Cited by 302Alzheimer's disease research and treatmentsMemory and Neural MechanismsOlfactory and Sensory Function Studies

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Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, Christian, Hallschmid, Manfred, Schmitz, Katrin, Schultes, Bernd, Ratter, Frank, Fehm, Horst L, Born, Jan, Kern, Werner·2007·Neuropsychopharmacology

DOI 10.1038/sj.npp.1301193

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Abstract

There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans. Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40 IU) and long-term (4 x 40 IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a between-subject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I. This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

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Self-citation

Authors: Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W.
Affiliations: University of Lübeck (DE)
Kantonsspital St. Gallen (CH)
Novo Nordisk (Germany) (DE)
Corresponding author: Benedict, Christian
ORCID: Benedict, Christian
Hallschmid, Manfred
Schultes, Bernd
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-08-16
Volume: 32
Issue: 1
Pages: 239-243
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1301193
OpenAlex: W2156600347
Cited by: 302
References: 43
Citations by year: 2026: 11 · 2025: 16 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 14
FWCI: 7.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB654)
Novo Nordisk
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: intranasal insulin, insulin aspart, regular insulin, declarative memory, memory enhancement, insulin analogues, word list recall, Alzheimer's disease, cognitive impairment treatment
MeSH terms: Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Blood Glucose, Double-Blind Method, Drug Administration Schedule, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Neuropsychological Tests, Insulin Aspart

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Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

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