A review of diffusion tensor imaging studies in schizophrenia
Open accessAbstract
Both post-mortem and neuroimaging studies have contributed significantly to what we know about the brain and schizophrenia. MRI studies of volumetric reduction in several brain regions in schizophrenia have confirmed early speculations that the brain is disordered in schizophrenia. There is also a growing body of evidence suggesting that a disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, are responsible for the clinical symptoms and cognitive dysfunctions observed in this disorder. Thus an interest in white matter fiber tracts, subserving anatomical connections between distant, as well as proximal, brain regions, is emerging. This interest coincides with the recent advent of diffusion tensor imaging (DTI), which makes it possible to evaluate the organization and coherence of white matter fiber tracts. This is an important advance as conventional MRI techniques are insensitive to fiber tract direction and organization, and have not consistently demonstrated white matter abnormalities. DTI may, therefore, provide important new information about neural circuitry, and it is increasingly being used in neuroimaging studies of psychopathological disorders. Of note, in the past five years 18 DTI studies in schizophrenia have been published, most describing white matter abnormalities. Questions still remain, however, regarding what we are measuring that is abnormal in this disease, and how measures obtained using one method correspond to those obtained using other methods? Below we review the basic principles involved in MR-DTI, followed by a review of the different methods used to evaluate diffusion. Finally, we review MR-DTI findings in schizophrenia.
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Patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.
“After more than 2 decades of neuroimaging research, it is now well established that patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [21]
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- Authors
- Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- McCarley, Robert
- Shenton, Martha E.
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 41
- Issue
- 1-2
- Pages
- 15-30
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC2768134
- OpenAlex
- W2137231705
- Cited by
- 769
- References
- 77
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 14 · 2023: 13 · 2022: 22 · 2021: 20 · 2020: 36 · 2019: 35 · 2018: 33 · 2017: 44 · 2016: 43 · 2015: 55 · 2014: 46 · 2013: 52 · 2012: 56
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (R01 MH 50747, K02 MH 01110, R01 NS 39335, R01 MH 40799, R03 MH068464-01, P41 RR13218)
- U.S. Department of Veterans Affairs
- National Center for Research Resources
- Korea Science and Engineering Foundation
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- schizophrenia, diffusion tensor imaging, white matter abnormalities, white matter tracts, brain connectivity, neural circuits, diffusion measurement methods, cognitive impairment
- MeSH terms
- Brain, Humans, Nerve Fibers, Nerve Net, Schizophrenia, Anisotropy, Diffusion Magnetic Resonance Imaging
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