Cited by 302Alzheimer's disease research and treatmentsMemory and Neural MechanismsOlfactory and Sensory Function Studies

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Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, Christian, Hallschmid, Manfred, Schmitz, Katrin, Schultes, Bernd, Ratter, Frank, Fehm, Horst L, Born, Jan, Kern, Werner·2007·Neuropsychopharmacology

DOI 10.1038/sj.npp.1301193

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Abstract

There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans. Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40 IU) and long-term (4 x 40 IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a between-subject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I. This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

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Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
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Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671
Untitled work
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Self-citation
Structure and function of declarative and nondeclarative memory systems
Squire, L. R., & Zola, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13515 · Cited by 1,327
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
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Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958
Transport of drugs from the nasal cavity to the central nervous system
Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907
Interference and forgetting.
Underwood, B. J. (1957) · Psychological Review · doi:10.1037/h0044616 · Cited by 853
Insulin and neurodegenerative disease: shared and specific mechanisms
Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830

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Talebian, A., Zare, P., Barfei, M., Darbi, S. Z. M., Bagheri, A. M., & Ranjbar, M. (2025) · The Neuroscience Journal of Shefaye Khatam · doi:10.61186/shefa.13.2.69 · Cited by 1
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Nabi, S. U., Rasool, I., Khan, A., Haq, A. U., Hussain, I., Khan, M. S., Majid, S., Rashid, S., Rashid, S. M., Sehar, N., et al. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-025-01781-w · Cited by 1
The Role of Insulin Resistance in Age-Related Cognitive Decline and Dementia
Watson, G. S., & Craft, S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-850-8_18 · Cited by 1
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Kamei, N., & Takeda‐Morishita, M. (2013) · Drug Delivery System · doi:10.2745/dds.28.287 · Cited by 1
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Self-citation
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Current awareness in human psychopharmacology
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Ott, V., Machleidt, F., & Jan Born, A. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_41
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Pei, Z., Lee, K.-C., Khan, A., & Wang, H.-Y. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079814122010014
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Sandusky, L. A. (2014) · doi:10.54014/ad6f-r6vs
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Antony, S., Agarwal, A., & Joseph, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-40559-4.00009-x
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Martin, H. (2021) · theses.fr (ABES) · doi:10.70675/63526938z3197z4632za668z0b62aa1e8cb8
Repurposing antidiabetics for Alzheimer’s disease and related neurodegenerative disorders: Translational challenges and role of nanoparticle-mediated CNS targeting
Alnsour, L., Al-Samydai, A. M., Sadek, B. S., & Akour, A. A. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119614
Cognitive-enhancing drugs in Phase II clinical trials for Alzheimer’s disease: emerging therapeutic candidates
Manzine, P. R., Carrasco, M., Fernandes, T. A. A., Alves, S. S., Guzman, L., Driouech, L., Millet, M., Cairasco, N. G., Olloquequi, J., Juan, M. E., et al. (2026) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2026.2710112
Metabolic and Neurophysiological Foundations of Cognitive Activity in Adolescents: The Role of Glucose Homeostasis during a Critical Period of Brain Maturation
Kruchinina, O. V., Shpakov, A. O., & Galperina, E. I. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040046
Effects of antipsychotics on brain insulin action in females: Study protocol for a placebo-controlled, crossover neuroimaging study
Stogios, N., Hahn, M. K., Remington, G. J., Graff‐Guerrero, A., Lai, M., & Agarwal, S. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0352262

Authors: Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W.
Affiliations: University of Lübeck (DE)
Kantonsspital St. Gallen (CH)
Novo Nordisk (Germany) (DE)
Corresponding author: Benedict, Christian
ORCID: Benedict, Christian
Hallschmid, Manfred
Schultes, Bernd
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-08-16
Volume: 32
Issue: 1
Pages: 239-243
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1301193
OpenAlex: W2156600347
Cited by: 302
References: 43
Citations by year: 2026: 11 · 2025: 16 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 14
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB654)
Novo Nordisk
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: intranasal insulin, insulin aspart, regular insulin, declarative memory, memory enhancement, insulin analogues, word list recall, Alzheimer's disease, cognitive impairment treatment
MeSH terms: Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Blood Glucose, Double-Blind Method, Drug Administration Schedule, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Neuropsychological Tests, Insulin Aspart

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Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

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