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Cited by 306Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior

Martinez, Diana, Broft, Allegra, Foltin, Richard W, Slifstein, Mark, Hwang, Dah-Ren, Huang, Yiyun, Perez, Audrey, Frankel, W Gordon, Cooper, Thomas, Kleber, Herbert D, Fischman, Marian W, Laruelle, Marc·2004·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300420
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Abstract

Striatal dopamine D2 receptors have been implicated in the neurobiology of cocaine addiction. Previous imaging studies showed reduced striatal D2 receptor availability in chronic cocaine abusers, and animal studies suggested that low D2 receptor availability promotes cocaine self-administration. Here, D2 receptor availability was assessed with positron emission tomography (PET) and [11C]raclopride in the limbic, associative, and sensori-motor subdivisions of the striatum in 17 recently detoxified chronic cocaine-dependent (CCD) subjects and 17 matched healthy control (HC) subjects. In addition, the relationship between regional D2 receptor availability and behavioral measures obtained in cocaine self-administration sessions was investigated in CCD subjects. [11C]Raclopride binding potential was significantly reduced by 15.2% in the limbic striatum, 15.0% in the associative striatum, and 17.1% in the sensori-motor striatum in CCD subjects compared to HC subjects. In CCD subjects, no relationship was detected between D2 availability in striatal regions and either the positive effects of smoked cocaine or the choice of cocaine over an alternative reinforcer (money) following a priming dose of cocaine (a laboratory model of relapse). Thus, this study confirms previous reports of a modest decrease in D2 receptor availability in CCD subjects, and establishes that this decrease is generalized throughout the striatum. However, this study failed to demonstrate a relationship between D2 receptor availability and cocaine-induced cocaine-taking behavior. Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects.

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Crossref · 10.1038/sj.npp.1300420

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Metadata

Authors
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., Fischman, M. W., & Laruelle, M.
Affiliations
Columbia University (US)
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2004-03-10
Volume
29
Issue
6
Pages
1190-1202
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300420
OpenAlex
W2088522292
Cited by
306
References
66
Citations by year
2026: 6 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 31 · 2019: 10 · 2018: 8 · 2017: 14 · 2016: 20 · 2015: 7 · 2014: 21 · 2013: 25 · 2012: 31
FWCI
3.75
Type
journal article
Language
en
Update notices
erratum (2004-08-23)
Open access
closed
Licence
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da010219-06)
  • National Institute on Drug Abuse (2-R01-DA10219-01, PA50 DA 09236-06, K08 DA00483-01, P50DA009236, 09236)
  • National Center for Research Resources (M01RR000645, M01 RR00645)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cocaine dependence, dopamine D2 receptor, striatum, [11C]raclopride, limbic striatum, associative striatum, sensorimotor striatum, cocaine self-administration, cocaine-seeking behavior, relapse, addiction vulnerability
MeSH terms
Adult, Binding Sites, Brain Mapping, Choice Behavior, Cocaine, Corpus Striatum, Dose-Response Relationship, Drug, Female, Humans, Male, Self Administration, Time Factors, Tomography, Emission-Computed, Case-Control Studies, Receptors, Dopamine D2, Dopamine Antagonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Raclopride

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