Cited by 1,201Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

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The role of STATs in transcriptional control and their impact on cellular function

Bromberg, Jacqueline, Darnell, James E·2000·Oncogene

DOI 10.1038/sj.onc.1203476

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Abstract

The STAT proteins (Signal Transducers and Activators of Transcription), were identified in the last decade as transcription factors which were critical in mediating virtually all cytokine driven signaling. These proteins are latent in the cytoplasm and become activated through tyrosine phosphorylation which typically occurs through cytokine receptor associated kinases (JAKs) or growth factor receptor tyrosine kinases. Recently a number of non-receptor tyrosine kinases (for example src and abl) have been found to cause STAT phosphorylation. Phosphorylated STATs form homo- or hetero-dimers, enter the nucleus and working coordinately with other transcriptional co-activators or transcription factors lead to increased transcriptional initiation. In normal cells and in animals, ligand dependent activation of the STATs is a transient process, lasting for several minutes to several hours. In contrast, in many cancerous cell lines and tumors, where growth factor dysregulation is frequently at the heart of cellular transformation, the STAT proteins (in particular Stats 1, 3 and 5) are persistently tyrosine phosphorylated or activated. The importance of STAT activation to growth control in experiments using anti-sense molecules or dominant negative STAT protein encoding constructs performed in cell lines or studies in animals lacking specific STATs strongly indicate that STATs play an important role in controlling cell cycle progression and apoptosis. Stat1 plays an important role in growth arrest, in promoting apoptosis and is implicated as a tumor suppressor; while Stats 3 and 5 are involved in promoting cell cycle progression and cellular transformation and preventing apoptosis. Many questions remain including: (1) a better understanding of how the STAT proteins through association with other factors increase transcription initiation; (2) a more complete definition of the sets of genes which are activated by different STATs and (3) how these sets of activated genes differ as a function of cell type. Finally, in the context of many cancers, where STATs are frequently persistently activated, an understanding of the mechanisms leading to their constitutive activation and defining the potential importance of persistent STAT activation in human tumorigenesis remains. Oncogene (2000).

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Self-citation
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
A Matter of Life and Cell Death
Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,528
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465

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Muromoto, R., Sekine, Y., Imoto, S., Ikeda, O., Okayama, T., Sato, N., & Matsuda, T. (2008) · International Immunology · doi:10.1093/intimm/dxm154 · Cited by 39
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Detjen, K. M., Murphy, D. B., Welzel, M., Farwig, K., Wiedenmann, B. J., & Rosewicz, S. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00011-3 · Cited by 39
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Page, B. D. G., Croucher, D. C., Li, Z., Haftchenary, S., Jimenez-Zepeda, V. H., Atkinson, J. M., Spagnuolo, P. A., Wong, Y. L., Colaguori, R., Lewis, A. M., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3017255 · Cited by 38
Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line
Ashizawa, T., Akiyama, Y., Miyata, H., Iizuka, A., Komiyama, M., Kume, A., Omiya, M., Sugino, T., Asai, A., Hayashi, N., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2439 · Cited by 38
The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?
Joerger, M., Finn, S. P., Cuffe, S. D., Byrne, A. T., & Gray, S. G. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1206891 · Cited by 39
STAT3 plays an important role in DNA replication by turning on WDHD1
Zhou, Y., & Chen, J. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-020-00524-x · Cited by 38
The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts
Zhong, Y., Deng, L., Shi, S., Huang, Q., Ouyang, S., Mo, J., Zhu, K., Qu, X., Liu, P., Wang, Y., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00718-0 · Cited by 38
JAK-STAT signaling pathway in non-infectious uveitis
Su, Y., Tao, T., Liu, X., & Su, W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115236 · Cited by 38
The STAT family: Key transcription factors mediating crosstalk between cancer stem cells and tumor immune microenvironment
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Intracellular signaling cascades following light irradiation
Wu, S., & Xing, D. (2013) · Laser & Photonics Review · doi:10.1002/lpor.201300015 · Cited by 38
Elevated Activity of STAT3C due to Higher DNA Binding Affinity of Phosphotyrosine Dimer Rather than Covalent Dimer Formation
Li, L., & Shaw, P. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606940200 · Cited by 38
Increased STAT1 Signaling in Endocrine-Resistant Breast Cancer
Huang, R., Faratian, D., Sims, A. H., Wilson, D. S., Thomas, J. S. J., Harrison, D. J., & Langdon, S. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094226 · Cited by 38
Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3
Shen, A., Chen, Y., Hong, F., Lin, J., Wei, L., Hong, Z., Sferra, T. J., & Peng, J. (2012) · Oncology Reports · doi:10.3892/or.2012.2067 · Cited by 38
Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
Macias, E., Rao, D., & DiGiovanni, J. (2013) · Journal of Skin Cancer · doi:10.1155/2013/684050 · Cited by 40
Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells
Lemmens, I. H. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng075 · Cited by 38
Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents
Lu, C., Wei, J., Gao, C., Sun, M., Dong, D., & Mu, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113373 · Cited by 37
Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia
Toniolo, P. A., Liu, S., Yeh, J., Ye, D. Q., Barbuto, J. A. M., & Frank, D. A. (2016) · Oncotarget · doi:10.18632/oncotarget.10093 · Cited by 38
Crocin promotes apoptosis of human skin cancer cells by inhibiting the JAK/STAT pathway
Wang, G., Zhang, B., Wang, Y., Han, S., & Wang, C. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6865 · Cited by 37
Retracted
Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells
Behbod, F., Nagy, Z. S., Stepkowski, S. M., Karras, J. G., Johnson, C. R., Jarvis, W. D., & Kirken, R. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.3919 · Cited by 37
STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species
Du, W., Wang, Y., Hong, J., Su, W., Lin, Y., Lu, R., Xiong, H., & Fang, J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22977 · Cited by 37
L-carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemia
Wang, J., Yang, Z.-T., Liu, C., He, Y., & Zhao, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.032 · Cited by 37
Synergistic Action of Prolactin (PRL) and Androgen on PRL-Inducible Protein Gene Expression in Human Breast Cancer Cells: A Unique Model for Functional Cooperation between Signal Transducer and Activator of Transcription-5 and Androgen Receptor
Carsol, J.-L., Gingras, S., & Simard, J. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0875 · Cited by 37
Gene set enrichment analysis and ingenuity pathway analysis of metastatic clear cell renal cell carcinoma cell line
Khan, M. I., Dębski, K. J., Dąbrowski, M., Czarnecka, A. M., & Szczylik, C. A. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00138.2016 · Cited by 38
Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents
Khalafalla, F. G., & Khan, M. W. (2017) · Cancer Growth and Metastasis · doi:10.1177/1179064417709287 · Cited by 37
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex
Rafei, M., Wu, J. H., Annabi, B., Lejeune, L., François, M., & Galipeau, J. (2006) · Blood · doi:10.1182/blood-2006-07-037473 · Cited by 38
Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer.
Huether, A., Höpfner, M., Sutter, A. P., Baradari, V., Schuppan, D., & Scherübl, H. (2006) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v12.i32.5160 · Cited by 37
Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells
Zhang, W., Niu, M., Yan, K., Zhai, X., Zhou, Q., Zhang, L., & Zhou, Y. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.12.019 · Cited by 36
Testicular Lumicrine Factors Regulate ERK, STAT, and NFKB Pathways in the Initial Segment of the Rat Epididymis to Prevent Apoptosis1
Xu, B., Abdel‐Fattah, R., Yang, L., Crenshaw, S. A., Black, M. B., & Hinton, B. T. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.090324 · Cited by 36
Esculetin inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia/reoxygenation injury
He, Y., Li, C., Ma, Q., & Chen, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.195 · Cited by 36
Diagnostic and Therapeutic Applications of Exosomes in Cancer with a Special Focus on Head and Neck Squamous Cell Carcinoma (HNSCC)
Ebnöther, E., & Müller, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124344 · Cited by 37
Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors
Hegde, M., & Joshi, M. B. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03519-4 · Cited by 37

Authors: Bromberg, J., & Darnell, J. E.
Affiliations: Rockefeller University (US)
ORCID: Bromberg, Jacqueline
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2468-2473
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203476
OpenAlex: W1977681992
Cited by: 1,201
References: 66
Citations by year: 2026: 10 · 2025: 22 · 2024: 21 · 2023: 24 · 2022: 37 · 2021: 40 · 2020: 46 · 2019: 41 · 2018: 42 · 2017: 51 · 2016: 46 · 2015: 49 · 2014: 59 · 2013: 67 · 2012: 56
FWCI: 6.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT proteins, transcriptional regulation, cytokine signaling, JAK kinases, tyrosine phosphorylation, STAT1, STAT3, STAT5, cell cycle progression, apoptosis, tumor suppressor, cell transformation, carcinogenesis, transcriptional coactivator
MeSH terms: Animals, Cell Division, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Humans, Milk Proteins, Neoplasms, Structure-Activity Relationship, Transcription, Genetic, Trans-Activators, STAT1 Transcription Factor, STAT3 Transcription Factor, STAT5 Transcription Factor

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The role of STATs in transcriptional control and their impact on cellular function

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