Cited by 1,201Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

The role of STATs in transcriptional control and their impact on cellular function

Bromberg, Jacqueline, Darnell, James E·2000·Oncogene

DOI 10.1038/sj.onc.1203476

Open this paper in CoChat — free account

Abstract

The STAT proteins (Signal Transducers and Activators of Transcription), were identified in the last decade as transcription factors which were critical in mediating virtually all cytokine driven signaling. These proteins are latent in the cytoplasm and become activated through tyrosine phosphorylation which typically occurs through cytokine receptor associated kinases (JAKs) or growth factor receptor tyrosine kinases. Recently a number of non-receptor tyrosine kinases (for example src and abl) have been found to cause STAT phosphorylation. Phosphorylated STATs form homo- or hetero-dimers, enter the nucleus and working coordinately with other transcriptional co-activators or transcription factors lead to increased transcriptional initiation. In normal cells and in animals, ligand dependent activation of the STATs is a transient process, lasting for several minutes to several hours. In contrast, in many cancerous cell lines and tumors, where growth factor dysregulation is frequently at the heart of cellular transformation, the STAT proteins (in particular Stats 1, 3 and 5) are persistently tyrosine phosphorylated or activated. The importance of STAT activation to growth control in experiments using anti-sense molecules or dominant negative STAT protein encoding constructs performed in cell lines or studies in animals lacking specific STATs strongly indicate that STATs play an important role in controlling cell cycle progression and apoptosis. Stat1 plays an important role in growth arrest, in promoting apoptosis and is implicated as a tumor suppressor; while Stats 3 and 5 are involved in promoting cell cycle progression and cellular transformation and preventing apoptosis. Many questions remain including: (1) a better understanding of how the STAT proteins through association with other factors increase transcription initiation; (2) a more complete definition of the sets of genes which are activated by different STATs and (3) how these sets of activated genes differ as a function of cell type. Finally, in the context of many cancers, where STATs are frequently persistently activated, an understanding of the mechanisms leading to their constitutive activation and defining the potential importance of persistent STAT activation in human tumorigenesis remains. Oncogene (2000).

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1203476

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Self-citation
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
A Matter of Life and Cell Death
Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,528
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465

Flagged first, then by citations

Show all 66 references

Sorted by citations

Items 601–700 of 1,000

Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation
Sexl, V., Kovačic, B., Piekorz, R. P., Moriggl, R., Stoiber, D., Hoffmeyer, A., Liebminger, R., Kudlacek, O., Weisz, E., Rothammer, K., et al. (2003) · Blood · doi:10.1182/blood-2001-11-0142 · Cited by 37
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.
Auzenne, E. J., Klostergaard, J., Mandal, P. K., Liao, W. S. ‐., Lü, Z., Gao, F., Bast, R. C., Robertson, F. M., & McMurray, J. S. (2012) · PubMed · Cited by 36
Analysis of intracellular regulatory proteins by immunoaffinity capillary electrophoresis coupled with laser‐induced fluorescence detection
Phillips, T. M., & Smith, P. (2003) · Biomedical Chromatography · doi:10.1002/bmc.240 · Cited by 36
Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
Kang, H. J., Yi, Y. W., Hou, S., Kim, H. J., Kong, Y., Bae, I., & Brown, M. L. (2015) · Oncotarget · doi:10.18632/oncotarget.4054 · Cited by 36
Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
Thyrell, L., Arulampalam, V., Hjortsberg, L., Farnebo, M., Grandér, D., & Tamm, K. P. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.08.007 · Cited by 37
GSTP1 negatively regulates Stat3 activation in epidermal growth factor signaling
Kou, X., Chen, N., Feng, Z., Luo, L., & Yin, Z. (2012) · Oncology Letters · doi:10.3892/ol.2012.1098 · Cited by 36
IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2
Tumang, J. R., Hsia, C. Y., Tian, W., Bromberg, J., & Liou, H. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(02)00513-0 · Cited by 35
Self-citation
Signal Transducer and Activator of Transcription 3 Is Expressed in the Decidualized Mesometrium of Pregnancy and Associates with the Progesterone Receptor Through Protein-Protein Interactions1
Liu, T., & Ogle, T. F. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.1.114 · Cited by 35
hCAF1/CNOT7 regulates interferon signalling by targeting STAT1
Chapat, C., Kolytcheff, C., Romancer, M. L., Auboeuf, D., de la Grange, P., Chettab, K., Sentis, S., & Corbo, L. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.11 · Cited by 35
Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction
Kim, E. O., Kang, S. E., Im, C. R., Lee, J., Ahn, K. S., Yang, W. M., Um, J., Lee, S., & Yun, M. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3441 · Cited by 36
Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E
Karsten, P., Plischke, I., Perrimon, N., & Zeidler, M. P. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.07.006 · Cited by 35
Transcriptional Activation of Signal Transducer and Activator of Transcription (STAT) 3 and STAT5B Partially Mediate Homeobox A1-Stimulated Oncogenic Transformation of the Immortalized Human Mammary Epithelial Cell
Mohankumar, K. M., Perry, J. K., Kannan, N., Kohno, K., Gluckman, P. D., Emerald, B. S., & Lobie, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1320 · Cited by 35
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines
Feys, T., Poppe, B. G., Preter, K. D., Roy, N. V., Verhasselt, B., Paepe, P. D., Paepe, A. D., & Speleman, F. (2007) · Haematologica · doi:10.3324/haematol.11073 · Cited by 35
Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors
Zheng, Y., Wang, J., Meng, L., Pei, X., Zhang, L., An, L., Li, C., & Miao, Y. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112934 · Cited by 35
Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer.
Zhang, Y., Ren, H., Li, J., Xue, R., Liu, H., Zhu, Z., Pan, C.-Y., Lin, Y., Hu, A., Gou, P., et al. (2021) · PubMed Central · Cited by 34
The reactive oxygen species–Src–Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high‐fluence low‐power laser irradiation
Sun, X., Wu, S., & Xing, D. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07884.x · Cited by 34
IFN Regulatory Factor-2 Regulates Macrophage Apoptosis through a STAT1/3- and Caspase-1-Dependent Mechanism
Cuesta, N., Nhu, Q. M., Zudaire, E., Polumuri, S. K., Cuttitta, F. F., & Vogel, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3602 · Cited by 36
Structural basis for the binding of high affinity phosphopeptides to Stat3
McMurray, J. S. (2007) · Biopolymers · doi:10.1002/bip.20901 · Cited by 35
STAT-3 activity in chemically-induced hepatocellular carcinoma
Sánchez, A., Nagy, P., & Thorgeirsson, S. S. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00393-9 · Cited by 34
KPNB1-mediated nuclear import in cancer
Shi, Q., Lin, M., Cheng, X., Zhang, Z., Deng, S., Lang, K., Yang, Z., & Sun, X. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175925 · Cited by 33
STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth
MacPherson, S., Horkoff, M. J., Gravel, C., Hoffmann, T., Zuber, J. A., & Lum, J. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.012 · Cited by 33
Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress
Amano, R., Yamashita, A., Kasai, H., Hori, T., Miyasato, S., Saito, S., Yokoe, H., Takahashi, K., Tanaka, T., Otoguro, T., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.07.018 · Cited by 33
Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
Budi, H. S., Izadi, S., Timoshin, A., Asl, S. H., Beyzai, B., Ghaderpour, A., Alian, F., Eshaghi, F. S., Mousavi, S. M., Rafiee, B., et al. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102373 · Cited by 33
Inhibition of STAT3 acetylation is associated with attenuated renal fibrosis in the obstructed kidney
Ni, J., Shen, Y., Wang, Z., Shao, D., Liu, J., Fu, L., Kong, Y.-L., Zhou, L., Xue, H., Huang, Y., et al. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.42 · Cited by 34
Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivaceus
Park, E., Kang, J.-H., Seo, J. S., Kim, G., Chung, J., & Choi, T. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-31 · Cited by 33
Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm
D’Cruz, O. J., Vassilev, A. O., & Uckun, F. M. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01896-9 · Cited by 33
Gene transcription of fgl2 in endothelial cells is controlled by Ets‐1 and Oct‐1 and requires the presence of both Sp1 and Sp3
Liu, M., Leibowitz, J. L., Clark, D. A., Mendicino, M., Ning, Q., Ding, J. W., D'Abreo, C., Fung, L. S., Marsden, P. A., & Levy, G. A. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03595.x · Cited by 33
Opposing cytokine‐specific effects of all trans‐retinoic acid on the activation and expression of signal transducer and activator of transcription (STAT)‐1 in THP‐1 cells
Chen, Q., Ma, Y., & Ross, A. C. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01485.x · Cited by 34
Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects
Barton, B. E., & Barton, B. E. (2012) · OncoTargets and Therapy · doi:10.2147/ott.s32559 · Cited by 32
The metabolomic signature of hematologic malignancies
Allegra, A., Innao, V., Gerace, D. G., Bianco, O., & Musolino, C. (2016) · Leukemia Research · doi:10.1016/j.leukres.2016.08.002 · Cited by 32
A comprehensive review on anticancer mechanism of bazedoxifene
Zafar, E., Maqbool, M. F., Iqbal, A., Maryam, A., Shakir, H. A., Irfan, M. I., Khan, M. N., Li, Y., & Ma, T. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2150 · Cited by 33
Characterization of Three-Dimensional Trophoblast Spheroids: An Alternative Model to Study the Physiological Properties of the Placental Unit
Stojanovska, V., Arnold, S., Bauer, M., Voss, H., Fest, S., & Zenclussen, A. C. (2022) · Cells · doi:10.3390/cells11182884 · Cited by 32
Preclinical Therapeutic Potential of a Nitrosylating Agent in the Treatment of Ovarian Cancer
Giri, S., Rattan, R., Deshpande, M., Maguire, J. L., Johnson, Z., Graham, R. P., & Shridhar, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097897 · Cited by 32
RhoA/ROCK Activation by Growth Hormone Abrogates p300/Histone Deacetylase 6 Repression of Stat5-mediated Transcription
Ling, L., & Lobie, P. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400601200 · Cited by 32
Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines
Fadlelmola, F. M., Zhou, M., de Leeuw, R. J., Dosanjh, N. S., Harmer, K., Huntsman, D. D., Lam, W. L., & Banerjee, D. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-2 · Cited by 32
Interleukin-1β can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
Park, J., Strock, C. J., Ball, D. W., & Nelkin, B. D. (2004) · Cytokine · doi:10.1016/j.cyto.2004.10.005 · Cited by 32
Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells
Sferra (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.413 · Cited by 32
Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors
Masciocchi, D., Villa, S., Meneghetti, F., Pedretti, A., Barlocco, D., Legnani, L., Toma, L., Kwon, B., Nakano, S., Asai, A., et al. (2012) · MedChemComm · doi:10.1039/c2md20018j · Cited by 32
IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells
Barton, B. E., Murphy, T. F., Adem, P. V., Watson, R. A., Irwin, R. J., & Huang, H. F. S. (2001) · BMC Cancer · doi:10.1186/1471-2407-1-19 · Cited by 32
Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary
Monahan, A., & Starz‐Gaiano, M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.03.022 · Cited by 34
CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response
Zhou, C., Huang, J., Chen, J., Lai, J., Zhu, F., Xu, X., & Wang, D. W. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445663 · Cited by 32
The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line
Akiyama, Y., Nonomura, C., Ashizawa, T., Iizuka, A., Kondou, R., Miyata, H., Sugino, T., Mitsuya, K., Hayashi, N., Nakasu, Y., et al. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.07.005 · Cited by 32
LL1, a novel and highly selective STAT3 inhibitor, displays anti‐colorectal cancer activities in vitro and in vivo
Liu, Z., Wang, H., Guan, L., Lai, C., Yu, W., & Lai, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14863 · Cited by 32
17β-Estradiol-Dependent Activation of Signal Transducer and Activator of Transcription-1 in Human Fetal Osteoblasts Is Dependent on Src Kinase Activity
Kennedy, A. M., Shogren, K. L., Zhang, M., Turner, R. T., Spelsberg, T. C., & Maran, A. (2004) · Endocrinology · doi:10.1210/en.2004-0486 · Cited by 32
Molecular Cloning of ADIR , a Novel Interferon Responsive Gene Encoding a Protein Related to the Torsins
Dron, M., Meritet, J. F., Dandoy‐Dron, F., Meyniel, J.-P., Maury, C., & Tovey, M. G. (2002) · Genomics · doi:10.1006/geno.2002.6709 · Cited by 32
Signalling mechanisms driving homeostatic and inflammatory effects of interleukin-15 on tissue lymphocytes
Skariah, N., James, O. J., & Swamy, M. (2024) · Discovery Immunology · doi:10.1093/discim/kyae002 · Cited by 31
Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer
Jia, J., Zhou, X. J., & Chu, Q. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04983-5 · Cited by 31
Long noncoding RNA PVT1 promotes hepatoblastoma cell proliferation through activating STAT3
Luo, Z., & Cao, P. (2019) · Cancer Management and Research · doi:10.2147/cmar.s213707 · Cited by 31
Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity
Kulesza, D. W., Carré, T., Chouaı̈b, S., & Kaminska, B. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.005 · Cited by 31
Role of interleukin-6 in Barrett’s esophagus pathogenesis
Dvorak, K. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i15.2307 · Cited by 31
Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices
Chan, H. Y., Siu, M. K. Y., Zhang, H. J., Wong, E., Ngan, H., Chan, K. Y. K., & Cheung, A. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03089.x · Cited by 31
Thyrotropin-Mediated Repression of Class II Trans -Activator Expression in Thyroid Cells: Involvement of STAT3 and Suppressor of Cytokine Signaling
Kim, H., Suh, J. M., Hwang, E. S., Kim, D. W., Chung, H. K., Song, J. H., Hwang, J. H., Park, K. C., Ro, H. K., Jo, E., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.616 · Cited by 31
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells
Mahboubi, K., & Pober, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107542200 · Cited by 31
Allosteric communication across STAT3 domains associated with STAT3 function and disease-causing mutation
Namanja, A. T., Wang, J., Buettner, R., Colson, L., & Chen, Y. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.01.003 · Cited by 31
Reconceptualizing Endothelial-to-mesenchymal transition in atherosclerosis: Signaling pathways and prospective targeting strategies
You, N., Liu, G., Yu, M., Chen, W., Fei, X., Sun, T., Han, M., Qin, Z., Wei, Z., & Wang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.12.049 · Cited by 31
Lack of FSH support enhances LIF–STAT3 signaling in granulosa cells of atretic follicles in cattle
Ilha, G. F., Rovani, M. T., Gasperin, B. G., Antoniazzi, A. Q., Gonçalves, P. B. D., Bordignon, V., & Duggavathi, R. (2015) · Reproduction · doi:10.1530/rep-15-0026 · Cited by 30
Neuroprotection by the Kappa-Opioid Receptor Agonist, BRL52537, is Mediated via Up-Regulating Phosphorylated Signal Transducer and Activator of Transcription-3 in Cerebral Ischemia/Reperfusion Injury in Rats
Fang, S., Xu, H., Lu, J.-R., Zhu, Y., & Jiang, H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1139-4 · Cited by 30
A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway
Zhang, Z., Mao, H., Du, X., Zhu, J., Xu, Y., Wang, S., Xu, X., Ji, P., Yu, Y., Cao, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6974 · Cited by 30
A Sesquiterpenoid from Farfarae Flos Induces Apoptosis of MDA-MB-231 Human Breast Cancer Cells through Inhibition of JAK–STAT3 Signaling
Jang, H., Ko, H., Song, K., & Kim, Y. S. (2019) · Biomolecules · doi:10.3390/biom9070278 · Cited by 30
Computational models of the JAK1/2-STAT1 signaling
Gambin, A., Charzyńska, A., Ellert‐Miklaszewska, A., & Rybiński, M. (2013) · JAK-STAT · doi:10.4161/jkst.24672 · Cited by 31
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen‐induced arthritis
Veenbergen, S., Bennink, M. B., de Hooge, A. S. K., Arntz, O. J., Smeets, R. L., van den Berg, W. B., & van de Loo, F. A. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24072 · Cited by 31
A novel approach in the treatment of neuroendocrine gastrointestinal tumors: Additive antiproliferative effects of interferon-γ and meta-iodobenzylguanidine
Höpfner, M., Sutter, A. P., Huether, A., Ahnert‐Hilger, G., & Scherübl, H. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-23 · Cited by 30
Empagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications
Vaziri, Z., Saleki, K., Aram, C., Alijanizadeh, P., Pourahmad, R., Azadmehr, A., & Ziaei, N. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115686 · Cited by 31
IL-32θ downregulates CCL5 expression through its interaction with PKCδ and STAT3
Bak, Y., Kang, J.-W., Kim, M. S., Park, Y. S., Kwon, T., Kim, S., Hong, J. T., & Yoon, D. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.09.015 · Cited by 30
STAT signaling as a marker of SLE disease severity and implications for clinical therapy
Goropevšek, A., Holcar, M., Pahor, A., & Avčin, T. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.08.010 · Cited by 29
Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo
Zhang, X., Liu, P., Zhang, B., Mao, H., Shen, L., & Ma, Y. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1431 · Cited by 29
The role of IL-21 in hematological malignancies
Ma, J., Ma, D., & Ji, C. (2011) · Cytokine · doi:10.1016/j.cyto.2011.07.011 · Cited by 29
Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation
Zhao, W. M., Zhang, T., Qu, B., Wu, X., Zhu, X. C., Meng, F., Gu, Y., Shu, Y., Shen, Y., Sun, Y., et al. (2010) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32833f44fd · Cited by 29
Self-Associating Poly(ethylene oxide)-block-poly(α-carboxyl-ε-caprolactone) Drug Conjugates for the Delivery of STAT3 Inhibitor JSI-124: Potential Application in Cancer Immunotherapy
Garg, S. M., Vakili, M. R., Molavi, O., & Lavasanifar, A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01119 · Cited by 30
Nuclear translocation of insulin receptor substrate‐1 by the insulin receptor in mouse embryo fibroblasts
Wu, A., Sciacca, L., & Baserga, R. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10261 · Cited by 29
Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development
Zhukovskaya, N. V., Fukuzawa, M., Tsujioka, M., Jermyn, K. A., Kawata, T., Abe, T., Zvelebil, M., & Williams, J. G. (2003) · Development · doi:10.1242/dev.00927 · Cited by 29
Inducible nuclear translocation of a STAT protein in Dictyostelium prespore cells: implications for morphogenesis and cell-type regulation
Dormann, D., Abe, T., Weijer, C. J., & Williams, J. G. (2001) · Development · doi:10.1242/dev.128.7.1081 · Cited by 29
Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer
Lango, M. N., Shin, D. M., & Grandis, J. R. (2001) · Current Opinion in Oncology · doi:10.1097/00001622-200105000-00007 · Cited by 29
IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice
Singh, K., Piprode, V., Mhaske, S. T., Barhanpurkar, A. P., & Wani, M. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601528 · Cited by 28
Evidence that DIF-1 and hyper-osmotic stress activate aDictyosteliumSTAT by inhibiting a specific protein tyrosine phosphatase
Araki, T., Langenick, J., Gamper, M., Firtel, R., & Williams, J. G. (2008) · Development · doi:10.1242/dev.009936 · Cited by 28
Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas
Breuck, S. D., Baeyens, L., & Bouwens, L. (2005) · Diabetologia · doi:10.1007/s00125-005-0079-1 · Cited by 28
MAPPIT: a cytokine receptor‐based two‐hybrid method in mammalian cells 1
Tavernier, J. H., Eyckerman, S., Lemmens, I. H., der Heyden, J. V., Vandekerckhove, J. S., & Ostade, X. V. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2745.2002.01520.x · Cited by 28
Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase
Wang, Y.-Z., Ingram, J. L., Walters, D. M., Rice, A. B., Santos, J. H., Houten, B. V., & Bonner, J. C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00399-x · Cited by 28
A Resveratrol Analogue Promotes ERKMAPK–Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells
Chelsky, Z. L., Yue, P., Kondratyuk, T. P., Paladino, D., Pezzuto, J. M., Cushman, M., & Turkson, J. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.099093 · Cited by 28
Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells
Jiang, Q., Li, Q., Chen, H., Shen, A., Cai, Q., Lin, J., & Peng, J. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2692 · Cited by 27
The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
Gujam, F. J. A., McMillan, D. C., & Edwards, J. (2016) · Oncotarget · doi:10.18632/oncotarget.12730 · Cited by 27
Crispenes F and G, cis-Clerodane Furanoditerpenoids from Tinospora crispa, Inhibit STAT3 Dimerization
Noman, M. A. A., Hossain, T., Ahsan, M., Jamshidi, S., Hasan, C. M., & Rahman, K. M. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00377 · Cited by 27
Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer
Chen, Y., Ji, M., Zhang, S., Xue, N., Xu, H., Lin, S., & Chen, X. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1452244 · Cited by 27
SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling
Chen, X., Zheng, Q., Li, W., Lu, Y. Q., Ni, Y., Ma, L., & Fu, Y. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s176533 · Cited by 27
Bayesian identification of candidate transcription factors for the regulation of Aqp2 gene expression
Kikuchi, H., Jung, H. J., Raghuram, V., Leo, K. T., Park, E., Yang, C., Chou, C.-L., Chen, L., & Knepper, M. A. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00204.2021 · Cited by 27
Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles
Misra, S. K., Wang, X., Srivastava, I., Imgruet, M. K., Graff, R. W., Ohoka, A., Kampert, T. L., Gao, H., & Pan, D. (2015) · Chemical Communications · doi:10.1039/c5cc07709e · Cited by 27
Effects of 5-fluorouracil and gemcitabine on a breast cancer cell line (MCF-7) via the JAK/STAT pathway
Uluer, E. T., Aydemir, I., İnan, S., Özbilgin, K., & Vatansever, S. (2011) · Acta Histochemica · doi:10.1016/j.acthis.2011.11.010 · Cited by 27
Influences of Electromagnetic Energy on Bio-Energy Transport through Protein Molecules in Living Systems and Its Experimental Evidence
Pang, X., Chen, S., Wang, X., & Zhong, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081130 · Cited by 27
Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer
Ostadhossein, F., Misra, S. K., Mukherjee, P., Ostadhossein, A., Daza, E., Tiwari, S., Mittal, S., Gryka, M. C., Bhargava, R., & Pan, D. (2016) · Small · doi:10.1002/smll.201601161 · Cited by 27
Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin
Kwon, H., Jeong, K., Hwang, E. M., Park, J., Hong, S.-G., Choi, W.-S., & Pak, Y. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.04.015 · Cited by 29
Cross-talk Between Retinoic Acid and STAT3 Signaling Pathways in Acute Promyelocytic Leukemia
Dong, S., Chen, S., & Tweardy, D. J. (2003) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819031000116670 · Cited by 27
Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells
Chen, J., Xu, L., Wang, X.-C., Qin, H.-Y., & Wang, J. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0922-2 · Cited by 27
Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway
Ji, P., Xu, X., Ma, S., Fan, J., Zhou, Q., Mao, X., & Qiao, C. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00228 · Cited by 27
Downregulation of DPF3 promotes the proliferation and motility of breast cancer cells through activating JAK2/STAT3 signaling
Lin, W., Dai, W., Xu, X., Yu, Q., Zhang, B., Li, J., & Li, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.170 · Cited by 26
WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling
Fu, Y., Zheng, Q., Mao, Y., Jiang, X., Chen, X., Liu, P., Lv, B., Huang, T., Yang, J., Cheng, Y., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01168 · Cited by 26
Exosomes and MicroRNAs in Biomedical Science
Mirzaei, H., Rahimian, N., Mirzaei, H. R., Nahand, J. S., & Hamblin, M. R. (2022) · Synthesis lectures on biomedical engineering · doi:10.2200/s01171ed1v01y202202bme062 · Cited by 27
Immunotherapy as part of a multidisciplinary approach to melanoma treatment
Adam, I. R. (2006) · Frontiers in bioscience · doi:10.2741/1775 · Cited by 26
An RNA biding protein, Y14 interacts with and modulates STAT3 activation
Ohbayashi, N., Taira, N., Kawakami, S., Togi, S., Sato, N., Ikeda, O., Kamitani, S., Muromoto, R., Sekine, Y., & Matsuda, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.073 · Cited by 26
The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction
Khan, A. I., Kapoor, A., Chen, J., Märtin, L., Rogazzo, M., Mercier, T., Decosterd, L. A., Collino, M., & Thiemermann, C. (2017) · Shock · doi:10.1097/shk.0000000000000963 · Cited by 26
STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis
Gao, Y., Basile, J. I., Classon, C., Gavier‐Widén, D., Yoshimura, A., Carow, B., & Rottenberg, M. E. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006809 · Cited by 26

Authors: Bromberg, J., & Darnell, J. E.
Affiliations: Rockefeller University (US)
ORCID: Bromberg, Jacqueline
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2000-05-25
Volume: 19
Issue: 21
Pages: 2468-2473
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203476
OpenAlex: W1977681992
Cited by: 1,201
References: 66
Citations by year: 2026: 10 · 2025: 22 · 2024: 21 · 2023: 24 · 2022: 37 · 2021: 40 · 2020: 46 · 2019: 41 · 2018: 42 · 2017: 51 · 2016: 46 · 2015: 49 · 2014: 59 · 2013: 67 · 2012: 56
FWCI: 6.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT proteins, transcriptional regulation, cytokine signaling, JAK kinases, tyrosine phosphorylation, STAT1, STAT3, STAT5, cell cycle progression, apoptosis, tumor suppressor, cell transformation, carcinogenesis, transcriptional coactivator
MeSH terms: Animals, Cell Division, Cell Transformation, Neoplastic, DNA-Binding Proteins, Gene Expression Regulation, Humans, Milk Proteins, Neoplasms, Structure-Activity Relationship, Transcription, Genetic, Trans-Activators, STAT1 Transcription Factor, STAT3 Transcription Factor, STAT5 Transcription Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of STATs in transcriptional control and their impact on cellular function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks