The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
Abstract
Striatal dopamine D2 receptors have been implicated in the neurobiology of cocaine addiction. Previous imaging studies showed reduced striatal D2 receptor availability in chronic cocaine abusers, and animal studies suggested that low D2 receptor availability promotes cocaine self-administration. Here, D2 receptor availability was assessed with positron emission tomography (PET) and [11C]raclopride in the limbic, associative, and sensori-motor subdivisions of the striatum in 17 recently detoxified chronic cocaine-dependent (CCD) subjects and 17 matched healthy control (HC) subjects. In addition, the relationship between regional D2 receptor availability and behavioral measures obtained in cocaine self-administration sessions was investigated in CCD subjects. [11C]Raclopride binding potential was significantly reduced by 15.2% in the limbic striatum, 15.0% in the associative striatum, and 17.1% in the sensori-motor striatum in CCD subjects compared to HC subjects. In CCD subjects, no relationship was detected between D2 availability in striatal regions and either the positive effects of smoked cocaine or the choice of cocaine over an alternative reinforcer (money) following a priming dose of cocaine (a laboratory model of relapse). Thus, this study confirms previous reports of a modest decrease in D2 receptor availability in CCD subjects, and establishes that this decrease is generalized throughout the striatum. However, this study failed to demonstrate a relationship between D2 receptor availability and cocaine-induced cocaine-taking behavior. Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are multiple lines of evidence that cocaine dependence is associated with a decrease in D2 receptor binding [164-167], a pattern that seems to persist after disease remission [165].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [164]
In the citing paper
“The first report was in 1990, where a study showed that cocaine abuse was associated with a decrease in D2 receptor availability in the striatum compared to controls (Volkow et al, 1990), and has been followed by a series of studies confirming this observation”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Martinez et al., 2004
Citations
Cites
A theory for multiresolution signal decomposition: the wavelet representation
Mallat, S. (1989) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/34.192463 · Cited by 21,463
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Rapid Automated Algorithm for Aligning and Reslicing PET Images
Woods, R. P., Cherry, S. R., & Mazziotta, J. C. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199207000-00024 · Cited by 1,901
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
MRI-PET Registration with Automated Algorithm
Woods, R. P., Mazziotta, J. C., & Cherry, A. S. R. (1993) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199307000-00004 · Cited by 1,636
Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020
Self-citationVolkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
Flagged first, then by citations
Research works printed but not linked: 4
- Beck A, Steer R, Brown G (1996). BDIII Beck Depression Inventory Manual, 2nd ed. Harcourt Brace & Company: San Antonio, TX.
- First M, Spitzer R, Gibbon M, Williams J (1995). Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I/P, Version 2.0). Biometrics Research Dept., New York State Psychiatric Institute: New York.
- First MB, Spitzer RL, Gibbon M, Williams JBW, Benjamin L (1994). Structured Clinical Interview for DSM-IV Axis II personality disorders (SCID-II, Version 2.0). Biometrics Research Department, New York State Psychiatric Department: New York.
- Lemarie PG (1988). Ondelettes with exponential localization. J Math Pure Appl 67: 227–236.
Cited by
Sorted by citations
Items 301–306 of 306
Cocaïne et crack : essor inquiétant et enjeu de santé publique
Vaivre‐Douret, L. (2026) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2026.06.006
Wu, C., Lin, Y., Huang, J., Ding, B., Terse, P., Nandre, R. M., Jin, H., Congdon, M., Shen, K., Sanderson, P. E. J., et al. (2026) · Medicinal Research Reviews · doi:10.1002/med.70101
Padilla-Velarde, E., Molina-Martínez, L. M., & Juárez, J. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174277
Neurocognitive risk and protective factors in addictive disorders
Smith, D. G. (2014) · Apollo (University of Cambridge) · doi:10.17863/cam.16469
Executive Dysfunction and Reward Dysregulation: Interactions in Drug Addiction
Morie, K. P. (2014) · CUNY Academic Works (City University of New York)
Metadata
- Authors
- Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., Fischman, M. W., & Laruelle, M.
- Affiliations
- Columbia University (US)
- Venue
- Neuropsychopharmacology
- Published
- 2004-03-10
- Volume
- 29
- Issue
- 6
- Pages
- 1190-1202
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2088522292
- Cited by
- 306
- References
- 66
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 31 · 2019: 10 · 2018: 8 · 2017: 14 · 2016: 20 · 2015: 7 · 2014: 21 · 2013: 25 · 2012: 31
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Update notices
- erratum (2004-08-23)
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da010219-06)
- National Institute on Drug Abuse (2-R01-DA10219-01, PA50 DA 09236-06, K08 DA00483-01, P50DA009236, 09236)
- National Center for Research Resources (M01RR000645, M01 RR00645)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine dependence, dopamine D2 receptor, striatum, [11C]raclopride, limbic striatum, associative striatum, sensorimotor striatum, cocaine self-administration, cocaine-seeking behavior, relapse, addiction vulnerability
- MeSH terms
- Adult, Binding Sites, Brain Mapping, Choice Behavior, Cocaine, Corpus Striatum, Dose-Response Relationship, Drug, Female, Humans, Male, Self Administration, Time Factors, Tomography, Emission-Computed, Case-Control Studies, Receptors, Dopamine D2, Dopamine Antagonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Raclopride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
