The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
p53 represses ribosomal gene transcription
Abstract
Induction of the tumor suppressor protein p53 restricts cellular proliferation. Since actively growing cells require the ongoing synthesis of ribosomal RNA to sustain cellular biosynthesis, we studied the effect of p53 on ribosomal gene transcription by RNA polymerase I (Pol I). We have measured rDNA transcriptional activity in different cell lines which either lack or overexpress p53 and demonstrate that wild-type but not mutant p53 inhibits cellular pre-rRNA synthesis. Conversely, pre-rRNA levels are elevated both in cells which express mutant p53 and in fibroblasts from p53 knock-out mice. Transient transfection assays with a set of rDNA deletion mutants demonstrate that intergenic spacer sequences are dispensable and the minimal rDNA promoter is sufficient for p53-mediated repression of Pol I transcription. However, in a cell-free transcription system, recombinant p53 does not inhibit rDNA transcription, indicating that p53 does not directly interfere with the basal Pol I transcriptional machinery. Thus, repression of Pol I transcription by p53 may be a consequence of p53-induced growth arrest.
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“Induction of p53 leads to downregulation of rRNA genes212, 213 and of genes that are required for import and export of ribosomal proteins from the nucleus.214”
From Census and evaluation of p53 target genes (2017) · cites this paper as [212]
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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
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Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
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Research works printed but not linked: 2
- Grummt I . 1998 Prog. Nucl. Acid Res. Mol. Biol. in press.
- Paule M . 1994 Transcription: Mechanism and Regulation. Conaway JW (ed). Raven Press: New York pp.83–106.
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Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971
Rubbi, C. P., & Milner, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg579 · Cited by 828
Divorcing ARF and p53: an unsettled case
Sherr, C. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1954 · Cited by 595
The cellular response to p53: the decision between life and death
Sionov, R. V., & Haupt, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203130 · Cited by 608
Transcriptional Regulation by P53
Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569
Metadata
- Authors
- Budde, A., & Grummt, I.
- Affiliations
- German Cancer Research Center (DE)
- ORCID
- Grummt, Ingrid
- Venue
- Oncogene
- Published
- 1999-01-28
- Volume
- 18
- Issue
- 4
- Pages
- 1119-1124
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2076958652
- Cited by
- 157
- References
- 37
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 13 · 2013: 10 · 2012: 7
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- p53, ribosomal DNA transcription, RNA polymerase I, pre-rRNA synthesis, transcriptional repression, tumor suppressor, growth arrest, mutant p53, p53 knockout mice, rDNA promoter, intergenic spacer, cell proliferation
- MeSH terms
- Animals, DNA, Ribosomal, RNA Polymerase I, RNA Precursors, Transcription, Genetic, Tumor Suppressor Protein p53, Mice, Knockout, Mice
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