Cited by 302Alzheimer's disease research and treatmentsMemory and Neural MechanismsOlfactory and Sensory Function Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, Christian, Hallschmid, Manfred, Schmitz, Katrin, Schultes, Bernd, Ratter, Frank, Fehm, Horst L, Born, Jan, Kern, Werner·2007·Neuropsychopharmacology

DOI 10.1038/sj.npp.1301193

Open this paper in CoChat — free account

Abstract

There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans. Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40 IU) and long-term (4 x 40 IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a between-subject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I. This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1301193

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
The Neurobiology of Consolidations, Or, How Stable is the Engram?
Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671
Untitled work
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Self-citation
Structure and function of declarative and nondeclarative memory systems
Squire, L. R., & Zola, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13515 · Cited by 1,327
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958
Transport of drugs from the nasal cavity to the central nervous system
Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907
Interference and forgetting.
Underwood, B. J. (1957) · Psychological Review · doi:10.1037/h0044616 · Cited by 853
Insulin and neurodegenerative disease: shared and specific mechanisms
Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830

Flagged first, then by citations

Show all 43 references

Sorted by citations

Items 101–200 of 301

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice
Yu, Y., Li, X., Blanchard, J., Li, Y., Iqbal, K., Liu, F., & Gong, C. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1294-z · Cited by 60
A Single-Dose Pilot Trial of Intranasal Rapid-Acting Insulin in Apolipoprotein E4 Carriers with Mild–Moderate Alzheimer’s Disease
Rosenbloom, M. H., Barclay, T. R., Pyle, M., Owens, B. L., Cagan, A., Anderson, C. P., Frey, W. H., & Hanson, L. R. (2014) · CNS Drugs · doi:10.1007/s40263-014-0214-y · Cited by 58
Antidiabetic Drugs in Alzheimer’s Disease and Mild Cognitive Impairment: A Systematic Review
Muñoz-Jiménez, M., Zaarkti, A., García-Arnés, J. A., & García‐Casares, N. (2020) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000510677 · Cited by 55
Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium
Shpakov, A. O., Zorina, I. I., & Derkach, K. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043278 · Cited by 59
Antidiabetic Drugs in Alzheimer’s Disease: Mechanisms of Action and Future Perspectives
Femminella, G. D., Bencivenga, L., Petraglia, L., Visaggi, L., Gioia, L., Grieco, F. V., de Lucia, C., Komici, K., Corbi, G., Edison, P., et al. (2017) · Journal of Diabetes Research · doi:10.1155/2017/7420796 · Cited by 57
Hyperinsulinemia, insulin resistance and cognitive decline in older cohort.
Zhong, Y., Miao, Y., Jia, W., Yan, H., Wang, B. Y., & Jin, J. (2012) · PubMed · doi:10.3967/0895-3988.2012.01.002 · Cited by 55
Alternatives routes of insulin delivery
Lassmann-Vague, V., & Raccah, D. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(06)72804-x · Cited by 55
Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits
Fadel, J. R., & Reagan, L. P. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.12.004 · Cited by 58
Intranasal breast milk for premature infants with severe intraventricular hemorrhage—an observation
Keller, T., Körber, F., Oberthuer, A., Schafmeyer, L., Mehler, K., Kuhr, K., & Kribs, A. (2018) · European Journal of Pediatrics · doi:10.1007/s00431-018-3279-7 · Cited by 56
Targeting Insulin Resistance to Treat Cognitive Dysfunction
Tyagi, A., & Pugazhenthi, S. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02283-3 · Cited by 59
Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres
Gavini, E., Rassu, G., Ferraro, L., Generosi, A., Rau, J. V., Brunetti, A., Giunchedi, P., & Dalpiaz, A. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22382 · Cited by 54
Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells
Nampoothiri, M., Reddy, N. D., John, J., Kumar, N., Nampurath, G. K., & Chamallamudi, M. R. (2014) · Behavioural Neurology · doi:10.1155/2014/674164 · Cited by 53
Intranasally delivered TGF-β1 enters brain and regulates gene expressions of its receptors in rats
Ma, Y., Ma, M., Song, G., Guo, R., Zhang, H., Frey, W. H., Xu, G., & Liu, X. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.06.021 · Cited by 50
A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer’s Disease
Rosenbloom, M. H., Barclay, T. R., Kashyap, B., Hage, L. M., O'Keefe, L. R., Svitak, A. L., Pyle, M., Frey, W. H., & Hanson, L. R. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00845-7 · Cited by 49
Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
Chen, Y., Run, X., Liang, Z., Zhao, Y., Dai, C., Iqbal, K., Liu, F., & Gong, C. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00100 · Cited by 48
Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer’s Disease and Diabetes
Stanciu, G. D., Rusu, R. N., Bild, V., Filipiuc, L. E., Tamba, B.-I., & Ababei, D. C. (2021) · Biomedicines · doi:10.3390/biomedicines9050576 · Cited by 47
Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets
Correa, D., Scheuber, M. I., Shan, H., Weinmann, O., Baumgartner, Y. A., Harten, A., Wahl, A.-S., Skaar, K., & Schwab, M. E. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200057120 · Cited by 51
Mechanisms of Risk Reduction in the Clinical Practice of Alzheimer’s Disease Prevention
Schelke, M. W., Attia, P., Palenchar, D. J., Kaplan, B., Mureb, M., Ganzer, C. A., Scheyer, O., Rahman, A., Kachko, R., Krikorian, R., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00096 · Cited by 52
Airborne inflammatory factors from the nose to the brain
Tonelli, L. H. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s52 · Cited by 47
Hippocampal calcium dysregulation at the nexus of diabetes and brain aging
Thibault, O., Anderson, K. L., DeMoll, C., Brewer, L. D., Landfield, P. W., & Porter, N. M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.024 · Cited by 46
Alzheimer's disease: Is this a brain specific diabetic condition?
Rani, V., Deshmukh, R. R., Jaswal, P., Kumar, P., & Bariwal, J. B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.041 · Cited by 46
Hypoglycemia During Sleep Impairs Consolidation of Declarative Memory in Type 1 Diabetic and Healthy Humans
Jauch‐Chara, K., Hallschmid, M., Gais, S., Schmid, S. M., Oltmanns, K. M., Colmorgen, C., Jan Born, A., & Schultes, B. (2007) · Diabetes Care · doi:10.2337/dc07-0067 · Cited by 46
Self-citation
Stimulating the sleeping brain: Current approaches to modulating memory-related sleep physiology
Cellini, N., & Mednick, S. C. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.11.011 · Cited by 45
Intranasal delivery: circumventing the iron curtain to treat neurological disorders
Jiang, Y., Li, Y., & Liu, X. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1065812 · Cited by 44
Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress‐reactive Wistar Kyoto rats
McCoy, C. R., Rana, S., Stringfellow, S. A., Day, J. J., Wyss, J. M., Clinton, S. M., & Kerman, I. A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13404 · Cited by 46
Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
Martín‐Segura, A., Ahmed, T., Casadomé‐Perales, Á., Palomares-Pérez, I., Palomer, E., Kerstens, A., Munck, S., Balschun, D., & Dotti, C. G. (2019) · Aging Cell · doi:10.1111/acel.12932 · Cited by 42
Intranasal treatment of neurodegenerative diseases and stroke
Gómez, D. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/252 · Cited by 43
Crosstalk between insulin and dopamine signaling: A basis for the metabolic effects of antipsychotic drugs
Nash, A. I. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.07.010 · Cited by 43
A review of brain insulin signaling in mood disorders: From biomarker to clinical target
Nguyen, T. T. L., Chan, L. C., Borreggine, K. L., Kale, R. P., Hu, C., & Tye, S. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.014 · Cited by 40
The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain
Soeda, Y., Tsuneki, H., Muranaka, H., Mori, N., Hosoh, S., Ichihara, Y., Kagawa, S., Wang, X., Toyooka, N., Takamura, Y., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0163 · Cited by 38
Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet
Xu, J., Ni, B., Ma, C., Rong, S., Gao, H. Y., Zhang, L., Xia, X., Huang, Q., Deng, Q., & Huang, F. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.04.015 · Cited by 39
Drug Delivery Systems for Diabetes Treatment
Zarić, B. L., Obradovic, M. M., Sudar-Milovanovic, E. M., Nedeljković, J. M., Lazic, V., & Isenović, E. R. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190306153838 · Cited by 38
Thyroid hormone’s role in regulating brain glucose metabolism and potentially modulating hippocampal cognitive processes
Jahagirdar, V., & McNay, E. C. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9291-0 · Cited by 37
Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes
Chen, Y., Dai, C., Wu, Z., Iqbal, K., Liu, F., Zhang, B., & Gong, C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00136 · Cited by 37
Intranasal insulin and orexins to treat age-related cognitive decline
Erichsen, J. M., Calva, C. B., Reagan, L. P., & Fadel, J. R. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113370 · Cited by 38
Fatigue and cognitive symptoms in patients with diabetes: Relationship with disease phenotype and insulin treatment
Lasselin, J., Layé, S., Barreau, J.-B., Rivet, A., Dulucq, M.-J., Gin, H., & Capuron, L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.016 · Cited by 37
Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
Feld, G. B., Wilhem, I., Benedict, C., Rüdel, B., Klameth, C., Born, J., & Hallschmid, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.312 · Cited by 36
Self-citation
Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?
Ladel, S., Flamm, J., Zadeh, A. S., Filzwieser, D., Walter, J.-C., Schlossbauer, P., Kinscherf, R., Lischka, K., Luksch, H., & Schindowski, K. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030107 · Cited by 36
Changes in the levels of 12/15-lipoxygenase, apoptosis-related proteins and inflammatory factors in the cortex of diabetic rats and the neuroprotection of baicalein
Li, Y., Chen, Q., Ran, D., Wang, H., Du, W., Luo, Y., Jiang, W., Yang, Y., & Yang, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.019 · Cited by 35
Outcomes and clinical implications of intranasal insulin administration to the central nervous system
Santiago, J. C. P., & Hallschmid, M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.007 · Cited by 37
Self-citation
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35
Self-citation
Brain insulin resistance as a mechanistic mediator links peripheral metabolic disorders with declining cognition
Ahmad, R. M. A. H., Ababneh, N. A., & Al-Domi, H. A. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102468 · Cited by 34
Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes
Shpakov, A. O., Chistyakova, O. V., Derkach, K. V., Moyseyuk, I. V., & Бондарева, В. М. (2011) · Open Life Sciences · doi:10.2478/s11535-011-0089-6 · Cited by 34
Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia
Ott, V., Lehnert, H., Staub, J., Wönne, K., Jan Born, A., & Hallschmid, M. (2014) · Diabetes · doi:10.2337/db14-0931 · Cited by 36
Self-citation
Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism
Anderson, K. L., Frazier, H. N., Maimaiti, S., Bakshi, V., Majeed, Z. R., Brewer, L. D., Porter, N. M., Lin, A., & Thibault, O. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw065 · Cited by 34
Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice
Bell, G. A., & Fadool, D. A. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.044 · Cited by 34
The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid)
Shingaki, T., Hidalgo, I. J., Furubayashi, T., Katsumi, H., Sakane, T., Yamamoto, A., & Yamashita, S. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.05.009 · Cited by 34
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice
Li, X., Run, X., Wei, Z. C., Zeng, K., Liang, Z., Huang, F., Ke, D., Wang, Q., Wang, J., Liu, R., et al. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666181031145045 · Cited by 33
Repositioning of Anti-Diabetic Drugs against Dementia: Insight from Molecular Perspectives to Clinical Trials
Mantik, K. E. K., Kim, S., Gu, B., Moon, S., Kwak, H., Park, D., & Kang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411450 · Cited by 36
The effect of glucose administration on the recollection and familiarity components of recognition memory
Sünram‐Lea, S. I., Dewhurst, S. A., & Foster, J. K. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.006 · Cited by 33
Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases
Plascencia‐Villa, G., & Perry, G. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512486 · Cited by 33
Intranasal delivery of growth differentiation factor 5 to the central nervous system
Hanson, L. R., Fine, J. M., Hoekman, J., Nguyen, T. M., Burns, R. B., Martinez, P. M., Pohl, J., & Frey, W. H. (2012) · Drug Delivery · doi:10.3109/10717544.2012.657720 · Cited by 32
Meloxicam Improves Cognitive Impairment of Diabetic Rats through COX2-PGE2-EPs-cAMP/pPKA Pathway
Li, H., Luo, Y., Xu, Y. D., Lü, Y., Hu, C., Chen, Q., Yang, Y., Ma, J., Zhang, J., Xia, H., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00532 · Cited by 32
Insulin Transport into the Brain and Cerebrospinal Fluid
Begg, D. P. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.007 · Cited by 31
Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway
El-Safty, H., Ismail, A., Abdelsalam, R. M., El-Sahar, A. E., & Saad, M. A. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.01.017 · Cited by 30
Central nervous system insulin signaling can influence the rate of insulin influx into brain
Nguyễn, V. H., Thomas, P., Pemberton, S., Babin, A., Noonan, C., Weaver, R. R., Banks, W. A., & Rhea, E. M. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00431-6 · Cited by 30
Mechanisms of action of brain insulin against neurodegenerative diseases
Ramalingam, M., & Kim, S. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1147-1 · Cited by 30
Nose-to-brain transport of melatonin from polymer gel suspensions: a microdialysis study in rats
Babu, R. J., Dayal, P., Pawar, K. R., & Singh, M. S. (2011) · Journal of drug targeting · doi:10.3109/1061186x.2011.558090 · Cited by 29
Toward a Model of Memory Enhancement in Schizophrenia: Glucose Administration and Hippocampal Function
Stone, W. S., & Seidman, L. J. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm041 · Cited by 28
Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men
Ritze, Y., Kern, W., Ebner, E.-M., Jahn, S., Benedict, C., & Hallschmid, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00663 · Cited by 28
Self-citation
Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs
Goodarzi, G., Tehrani, S. S., Fana, S. E., Moradi‐Sardareh, H., Panahi, G., Maniati, M., & Meshkani, R. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01225-3 · Cited by 29
Memory advancement by intranasal insulin in type 2 diabetes (MemAID) randomized controlled clinical trial: Design, methods and rationale
Mendez, B. G., Trevino, J. A., McGlinchey, R. E., Fortier, C. B., Lioutas, V., Novák, P., Mantzoros, C. S., Ngo, L. H., & Novak, V. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.105934 · Cited by 29
Insulin to treat Alzheimer’s disease: just follow your nose?
Schiöth, H. B., Frey, W. H., Brooks, S. J., & Benedict, C. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.70 · Cited by 26
Self-citation
Nutritional Controls of Food Reward
Fernandes, M. F., Sharma, S., Hryhorczuk, C., Auguste, S., & Fulton, S. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.04.004 · Cited by 27
Nasal Delivery of P-gp Substrates to the Brain through the Nose–Brain Pathway
Shingaki, T., Hidalgo, I. J., Furubayashi, T., Sakane, T., Katsumi, H., Yamamoto, A., & Yamashita, S. (2011) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.dmpk-10-rg-108 · Cited by 27
Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: Dynamic responses to depolarization and sensitivity to pioglitazone
Pancani, T., Anderson, K. L., Porter, N. M., & Thibault, O. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.09.002 · Cited by 25
Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration
Soleimanizadeh, A., Dinter, H., & Schindowski, K. (2021) · Antibodies · doi:10.3390/antib10040047 · Cited by 26
Reprint of: ‘Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes’
McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.11.001 · Cited by 26
Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron
Xourgia, E., Papazafiropoulou, A. K., & Melidonis, A. J. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i3.169 · Cited by 24
Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice
Dai, C., Li, H., Hu, X. Y., Zhang, J., Liu, F., Iqbal, K., & Gong, C. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00223-y · Cited by 24
Emerging Evidence for the Use of Antidiabetic Drugs, Glucagon-like Peptide 1 Receptor Agonists, for the Treatment of Alzheimer’s Disease
Colin, I. M., Szczepanski, L. W., Gérard, A.-C., & Elosegi, J. A. (2023) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2023.19.1.16 · Cited by 25
Effects of intranasal insulin as an enhancer of fear extinction: a randomized, double-blind, placebo-controlled experimental study
de Sá, D. S. F., Römer, S., Brueckner, A. H., Issler, T. C., Hauck, A., & Michael, T. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0593-3 · Cited by 24
Prediabetes and working memory in older adults
Ennis, G. E., Saelzler, U. G., Umpierrez, G. E., & Moffat, S. D. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820961725 · Cited by 23
Brain insulin responsiveness is linked to age and peripheral insulin sensitivity
Wagner, L., Veit, R., Kübler, C., Fritsche, A., Häring, H., Birkenfeld, A. L., Heni, M., Preissl, H., & Kullmann, S. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15094 · Cited by 22
Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer’s Disease
Ahlawat, A., Walia, V., & Garg, M. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-024-02706-7 · Cited by 26
Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor inC. elegansmodel of Parkinson’s disease
Haque, R., Shamsuzzama, S., Kumar, L., Sharma, T., Fatima, S., Jadiya, P., Siddiqi, M. I., & Nazir, A. (2020) · Oncotarget · doi:10.18632/oncotarget.27366 · Cited by 23
Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administration
Hallschmid, M., Benedict, C., Jan Born, A., & Kern, W. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.4.319 · Cited by 22
Self-citation
Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice
Wang, Z., Xiong, L., Wan, W., Duan, L., Bai, X., & Zu, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00032 · Cited by 22
Emerging role of Metformin in Alzheimer’s disease: A translational view
Ríos, J. A., Bórquez, J. C., Godoy, J. A., Zolezzi, J. M., Furrianca, M. C., & Inestrosa, N. C. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102439 · Cited by 21
Changes in insulin-signaling transduction pathway underlie learning/memory deficits in an Alzheimer’s disease rat model
Han, X., Ma, Y., Liu, X., Wang, L., Qi, S., Zhang, Q., & Du, Y. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0803-1 · Cited by 20
FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review
Fieux, M., Quellec, S. L., Bartier, S., Coste, A., Louis, B., Giroudon, C., Nourredine, M., & Béquignon, É. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126475 · Cited by 20
Insulin, Insulin-Like Growth Factors??and Incretins
McIntyre, R. S., Vagic, D., Swartz, S. A., Soczynska, J. K., Woldeyohannes, H. O., Voruganti, L. P., & Konarski, J. Z. (2008) · CNS Drugs · doi:10.2165/00023210-200822060-00001 · Cited by 20
A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function
Jaggi, A., Conole, E. L. S., Raisi‐Estabragh, Z., Gkontra, P., McCracken, C., Szabó, L. E., Neubauer, S., Petersen, S. E., Cox, S. R., & Lekadir, K. (2023) · Imaging Neuroscience · doi:10.1162/imag_a_00063 · Cited by 19
Role of simvastatin and insulin in memory protection in a rat model of diabetes mellitus and dementia
Fahim, V. F., Wadie, W., Shafik, A. N., & Attallah, M. I. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.012 · Cited by 19
The Rationale for Insulin Therapy in Alzheimer’s Disease
Ribarič, S. (2016) · Molecules · doi:10.3390/molecules21060689 · Cited by 20
Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
Woodfield, A., Gonzales, T., Helmerhorst, E., Laws, S. M., Newsholme, P., Porter, T., & Verdile, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415811 · Cited by 19
Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats
Frazier, H. N., Ghoweri, A. O., Sudkamp, E., Johnson, E. S., Anderson, K. L., Fox, G. A., Vatthanaphone, K., Xia, M., Lin, R., Hargis-Staggs, K. E., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz105 · Cited by 18
Inhibitory Activity of Insulin on Aβ Aggregation Is Restricted Due to Binding Selectivity and Specificity to Polymorphic Aβ States
Baram, M., & Miller, Y. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00645 · Cited by 18
Reestablishment of the nasal permeability barrier to several peptides following exposure to the absorption enhancer tetradecyl-β-D-maltoside
Arnold, J. J., Fyrberg, M. D., Meezan, E., & Pillion, D. J. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21977 · Cited by 17
Intranasal Insulin Increases Synaptic Protein Expression and Prevents Anesthesia-Induced Cognitive Deficits Through mTOR-eEF2 Pathway
Yu, Q., Dai, C., Zhang, Y., Chen, Y., Wu, Z., Iqbal, K., Liu, F., & Gong, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190280 · Cited by 17
Insulin Inhibits Aβ42 Aggregation and Prevents Aβ42-Induced Membrane Disruption
Long, K., Williams, T., & Urbanc, B. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00696 · Cited by 17
Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels
Plomgaard, P., Hansen, J. S., Ingerslev, B., Clemmesen, J. O., Secher, N. H., van Hall, G., Fritsche, A., Weigert, C., Lehmann, R., Häring, H., et al. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13615 · Cited by 16
Extending Arms of Insulin Resistance from Diabetes to Alzheimer’s Disease: Identification of Potential Therapeutic Targets
Gupta, S. N., Singhal, N. K., Ganesh, S., & Sandhir, R. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666181114163515 · Cited by 16
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy
Peng, S., Yang, J., Wang, Y., Yang, F., Tang, F., Hou, C., Yu, J., Wang, X., & Jiang, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146474 · Cited by 16
Nasal absorption of mixtures of fast-acting and long-acting insulins
Pillion, D. J., Fyrberg, M. D., & Meezan, E. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.013 · Cited by 15
The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline
Bang, E., Lee, B., Park, J.-O., Jang, Y., Kim, A., Kim, S., & Shin, H. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.1.45 · Cited by 15
Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome
Rosenbloom, M. H., Barclay, T. R., Johnsen, J., Erickson, L. O., Svitak, A. L., Pyle, M., Frey, W. H., & Hanson, L. R. (2020) · Drugs in R&D · doi:10.1007/s40268-020-00296-2 · Cited by 15
Placebo controlled phase II clinical trial: Safety and efficacy of combining intranasal insulin & acute exercise
Gwizdala, K. L., Ferguson, D. P., Kovan, J. R., Novak, V., & Pontifex, M. B. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00727-2 · Cited by 16
Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1
Roque, P. S., Hooshmandi, M., Neagu-Lund, L., Yin, S., Yousefpour, N., Sato, H., Sato, T., Nakadate, Y., Kawakami, A., Tahmasebi, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94849-3 · Cited by 15
Diabetes and the Nervous System
Zochodne, D. W., & Toth, C. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407710-2.00019-9 · Cited by 15

Authors: Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W.
Affiliations: University of Lübeck (DE)
Kantonsspital St. Gallen (CH)
Novo Nordisk (Germany) (DE)
Corresponding author: Benedict, Christian
ORCID: Benedict, Christian
Hallschmid, Manfred
Schultes, Bernd
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-08-16
Volume: 32
Issue: 1
Pages: 239-243
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1301193
OpenAlex: W2156600347
Cited by: 302
References: 43
Citations by year: 2026: 11 · 2025: 16 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 14
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB654)
Novo Nordisk
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: intranasal insulin, insulin aspart, regular insulin, declarative memory, memory enhancement, insulin analogues, word list recall, Alzheimer's disease, cognitive impairment treatment
MeSH terms: Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Blood Glucose, Double-Blind Method, Drug Administration Schedule, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Neuropsychological Tests, Insulin Aspart

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks