks, W. J. A. J., Bourgonje, A. M., Leenders, W. P. J., & Pulido, R. (2018) · Molecules · doi:10.3390/molecules23020395 · Cited by 25 · see citing works
Takahashi, N., Nielsen, K. S., Aleksić, B., Petersen, S., Ikeda, M., Kushima, I., Vacaresse, N., Ujike, H., Iwata, N., Dubreuil, V., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.016 · Cited by 24 · see citing works
Self-citationYu, Q.-S., Feng, W.-Q., Shi, L., Niu, R., & Liu, J. (2022) · Brain Sciences · doi:10.3390/brainsci12081022 · Cited by 23 · see citing works
Sharif, A., & Prévot, V. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.05.012 · Cited by 22 · see citing works
Zhang, N., Zhong, P., Shin, S. M., Metallo, J., Danielson, E., Olsen, C. M., Liu, Q.-S., & Lee, S. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3658-14.2015 · Cited by 21 · see citing works
A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer
Kotelevets, L., & Chastre, E. (2021) · Cancers · doi:10.3390/cancers13174264 · Cited by 21 · see citing works
Unearthing of Key Genes Driving the Pathogenesis of Alzheimer’s Disease via Bioinformatics
Zhao, X., Yao, H., & Li, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.641100 · Cited by 20 · see citing works
Protein Tyrosine Phosphatase Receptor Zeta 1 as a Potential Target in Cancer Therapy and Diagnosis
Papadimitriou, Ε., & Kanellopoulou, V. Κ. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098093 · Cited by 18 · see citing works
Takebayashi, H., Yamamoto, N., Umino, A., & Nishikawa, T. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009997 · Cited by 17 · see citing works
Chen, X., Feng, L., Cai, B., Chen, X., & Chen, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.043 · Cited by 17 · see citing works
Wang, D., Fu, D., Wu, X., Shapiro, A., Favis, R., Savitz, A. J., Chung, H., Alphs, L. D., Gopal, S., Haas, M., et al. (2015) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000122 · Cited by 16 · see citing works
Jin, K., Lv, Z., Pang, X., Zhu, C., Liu, R., Wei, Y., & Pang, C.-Y. (2024) · Aging advances. · doi:10.4103/agingadvances.agingadv-d-24-00004 · Cited by 15 · see citing works
Piluso, G., Monteleone, P., Galderisi, S., Giugliano, T., Bertolino, A., Rocca, P., Rossi, A., Mucci, A., Aguglia, E., Andriola, I., et al. (2019) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1395072 · Cited by 12 · see citing works
The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders
Palmisano, A., Pandit, S., Smeralda, C. L., Demchenko, I., Rossi, S., Battelli, L., Rivolta, D., Bhat, V., & Santarnecchi, E. (2024) · Life · doi:10.3390/life14050578 · Cited by 16 · see citing works
Yukawa, T., Iwakura, Y., Takei, N., Saito, M., Watanabe, Y., Toyooka, K., Igarashi, M., Niizato, K., Oshima, K., Kunii, Y., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.10.062 · Cited by 12 · see citing works
Role of TARP interaction in S-SCAM-mediated regulation of AMPA receptors
Danielson, E., Metallo, J., & Lee, S. H. (2012) · Channels · doi:10.4161/chan.21301 · Cited by 12 · see citing works
Paron, F., Barattucci, S., Cappelli, S., Romano, M., Berlingieri, C., Stuani, C., Laurents, D. V., Mompeán, M., & Buratti, E. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102252 · Cited by 11 · see citing works
Xing, J., Wang, C., Kimura, H., Takasaki, Y., Kunimoto, S., Yoshimi, A., Nakamura, Y., Koide, T., Banno, M., Kushima, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112531 · Cited by 10 · see citing works
MAGI-1 acts as a scaffolding molecule for NGF receptor-mediated signaling pathway.
Ito, H., Morishita, R., Iwamoto, I., Mizuno, M., & Nagata, K.-I. (2013) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2013.06.005 · Cited by 12 · see citing works
Obray, J. D., Denton, A. R., Carroll-Deaton, J., Marquardt, K., Chandler, L. J., & Scofield, M. D. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.12.006 · Cited by 8 · see citing works
Douet, V., Chang, L., Lee, K., & Ernst, T. M. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9363-y · Cited by 7 · see citing works
Ito, Y., Yamada, S., Takahashi, N., Saito, S., Yoshimi, A., Inada, T., Noda, Y., & Ozaki, N. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30692 · Cited by 7 · see citing works
Chondroitin Sulphate Proteoglycan Axonal Coats in the Human Mediodorsal Thalamic Nucleus
Pantazopoulos, H., Hossain, N. M., Chelini, G., Durning, P. T., Barbas, H., Zikopoulos, B., & Berretta, S. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.934764 · Cited by 5 · see citing works
Ciobanu, A. M., Geza, L., David, I. G., Popa, D. E., Buleandră, M., Ciucu, A. A., & Dehelean, L. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10320 · Cited by 4 · see citing works
Hendriks, W. J. A. J., van Cruchten, R. T. P., & Pulido, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1051311 · Cited by 4 · see citing works
Astrocyte-Derived PTPRZ1 Regulates Excitatory Synapse Density in the Mouse Cortex
Eaker, A. R., Spence-Osorio, H. E., Coble, M. G., Dogan, B. C., & Baldwin, K. T. (2026) · eNeuro · doi:10.1523/eneuro.0386-25.2026 · Cited by 7 · see citing works
S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner
Kearney, G., Grau, D., Torres, D. N., Shin, S. M., & Lee, S. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-08220-1 · Cited by 3 · see citing works
Astrocyte-derived PTPRZ1 regulates astrocyte morphology and excitatory synaptogenesisPreprint
Eaker, A. R., Spence-Osorio, H. E., & Baldwin, K. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651514 · Cited by 3 · see citing works
Su, Y., Bousman, C., Liu, Q., Lv, X., Li, J., Lin, J., Yu, X., Tian, L., & Si, T. (2021) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000437 · Cited by 2 · see citing works
Phosphatase Signaling as a Therapeutic Strategy in Schizophrenia
Molony, L. E., & Tautz, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062822 · Cited by 1 · see citing works
Bahadori, Z., Behmanesh, M., Sahraeian, & Heidari, M. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Scaffolding functions of MAGI-2 in the PTEN mediated attenuation of the PI3K/Akt signalling pathway
Poland, S. F. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Conditional activation of NRG1 signaling in the brain modulates cortical circuitry
Unterbarnscheidt, T. (2015) · doi:10.53846/goediss-5394
Bahadori, Z., Behmanesh, M., Sahraian, M. A., & Heidari, M. (2010)
Modelling schizophrenia endophenotypes by overexpression of Neuregulin-1 isoforms in transgenic mice
Soto‐Bernardini, M. C. (2017) · doi:10.53846/goediss-6480
Khan, M. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
The potential role of collagens in congenital Zika syndrome: A systems biology approachPreprint
Aguiar, R. S., Pohl, F. B., de Morais, G. L., Nogueira, F. C. S., de Carvalho, J. B., Guida, L. D. C., Arge, L. W., Melo, A., Moreira, M. E., Cunha, D. P., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/541268
Xu, X., Kodaka, M., Iwasa, H., & Hata, Y. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101774-1
Xu, X., Kodaka, M., Iwasa, H., & Hata, Y. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101774
Weller, A. E., Ferraro, T. N., Doyle, G. A. R., Reiner, B. C., Berrettini, W. H., & Crist, R. C. (2024) · Genes & Genomics · doi:10.1007/s13258-024-01545-3
Vastrad, B. M., Pattanashetti, S., & Vastrad, C. M. (2025) · Research Square · doi:10.21203/rs.3.rs-8284834/v1
- Authors
- Buxbaum, J. D., Georgieva, L., Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., Moskvina, V, Norton, N., Peirce, T., Williams, H., Craddock, N. J., Carroll, L., Corfas, G., Davis, K. L., Owen, M. J., Harroch, S., Sakurai, T., & O'Donovan, M. C.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Cardiff University (GB)
- Harvard University (US)
- Institut Pasteur (FR)
- Corresponding author
- Buxbaum, J D
- Venue
- Molecular Psychiatry
- Published
- 2007-04-17
- Volume
- 13
- Issue
- 2
- Pages
- 162-172
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC5567789
- OpenAlex
- W2025845611
- Cited by
- 86
- References
- 81
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 3 · 2013: 7 · 2012: 5
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute of Mental Health (P50MH066392, MH063392)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- schizophrenia, PTPRZ1, RPTPβ/ζ, ErbB4, neuregulin signaling, protein-protein interaction, tyrosine phosphorylation, genetic susceptibility, single nucleotide polymorphisms, genetic association
- MeSH terms
- Female, Glioma, Humans, Male, Models, Molecular, Nerve Tissue Proteins, Schizophrenia, Transfection, Tyrosine, Signal Transduction, Chi-Square Distribution, Case-Control Studies, Protein Tyrosine Phosphatases, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Neuregulin-1, Cell Line, Tumor, Immunoprecipitation, Receptor-Like Protein Tyrosine Phosphatases, Class 5, ErbB Receptors, Receptor, ErbB-4
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