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Cited by 302Alzheimer's disease research and treatmentsMemory and Neural MechanismsOlfactory and Sensory Function Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, Christian, Hallschmid, Manfred, Schmitz, Katrin, Schultes, Bernd, Ratter, Frank, Fehm, Horst L, Born, Jan, Kern, Werner·2007·Neuropsychopharmacology
DOI 10.1038/sj.npp.1301193
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Abstract

There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans. Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40 IU) and long-term (4 x 40 IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a between-subject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I. This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

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Metadata

Authors
Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W.
Affiliations
  • University of Lübeck (DE)
  • Kantonsspital St. Gallen (CH)
  • Novo Nordisk (Germany) (DE)
Corresponding author
Benedict, Christian
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2006-08-16
Volume
32
Issue
1
Pages
239-243
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1301193
OpenAlex
W2156600347
Cited by
302
References
43
Citations by year
2026: 11 · 2025: 16 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 14
FWCI
7.73
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB654)
  • Novo Nordisk
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
intranasal insulin, insulin aspart, regular insulin, declarative memory, memory enhancement, insulin analogues, word list recall, Alzheimer's disease, cognitive impairment treatment
MeSH terms
Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Blood Glucose, Double-Blind Method, Drug Administration Schedule, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Neuropsychological Tests, Insulin Aspart

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